View source for Orthohantavirus

{{short description|Genus of viruses}}
{{Virusbox
| image = Sin Nombre hanta virus TEM PHIL 1136 lores.jpg
| image_alt = Transmission electron micrograph of "Sin Nombre orthohantavirus"
| image_caption = [[Transmission electron micrograph]] of ''[[Sin Nombre orthohantavirus]]''
| taxon = Orthohantavirus
| synonyms = ''Hantavirus''
| synonyms_ref = <ref>{{cite web |title=ICTV Taxonomy all history: ''Orthohantavirus'' |url=https://ictv.global/taxonomy/taxondetails?taxnode_id=20180020 |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=28 January 2019 |language=en }}</ref>
| subdivision_ranks = Species
| subdivision_ref = <ref>{{cite web |title=Virus Taxonomy: 2018b Release |url=https://ictv.global/taxonomy |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=18 March 2019 |language=en |date=March 2019}}</ref>
| subdivision =
}}

'''''Orthohantavirus''''' is a genus of single-stranded, enveloped, [[negative-sense]] [[RNA virus]]es in the family ''[[Hantaviridae]]'' within the order ''[[Bunyavirales]]''.<ref name=ECDC>{{Cite web|url=https://ecdc.europa.eu/en/climate-change/climate-change-europe/rodent-borne-diseases|title=Rodent-borne diseases|website=European Centre for Disease Prevention and Control|date=2 June 2017 |language=en|access-date=2018-06-04}}</ref> Members of this genus may be called '''orthohantaviruses''' or simply '''hantaviruses'''.

Orthohantaviruses typically cause chronic [[subclinical infection|asymptomatic infection]] in [[rodent]]s.<ref name=ECDC /><ref name="SchmaljohnTrends2000">{{cite journal |last1=Meyer |first1=Barbara J |last2=Schmaljohn |first2=Connie S |title=Persistent hantavirus infections: characteristics and mechanisms |journal=Trends in Microbiology |date=February 2000 |volume=8 |issue=2 |pages=61–67 |doi=10.1016/S0966-842X(99)01658-3 |pmid=10664598 |url=http://digitalcommons.unl.edu/cgi/viewcontent.cgi?article=1288&context=usarmyresearch |language=en}}</ref> Humans may become infected with hantaviruses through contact with rodent urine, saliva, or feces. Some strains cause potentially fatal diseases in humans, such as [[hantavirus hemorrhagic fever with renal syndrome]] (HFRS), or [[hantavirus pulmonary syndrome]] (HPS), also known as hantavirus cardiopulmonary syndrome (HCPS),<ref name="publichealth_CA_2015">{{cite report|url=http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/15vol41/dr-rm41-06/ar-02-eng.php|title=Hantavirus pulmonary syndrome in Canada: An overview of clinical features, diagnostics, epidemiology and prevention|last1=Drebot|first1=Jones S.|last2=Grolla|first2=A.|date=4 June 2015|publisher=[[National Microbiology Laboratory]], [[Public Health Agency of Canada]]|location=Winnipeg, MB|volume=41-6|pages=40|last3=Safronetz|first3=D.|last4=Strong|first4=J. E.|author5-link=Gary Kobinger|last5=Kobinger|first5=G.|last6=Lindsay|first6=R. L.|journal=Canada Communicable Disease Report|issn=1481-8531|series=Vector-borne diseases in Canada}}</ref> while others have not been associated with known human disease (e.g. [[Prospect Hill virus]]).<ref name="KrugerKlempaHumanVaccines2011">{{cite journal |last1=Krüger |first1=Detlev H. |last2=Schönrich |first2=Günther |last3=Klempa |first3=Boris |title=Human pathogenic hantaviruses and prevention of infection |journal=Human Vaccines |date=June 2011 |volume=7 |issue=6 |pages=685–693 |doi=10.4161/hv.7.6.15197|pmid=21508676 |pmc=3219076 }}</ref> HPS (HCPS) is a "rare respiratory illness associated with the inhalation of aerosolized rodent excreta (urine and feces) contaminated by hantavirus particles".<ref name="publichealth_CA_2015" />

Human infections of hantaviruses have almost entirely been linked to human contact with rodent excrement; however, in 2005 and 2019, human-to-human transmission of the [[Andes virus]] was reported in South America.<ref name="WatsonCriticalRev2014">{{cite journal |last1=Watson |first1=Dionysios Christos |last2=Sargianou |first2=Maria |last3=Papa |first3=Anna |last4=Chra |first4=Paraskevi |last5=Starakis |first5=Ioannis |last6=Panos |first6=George |title=Epidemiology of Hantavirus infections in humans: A comprehensive, global overview |journal=[[Critical Reviews in Microbiology]] |date=August 2014 |volume=40 |issue=3 |pages=261–272 |doi=10.3109/1040841X.2013.783555 |pmid=23607444|s2cid=42311842 }}</ref>

Orthohantaviruses are named for the Greek word ''ortho''- meaning "straight" or "true" and for the [[Hantan River]] in [[South Korea]], where the first member species ([[Hantaan virus]]) was identified and isolated in 1976 by [[Ho Wang Lee]].<ref>{{cite journal |last1=Mir |first1=Mohammed |title=Hantaviruses |journal=Clinics in Laboratory Medicine |date=March 2010 |volume=30 |issue=1 |pages=67–91 |doi=10.1016/j.cll.2010.01.004 |pmc=2880890 |pmid=20513542 |issn=0272-2712}}</ref><ref name="ICTV9">{{cite web |title=ICTV 9th Report (2011) – Negative Sense RNA Viruses – Bunyaviridae |url=https://ictv.global/report/chapter/peribunyaviridae |website=International Committee on Taxonomy of Viruses (ICTV) |access-date=31 January 2019 |language=en |quote=Hanta: from Hantaan, river in South Korea near where type virus was isolated.}}</ref>
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== Signs and symptoms ==
{{Infobox medical condition (new)
| name            = Hantavirus
| synonyms        = Orthohantavirus
| image           = Sigmodon hispidus1.jpg
| caption         = The cotton rat, ''[[Sigmodon hispidus]]'', is a hantavirus carrier that becomes a threat when it enters human habitation in rural and suburban areas.
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| field           = [[Infectious disease (medical specialty)|Infectious disease]]
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Overall, three syndromes are caused by hantaviruses: 

(1) Haemorrhagic fever with renal syndrome (HFRS), mainly in Europe and Asia; 

(2) Nephropathia epidemica (NE), a mild form of HFRS, caused by Puumala hantavirus, and occurring in Europe; 

(3) Hantavirus cardiopulmonary syndrome (HCPS), in the Americas.<ref name=":1">{{Cite web |date=2017-06-19 |title=Facts about hantavirus |url=https://www.ecdc.europa.eu/en/hantavirus-infection/facts |access-date=2024-09-21 |website=www.ecdc.europa.eu |language=en}}</ref>

'''[[Hantavirus hemorrhagic fever with renal syndrome|Hemorrhagic fever with renal syndrome (HFRS)]]''' is another hantavirus-related illness, primarily found in Europe and Asia. However, the '''[[Seoul orthohantavirus|Seoul virus]]''', which causes HFRS, has a global distribution, including the United States.

