View source for Talk:Simeticone

{{Reliable sources for medical articles|synonym1=simethicone}}
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==Untitled==
This article still needs one of those fancy tables with a picture of the chemical and etc. found on other pages like [[advil]] [[User:Graniterock|Granite T. Rock]] 06:20, July 30, 2005 (UTC)
:I don't think this is possible. See the [[Polydimethylsiloxane|PDMS]] article. It says: ''Activated dimethicone, a mixture of polydimethylsiloxanes and silicon dioxide (sometimes called simethicone), is used in over-the-counter drug as an anti-foaming agent and carminative.'' Since it's a mixture (including polymeres, which have variable molecular formulas and thus variable molecular weight) molecular weight, formula etc do not apply. [[User:Kevin Hughes|Kevin Hughes]] 00:40, 18 October 2006 (UTC)

Like this one?  
{{drugbox
| verifiedrevid = 371694030
| IUPAC_name = 2-[4-(2-methylpropyl)phenyl]propanoic acid
| image = 
| image2 = 
| CAS_number = 
| ATC_prefix = A03
| ATC_suffix = AX13
| PubChem = 
| DrugBank = 
| C=8 | H=24 | O=2|Si=3
| molecular_weight = 
| melting_point = 
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = Renal
| pregnancy_AU = 
| pregnancy_US = 
| pregnancy_category = 
| legal_AU = 
| legal_UK = 
| legal_US = OTC
| routes_of_administration = Oral
}}
I've deleted all references to Ibuprofin so we can fill it in with the proper info before pasting it to the main article.  I've been able to find some info, but not all.  Hopefully, it'll be filled in before long. [[User:Micahbrwn|Micahbrwn]] 07:23, 8 October 2006 (UTC)
:{{done}}, although not "before long"... --[[User:Anypodetos|ἀνυπόδητος]] ([[User talk:Anypodetos|talk]]) 07:08, 22 August 2009 (UTC)

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Simethicone is also sold (in the UK at least) under the name Infacol, used to treat colic in newborns... So I guess the article needs editing in both sections for baby dosages? not really sure best to write it. <small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/82.35.163.246|82.35.163.246]] ([[User talk:82.35.163.246|talk]]) 16:44, 13 October 2006 (UTC)</small><!-- Template:Unsigned IP -->

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The structural formula for simethicone can be found at http://www.newdruginfo.com/pharmacopeia/usp28/v28230/usp28nf23s0_m75400.htm  

The ''Merk Index, tenth edition'' lists it as compound # 8374 and indicates that Simethicone is also called dimethicone.  Many skin barrier creams contain simethicone.  Since  the ''Merk Index'' indicates that it is immiscible with both water and alcohol, logic follows that barrier creams using it as an ingredient would help protect hands when alcohol based hand disinfectants are used.
[[User:FrodoGem|FrodoGem]] ([[User talk:FrodoGem|talk]]) 18:25, 19 March 2008 (UTC)

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== Infant colic ==

"Despite being useful in the treatment of gas, simethicone does not appear to be useful in the treatment of infant colic."

This implies that colic is caused by gas, which isn't the case. [[User:Shermozle|Shermozle]] ([[User talk:Shermozle|talk]]) 01:01, 5 November 2009 (UTC)

== Image inconsistent with text ==

The text says that Simethicone is a mixture of polydimethylsiloxane with silica gel, while the image in the box shows a mixture of polydimethylsiloxane with silicon dioxide. Unless silica gel and silicon dioxide are the same thing (and then their articles are wrong), one of them (text or image) is wrong. [[User:Albmont|Albmont]] ([[User talk:Albmont|talk]]) 19:12, 31 May 2010 (UTC)

== Side Effects reported in article are inconsistent with NIH Claims ==

The text says that Side Effects of Simethicone may include constipation, diarrhea, gas, bloating and heartburn. However, NIH claims it usually has no side effects when taken as directed. See: http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000747/
Also, NIH says Simethicone is used to treat gas and other conditions; the text says Simethicone is used to treat the same conditions that are reported as Side Effects (constipation, diarrhea, gas, bloating and heartburn). This seems contradictory. Since no source is provided for the claims of Side Effects, I am replacing the text with the NIH information, citing http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000747/ as the source. [[User:KiAnCaFleur|KiAnCaFleur]] ([[User talk:KiAnCaFleur|talk]]) 04:53, 22 March 2011 (UTC) KiAnCaFleur

:I was also unable to find side-affects claims.  The [http://en.wikipedia.org/enwiki/w/index.php?title=Simethicone&oldid=550246510#Side_effects current '''Side-Affects''' section reads]
::''The most common adverse effects of simethicone are gastrointestinal symptoms, including mild diarrhea, nausea, regurgitation, and vomiting''
:There is merely a reference that reads ''from Micromedex Dug Information. Retrieved 2013-01-13''.  However, [http://www.drugs.com/ppa/simethicone.html drugs.com] lists no side-affects.  [http://www.webmd.com/drugs/mono-8265-SIMETHICONE+-+ORAL.aspx?drugid=341&drugname=simethicone+oral webmd.com] also lists no known side-affects.
:I recommend changing the side-affects claim to 
::''no known side affects''
[[User:Jtmoon|J_Tom_Moon_79]] ([[User talk:Jtmoon|talk]]) 07:52, 23 May 2013 (UTC)

== Page move ==

This article was originally created under the INN , simeticone.  In 2008 it was moved to the USAN name, simethicone (which you can't see anymore).  I had it moved back to the INN today, when I realized what the INN was.  There is very solid consensus per [[WP:PHARMMOS]] that we name drug articles per INN. [[User:Jytdog|Jytdog]] ([[User talk:Jytdog|talk]]) 07:15, 27 August 2017 (UTC)

== There is 'no evidence', is poorly backed up ==

Citation 3, GI.org, has this to say "Simethicone products have been promoted as treatment for gaseousness but their efficacy has not been convincing."

