View source for Talk:Thrombocytopenia/Archive 1


==Reaction==
I reacted to an anticoagulation medicine in the hospital (Reopro)and wound up having thrombocytopenia and having to have 4 bags of platelets. What a scary disease, I had purple bruises from my head to my toes. -- {{User3|Williamb}} 04:59, 30 June 2004 (UTC)
:Although rare, it is possible to get thrombocytopenia from malaria as well.  Enlarged spleen is the key identifier of this.  (Along with all of the normal bruising, etc.)  I had this, and it dropped my platelet count below 1,000.  (Normal ranges are from about 120,000 to 400,000)  I thought I might add this as it is not on the causes list. {{User3|212.143.118.240}} 06:46, 21 June 2006 (UTC)

== Genetic Causes ==
As a layperson without any medical background, I'm hesitant to edit an article like this, but should it also mention genetic causes of Thrombocytopenia? (e.g. [[TAR syndrome]] which both my brothers-in-law have)
[[User:Dramatic|dramatic]] 07:46, 25 September 2006 (UTC)

:Dramatic, you have an excellent point, and this seems to have been overlooked.--[[User:Dr.michael.benjamin|Dr.michael.benjamin]] 04:03, 15 February 2007 (UTC)

Amgen has filed for the approval of Romiplostim with the FDA.  Romiplostim, a thrombopoiesis stimulating Fc fusion protein (peptibody), potentially represents a new approach to treating ITP by working to increase platelet production and sustain platelet levels for as long as needed. Romiplostim works similarly to thrombopoietin (TPO), a natural protein in the body. It contains an active peptide component that stimulates the TPO receptor, which is necessary for growth and maturation of the bone marrow cells that produce platelets and therefore, plays an important role in increasing platelet production.  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/198.176.189.201|198.176.189.201]] ([[User talk:198.176.189.201|talk]]) 16:13, 26 October 2007 (UTC)</small><!-- Template:UnsignedIP --> <!--Autosigned by SineBot-->

== Immunotherepy ==

While technically not a drug, Interleukin-2 therapy is known to induce thrombocytopenia in some patients through platelet destruction by the immune system. The effect increases over increasing cycles. This may be too specialized for inclusion.  <small>—Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[User:Miglewis|Miglewis]] ([[User talk:Miglewis|talk]] • [[Special:Contributions/Miglewis|contribs]]) 15:06, 9 May 2008 (UTC)</small><!-- Template:Unsigned --> <!--Autosigned by SineBot-->

== Synchronize with Heparin-induced thrombocytopenia and thrombosis (HITT) ==

[[Thrombocytopenia#Heparin-induced thrombocytopenia and thrombosis (HITT)]] should be synchronized with [[Heparin-induced thrombocytopenia#Treatment]], and summarize it.  Could an expert do this please? --[[User:Hro%C3%B0ulf|Hroðulf]] (or Hrothulf) ([[User talk:Hro%C3%B0ulf|Talk]]) 08:12, 22 May 2008 (UTC)

== should i be concerned??? ==

Around a bout 1 year ago I was taken in for a minor operation to have my adanoids removed to help me breath better, pre op the surgeon came to see me and stated he was concerned with the fact I had thrombocytopenia and that I, basicaly, may bleed to death on his operating table.
Obviously concerned and worried and unaware I had this condition I asked the surgeon to elaborate and explain what thrombocytopenia was, he replied that my platelets were considered low which determined I had this illness.
1 year on I have found myself tiring very easily and suffering from fatigue on a regular basis as well as random bruising mainly on my arms and legs. Should I be worried??? I have had my bloods done and am waiting for a follow up with my GP.([[Special:Contributions/194.193.83.126|194.193.83.126]] ([[User talk:194.193.83.126|talk]]) 23:02, 9 June 2010 (UTC))(twinnee)

:In no way, shape or form can Wikipedia give medical advice, particularly in individual cases.  I think that nih.gov might have a question section, as do other sites.  But if I were worried that my physician was not giving me all the information I felt I needed, I might seek a second opinion from another doctor of my choice.  I might also (or instead) seek a referral to a specialist like a Hematologist (Blood Doctor.)  
:Insurance plans seem to cover second opinions at varying rates. from not at all to fully 100%, so I would tend to check with  my insurer first.  That's just what '''''<u>I</u>''''' would do.

:BTW, as you will discover if you spend enough time on Wikipedia (or elsewhere)researching the subject, you'll see that Thrombocytopenia can be a symptom of a deeper underlying problem.  Knowledge is power.  Do your own research!  Arm yourself with knowledge!  