In the Western Hemisphere, including the United States, hantaviruses can cause [[Hantavirus pulmonary syndrome|'''hantavirus pulmonary syndrome (HPS)''']]. The deer mouse is a common carrier of the hantavirus that leads to HPS in the U.S. <ref name=":2">{{Cite web |last=CDC |date=2024-06-04 |title=About Hantavirus |url=https://www.cdc.gov/hantavirus/about/index.html |access-date=2024-09-21 |website=Hantavirus |language=en-us}}</ref>

In the Americas, hantaviruses can cause Hantavirus cardiopulmonary syndrome (HCPS). HCPS is a lung infection caused by viruses found in the saliva, urine, and droppings of some rodents. The illness is rare but can be deadly.<ref name=":3">{{Cite web |title=What is Hantavirus Cardiopulmonary Syndrome? Symptoms and treatments {{!}} CommonSpirit Health |url=https://www.commonspirit.org/conditions-treatments/hantavirus-cardiopulmonary-syndrome |access-date=2024-09-21 |website=CommonSpirit |language=en-US}}</ref>

Hantavirus infections in humans caused by Old World and New World hantaviruses, respectively. A common feature of the two diseases is increased vascular permeability, which causes [[hypotension]], [[thrombocytopenia]], and [[leukocytosis]]. The pulmonary illness is the more fatal of the two, whereas the hemorrhagic fever is much more common. Treatment for both is primarily supportive as there is no specific treatment for hantavirus infections.<ref name="avsic">{{cite journal|vauthors=Avšič-Županc T, Saksida A, Korva M|date=2019|title=Hantavirus infections.|journal=Clin Microbiol Infect|volume=21S|pages=e6–e16|doi=10.1111/1469-0691.12291|pmid=24750436|doi-access=free}}</ref> While many hantaviruses cause either of the two diseases, some are not known to cause illness, such as the ''[[Prospect Hill orthohantavirus]]''.<ref name="gravinatti">{{cite journal|vauthors=Gravinatti ML, Barbosa CM, Soares RM, Gregori F|date=2020|title=Synanthropic rodents as virus reservoirs and transmitters.|journal=Rev Soc Bras Med Trop|volume=53|page=e20190486|doi=10.1590/0037-8682-0486-2019|pmc=7083353|pmid=32049206}}</ref>

=== Hemorrhagic fever with renal syndrome (HFRS) ===
{{main|Hantavirus hemorrhagic fever with renal syndrome}}The severity of the disease varies depending on the virus causing the infection. Hantaan and Dobrava virus infections usually cause severe symptoms where 5-15% of cases are fatal. In contrast, Seoul, Saaremaa, and Puumala virus infections are usually more moderate with less than 1% dying from the disease. Complete recovery can take several weeks to months.<ref name=":2" />

HFRS is caused chiefly by hantaviruses in Asia and Europe. Clinical presentation varies from subclinical to fatal, depending on the virus. After an [[incubation period]] of 2–4 weeks, the typical illness starts with non-specific symptoms such as high fever, chills, headache, backache, abdominal pains, nausea, and vomiting. After the initial period, bleeding under the skin begins, often paired with low blood pressure, followed by further internal bleeding throughout the body. [[Kidney failure|Renal dysfunction]] leading to further health issues begins thereafter, which may cause death.<ref name="avsic" /> A more mild form of HFRS that occurs in Europe is called "nephropathia epidemica" (NE).<ref name="jiang">{{cite journal|vauthors=Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X|date=2017|title=Hantavirus infection: a global zoonotic challenge.|journal=Virol Sin|volume=32|issue=1|pages=32–43|doi=10.1007/s12250-016-3899-x|pmc=6598904|pmid=28120221}}</ref> [[Trench nephritis]] during World War I is now thought to have been HFRS.{{citation needed|date=June 2022}}

=== Hantavirus pulmonary syndrome (HPS) ===
{{main|Hantavirus pulmonary syndrome}}
=== Hantavirus cardiopulmonary syndrome (HCPS) ===
Hantavirus cardiopulmonary syndrome (HCPS) is a potentially fatal respiratory illness caused by a virus found in the saliva, urine, and droppings of some rodents. People can become infected with the virus by breathing contaminated dust, touching an infected rodent or rodent urine or droppings, or being bitten by an infected rodent.

Fever, fatigue, and muscle aches develop about 2 to 3 weeks after being exposed to the virus. A few days later, coughing and shortness of breath become severe as fluid builds up in the lungs (pulmonary edema). HCPS is diagnosed with laboratory tests.

Early treatment for HCPS is important for survival. Treatment includes supportive care for breathing and prevention of shock. HCPS can be prevented by avoiding contact with rodents and their droppings.

Symptoms usually start 2 to 3 weeks after a person has been exposed to the virus. Early symptoms may include:

* A fever and chills.
* Muscle aches and headache.
* Fatigue.
* Nausea, vomiting, diarrhea, and belly pain.

The patient can quickly become very sick. Within a few days, more serious symptoms may appear, such as:

* Shortness of breath.
* Coughing.
* A fast heartbeat and fast breathing. These are signs of fluid build-up in the lungs (pulmonary edema).

HCPS is a serious lung problem that can be deadly.<ref name=":3" />

=== Transmission ===
Hantaviruses are a global health concern, capable of causing severe illness in humans. These viruses are transmitted primarily through contact with rodents, such as rats and mice. Exposure to their urine, droppings, or saliva can increase the risk of infection. While less common, bites or scratches from infected rodents can also lead to transmission.<ref name=":2" /> The manner of transmission is the same for both diseases caused by hantaviruses. Among the HCPS-causing hantaviruses is the ''[[Andes orthohantavirus]]'', which is the only hantavirus confirmed to be capable of spreading from person to person, though this is rare.<ref name=avsic /><ref name=gravinatti />

=== Diagnosis ===
Detecting hantavirus infection within the first 72 hours can be challenging. Initial tests may be negative if the virus hasn't reached detectable levels. Repeat testing is often recommended after 72 hours of symptom onset. Early symptoms like fever, headache, muscle aches, nausea, and fatigue can be easily mistaken for influenza.

A diagnosis of HPS or HFRS should be considered in individuals with a history of rodent exposure and symptoms consistent with these conditions. If you suspect hantavirus infection, seek medical attention promptly and inform your doctor of any potential rodent contact. <ref name=":2" />

Hantavirus diagnosis primarily depends on detecting antibodies in the blood. This is typically done using immuno-fluorescent assays (IFA) or enzyme immuno assays (EIA). During the early stages of infection, antibodies may not be specific. However, certain characteristics of IgG antibodies and the pattern of fluorescence in IFA can help distinguish new infections from past ones.

