View source for Amlodipine/benazepril

{{Short description|Antihypertensive medication}}
{{Use dmy dates|date=February 2024}}
{{Drugbox
| Verifiedfields = changed
| Watchedfields = changed
| verifiedrevid = 415479203
| type = combo
| image = Amlodipine.svg
| alt = 
| image2 = Benazepril.svg
| alt2 = 

<!-- Combo data -->
| component1 = Amlodipine
| class1 = [[Calcium channel blocker]]
| component2 = Benazepril
| class2 = [[ACE inhibitor]]

<!-- Clinical data -->
| tradename = Lotrel
| Drugs.com = {{drugs.com|ppa|amlodipine-and-benazepril}}
| DailyMedID = Amlodipine and benazepril
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_category = 
| routes_of_administration = [[Oral administration|By mouth]]
| ATC_prefix = C09
| ATC_suffix = BB13

<!-- Legal status -->
| legal_AU          = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled -->
| legal_AU_comment  = 
| legal_BR          = <!-- OTC, A1, A2, A3, B1, B2, C1, C2, C3, C4, C5, D1, D2, E, F -->
| legal_BR_comment  = 
| legal_CA          = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_CA_comment  = 
| legal_DE          = <!-- Anlage I, II, III or Unscheduled -->
| legal_DE_comment  = 
| legal_NZ          = <!-- Class A, B, C -->
| legal_NZ_comment  = 
| legal_UK          = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM / Class A, B, C -->
| legal_UK_comment  = 
| legal_US          = Rx-only
| legal_US_comment  = <ref name="Lotrel FDA label">{{cite web | title=Lotrel- amlodipine besylate and benazepril hydrochloride capsule | work = DailyMed | publisher = U.S. National Library of Medicine | url=https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=94ae6054-b7ae-4212-a567-4f803af8f2c7 | access-date=20 June 2021}}</ref>
| legal_EU          = 
| legal_EU_comment  = 
| legal_UN          = <!-- N I, II, III, IV / P I, II, III, IV -->
| legal_UN_comment  = 
| legal_status      = <!-- For countries not listed above -->

<!-- Identifiers -->
| CAS_number_Ref = {{cascite|changed|??}}
| CAS_number = 357437-90-2
| PubChem = 5746247
| DrugBank = 
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4676979
| KEGG = D11069
}}

<!-- Definition and medical uses -->
'''Amlodipine/benazepril''', sold under the brand name '''Lotrel''' among others, is a [[fixed-dose combination]] medication used to treat [[high blood pressure]].<ref name="Lotrel FDA label" /> It is a combination of [[amlodipine]], as the besilate, a [[calcium channel blocker]], and [[benazepril]], an [[angiotensin converting enzyme inhibitor]].<ref name="Lotrel FDA label"/> It may be used if a single agent is not sufficient.<ref name="Lotrel FDA label"/> It is taken [[by mouth]].<ref name="Lotrel FDA label"/>

<!-- Side effects and mechanisms -->
Common side effects include cough, dizziness, and swelling.<ref name="Lotrel FDA label"/> Serious side effects may include [[angioedema]], [[myocardial infarction]], [[high blood potassium]], [[liver problems]], and [[low blood pressure]].<ref name="Lotrel FDA label"/> Use in [[pregnancy]] is not recommended.<ref name="Lotrel FDA label"/> Amlodipine works by [[vasodilation|increasing the size of arteries]] while benazepril works by decreasing [[Renin–angiotensin system|renin-angiotensin-aldosterone system]] activity.<ref name="Lotrel FDA label"/>

<!-- Society and culture -->
The combination was approved for medical use in the United States in 1995.<ref name=MTM2019>{{cite web | author = Cerner Multum |title=Amlodipine and benazepril Uses, Side Effects & Warnings |url=https://www.drugs.com/mtm/amlodipine-and-benazepril.html |website=Drugs.com |access-date=10 March 2019 |language=en}}</ref> It is available as a [[generic medication]].<ref>{{cite book | vauthors = Bope ET, Kellerman RD |title=Conn's Current Therapy 2017 E-Book |date=2016 |publisher=Elsevier Health Sciences |isbn=978-0-323-44335-7 |page=124 |url=https://books.google.com/books?id=UitFDQAAQBAJ&pg=PT158 }}</ref> In 2022, it was the 170th most commonly prescribed medication in the United States, with more than 3{{nbsp}}million prescriptions.<ref>{{cite web | title=The Top 300 of 2022 | url=https://clincalc.com/DrugStats/Top300Drugs.aspx | website=ClinCalc | access-date=30 August 2024 | archive-date=30 August 2024 | archive-url=https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx | url-status=live }}</ref><ref>{{cite web | title = Amlodipine; Benazepril Drug Usage Statistics, United States, 2013 - 2022 | website = ClinCalc | url = https://clincalc.com/DrugStats/Drugs/AmlodipineBenazepril | access-date = 30 August 2024 }}</ref>

==Medical uses==
It is used to treat [[high blood pressure]].<ref name="Lotrel FDA label"/> It is not a first-line treatment.<ref>{{cite journal | vauthors = Faulkner MA, Hilleman DE | title = Amlodipine/benazepril: fixed dose combination therapy for hypertension | journal = Expert Opinion on Pharmacotherapy | volume = 2 | issue = 1 | pages = 165–178 | date = January 2001 | pmid = 11336577 | doi = 10.1517/14656566.2.1.165 | s2cid = 23021242 }}</ref>

== References ==
{{Reflist}}

{{ACE inhibitors}}
{{Calcium channel blockers}}
{{Portal bar|Medicine}}

{{DEFAULTSORT:Amlodipine Benazepril}}
[[Category:Combination antihypertensive drugs]]
[[Category:Drugs developed by Novartis]]
[[Category:Prodrugs]]
[[Category:Wikipedia medicine articles ready to translate]]


{{cardiovascular-drug-stub}}