:Good luck and best wishes!

:[[User:Michaeloqu|Michaeloqu]] ([[User talk:Michaeloqu|talk]]) 22:48, 31 May 2011 (UTC)

== Critical illness ==

Treating thrombocytopenia in critical illness with platelet transfusions is not based on solid evidence [[doi:10.1182/blood-2013-02-435693]] (good review). [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 20:33, 20 February 2014 (UTC)

=== Deleted Comparing coagulation tests - irrelevant ===

I deleted the table with above title - coagulation test have absolutely nothing to do with thrombocytopenia.

[[User:IiKkEe|IiKkEe]] ([[User talk:IiKkEe|talk]]) 06:48, 13 May 2014 (UTC)

=== Tags for inreferenced sections ===

I tagged all sections with no references

[[User:IiKkEe|IiKkEe]] ([[User talk:IiKkEe|talk]]) 07:20, 13 May 2014 (UTC)

=== Irrelevant citations ===

References 1,2,3 do not support statements in text.

[[User:IiKkEe|IiKkEe]] ([[User talk:IiKkEe|talk]]) 07:25, 13 May 2014 (UTC)

== condense ''treatment table''?..[[Wikipedia_talk:WikiProject_Medicine]] ==

I think that if table is eliminated for a small section (condition by condition) it would help the article --[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 16:27, 19 May 2015 (UTC)

:Hello {{U|Ozzie10aaaa}}. I would argue that we shouldn't be discussing treatment on this page at all. Often, the decision making on treatment has many determinants, and the reader would be getting the wrong impression if we said that ITP is always treated with, say, azathioprine or romiplostim. We should be discussing treatment in very broad terms (e.g. slightly reduced thrombocyte counts may not require treatment) and direct the reader to the relevant articles. [[User:Jfdwolff|JFW]]&nbsp;&#124;&nbsp;[[User_talk:Jfdwolff|<small>T@lk</small>]] 14:16, 20 May 2015 (UTC)
::agree--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 14:49, 20 May 2015 (UTC)
==  Essential thrombocytopenia=tumorentity ==

>sepratearticl![[Special:Contributions/81.11.206.29|81.11.206.29]] ([[User talk:81.11.206.29|talk]]) 20:38, 15 October 2016 (UTC)

=== 1.2technicl2.nonsequitur? ===

These limits are determined by the 2.5th lower and upper percentile, so values outside this range do not necessarily indicate disease.[[Special:Contributions/81.11.206.29|81.11.206.29]] ([[User talk:81.11.206.29|talk]]) 20:40, 15 October 2016 (UTC)
:could you be clearer on ''Essential thrombocytopenia=tumorentity''?(as well as expand on you bottom post)--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 23:15, 16 December 2016 (UTC)
== Abciximab induced ==
It really should be added, it in particular can be really severe. It almost killed me. [[User:Williamb|Williamb]] ([[User talk:Williamb|talk]]) 11:50, 24 February 2017 (UTC)
:a reference per MEDRS?--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 11:56, 24 February 2017 (UTC)
:If anyone has a source, I'd be happy to add it. <span style="background:lemonchiffon;padding:2px 10px;font-size:14px;font-family:Garamond">[[User:Photosynthetic430|<span style="color:forestgreen">Photosynthetic430</span>]] [[User talk:Photosynthetic430|<span style="color:forestgreen">❧</span>]]</span> 21:30, 12 May 2017 (UTC)

== Essential Thrombocytopenia redirection ==
It does not make sense for a search for "Essential Thrombocytopenia" to redirect here. If someone types that in it is almost certainly a mistake and they meant essential thrombocythemia, which is basically the opposite of thrombocytopenia. A search for "Essential Thrombocytopenia" should either redirect to Essential Thrombocytosis of ask the user if they meant "Essential Thrombocythemia".  <!-- Template:Unsigned IP --><small class="autosigned">—&nbsp;Preceding [[Wikipedia:Signatures|unsigned]] comment added by [[Special:Contributions/216.52.10.164|216.52.10.164]] ([[User talk:216.52.10.164#top|talk]]) 18:31, 28 February 2018 (UTC)</small> <!--Autosigned by SineBot-->
:one could do [[Essential thrombocytopenia]] as a separate article, however...[https://www.ncbi.nlm.nih.gov/pubmed/?term=(+%22essential+thrombocytopenia%22+)+AND+Review%5Bptyp%5D]--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 19:17, 28 February 2018 (UTC)
== New virus causing T~ ==

http://stm.sciencemag.org/content/10/459/eaat4162
--[[User:Rainald62|Rainald62]] ([[User talk:Rainald62|talk]]) 19:07, 24 September 2018 (UTC)
:thank you for posting--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 19:48, 24 September 2018 (UTC)
== Research article as source==