In recent years, rapid point-of-care tests based on immuno-chromatographic IgM assays have become available. Additionally, RT-PCR analysis of patient blood samples is gaining popularity for hantavirus diagnosis.<ref name=":1" />

== Characteristics ==
=== Structure ===
Hantavirus virions are about 80–120 [[nanometer|nm]] in diameter. The lipid bilayer of the [[viral envelope]] is about 5&nbsp;nm thick and is embedded with viral surface proteins to which sugar residues are attached. These glycoproteins, known as Gn and Gc, are encoded by the M segment of the viral genome. They tend to associate ([[Dimer (chemistry)|heterodimerize]]) with each other and have both an interior tail and an exterior domain that extends to about 6&nbsp;nm beyond the envelope surface.{{citation needed|date=April 2018}}

Inside the envelope are the nucleocapsids. These are composed of many copies of the nucleocapsid protein N, which interact with the three segments of the viral genome to form helical structures. The virally encoded [[RNA polymerase]] is also found in the interior. By mass, the virion is greater than 50% protein, 20–30% lipid, and 2–7% carbohydrate. The density of the virions is 1.18&nbsp;g/cm<sup>3</sup>. These features are common to all members of the family ''Hantaviridae''.{{citation needed|date=April 2018}}

=== Genome ===
The genome of hantaviruses is [[negative-sense single-stranded RNA virus|negative-sense, single-stranded RNA]]. Their genomes are composed of three segments: the small (S), medium (M), and large (L) segments. The S segment, 1–3 kilobases (kb) in length, encodes for the [[nucleocapsid]] (N) protein. The M segment, 3.2–4.9&nbsp;kb in length, encodes a [[glycoprotein]] precursor [[polyprotein]] that is co-translationally cleaved into the envelope glycoproteins Gn and Gc, alternatively called G1 and G2. The L segment, 6.8–12&nbsp;kb in length, encodes the L protein which functions primarily as the viral [[RNA-dependent RNA polymerase]] used for transcription and replication.<ref name=gravinatti /><ref name=klempa >{{cite journal|vauthors=Klempa B|date=2018|title=Reassortment events in the evolution of hantaviruses.|journal=Virus Genes|volume=54|issue=5|pages=638–646|doi=10.1007/s11262-018-1590-z|pmc=6153690|pmid=30047031}}</ref>

Within [[virion]]s, the genomic RNAs of hantaviruses are thought to complex with the N protein to form helical nucleocapsids, the RNA component of which circularizes due to sequence complementarity between the 5′ and 3′ terminal sequences of genomic segments.{{citation needed|date=April 2018}}

As with other ''Bunyavirales'', each of the three segments has a consensus 3′-terminal [[nucleotide]] sequence (AUCAUCAUC), which is complementary to the 5′-terminal sequence and is distinct from those of the other four genera in the family.<ref>{{cite journal | author = Elliott RM | title = Molecular biology of the Bunyaviridae | journal = The Journal of General Virology | volume = 71 | issue = 3 | pages = 501–522 | year = 1990 | pmid = 2179464 | doi = 10.1099/0022-1317-71-3-501 | doi-access = free }}</ref> These sequences appear to form a panhandle structure, which likely plays a role in replication and [[encapsidation]], facilitated by binding with the viral nucleocapsid (N) protein.<ref>{{cite journal |vauthors=Mir MA, Panganiban AT | title = The Hantavirus Nucleocapsid Protein Recognizes Specific Features of the Viral RNA Panhandle and is Altered in Conformation upon RNA Binding | journal = Journal of Virology | volume = 79 | issue = 3 | pages = 1824–1835 | year = 2005 | pmid = 15650206 | pmc = 544099 | doi = 10.1128/JVI.79.3.1824-1835.2005 }}</ref> The large segment is 6530–6550 nucleotides (nt) in length, the medium is 3613–3707&nbsp;nt in length and the small is 1696–2083 nt in length.{{citation needed|date=April 2018}}

No nonstructural proteins are known, unlike the other genera in this family. At the 5′ and 3′ of each segment are short noncoding sequences: the noncoding segment in all sequences at the 5′ end is 37–51&nbsp;nt. The 3′ noncoding regions differ: L segment 38–43&nbsp;nt; M segment 168–229&nbsp;nt; and S segment 370–730&nbsp;nt. The 3′ end of the S segment is conserved between the genera suggesting a functional role.{{citation needed|date=April 2018}}

=== Lifecycle ===
<!--Entry-->
[[Viral entry]] into host cells initiates by binding to surface cell receptors. [[Integrin]]s are considered to be the main receptors for hantaviruses ''in vitro'', but [[Decay-accelerating factor|complement decay-accelerating factor]] (DAF) and globular heads of [[Complement component 1q|complement C1q receptor]] (gC1qR) have mediated attachment in cultured cells too. Entry may proceed through a number of possible routes, including [[clathrin]]-dependent [[endocytosis]], clathrin-independent receptor-mediated endocytosis, and micro[[pinocytosis]]. Viral particles are then transported to late [[endosome]]s. Gc-mediated membrane fusion with the [[endosomal membrane]], triggered by low [[pH]], releases the nucleocapsid into the [[cytoplasm]].<ref name=klempa />

After the release of the nucleocapsids into cytoplasm, the complexes are targeted to the endoplasmic reticulum–Golgi intermediate compartments (ERGIC) through [[microtubule|microtubular]]-associated movement resulting in the formation of viral factories at ERGIC.{{citation needed|date=April 2018}}

These factories then facilitate transcription and subsequent translation of the viral proteins. Transcription of viral genes must be initiated by association of the L protein with the three nucleocapsid species. In addition to transcriptase and replicase functions, the viral L protein is also thought to have an endonuclease activity that cleaves cellular messenger RNAs (mRNAs) for the production of capped primers used to initiate transcription of viral mRNAs. As a result of this [[cap snatching]], the mRNAs of hantaviruses are capped and contain nontemplated 5′-terminal extensions.<ref>{{cite journal|last1=Garcin|first1=D.|last2=Lezzi|first2=M.|last3=Dobbs|first3=M.|last4=Elliott|first4=R. M.|last5=Schmaljohn|first5=C.|last6=Kang|first6=C. Y.|last7=Kolakofsky|first7=D.|date=September 1995|title=The 5′ ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis|journal=Journal of Virology|volume=69|issue=9|pages=5754–5762|issn=0022-538X|pmc=189436|pmid=7637020|doi=10.1128/JVI.69.9.5754-5762.1995}}</ref>

The G1 (or Gn) and G2 (Gc) glycoproteins form [[hetero-oligomers]] and are then transported from the [[endoplasmic reticulum]] to the [[Golgi complex]], where [[glycosylation]] is completed. The L protein produces nascent genomes by replication via a positive-sense RNA intermediate. Hantavirus virions are believed to assemble by association of nucleocapsids with glycoproteins embedded in the membranes of the Golgi, followed by budding into the [[Golgi cisternae]]. Nascent virions are then transported in secretory [[Vesicle (biology)|vesicles]] to the [[plasma membrane]] and released by [[exocytosis]].{{citation needed|date=April 2018}}

