View source for Cu2+-exporting ATPase

{{Infobox enzyme
| Name       = Cu<sup>2+</sup>-exporting ATPase
| EC_number  = 3.6.3.4
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
'''Cu<sup>2+</sup>-exporting ATPase''' ({{EC number|3.6.3.4}}) is an [[enzyme]] with [[List of enzymes|systematic name]] ''ATP phosphohydrolase (Cu<sup>2+</sup>-exporting)''.<ref>{{cite journal | vauthors = Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J | title = Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase | journal = Nature Genetics | volume = 3 | issue = 1 | pages = 7–13 | date = January 1993 | pmid = 8490659 | doi = 10.1038/ng0193-7 }}</ref><ref>{{cite journal | vauthors = Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC | title = Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions | journal = Human Molecular Genetics | volume = 3 | issue = 9 | pages = 1647–56 | date = September 1994 | pmid = 7833924 | doi = 10.1093/hmg/3.9.1647 }}</ref><ref>{{cite journal | vauthors = Fagan MJ, Saier MH | title = P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees | journal = Journal of Molecular Evolution | volume = 38 | issue = 1 | pages = 57–99 | date = January 1994 | pmid = 8151716 | doi = 10.1007/bf00175496 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: ATP + H<sub>2</sub>O + Cu<sup>2+</sup><sub>in</sub> <math>\rightleftharpoons</math> ADP + [[phosphate]] + Cu<sup>2+</sup><sub>out</sub>

This [[P-type ATPase]] undergoes [[covalent]] [[phosphorylation]] during the transport cycle.

== See also ==
* [[ATP7A]]

== References ==
{{reflist}}

== External links ==
* {{MeshName|Cu2+-exporting+ATPase}}

{{Acid anhydride hydrolases}}
{{Enzymes}}
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[[Category:EC 3.6.3]]