There was no evidence linked on the page, just names of the authors. A Physician is not data.

It should be noted I have seen cause and effect relationships using Simeticone on my baby. Effect, he stops crying(assuming it killed his gas). 

I find the language too dismissive given the weak citations. Parents everywhere talk about Simeticone. This article desperately needs to talk about the use in babies. 

Regarding the Drug.com citations are to the "Food and Drug Administration. Digestive aid products for over-the-counter human use; tentative final monograph. [21 CFR Part 357; Docket No. 81N-0106] Fed Regist. 1988; 53:2706-14. (IDIS 240339)", but I was unsuccessful finding this.  <!-- Template:Unsigned --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:TangleUSB|TangleUSB]] ([[User talk:TangleUSB#top|talk]] • [[Special:Contributions/TangleUSB|contribs]]) 22:14, 26 June 2019 (UTC)</small> <!--Autosigned by SineBot-->

== Adding more sources & studies that indicate an effectiveness of Simeticone ==

An extensive online search produced more studies that seem to support both
# the effectiveness of Simeticone ''in vitro''
# the effectiveness of Simeticone in treating certain bowel symptoms
I would amend the corresponding sections with information from these studies, while being aware that several guidelines do not agree on an established effectiveness in vivo.
If anyone should find an error in my assessment of the sources' quality, I would welcome a correction of my edits.
Here's a rough list of sources I will be including:
* https://www.nhs.uk/medicines/simeticone/
* https://www.pdr.net/drug-summary/Gas-X-simethicone-2675
* https://www.kup.at/kup/pdf/9192.pdf
* https://www.researchgate.net/publication/15114732_Mechanism_of_antifoaming_action_of_simethicone
* https://onlinelibrary.wiley.com/doi/full/10.1046/j.1365-2036.2002.01322.x
* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256934/
* https://www.researchgate.net/publication/298082623_A_comparative_study_of_dimethicone_and_supermint_anti-flatulence_effects_on_reducing_flatulence_in_patients_with_irritable_bowel_syndrome
* https://www.karger.com/Article/PDF/286002
[[User:LordPeterII|LordPeterII]] ([[User talk:LordPeterII|talk]]) 11:55, 30 January 2020 (UTC)
:I see you have removed one of the sources I quoted, {{user link|Headbomb}}. I am not angry about that, much to the contrary! However, could you please share with me how you identified it as a predatory source? I tried as best as I could to only quote legitimate articles, and could not at the time identify this journal as predatory (it ''claims'' what you'd expect for it to be legitimate, peer-review and such-and-such). I'd like to avoid such mistakes in the future, hence the question. Also, I am going to remove that part of the section, since the claim is no longer substantiated. --[[User:LordPeterII|LordPeterII]] ([[User talk:LordPeterII|talk]]) 13:22, 23 July 2020 (UTC)
::{{re|LordPeterII}} There's a few ways to check. The easiest is to make use of [[WP:UPSD]] (if installed correctly, you'll see that reference in red in [https://en.wikipedia.org/enwiki/w/index.php?title=Simeticone&oldid=947914052 this revision]). There's also [[WP:CITEWATCH]] and [[User:JzG/Predatory|JzG's lists]] which supplement those efforts. &#32;<span style="font-variant:small-caps; whitespace:nowrap;">[[User:Headbomb|Headbomb]] {[[User talk:Headbomb|t]] · [[Special:Contributions/Headbomb|c]] · [[WP:PHYS|p]] · [[WP:WBOOKS|b]]}</span> 14:23, 23 July 2020 (UTC)
:::It will also warn to double check the ResearchGate links above for instance, since ResearchGate does not filter against preprints and predatory journals. The second RG link above, for instance, is to ''Der Pharmacia Lettre'', which is not reliable. &#32;<span style="font-variant:small-caps; whitespace:nowrap;">[[User:Headbomb|Headbomb]] {[[User talk:Headbomb|t]] · [[Special:Contributions/Headbomb|c]] · [[WP:PHYS|p]] · [[WP:WBOOKS|b]]}</span> 14:26, 23 July 2020 (UTC)
::::Thanks, that indeed works. Kudos for creating such an automated script, it'll certainly help me in the future :) And true, I already realized ResearchGate is problematic, hence why I switched to citing the source directly in the end. But good to know the script also reminds about that. --[[User:LordPeterII|LordPeterII]] ([[User talk:LordPeterII|talk]]) 15:14, 23 July 2020 (UTC)