=== Pathogenesis ===
The [[pathogenesis]] of hantavirus infections is unclear as there is a lack of animal models to describe it (rats and mice do not seem to acquire severe disease). While the primary site of viral replication in the body is not known, in HFRS the main effect is in the blood vessels while in HPS most symptoms are associated with the lungs. In HFRS, there are increased vascular permeability and decreased blood pressure due to endothelial dysfunction and the most dramatic damage is seen in the kidneys, whereas in HPS, the lungs, spleen, and gall bladder are most affected. Early symptoms of HPS tend to present similarly to the [[influenza|flu]] (muscle aches, fever and fatigue) and usually appear around 2 to 3 weeks after exposure. Later stages of the disease (about 4 to 10 days after symptoms start) include difficulty breathing, shortness of breath and coughing.<ref name=CLA>{{cite web |title=Hantavirus: Canadian Lung Association  |publisher=Canadian Lung Association  |date=26 November 2015  |url=https://www.lung.ca/lung-health/lung-disease/hantavirus  |access-date=23 April 2018  |url-status=live  |archive-url=https://web.archive.org/web/20110302114405/http://www.lung.ca/diseases-maladies/a-z/hantavirus-hantavirus/index_e.php  |archive-date=2 March 2011  }}</ref>

=== Evolution ===
Findings of significant congruence between phylogenies of hantaviruses and phylogenies of their rodent reservoirs have led to the theory that rodents, although infected by the virus, are not harmed by it because of long-standing hantavirus–rodent host [[coevolution]],<ref name="doi10.1099/0022-1317-77-11-2677">{{cite journal | vauthors = Plyusnin A, Vapalahti O, Vaheri A | title = Hantaviruses: genome structure, expression and evolution | journal = J. Gen. Virol. | volume = 77 | issue = 11| pages = 2677–2687 | year = 1996 | pmid = 8922460 | doi = 10.1099/0022-1317-77-11-2677 | doi-access = free }}</ref><ref>{{cite journal |vauthors=Jackson AP, Charleston MA | title = A Cophylogenetic Perspective of RNA-Virus Evolution | journal = Molecular Biology and Evolution | volume = 21 | issue = 1 | pages = 45–57 | year = 2003 | pmid = 12949128 | doi = 10.1093/molbev/msg232 | doi-access = free }}</ref> although findings in 2008 led to new hypotheses regarding hantavirus evolution.<ref name="doi10.1128/CMR.00062-09">{{cite journal |vauthors=Jonsson CB, Figueiredo LT, Vapalahti O | title = A Global Perspective on Hantavirus Ecology, Epidemiology, and Disease | journal = Clinical Microbiology Reviews | volume = 23 | issue = 2 | pages = 412–441 | year = 2010 | pmid = 20375360 | pmc = 2863364 | doi = 10.1128/CMR.00062-09 }}</ref><ref name="doi10.1093/molbev/msn234">{{cite journal |vauthors=Ramsden C, Holmes EC, Charleston MA | title = Hantavirus Evolution in Relation to Its Rodent and Insectivore Hosts: No Evidence for Codivergence | journal = Molecular Biology and Evolution | volume = 26 | issue = 1 | pages = 143–153 | year = 2008 | pmid = 18922760 | doi = 10.1093/molbev/msn234 | doi-access = free }}</ref>

Various hantaviruses have been found to infect multiple rodent species, and cases of cross-species transmission ([[host switch]]ing) have been recorded.<ref>{{cite journal |vauthors=Delfraro A, Tomé L, D'Elía G, Clara M, Achával F, Russi JC, Arbiza Rodonz JR | title = Juquitiba-like Hantavirus from 2 Nonrelated Rodent Species, Uruguay | journal = Emerging Infectious Diseases | volume = 14 | issue = 9 | pages = 1447–1451 | year = 2008 | pmid = 18760017 | pmc = 2603116 | doi = 10.3201/eid1409.080455 }}</ref><ref>{{cite journal |vauthors=Plyusnina A, Ibrahim IN, Plyusnin A | title = A newly recognized hantavirus in the Asian house rat (Rattus tanezumi) in Indonesia | journal = Journal of General Virology | volume = 90 | issue = Pt 1 | pages = 205–209 | year = 2009 | pmid = 19088290 | doi = 10.1099/Vir.0.006155-0 | doi-access = free }}</ref><ref name="doi10.1128/Jvi.01226-09">{{cite journal |vauthors=Schmidt-Chanasit J, Essbauer S, Petraityte R, Yoshimatsu K, Tackmann K, Conraths FJ, Sasnauskas K, Arikawa J, Thomas A, Pfeffer M, Scharninghausen JJ, Splettstoesser W, Wenk M, Heckel G, Ulrich RG | title = Extensive Host Sharing of Central European Tula Virus | journal = Journal of Virology | volume = 84 | issue = 1 | pages = 459–474 | year = 2009 | pmid = 19889769 | pmc = 2798396 | doi = 10.1128/Jvi.01226-09 }}</ref>  Additionally, rates of substitution based on nucleotide sequence data reveal that hantavirus clades and rodent subfamilies may not have diverged at the same time.<ref name="doi10.1093/molbev/msn234"/><ref>{{cite journal |vauthors=Ramsden C, Melo FL, Figueiredo LM, Holmes EC, Zanotto PM | title = High Rates of Molecular Evolution in Hantaviruses | journal = Molecular Biology and Evolution | volume = 25 | issue = 7 | pages = 1488–1492 | year = 2008 | pmid = 18417484 | doi = 10.1093/molbev/msn093 | doi-access = free }}</ref>  Furthermore, as of 2007 hantaviruses have been found in multiple species of non-rodent shrews and moles.<ref name="doi10.1093/molbev/msn234"/><ref name="doi10.1128/Jvi.02450-10">{{cite journal |vauthors=Kang HJ, Bennett SN, Hope AG, Cook JA, Yanagihara R | title = Shared Ancestry between a Newfound Mole-Borne Hantavirus and Hantaviruses Harbored by Cricetid Rodents | journal = Journal of Virology | volume = 85 | issue = 15 | pages = 7496–7503 | year = 2011 | pmid = 21632770 | pmc = 3147906 | doi = 10.1128/JVI.02450-10 }}</ref><ref>{{cite journal |vauthors=Song JW, Baek LJ, Schmaljohn CS, Yanagihara R | title = Thottapalayam Virus, a Prototype Shrewborne Hantavirus | journal = Emerging Infectious Diseases | volume = 13 | issue = 7 | pages = 980–985 | year = 2007 | pmid = 18214168 | pmc = 2254531 | doi = 10.3201/eid1307.070031 }}</ref><ref>{{cite journal |vauthors=Song JW, Kang HJ, Song KJ, Truong TT, Bennett SN, Arai S, Truong NU, Yanagihara R | title = Newfound Hantavirus in Chinese Mole Shrew, Vietnam | journal = Emerging Infectious Diseases | volume = 13 | issue = 11 | pages = 1784–1787 | year = 2007 | pmid = 18217572 | pmc = 2262106 | doi = 10.3201/eid1311.070492 }}</ref>

