View source for RPS6KA1

{{Short description|Enzyme}}
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{{Infobox_gene}}
'''Ribosomal protein S6 kinase alpha-1''' is an [[enzyme]] that in humans is encoded by the ''RPS6KA1'' [[gene]].<ref name="pmid8141249">{{cite journal | vauthors = Moller DE, Xia CH, Tang W, Zhu AX, Jakubowski M | title = Human rsk isoforms: cloning and characterization of tissue-specific expression | journal = The American Journal of Physiology | volume = 266 | issue = 2 Pt 1 | pages = C351–9 | date = Feb 1994 | pmid = 8141249 | doi =  10.1152/ajpcell.1994.266.2.C351}}</ref>

== Function ==

This gene encodes a member of the RSK (ribosomal S6 kinase) family of [[serine/threonine kinases]]. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase ([[MAPK]]) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6195}}</ref>

== Interactions ==

RPS6KA1 has been shown to [[Protein-protein interaction|interact]] with:
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* [[IκBα]],<ref name = pmid9214631>{{cite journal | vauthors = Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A | title = IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase | journal = The EMBO Journal | volume = 16 | issue = 11 | pages = 3133–44 | date = Jun 1997 | pmid = 9214631 | pmc = 1169932 | doi = 10.1093/emboj/16.11.3133 }}</ref> 
* [[MAPK1]],<ref name = pmid12832467>{{cite journal | vauthors = Roux PP, Richards SA, Blenis J | title = Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity | journal = Molecular and Cellular Biology | volume = 23 | issue = 14 | pages = 4796–804 | date = Jul 2003 | pmid = 12832467 | pmc = 162206 | doi =  10.1128/mcb.23.14.4796-4804.2003}}</ref><ref name = pmid12594221>{{cite journal | vauthors = Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM, Weber MJ | title = Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 14926–35 | date = Apr 2003 | pmid = 12594221 | doi = 10.1074/jbc.M300485200 | doi-access = free }}</ref><ref name = pmid9915826>{{cite journal | vauthors = Smith JA, Poteet-Smith CE, Malarkey K, Sturgill TW | title = Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo | journal = The Journal of Biological Chemistry | volume = 274 | issue = 5 | pages = 2893–8 | date = Jan 1999 | pmid = 9915826 | doi =  10.1074/jbc.274.5.2893| doi-access = free }}</ref> 
* [[TOB1]]<ref name = pmid11260258>{{cite journal | vauthors = Suzuki T, Matsuda S, Tsuzuku JK, Yoshida Y, Yamamoto T | title = A serine/threonine kinase p90rsk1 phosphorylates the anti-proliferative protein Tob | journal = Genes to Cells | volume = 6 | issue = 2 | pages = 131–8 | date = Feb 2001 | pmid = 11260258 | doi =  10.1046/j.1365-2443.2001.00406.x| doi-access = free }}</ref> 
* [[TSC2]],<ref name = pmid15342917>{{cite journal | vauthors = Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J | title = Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 37 | pages = 13489–94 | date = Sep 2004 | pmid = 15342917 | pmc = 518784 | doi = 10.1073/pnas.0405659101 | bibcode = 2004PNAS..10113489R | doi-access = free }}</ref><ref name = pmid15757502>{{cite journal | vauthors = Rolfe M, McLeod LE, Pratt PF, Proud CG | title = Activation of protein synthesis in cardiomyocytes by the hypertrophic agent phenylephrine requires the activation of ERK and involves phosphorylation of tuberous sclerosis complex 2 (TSC2) | journal = The Biochemical Journal | volume = 388 | issue = Pt 3 | pages = 973–84 | date = Jun 2005 | pmid = 15757502 | pmc = 1183479 | doi = 10.1042/BJ20041888 }}</ref> and
* [[YWHAB]].<ref name = pmid12618428>{{cite journal | vauthors = Cavet ME, Lehoux S, Berk BC | title = 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity | journal = The Journal of Biological Chemistry | volume = 278 | issue = 20 | pages = 18376–83 | date = May 2003 | pmid = 12618428 | doi = 10.1074/jbc.M208475200 | doi-access = free }}</ref> 
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== See also ==
* [[Ribosomal s6 kinase]]

