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| miRBase =
| miRBase =
| miRBase_family =
| miRBase_family =
| RNA_type = [[Gene]]; [[Small_nuclear_RNA | snRNA]]; [[Small_nucleolar_RNA | snoRNA]]; CD-box
| RNA_type = [[Gene]]; [[Small nuclear RNA|snRNA]]; [[Small nucleolar RNA|snoRNA]]; C/D-box
| Tax_domain = [[Eukaryota]]
| Tax_domain = [[Eukaryota]]
| GO = {{GO|0006396}} {{GO|0005730}}
| GO = {{GO|0006396}} {{GO|0005730}}
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}}
}}


'''Small Nucleolar RNA SNORD111''' (also known as HBII-82) is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis (modification) of other [[small nuclear RNA]]s (snRNAs). This type of modifiying RNA is located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA) and also often referred to as a guide RNA.
In [[molecular biology]], '''Small Nucleolar RNA SNORD111''' (also known as HBII-82) is a [[non-coding RNA]] (ncRNA) molecule which functions in the biogenesis (modification) of other [[small nuclear RNA]]s (snRNAs). This type of modifying RNA is located in the [[nucleolus]] of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a [[snoRNA|small nucleolar RNA]] (snoRNA) and also often referred to as a guide RNA.

SNORD111 belongs to the [[SnoRNA#C/D box|C/D box]] class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-[[methylation]] of substrate RNAs.<ref>{{cite journal | vauthors = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6663–6668 | date = October 2002 | pmid = 12215523 | pmc = 134041 | doi = 10.1128/MCB.22.19.6663-6668.2002 }}</ref>

⚫
SNORD111 is predicted to guide the 2′O-ribose methylation of 28S [[ribosomal RNA]] (rRNA) at residue G3923.<ref>{{cite journal | vauthors = Lestrade L, Weber MJ | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D158–162 | date = January 2006 | pmid = 16381836 | pmc = 1347365 | doi = 10.1093/nar/gkj002 | citeseerx = 10.1.1.105.7552 }}</ref><ref name="pmid11387227">{{cite journal | vauthors = Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = The EMBO Journal | volume = 20 | issue = 11 | pages = 2943–2953 | date = June 2001 | pmid = 11387227 | pmc = 125495 | doi = 10.1093/emboj/20.11.2943 }}</ref>


⚫
SNORD111 belongs to the [[SnoRNA#C.2FD_box|C/D box]] class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2'-O-[[methylation]] of substrate RNAs.<ref>{{cite journal |author= Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I; |title= Purified box C/D snoRNPs are able to reproduce site-specific2'-O-methylation of target RNA in vitro. |journal= Mol Cell Biol |volume= 22 |issue= |pages= 6663–6668 |year= 2002 |pmid=12215523 |doi= 10.1128/MCB.22.19.6663-6668.2002 |pmc=134041}}</ref> SNORD111 is predicted to guide the 2'O-ribose methylation of 28S [[ribosomal RNA]] (rRNA) at residue G3923.<ref>{{cite journal |author= Lestrade L, Weber MJ; |title= snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D boxsnoRNAs. |journal= Nucleic Acids Res |volume= 34 |issue= |pages= D158–D162 |year= 2006 |pmid=16381836 |doi= 10.1093/nar/gkj002 |pmc=1347365}}</ref><ref name="pmid11387227">{{cite journal |author=Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J |title=RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. |journal=EMBO J |volume=20 |issue=11 |pages=2943–53 |year=2001 |pmid=11387227 |doi=10.1093/emboj/20.11.2943 |pmc=125495}}</ref>
The exact role of these molecules, however, is not currently known.
The exact role of these molecules, however, is not currently known.
⚫
==References==


⚫
== References ==
{{reflist|1}}
{{Reflist}}


==External links==
== External links ==
* {{Rfam|id=RF00611|name=Small Nucleolar RNA SNORD111}}
* {{Rfam|id=RF00611|name=Small Nucleolar RNA SNORD111}}
* [http://www-snorna.biotoul.fr/plus.php?id=HBII-82 snoRNABase entry for SNORD111]
* {{snoRNABase|id=HBII-82|name=SNORD111}}


{{Small nucleolar RNA}}
{{Small nucleolar RNA}}


[[Category:Non-coding RNA]]
[[Category:Non-coding RNA]]



{{molecular-cell-biology-stub}}
{{molecular-cell-biology-stub}}

Latest revision as of 20:32, 27 October 2021

Small Nucleolar RNA SNORD111
Predicted secondary structure and sequence conservation of SNORD111
Identifiers
SymbolSNORD111
RfamRF00611
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

In molecular biology, Small Nucleolar RNA SNORD111 (also known as HBII-82) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

SNORD111 belongs to the C/D box class of snoRNAs which contain the C (UGAUGA) and D (CUGA) box motifs. Most of the members of the box C/D family function in directing site-specific 2′-O-methylation of substrate RNAs.[1]

SNORD111 is predicted to guide the 2′O-ribose methylation of 28S ribosomal RNA (rRNA) at residue G3923.[2][3]

The exact role of these molecules, however, is not currently known.

References

[edit]
  1. ^ Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2′-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. ^ Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
  3. ^ Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–2953. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
[edit]


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