Taking into account the inconsistencies in the theory of coevolution, it was proposed in 2009 that the patterns seen in hantaviruses in relation to their reservoirs could be attributed to preferential host switching directed by geographical proximity and adaptation to specific host types.<ref name="doi10.1093/molbev/msn234"/> Another proposal from 2010 is that geographical clustering of hantavirus sequences may have been caused by an isolation-by-distance mechanism.<ref name="doi10.1128/Jvi.01226-09"/> Upon comparison of the hantaviruses found in hosts of orders [[Rodent]]ia and [[Eulipotyphla]], it was proposed in 2011 that the hantavirus evolutionary history is a mix of both host switching and codivergence and that ancestral shrews or moles, rather than rodents, may have been the early original hosts of ancient hantaviruses.<ref name="doi10.1128/Jvi.02450-10"/>

A [[Bayesian inference in phylogeny|Bayesian]] analysis in 2014 suggested a common origin for these viruses ~2000 years ago. The association with particular rodent families appears to have been more recent. The viruses carried by the subfamilies [[Arvicolinae]] and [[Murinae]] originated in [[Asia]] 500–700 years ago. These subsequently spread to [[Africa]], [[Europe]], North America and [[Siberia]] possibly carried by their hosts. The species infecting the subfamily [[Neotominae]] evolved 500–600 years ago in Central America and then spread toward North America. The species infecting [[Sigmodontinae]] evolved in [[Brazil]] 400 years ago. Their ancestors may have been a Neotominae-associated virus from northern South America.<ref name=Souza2013>{{cite journal |vauthors=Souza WM, Bello G, Amarilla AA, Alfonso HL, Aquino VH, Figueiredo LT | title = Phylogeography and evolutionary history of rodent-borne hantaviruses | journal = Infect. Genet. Evol. | volume = 21 | pages = 198–204 | year = 2014 | pmid = 24287104 | doi = 10.1016/j.meegid.2013.11.015  | bibcode = 2014InfGE..21..198S }}</ref>

The evolution of [[shrew]]-borne hantaviruses appears to have involved natural occurrences of [[homologous recombination]] events and the reassortment of [[genome]] segments.<ref>{{cite journal | vauthors = Lee SH, Kim WK, No JS, Kim JA, Kim JI, Gu SH, Kim HC, Klein TA, Park MS, Song JW | year = 2017 | title = Dynamic Circulation and Genetic Exchange of a Shrew-borne Hantavirus, Imjin virus, in the Republic of Korea | journal = Sci. Rep. | volume = 7 | page = 44369 | doi = 10.1038/srep44369 | pmid = 28295052 | pmc = 5353647 | bibcode = 2017NatSR...744369L }}</ref>  The evolution of [[Tula orthohantavirus]] carried by the European [[common vole]] also appears to have involved [[homologous recombination]] events.<ref>{{cite journal | pmid = 9847372 | volume=73 | title=Recombination in Tula hantavirus evolution: analysis of genetic lineages from Slovakia | pmc=103873 | year=1999 | journal=J Virol | pages=667–75 | vauthors=Sibold C, Meisel H, Krüger DH, Labuda M, Lysy J, Kozuch O, Pejcoch M, Vaheri A, Plyusnin A | issue=1 | doi=10.1128/jvi.73.1.667-675.1999 }}</ref>

== Taxonomy ==
Orthohantaviruses belong to the family ''[[Hantaviridae]]'' and members of both the genus and the family are called hantaviruses. The genus also belongs to the subfamily ''[[Mammantavirinae]]'', the [[mammal]]ian hantaviruses, with three other genera. Orthohantaviruses specifically are mammalian hantaviruses that are transmitted among rodents.<ref name=mamma >{{cite web|url=https://ictv.global/taxonomy/taxondetails?taxnode_id=201906434|title=ICTV Taxonomy history: Mammantavirinae|website=talk.ictvonline.org|publisher=International Committee on Taxonomy of Viruses|access-date=24 April 2020}}</ref> The genus contains these 38 species:<ref name=ortho >{{cite web |title=Virus Taxonomy: 2020 Release |url=https://ictv.global/taxonomy |publisher=International Committee on Taxonomy of Viruses (ICTV) |date=March 2021 |access-date=19 May 2021}}</ref>
{{Div col|colwidth=15em}}
* ''[[Andes orthohantavirus]]''
* ''[[Asama orthohantavirus]]''
* ''[[Asikkala orthohantavirus]]''
* ''[[Bayou orthohantavirus]]''
* ''[[Black Creek Canal orthohantavirus]]''
* ''[[Bowe orthohantavirus]]''
* ''[[Bruges orthohantavirus]]''
* ''[[Cano Delgadito orthohantavirus]]''
* ''[[Cao Bang orthohantavirus]]''
* ''[[Choclo orthohantavirus]]''
* ''[[Dabieshan orthohantavirus]]''
* ''[[Dobrava-Belgrade orthohantavirus]]''
* ''[[El Moro Canyon orthohantavirus]]''
* ''[[Fugong orthohantavirus]]''
* ''[[Fusong orthohantavirus]]''
* ''[[Hantaan orthohantavirus]]''
* ''[[Jeju orthohantavirus]]''
* ''[[Kenkeme orthohantavirus]]''
* ''[[Khabarovsk orthohantavirus]]''
* ''[[Laguna Negra orthohantavirus]]''
* ''[[Luxi orthohantavirus]]''
* ''[[Maporal orthohantavirus]]''
* ''[[Montano orthohantavirus]]''
* ''[[Necocli orthohantavirus]]''
* ''[[Oxbow orthohantavirus]]''
* ''[[Ozark Orthohantavirus]]''
* ''[[Prospect Hill orthohantavirus]]''
* ''[[Puumala orthohantavirus]]''
* ''[[Robina orthohantavirus]]''
* ''[[Rockport orthohantavirus]]''
* ''[[Saaremaa orthohantavirus]]''
* ''[[Sangassou orthohantavirus]]''
* ''[[Seewis orhtohantavirus]]''
* ''[[Seoul orthohantavirus]]''
* ''[[Sin Nombre orthohantavirus]]''
* ''[[Tatenale orthohantavirus]]''
* ''[[Thailand orthohantavirus]]''
* ''[[Tigray orthohantavirus]]''
* ''[[Tula orthohantavirus]]''
* ''[[Yakeshi orthohantavirus]]''
{{div col end}}

