WPP domain: Difference between revisions
Content deleted Content added
Alexbateman (talk | contribs) Added alignment figure |
Citation bot (talk | contribs) Add: doi-access. | Use this bot. Report bugs. | Suggested by Headbomb | Linked from Wikipedia:WikiProject_Academic_Journals/Journals_cited_by_Wikipedia/Sandbox | #UCB_webform_linked 65/855 |
||
| (10 intermediate revisions by 9 users not shown) | |||
| Line 1: | Line 1: | ||
{{Infobox protein family |
|||
| ⚫ | The '''WPP domain''' is a [[protein domain]] thought to be exclusively found in plants, first identified in |
||
| Symbol = WPP |
|||
| Name = WPP domain |
|||
| image = |
|||
| width = |
|||
| caption = |
|||
| Pfam = PF13943 |
|||
| Pfam_clan = |
|||
| InterPro = |
|||
| SMART = |
|||
| PROSITE = |
|||
| MEROPS = |
|||
| SCOP = |
|||
| TCDB = |
|||
| OPM family = |
|||
| OPM protein = |
|||
| CAZy = |
|||
| CDD = |
|||
}} |
|||
| ⚫ | The '''WPP domain''' is a [[protein domain]] thought to be exclusively found in plants, first identified in 2000.<ref name=discovery>{{cite journal |author=Meier I |title=A novel link between ran signal transduction and nuclear envelope proteins in plants |journal=[[Plant Physiology (journal)|Plant Physiology]] |volume=124 |issue=4 |pages=1507–10 |date=December 2000 |pmid=11115866 |pmc=1539304 |doi= 10.1104/pp.124.4.1507}}</ref> The domain is about 90 amino acid residues long. |
||
The domain is known to direct [[RanGAP]] to the [[nuclear envelope]].<ref name=nuclearEnvelopeTargeting>{{cite journal | |
The domain is known to direct [[RanGAP]] to the [[nuclear envelope]].<ref name=nuclearEnvelopeTargeting>{{cite journal |vauthors=Rose A, Meier I |title=A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim |journal=[[Proceedings of the National Academy of Sciences of the United States of America]] |volume=98 |issue=26 |pages=15377–82 |date=December 2001 |pmid=11752475 |pmc=65037 |doi=10.1073/pnas.261459698 |doi-access=free }}</ref> Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1),<ref name=discovery /> WPP1<ref name=wpp2and2>{{cite journal |vauthors=Patel S, Rose A, Meulia T, Dixit R, Cyr RJ, Meier I |title=Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division |journal=[[The Plant Cell]] |volume=16 |issue=12 |pages=3260–73 |date=December 2004 |pmid=15548735 |pmc=535872 |doi=10.1105/tpc.104.026740 }}</ref> and WPP2.<ref name=wpp2and2/> |
||
The WPP stands for a [[tryptophan]]-[[proline]]-proline motif that is highly conserved in the domain.<ref name=discovery/> Either deletion of the WPP domain or mutation of both the namesake tryptophan and first proline residues into [[alanine]] in the ''Arabidopsis thaliana'' protein RanGAP1 leads to mis-targeting in the majority of cells.<ref name=nuclearEnvelopeTargeting/> |
The WPP stands for a [[tryptophan]]-[[proline]]-proline motif that is highly conserved in the domain.<ref name=discovery/> Either deletion of the WPP domain or mutation of both the namesake tryptophan and first proline residues into [[alanine]] in the ''Arabidopsis thaliana'' protein RanGAP1 leads to mis-targeting in the majority of cells.<ref name=nuclearEnvelopeTargeting/> |
||
[[File:WPP domain alignment.PNG|thumb|A [[multiple sequence alignment]] of proteins containing a WPP domain showing the conserved WPP sequence motif to the left.|700px| |
[[File:WPP domain alignment.PNG|thumb|A [[multiple sequence alignment]] of proteins containing a WPP domain showing the conserved WPP sequence motif to the left.|700px|center]] |
||
=References= |
==References== |
||
<references/> |
<references/> |
||
[[Category:Protein domains]] |
[[Category:Protein domains]] |
||
Latest revision as of 22:50, 23 September 2021
| WPP domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | WPP | ||||||||
| Pfam | PF13943 | ||||||||
| |||||||||
The WPP domain is a protein domain thought to be exclusively found in plants, first identified in 2000.[1] The domain is about 90 amino acid residues long.
The domain is known to direct RanGAP to the nuclear envelope.[2] Non-RanGAP nuclear envelope proteins are also known to encode WPP domains, such as MFP1 attachment factor 1 (MAF1),[1] WPP1[3] and WPP2.[3]
The WPP stands for a tryptophan-proline-proline motif that is highly conserved in the domain.[1] Either deletion of the WPP domain or mutation of both the namesake tryptophan and first proline residues into alanine in the Arabidopsis thaliana protein RanGAP1 leads to mis-targeting in the majority of cells.[2]
References
[edit]- ^ a b c Meier I (December 2000). "A novel link between ran signal transduction and nuclear envelope proteins in plants". Plant Physiology. 124 (4): 1507–10. doi:10.1104/pp.124.4.1507. PMC 1539304. PMID 11115866.
- ^ a b Rose A, Meier I (December 2001). "A domain unique to plant RanGAP is responsible for its targeting to the plant nuclear rim". Proceedings of the National Academy of Sciences of the United States of America. 98 (26): 15377–82. doi:10.1073/pnas.261459698. PMC 65037. PMID 11752475.
- ^ a b Patel S, Rose A, Meulia T, Dixit R, Cyr RJ, Meier I (December 2004). "Arabidopsis WPP-domain proteins are developmentally associated with the nuclear envelope and promote cell division". The Plant Cell. 16 (12): 3260–73. doi:10.1105/tpc.104.026740. PMC 535872. PMID 15548735.