A primary source, the journal article<small>{{refn|group=Note|More clinical guidance, or generalised observations to inform clinical guidelines, using an extreme case report for educational purposes, rather than 'research' as such.}}</small> was used to reference [[Thrombocytopenia#Alcohol-induced|this]] pre-existing, longstanding  statement:
<blockquote>Clinically significant hemorrhage is rare in alcohol-induced thrombocytopenia, and platelet count begins to rise after 2 to 5 days' abstinence from alcohol. The condition itself in such cases is generally benign.<ref name="Pelz 1991">{{cite journal |last1=Peltz |first1=Steven |title=Severe thrombocytopenia secondary to alcohol use |journal=Postgraduate Medicine |date=1 May 1991 |volume=89 |issue=6 |pages=75–85 |doi=10.1080/00325481.1991.11700918  |postscript=. "Thrombocytopenia is commonly seen among alcoholic patients admitted to the hospital. Dr Peltz reviews a severe case of the disorder and '''discusses the causes, treatment, and prognosis'''. The patient described here is unique in having the lowest platelet count ever reported for this condition." [Taylor and Francis Online blurb; Emphasis added.] <br>''Pelz'' reported in: Silczuk, Andrzej; Habrat, Bogusław (August 2020). [https://www.sciencedirect.com/science/article/pii/S0741832920301804?via%3Dihub#bib78 "Alcohol-induced thrombocytopenia: Current review"]. ''Alcohol''. '''86''': 9–16. doi:10.1016/j.alcohol.2020.02.166. Retrieved 19 March 2021. The potential predictive value of thrombocytopenia was first reported in studies with small number of participants in: Berggren, U.; Fahlke, C.; Balldin, J. (2000). "Transient increase in platelet monoamine oxidase-B activity during early abstinence in alcoholics: Implications for research." ''Alcohol and Alcoholism''. '''35''' (4): 377–380. doi:10.1093/alcalc/35.4.377 |pmid=2020651 |url=https://pubmed.ncbi.nlm.nih.gov/2020651/ |access-date=19 March 2021}}</ref></blockquote>
Although not preferable as a source - as in [[WP:MEDRS]] - the actual '''research''' itself was not relied upon as support, but only the paper's background discussion<sup>[See [[Talk:Thrombocytopenia#_note-1|Note 1]]]</sup> of the condition (i.e. the paper's assertion paraphrased above, did not arise from the authors' own research). If truly not acceptable to use for this purpose, perhaps other, more '''knowledgeable editors can ''easily'' find a source''' for a seemingly uncontentious point.{{refn|group=Note|[[Wikipedia:Identifying reliable sources (medicine)#Other sources|"...never used to '''support surprising claims''', and carefully identified in the text as preliminary work. Medical information resources such as WebMD and eMedicine are usually acceptable sources for '''uncontroversial information''']]."[Emphasis added.] I had thought, given its standing in the article for 12 years, with no cites for any contradictory claim (although I did attempt to add cautionary and contrasting info), and having a cn tag for 3+ years, without action, claims of it being "benign" could be considered fairly uncontroversial.}} I would prefer not to leave it uncited, (and, once again, the assertion has been there for [https://en.wikipedia.org/enwiki/w/index.php?title=Thrombocytopenia&diff=prev&oldid=312223094 many years], at some point [https://en.wikipedia.org/enwiki/w/index.php?title=Thrombocytopenia&diff=prev&oldid=780085389 being tagged],'CN'. Now it has neither a CN tag nor a source.) Thanks [[Special:Contributions/49.177.64.138|49.177.64.138]] ([[User talk:49.177.64.138|talk]]) 12:36, 20 March 2021 (UTC)
:Composed above, and later saw msg left on Talk page. No worries, it's just easier to put it back the way it was with only partial info. I had already looked at WP:MEDRS, the gist of which I thought I had digested; obviously not! Although I cited primary sources, MEDRS did not seem to disallow in a blanket way - just rejects over-reliance. It allows clinical guidelines{{refn|group=Note|[[Wikipedia:Identifying reliable sources (medicine)#Other sources|"UpToDate is less preferred as it is not possible to reference specific versions of their articles, archives do not exist, and it can be difficult to access.]]"}} from reputable sources. (I acknowledge the point, of course, that UpToDate is less desirable - but not disallowed.) Research cited was in conjunction with a Review [[Talk:Thrombocytopenia#References|(Silczuk, 2020)]], also cited, and was from high quality journals, e.g. titles in the BMJ stable. So thought that, used together, these, even if not ideal, would be better than a half-arsed explication of alcohol-related, sitting untouched for years past (since 2009!), without any cites.[[Special:Contributions/49.177.64.138|49.177.64.138]] ([[User talk:49.177.64.138|talk]]) 13:16, 20 March 2021 (UTC)