Hantaviruses that were formerly classified as species in this genus and which were not reassigned as member viruses of any existing species include:<ref>{{cite web|author4-link=Charles Calisher |vauthors=Briese T, Alkhovsky S, Beer M, Calisher CH, Charrel R, Ebihara H, Jain R, Kuhn JH, Lambert A, Maes P, Nunes M, Plyusnin A, Schmaljohn C, Tesh RB, Yeh SD |title=In the genus ''Hantavirus'' (proposed family ''Hantaviridae'', proposed order ''Bunyavirales''), create 24 new species, abolish 7 species, change the demarcation criteria, and change the name of the genus to ''Orthohantavirus''; likewise, rename its constituent species. |url=https://ictv.global/ictv/proposals/2016.023a-cM.A.v2.Hantavirus_sprev.pdf |date=21 September 2016 |access-date=26 July 2021}}</ref>
* ''Isla Vista hantavirus'', also called Isla Vista virus
* ''Muleshoe hantavirus'', also called Muleshoe virus
* ''Rio Segundo hantavirus'', also called Rio Segundo virus

== Prevention ==
According to the U.S. CDC, the best prevention against contracting hantavirus is to eliminate or minimize contact with rodents in the home, workplace, or campsite.<ref>{{cite web | url=https://www.cdc.gov/hantavirus/hps/prevention.html | title=Hantavirus Prevention|website=CDC|publisher=USA.gov | date=2019-02-22}}</ref>  As the virus can be transmitted by rodent saliva, excretions, and bites, control of rats and mice in areas frequented by humans is key for disease prevention. General prevention can be accomplished by disposing of rodent nests, sealing any cracks and holes in homes where mice or rats could enter, setting traps, or laying down poisons or using natural predators such as cats in the home.<ref name=CLA/> Clean up any easy-to-get food, that might attract rodents. <ref name=":2" /> 

The duration that hantaviruses remain infectious in the environment varies based on factors such as the rodent's diet, temperature, humidity, and whether indoors or outdoors. The viruses have been demonstrated to remain active for 2–3 days at normal room temperature, while ultraviolet rays in direct sunlight kill them within a few hours. Rodent droppings or urine of indeterminate age, though, should always be treated as infectious.<ref>{{cite web |url=http://wisha-training.lni.wa.gov/training/presentations/hantavirus.ppt |title=Hantavirus Pulmonary Syndrome (HPS) and the workplace |author=Washington State Department of Labor & Industries |website=wisha-training.lni.wa.gov |date=April 2010 |access-date=2017-08-25}}</ref><ref>{{cite web |url=https://www.ccohs.ca/oshanswers/diseases/hantavir.html |title=Hantavirus : OSH Answers |author=Canadian Centre for Occupational Health and Safety |website=www.ccohs.ca |date=2016-01-08 |access-date=2017-08-25}}</ref><ref>{{cite web |url=http://www.doh.wa.gov/YouandYourFamily/IllnessandDisease/Hantavirus |title=Hantavirus  |author=Washington State Department of Health |website=www.doh.wa.gov |date=2017 |access-date=2017-08-25|author-link=Washington State Department of Health }}</ref>

=== Vaccine ===
{{Main|Hantavirus vaccine}}
{{As of |2021}}, no vaccines against hantaviruses have been approved by the U.S. FDA, but whole virus [[Inactivated vaccine|inactivated]] bivalent vaccines against Hantaan virus and Seoul virus are available in China and South Korea. In both countries, the use of the vaccine, combined with other preventive measures, has significantly reduced the incidence of hantavirus infections. Apart from these vaccines, four types of vaccines have been researched: DNA vaccines targeting the M genome segment and the S genome segment, subunit vaccines that use recombinant Gn, Gc, and N proteins of the virus, virus vector vaccines that have recombinant hantavirus proteins inserted in them, and virus-like particle vaccines that contain viral proteins, but lack genetic material. Of these, only DNA vaccines have entered into clinical trials.<ref>{{cite journal |vauthors=Liu R, Ma H, Shu J, Zhang Q, Han M, Liu Z, Jin X, Zhang F, Wu X|date=2020|title=Vaccines and Therapeutics Against Hantaviruses.|journal=Front Microbiol|volume=10|page=2989|doi=10.3389/fmicb.2019.02989|pmc=7002362|pmid=32082263|doi-access=free}}</ref><ref>{{cite journal|vauthors=Brocato RL, Hooper JW|date=2019|title=Progress on the Prevention and Treatment of Hantavirus Disease.|journal=Viruses|volume=11|issue=7|page=610|doi=10.3390/v11070610|pmc=6669544|pmid=31277410|doi-access=free}}</ref>

== Treatment ==
'''Currently, there's no specific cure for hantavirus infection.''' Treatment focuses on providing supportive care, such as rest, hydration, and managing symptoms.

'''HPS can lead to respiratory complications.''' Patients may require breathing assistance, including intubation. This procedure involves inserting a tube into the lungs to facilitate oxygen delivery.

'''HFRS can impair kidney function.''' In severe cases, patients may need dialysis to remove waste products from the blood and regulate fluid balance when the kidneys are compromised.<ref name=":2" />

Ribavirin may be a drug for HPS and HFRS, but its effectiveness remains unknown; still, spontaneous recovery is possible with supportive treatment. People with suspected hantavirus infection may be admitted to a hospital, and given oxygen and mechanical ventilation support to help them breathe during the acute pulmonary stage with severe respiratory distress.<ref name="CLA" /><ref>{{Cite web|url=https://www.cdc.gov/hantavirus/hps/diagnosis.html|title=CDC – Diagnosing and Treating Hantavirus Pulmonary Syndrome (HPS) – Hantavirus|website=www.cdc.gov|language=en-us|access-date=2016-11-09}}</ref> Immunotherapy, administration of human neutralizing antibodies during acute phases of hantavirus, has been studied only in mice, hamsters, and rats. No controlled clinical trials have been reported.<ref name=":0">{{cite journal|last1=Jonsson|first1=Colleen B.| last2=Hooper|first2=Jay|last3=Mertz|first3=Gregory|date=2008-04-01|title=Treatment of hantavirus pulmonary syndrome|journal=Antiviral Research|series=Special Issue: Treatment of highly pathogenic RNA viral infections| volume=78|issue=1| pages=162–169|doi=10.1016/j.antiviral.2007.10.012|pmc=2810485|pmid=18093668}}</ref>

== Epidemiology ==
Hantavirus infections have been reported from all continents except Australia. Regions especially affected by HFRS include [[China]], the [[Korean Peninsula]], [[Russia]] (Hantaan, Puumala, and Seoul viruses), and Northern and Western [[Europe]] ([[Puumala virus|Puumala]] and Dobrava virus). Regions with the highest incidences of hantavirus pulmonary syndrome include [[Argentina]], [[Chile]], [[Brazil]], the [[United States]], [[Canada]], and [[Panama]].{{cn|date=March 2023}}

=== Africa ===
In 2010, a novel hantavirus, [[Sangassou virus]], was isolated in Africa, which causes HFRS.<ref name=Klempa2012>{{cite journal |vauthors=Klempa B, Witkowski PT, Popugaeva E, Auste B, Koivogui L, Fichet-Calvet E, Strecker T, Ter Meulen J, Krüger DH | title = Sangassou Virus, the First Hantavirus Isolate from Africa, Displays Genetic and Functional Properties Distinct from Those of Other Murinae-Associated Hantaviruses | journal = Journal of Virology | volume = 86 | issue = 7 | pages = 3819–3827 | year = 2012 | pmid = 22278233 | pmc = 3302504 | doi = 10.1128/JVI.05879-11 }}</ref>

