View source for Talk:Antiphospholipid syndrome

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==Rename article==
The suggestion is made in this article that the anti phospholipid syndrome is caused by auto antibodies directed against negatively charged phospholipids on the cell/platelet surface. However for almost 15 years it is known that most of the antibodies in this syndrome are directed against proteins that bind negatively charged phospholipids such as prothrombin and beta-2-glycoprotein-1. It is the binding of antibodies to coagulation proteins that causes altered coagulation processes not the binding of antibodies against negatively charged phospholipids. 

I suggest to change the article to correct this misunderstanding. Bio2mancer 24 june 2006.

:{{tl|sofixit}} [[User:Jfdwolff|JFW]]&nbsp;|&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 20:58, 4 July 2006 (UTC)

==Sapporo criteria==
We should mention the Sapporo criteria: {{PMID|10403256}} . [[User:Jfdwolff|JFW]]&nbsp;|&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 20:58, 4 July 2006 (UTC)

:And a recent amendment: {{PMID|16420554}} . [[User:Jfdwolff|JFW]]&nbsp;|&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 20:59, 4 July 2006 (UTC)

== Recent review ==

A recent systematic review on the treatment shows how little we actually know about optimal treatment for this: {{PMID|16507806}}. [[User:Jfdwolff|JFW]]&nbsp;|&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 21:01, 4 July 2006 (UTC)

Furthermore, a new study in the New England Journal of Medicine -- Kaandorp SP et al, N Engl J Med 362;17p1586–1596 shows no benefit of aspirin + LMWH over placebo -- in women  with recurrent miscarriage -- and the accompanying editorial states that although inherited thrombophilia is associated with miscarriage, anticoagulants in this indication don't help. We know less than we think!

== Page has massive changes ==

Since 07 NOV 06...actually making this page very inaccurate.  Please revert back to previous revision before 07 NOV 06.  Tried to get the categories back in.  Hopefully I did it right.eyz 00:10, 21 November 2006 (UTC)

== Typo ==

Changed a typo (phosphotidylserine to Phosphatidylserine). [[User:Rage italic|Rage italic]] 15:54, 30 March 2007 (UTC)

== APSFA Page ==

Actaully that page is cited and is HONCode certifed.  Very few sites can say that.  It has a bio. upon request.eyz 17:53, 20 May 2007 (UTC)

== APSCORE ==

APSCORE is no longer functioning due to lack of funding from the CDC and NIH.  Link Removed. eyz

== Nature of antibodies ==

Some antibodies are more aborto/thrombogenic than others {{PMID|17440049}} [[User:Jfdwolff|JFW]]&nbsp;|&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 06:42, 7 August 2007 (UTC)

== Blood! ==

{{DOI|10.1182/blood-2007-12-129627}} - how we diagnose APS. [[User:Jfdwolff|JFW]]&nbsp;|&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 17:29, 1 February 2009 (UTC)

== Source ==

Is ''House MD'' a reliable and authentic source?  <span style="font-size: smaller;" class="autosigned">— Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/93.208.112.205|93.208.112.205]] ([[User talk:93.208.112.205|talk]]) 20:15, 21 September 2011 (UTC)</span><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

:Absolutely not. House MD is entertainment, not a reliable source for anything.[[User:Wzrd1|Wzrd1]] ([[User talk:Wzrd1|talk]]) 17:53, 3 February 2012 (UTC)

== Review ==

[[doi:10.1182/blood-2012-03-378646]] the relevance of anti-β2-glycoprotein I antibodies. [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 20:57, 12 July 2012 (UTC)

:NEJM mechanisms of disease: [[doi:10.1056/NEJMra1112830]] [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 16:09, 14 March 2013 (UTC)

::Historical review in ''Br J Haem'' [[doi:10.1111/bjh.12848]] [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 18:59, 31 March 2014 (UTC)

== Laboratory technique ==

[[doi:10.1111/jth.12537]] ISTH [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 07:17, 25 May 2014 (UTC)

== Sentence ==

Hi. In the section under the subsubhead 2.1, Lupus anticoagulant, we currently begin the second paragraph thus: "Distinguishing a lupus antibody from a specific coagulation factor inhibitor (eg: Factor VIII)." This is not a sentence and does not make sense on its own. I'd fix it if I was sure how to without distorting the intended sense, but I'm not. (I was tempted to weld it into the next sentence but I'm not 100% certain that works - or was it like a yet another subhead perhaps??) Can someone who can see the sense of the whole thing please sort it out? Thanks and best wishes, [[User:DisillusionedBitterAndKnackered|DBaK]] ([[User talk:DisillusionedBitterAndKnackered|talk]]) 11:21, 20 November 2009 (UTC)
:Fixed, though it's likely the whole section (and many others) should be drastically cut back; encyclopedias don't normally, and shouldn't, give specific diagnostic criteria and protocols - especially when these vary from place to place. [[User:Grothmag|Grothmag]] ([[User talk:Grothmag|talk]]) 00:13, 9 February 2016 (UTC)

== Request to create disambiguation(s) ==

I only recently heard of this disease, and had quite a bit of difficulty finding information about it until someone mentioned that it was called by names, including “APLS or APLA in the United States and Hughes Syndrome or Sticky Blood in the UK” (information taken from the [http://www.apsfa.org/ APS Foundation of America]).  Given the disparity of naming for the condition, I would think it appropriate to include it on various disambiguation pages and/or redirects, as appropriate, to make this information easier to locate.

I’m not familiar enough with Wikipedia’s policies to be comfortable introducing such changes myself, but I welcome others to consider those additions.  Much thanks!

jF 11:48, 3 June 2016 (UTC)  <small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/2601:3CA:204:F860:D824:EC9F:804C:D3BF|2601:3CA:204:F860:D824:EC9F:804C:D3BF]] ([[User talk:2601:3CA:204:F860:D824:EC9F:804C:D3BF|talk]]) </small><!-- Template:Unsigned IP --> <!--Autosigned by SineBot-->

== New review ==

[[doi:10.1111/bjh.14632]] [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 19:55, 26 March 2017 (UTC)

:ISTH criteria for laboratory diagnosis: [[doi:10.1111/jth.13976]] [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 21:21, 17 February 2018 (UTC)

::Something about the DOACs for thromboprophylaxis. [[doi:10.1111/jth.14017]] [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 21:23, 12 April 2018 (UTC)

:::NEJM this week [[doi:10.1056/NEJMra1705454]] [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 11:33, 24 May 2018 (UTC)
== "New bloody syndrome" listed at [[Wikipedia:Redirects for discussion|Redirects for discussion]] ==
[[File:Information.svg|30px]]
A discussion is taking place to address the redirect [[:New bloody syndrome]]. The discussion will occur at [[Wikipedia:Redirects for discussion/Log/2020 August 2#New bloody syndrome]] until a consensus is reached, and readers of this page are welcome to contribute to the discussion. <!-- from Template:RFDNote --> [[User:Steel1943|<span style="color: #2F4F4F;">'''''Steel1943'''''</span>]] ([[User talk:Steel1943|talk]]) 20:40, 2 August 2020 (UTC)