::One can place the cn tag back, however the source as MEDRS indicates{{refn|group=Note|[[Wikipedia:Identifying reliable sources (medicine)#Biomedical_journals|"In addition to experiments, primary sources normally contain introductory, background, or review sections that place their research in the context of previous work; these sections may be cited in Wikipedia with care: they are often incomplete."]]}} should be 1) review article 5 years or less, 2) WHO, NIH,CDC or NHS,{{refn|group=Note|Or, at least, organisations with similar standing (e.g NHMRC?), and not solely those you note at 2), as in WP:MEDRS: [[Wikipedia:Identifying reliable sources (medicine)#Medical and scientific organizations|"Statements and information from reputable major medical and scientific bodies may be valuable encyclopedic sources. These bodies include the U.S. National Academies (including the National Academy of Medicine and the National Academy of Sciences), the British National Health Service, the U.S. National Institutes of Health and Centers for Disease Control and Prevention, and the World Health Organization."]]}} 3) medical textbook--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 14:52, 20 March 2021 (UTC)
:::I think I will let this one through to the keeper, thanks all the same. 'One' can indeed restore the cn, but it might be better to leave that to the experienced Medical editors on Wikiproject Medicine, one of whom originally placed the [https://en.wikipedia.org/enwiki/w/index.php?title=Thrombocytopenia&diff=prev&oldid=780085389 cn tag in 2017]. Cheers, [[Special:Contributions/49.177.64.138|49.177.64.138]] ([[User talk:49.177.64.138|talk]]) 00:50, 21 March 2021 (UTC)
:::To sum up [(!} sorry for the TL:DR] it is difficult to understand the full rationale for removing  - admittedly less than gold standard - refs that were deleted. Leaving the 'better source needed' tag for the 'Up To date' reference is one thing, but removing refs because they're research / primary sources (although used only in a secondary capacity), while leaving [[Thrombocytopenia#References|many, many others in situ elsewhere]]{{refn|group=Note|e.g 40. Roberts; 41. Guida; 42. Pacifico; 43. Rempen; 44. Olver; 45. Kotiw.}} in the article... well it's just hard to assimilate -and therefore learn - especially as I don't seem to be seeing in WP:MEDRS  the absolute prohibitions seemingly implied in your 1), 2), and 3), above! However, I bow to your greater expertise and experience. [[Special:Contributions/49.177.64.138|49.177.64.138]] ([[User talk:49.177.64.138|talk]]) 05:57, 21 March 2021 (UTC)
::::[[Wikipedia:Identifying reliable sources (medicine)]] any reference can be changed as long as it follows MEDRS, should there be any you believe can be improved please do, thanks--[[User:Ozzie10aaaa|Ozzie10aaaa]] ([[User talk:Ozzie10aaaa|talk]]) 11:55, 21 March 2021 (UTC)
:::::Well, of course, I ''could'' do that. I don't see those refs as a problem, though, in my reading of WP:MEDRS. Just noted them to query and contrast the differing application of WP:MEDRS, that's confusing to me. Point wasn't to imply those were offending references, but to seek understanding of ... I don't know ... varying ways in which WP policy is applied within one article? Something like that. I was trying to ascertain the pattern! So I could do it properly! As I said earlier, I can't see in WP:MEDRS what you contend. And if sources are ''capriciously'' expunged, or allowed to stand, according to some (to me) impenetrable shibboleth, how can one work it out? It's okay though, it really is probably most efficient just to leave it to the Wikiproject Medicine editors. Thanks for listening; I will resign the rant-y soapbox now. [[Special:Contributions/49.177.64.138|49.177.64.138]] ([[User talk:49.177.64.138|talk]]) 14:57, 21 March 2021 (UTC) 
====Notes====
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