=== Asia ===
In China, Hong Kong, the Korean Peninsula, and Russia, HFRS is caused by Hantaan, Puumala, and Seoul viruses.<ref>{{cite web | url=http://hk.on.cc/hk/bkn/cnt/news/20170330/bkn-20170330165102561-0330_00822_001.html?refer=fn2 | title=男生患漢坦食署Hea補鑊 住處附近僅派傳單| date=30 March 2017}}</ref>

==== China ====
In March 2020, a man from [[Yunnan]] tested positive for hantavirus. He died while travelling to [[Shandong]] for work on a chartered bus. According to the ''[[Global Times]]'' reports, around 32 other people have been tested for the virus.<ref>{{Cite web|url=https://www.freepressjournal.in/world/man-in-china-dies-after-testing-positive-for-hantavirus-what-exactly-is-it|title=Man in China dies after testing positive for hantavirus – what exactly is it?|website=The Free Press Journal|access-date=2020-03-24}}</ref><ref>{{Cite web|url=https://www.newsweek.com/what-hantavirus-man-china-tests-positive-after-dying-infection-spread-rodents-1493924|title=What is hantavirus? Man in China tests positive after dying of infection spread by rodents|date=2020-03-24|website=Newsweek|language=en|access-date=2020-03-24}}</ref><ref>{{cite web|url=https://www.washingtonexaminer.com/news/do-not-panic-unless-you-plan-to-eat-rats-man-who-died-in-china-tests-positive-for-hantavirus|title='Do not panic, unless you plan to eat rats': Man who died in China tests positive for hantavirus|publisher=Washington Examiner|first=Anthony|last=Leonardi|date=March 24, 2020|access-date=March 24, 2020}}</ref>

=== Australia ===
{{As of |2005}},  no human infections have been reported in Australia, though rodents were found to carry antibodies.<ref>{{Cite journal |doi = 10.1111/j.1445-5994.2005.00954.x|pmid = 16248862|title = Are humans infected by Hantaviruses in Australia?|journal = Internal Medicine Journal|volume = 35|issue = 11|pages = 672–674|year = 2005|last1 = Bi|first1 = P.|last2 = Cameron|first2 = S.|last3 = Higgins|first3 = G.|last4 = Burrell|first4 = C.|s2cid = 37603482}}</ref>

=== Europe ===
In Europe, two hantaviruses&nbsp;– ''Puumala'' and ''Dobrava-Belgrade'' viruses&nbsp;– are known to cause HFRS.<ref name=Vapalahti2003>{{cite journal |vauthors=Vapalahti O, Mustonen J, Lundkvist A, Henttonen H, Plyusnin A, Vaheri A | title = Hantavirus infections in Europe | journal = The Lancet Infectious Diseases | volume = 3 | issue = 10 | pages = 653–661 | year = 2003 | pmid = 14522264 | doi = 10.1016/S1473-3099(03)00774-6 }}</ref> ''Puumala'' usually causes a generally mild disease, [[Hantavirus hemorrhagic fever with renal syndrome|nephropathia epidemica]], which typically presents with fever, headache, gastrointestinal symptoms, impaired renal function, and blurred vision. ''Dobrava'' infections are similar, except that they often also have hemorrhagic complications.{{cn|date=March 2023}}

''Puumala'' virus is carried by its rodent host, the [[bank vole]] (''Clethrionomys glareolus''), and is present throughout most of Europe, except for the Mediterranean region. Four ''Dobrava'' virus genotypes are known, each carried by a different rodent species. Genotype ''Dobrava'' is found in the [[yellow-necked mouse]] (''Apodemus flavicollis''), genotypes ''Saaremaa'' and ''Kurkino'' in the [[striped field mouse]] (''Apodemus agrarius''), and genotype ''Sochi'' in the [[Black Sea field mouse]] (''Apodemus ponticus'').{{cn|date=March 2023}}

In 2017 alone, the Robert Koch Institute (RKI) in Germany received 1,713 notifications of hantavirus infections.<ref>{{cite journal | vauthors = Hofmann J, Krüger DH, Loyen M | year = 2018 | title = Hantavirus-Infektionen in Deutschland&nbsp;– ein Rückblick auf das Ausbruchsjahr 2017 | journal = Epid Bull | volume = 15 | pages = 143–146 | doi = 10.17886/EpiBull-2018-018 }}</ref>

=== North America ===
==== Canada ====
The primary cause of the disease in Canada is Sin Nombre virus-infected deer mice. Between 1989 and 2014,  109 confirmed cases were reported, with the death rate estimated at 29%.<ref name="publichealth_CA_2015" /> The virus exists in deer mice nationwide, but cases were concentrated in western Canada (British Columbia, Alberta, Saskatchewan, and Manitoba) with only one case in eastern Canada. In Canada, "[a]ll cases occurred in rural settings and approximately 70% of the cases have been associated with domestic and farming activities."<ref name="publichealth_CA_2015" />

==== United States ====
In the United States, minor cases of HPS include [[Sin Nombre orthohantavirus]], [[New York orthohantavirus]], [[Bayou orthohantavirus]], and possibly [[Black Creek Canal orthohantavirus]].{{cn|date=March 2023}}

{{As of |2017|01}}, 728 cases of hantavirus had been reported in the United States cumulatively since 1995, across 36 states, not including cases with presumed exposure outside the United States. More than 96% of cases have occurred in states west of the [[Mississippi River]]. The top 10 states by number of cases ''reported'' (which differs slightly from a count ordered by the state of original ''exposure'') were [[New Mexico]] (109), [[Colorado]] (104), [[Arizona]] (78), [[California]] (61), [[Washington (state)|Washington]] (50), [[Texas]] (45), [[Montana]] (43), [[Utah]] (38), [[Idaho]] (21), and [[Oregon]] (21); 36% of the total reported cases have resulted in death.<ref>{{Cite web |url=https://www.cdc.gov/hantavirus/surveillance/reporting-state.html |title=Hantavirus Cases, by State of Reporting {{!}} Hantavirus {{!}} DHCPP  |publisher=[[Centers for Disease Control and Prevention]] |date=2017-07-19 |access-date=2017-08-25}}</ref>

