View source for Low-density-lipoprotein receptor kinase

{{infobox enzyme
| Name       = low-density lipoprotein kinase
| EC_number  = 2.7.11.29
| CAS_number = 107445-00-1
| GO_code    = 0050063
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''low-density-lipoprotein receptor kinase''' ({{EC number|2.7.11.29}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + [low-density-lipoprotein receptor]-L-serine <math>\rightleftharpoons</math> ADP + [low-density-lipoprotein receptor]-O-phospho-L-serine

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[[low-density-lipoprotein receptor]-L-serine]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[[low-density-lipoprotein receptor]-O-phospho-L-serine]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring a phosphate group to the sidechain [[oxygen]] atom of [[serine]] or [[threonine]] residues in [[protein]]s ([[protein-serine/threonine kinase]]s). The [[List of enzymes|systematic name]] of this enzyme class is '''ATP:[low-density-lipoprotein receptor]-L-serine O-phosphotransferase'''. Other names in common use include '''ATP:low-density-lipoprotein-L-serine O-phosphotransferase''', '''LDL receptor kinase''', '''[low-density-lipoprotein] kinase''', '''low-density lipoprotein kinase''', '''low-density-lipoprotein receptor kinase (phosphorylating)''', and '''STK7'''.

==References==
{{Reflist}}
* {{cite journal | vauthors = Kishimoto A, Brown MS, Slaughter CA, Goldstein JL | date = 1987 | title = Phosphorylation of serine 833 in cytoplasmic domain of low density lipoprotein receptor by a high molecular weight enzyme resembling casein kinase II | journal = J. Biol. Chem. | volume = 262 | pages = 1344&ndash;51  | pmid = 3100530 | issue = 3 }}
* {{cite journal | vauthors = Kishimoto A, Goldstein JL, Brown MS | date = 1987 | title = Purification of catalytic subunit of low density lipoprotein receptor kinase and identification of heat-stable activator protein | journal = J. Biol. Chem. | volume = 262 | pages = 9367&ndash;73  | pmid = 3597414 | issue = 19 }}

{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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[[Category:EC 2.7.11]]
[[Category:Enzymes of unknown structure]]


{{2.7-enzyme-stub}}