== References ==
{{Reflist}}

== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Chen RH, Sarnecki C, Blenis J | title = Nuclear localization and regulation of erk- and rsk-encoded protein kinases | journal = Molecular and Cellular Biology | volume = 12 | issue = 3 | pages = 915–27 | date = Mar 1992 | pmid = 1545823 | pmc = 369523 | doi =  10.1128/mcb.12.3.915}}
* {{cite journal | vauthors = Tratner I, Ofir R, Verma IM | title = Alteration of a cyclic AMP-dependent protein kinase phosphorylation site in the c-Fos protein augments its transforming potential | journal = Molecular and Cellular Biology | volume = 12 | issue = 3 | pages = 998–1006 | date = Mar 1992 | pmid = 1545828 | pmc = 369532 | doi =  10.1128/mcb.12.3.998}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Chen RH, Abate C, Blenis J | title = Phosphorylation of the c-Fos transrepression domain by mitogen-activated protein kinase and 90-kDa ribosomal S6 kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 90 | issue = 23 | pages = 10952–6 | date = Dec 1993 | pmid = 8248197 | pmc = 47899 | doi = 10.1073/pnas.90.23.10952 | bibcode = 1993PNAS...9010952C | doi-access = free }}
* {{cite journal | vauthors = Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME | title = A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity | journal = Molecular and Cellular Biology | volume = 13 | issue = 10 | pages = 6260–73 | date = Oct 1993 | pmid = 8413226 | pmc = 364685 | doi =  10.1128/mcb.13.10.6260}}
* {{cite journal | vauthors = Chen ZJ, Parent L, Maniatis T | title = Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity | journal = Cell | volume = 84 | issue = 6 | pages = 853–62 | date = Mar 1996 | pmid = 8601309 | doi = 10.1016/S0092-8674(00)81064-8 | s2cid = 112412 | doi-access = free }}
* {{cite journal | vauthors = Barge RM, de Koning JP, Pouwels K, Dong F, Löwenberg B, Touw IP | title = Tryptophan 650 of human granulocyte colony-stimulating factor (G-CSF) receptor, implicated in the activation of JAK2, is also required for G-CSF-mediated activation of signaling complexes of the p21ras route | journal = Blood | volume = 87 | issue = 6 | pages = 2148–53 | date = Mar 1996 | doi = 10.1182/blood.V87.6.2148.bloodjournal8762148 | pmid = 8630373 | doi-access = free }}
* {{cite journal | vauthors = Wong EV, Schaefer AW, Landreth G, Lemmon V | title = Involvement of p90rsk in neurite outgrowth mediated by the cell adhesion molecule L1 | journal = The Journal of Biological Chemistry | volume = 271 | issue = 30 | pages = 18217–23 | date = Jul 1996 | pmid = 8663493 | doi = 10.1074/jbc.271.30.18217 | doi-access = free }}
* {{cite journal | vauthors = Xing J, Ginty DD, Greenberg ME | title = Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase | journal = Science | volume = 273 | issue = 5277 | pages = 959–63 | date = Aug 1996 | pmid = 8688081 | doi = 10.1126/science.273.5277.959 | bibcode = 1996Sci...273..959X | s2cid = 22226803 }}
* {{cite journal | vauthors = Nakajima T, Fukamizu A, Takahashi J, Gage FH, Fisher T, Blenis J, Montminy MR | title = The signal-dependent coactivator CBP is a nuclear target for pp90RSK | journal = Cell | volume = 86 | issue = 3 | pages = 465–74 | date = Aug 1996 | pmid = 8756728 | doi = 10.1016/S0092-8674(00)80119-1 | doi-access = free }}
* {{cite journal | vauthors = Zhao Y, Bjorbaek C, Moller DE | title = Regulation and interaction of pp90(rsk) isoforms with mitogen-activated protein kinases | journal = The Journal of Biological Chemistry | volume = 271 | issue = 47 | pages = 29773–9 | date = Nov 1996 | pmid = 8939914 | doi = 10.1074/jbc.271.47.29773 | doi-access =free  }}
* {{cite journal | vauthors = Zaheer A, Lim R | title = Protein kinase A (PKA)- and protein kinase C-phosphorylated glia maturation factor promotes the catalytic activity of PKA | journal = The Journal of Biological Chemistry | volume = 272 | issue = 8 | pages = 5183–6 | date = Feb 1997 | pmid = 9030586 | doi = 10.1074/jbc.272.8.5183 | doi-access = free }}
* {{cite journal | vauthors = Schouten GJ, Vertegaal AC, Whiteside ST, Israël A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A | title = IkappaB alpha is a target for the mitogen-activated 90 kDa ribosomal S6 kinase | journal = The EMBO Journal | volume = 16 | issue = 11 | pages = 3133–44 | date = Jun 1997 | pmid = 9214631 | pmc = 1169932 | doi = 10.1093/emboj/16.11.3133 }}
* {{cite journal | vauthors = Li HL, Forman MS, Kurosaki T, Puré E | title = Syk is required for BCR-mediated activation of p90Rsk, but not p70S6k, via a mitogen-activated protein kinase-independent pathway in B cells | journal = The Journal of Biological Chemistry | volume = 272 | issue = 29 | pages = 18200–8 | date = Jul 1997 | pmid = 9218456 | doi = 10.1074/jbc.272.29.18200 | doi-access = free }}
* {{cite journal | vauthors = Chang YW, Traugh JA | title = Phosphorylation of elongation factor 1 and ribosomal protein S6 by multipotential S6 kinase and insulin stimulation of translational elongation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 45 | pages = 28252–7 | date = Nov 1997 | pmid = 9353277 | doi = 10.1074/jbc.272.45.28252 | doi-access = free }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = del Peso L, González-García M, Page C, Herrera R, Nuñez G | title = Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt | journal = Science | volume = 278 | issue = 5338 | pages = 687–9 | date = Oct 1997 | pmid = 9381178 | doi = 10.1126/science.278.5338.687 | bibcode = 1997Sci...278..687D }}
* {{cite journal | vauthors = Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P | title = Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1496–505 | date = Jan 1998 | pmid = 9430688 | doi = 10.1074/jbc.273.3.1496 | doi-access = free }}
* {{cite journal | vauthors = Joel PB, Smith J, Sturgill TW, Fisher TL, Blenis J, Lannigan DA | title = pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167 | journal = Molecular and Cellular Biology | volume = 18 | issue = 4 | pages = 1978–84 | date = Apr 1998 | pmid = 9528769 | pmc = 121427 | doi =  10.1128/mcb.18.4.1978}}
{{Refend}}

{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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[[Category:EC 2.7.11]]