==== Mexico ====
In Mexico, rodents have been found to carry hantaviruses include [[Thomas's giant deer mouse]] ''(Megadontomys thomasi)'', the [[pack rat]] ''Neotoma picta'', [[Orizaba deer mouse]] ''(Peromyscus beatae)'', [[Western harvest mouse]] ''(Reithrodontomys megalotis)'' and [[Sumichrast's harvest mouse]] ''(Reithrodontomys sumichrasti)''.<ref>{{Cite journal |vauthors=Kariwa H, Yoshida H, Sánchez-Hernández C, Romero-Almaraz Mde L, Almazán-Catalán JA, Ramos C, Miyashita D, Seto T, Takano A, Totani M, Murata R, Saasa N, Ishizuka M, Sanada T, Yoshii K, Yoshimatsu K, Arikawa J, Takashima I | title = Genetic diversity of hantaviruses in Mexico: Identification of three novel hantaviruses from Neotominae rodents | journal = Virus Research | volume = 163 | issue = 2 | pages = 486–494 | year = 2012 | pmid = 22138671 | doi = 10.1016/j.virusres.2011.11.013}}</ref>

=== South America ===
Agents of HPS found in [[South America]] include the [[Andes virus]] (also called Oran, Castelo de Sonhos&nbsp;– Portuguese for "Castle of Dreams", Lechiguanas, Juquitiba, Araraquara, and Bermejo virus, among many other synonyms), which is the only hantavirus that has shown an interpersonal form of transmission, and the [[Laguna Negra virus]], an extremely close relative of the previously known Rio Mamore virus.{{cn|date=March 2023}}

Rodents that have been shown to carry hantaviruses include ''[[Abrothrix longipilis]]'' and ''[[Oligoryzomys longicaudatus]]''.<ref name="Medina2009">{{cite journal |vauthors=Medina RA, Torres-Perez F, Galeno H, Navarrete M, Vial PA, Palma RE, Ferres M, Cook JA, Hjelle B | title = Ecology, Genetic Diversity, and Phylogeographic Structure of Andes Virus in Humans and Rodents in Chile | journal = Journal of Virology | volume = 83 | issue = 6 | pages = 2446–2459 | year = 2008 | pmid = 19116256 | pmc = 2648280 | doi = 10.1128/JVI.01057-08 }}</ref>

== History ==
Hantavirus HFRS was likely first referenced in China in the 12th century. The first clinical recognition was in 1931 in northeast China. Around the same time in the 1930s, NE was identified in Sweden. HFRS came to the recognition of western physicians during the [[Korean War]] between 1951 and 1954 when more than 3,000 [[United Nations]] soldiers fell ill in an outbreak. In 1976, the first pathogenic hantavirus, the ''[[Hantaan orthohantavirus]]'', was isolated from rodents near the [[Hantan River]] in [[South Korea]]. Other prominent hantaviruses that cause HFRS, including the ''[[Dobrava-Belgrade orthohantavirus]]'', ''[[Puumala orthohantavirus]]'', and ''[[Seoul orthohantavirus]]'', were identified in the years after then and are collectively referred to as the Old World hantaviruses.<ref name=jiang />

In 1993, an [[1993 Four Corners hantavirus outbreak|outbreak of HCPS]], then unrecognized, occurred in the [[Four Corners]] region of the United States and led to the discovery of the ''[[Sin Nombre orthohantavirus]]''. Since then, approximately 43 hantavirus strains, of which 20 are pathogenic, have been found in the Americas and are referred to as the New World hantaviruses. This includes the ''[[Andes orthohantavirus]]'', one of the primary causes of HCPS in South America and the only hantavirus known to be capable of person-to-person transmission.<ref name=jiang />

In late [[medieval England]] a mysterious [[sweating sickness]] swept through the country in 1485 just before the [[Battle of Bosworth Field]]. Noting that the symptoms overlap with hantavirus pulmonary syndrome, several scientists have theorized that the virus may have been the cause of the disease.<ref>{{cite journal |vauthors=Thwaites G, Taviner M, Gant V | title = The English Sweating Sickness, 1485 to 1551 | journal = New England Journal of Medicine | volume = 336 | issue = 8 | pages = 580–582 | year = 1997 | pmid = 9023099 | doi = 10.1056/NEJM199702203360812 }}</ref><ref>{{cite journal |vauthors=Taviner M, Thwaites G, Gant V | title = The English sweating sickness, 1485–1551: a viral pulmonary disease? | journal = Medical History | volume = 42 | issue = 1 | pages = 96–98 | year = 1998 | pmid = 9536626 | pmc = 1043971 | doi = 10.1017/S0025727300063365 }}</ref> The hypothesis was criticized because sweating sickness was recorded as being transmitted from human to human, whereas hantaviruses were not known to spread in this way.<ref>{{cite journal|url=http://www.findarticles.com/p/articles/mi_qa3874/is_200101/ai_n8939673 |archive-url=https://web.archive.org/web/20060324144652/http://www.findarticles.com/p/articles/mi_qa3874/is_200101/ai_n8939673 |url-status=dead |archive-date=2006-03-24 |title=English 'sweate' (Sudor Anglicus) and Hantavirus pulmonary syndrome, The |journal=British Journal of Biomedical Science |year=2001 |last=Bridson |first=Eric |volume=58 |issue=1 |pages=1–6 |pmid=11284216 }}</ref>

== See also ==
{{Portal|Medicine|Viruses}}
* [[1993 Four Corners hantavirus outbreak]]
* [[Bat-borne virus]]
* [[Cocoliztli epidemics]]
* [[Conjunctival suffusion]]
* [[Limestone Canyon virus]]
* [[List of cutaneous conditions]]

== References ==
{{reflist}}

== External links ==
{{Commons category}}
* [https://web.archive.org/web/20130420124348/http://bvs.insp.mx/articulos/5/22/092001.htm "Hantaviruses, with emphasis on Four Corners Hantavirus"] by Brian Hjelle, M.D., Department of Pathology, School of Medicine, University of New Mexico
* [https://www.cdc.gov/hantavirus/pdf/hps_brochure.pdf CDC's Hantavirus Fact Sheet (PDF)]
* [https://www.cdc.gov/ncidod/diseases/hanta/hps/noframes/phys/technicalinfoindex.htm CDC's Hantavirus Technical Information Index page]
* [http://www.expasy.org/viralzone/all_by_species/213.html Viralzone: Hantavirus]
* [https://www.viprbrc.org/brc/home.spg?decorator=hanta Virus Pathogen Database and Analysis Resource (ViPR): Hantaviridae]
* [https://web.archive.org/web/20120310150611/http://www.paho.org/English/AD/DPC/CD/hantavirus-1993-2004.htm Occurrences and deaths in North and South America]

{{Medical resources
|  DiseasesDB     = 5629
|  ICD11          = {{ICD11|1D62}}
|  ICD10          = {{ICD10|B|33|4|b|25}}
|  ICD9           = {{ICD9|079.81}}
|  ICDO           =
|  OMIM           =
|  MedlinePlus    = 001382
|  eMedicineSubj  =
|  eMedicineTopic =
|  MeshID         = D018778
}}
{{Zoonotic viral diseases}}
{{Baltimore_(virus_classification)}}
{{Taxonbar|from1=Q29001073|from2=Q276201}}
{{Authority control}}

[[Category:Hantaviridae]]
[[Category:Hemorrhagic fevers]]
[[Category:Rodent-carried diseases]]
[[Category:Viral diseases]]
[[Category:Virus genera]]