View source for 8-amino-7-oxononanoate synthase

{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 8-amino-7-oxononanoate synthase
| EC_number  = 2.3.1.47
| CAS_number = 9075-61-0
| GO_code    = 0008710
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''8-amino-7-oxononanoate synthase''' ({{EC number|2.3.1.47}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:6-carboxyhexanoyl-CoA + L-alanine <math>\rightleftharpoons</math> 8-amino-7-oxononanoate + CoA + CO<sub>2</sub>

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[6-carboxyhexanoyl-CoA]] and [[L-alanine]], whereas its 3 [[product (chemistry)|products]] are [[8-amino-7-oxononanoate]], [[coenzyme A|CoA]], and [[carbon dioxide|CO<sub>2</sub>]].

This enzyme participates in [[biotin metabolism]].  It employs one [[cofactor (biochemistry)|cofactor]], [[pyridoxal phosphate]].

== Nomenclature ==

This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups.  The [[List of enzymes|systematic name]] of this enzyme class is 6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating). Other names in common use include 7-keto-8-aminopelargonic acid synthetase, 7-keto-8-aminopelargonic synthetase, and 8-amino-7-oxopelargonate synthase.

== References ==
{{reflist}}

== Further reading ==
{{refbegin}}
* {{cite journal | vauthors = Eisenberg MA, Star C | title = Synthesis of 7-oxo-8-aminopelargonic acid, a biotin vitamer, in cell-free extracts of Escherichia coli biotin auxotrophs | journal = Journal of Bacteriology | volume = 96 | issue = 4 | pages = 1291–7 | date = October 1968 | doi = 10.1128/JB.96.4.1291-1297.1968 | pmid = 4879561 | pmc = 252447 }}
* {{cite journal | vauthors = Alexeev D, Alexeeva M, Baxter RL, Campopiano DJ, Webster SP, Sawyer L | title = The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme | journal = Journal of Molecular Biology | volume = 284 | issue = 2 | pages = 401–19 | date = November 1998 | pmid = 9813126 | doi = 10.1006/jmbi.1998.2086 }}
* {{cite journal | vauthors = Ploux O, Breyne O, Carillon S, Marquet A | title = Slow-binding and competitive inhibition of 8-amino-7-oxopelargonate synthase, a pyridoxal-5'-phosphate-dependent enzyme involved in biotin biosynthesis, by substrate and intermediate analogs. Kinetic and binding studies | journal = European Journal of Biochemistry | volume = 259 | issue = 1–2 | pages = 63–70 | date = January 1999 | pmid = 9914476 | doi = 10.1046/j.1432-1327.1999.00006.x | doi-access = free }}
* {{cite journal | vauthors = Webster SP, Alexeev D, Campopiano DJ, Watt RM, Alexeeva M, Sawyer L, Baxter RL | title = Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies | journal = Biochemistry | volume = 39 | issue = 3 | pages = 516–28 | date = January 2000 | pmid = 10642176 | doi = 10.1021/bi991620j }}
{{refend}}

{{Acyltransferases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 2.3.1]]
[[Category:Pyridoxal phosphate enzymes]]
[[Category:Enzymes of known structure]]


{{2.3-enzyme-stub}}