GNG4: Difference between revisions

GNG4
Identifiers
Aliases	GNG4, G protein subunit gamma 4, HG3C
External IDs	OMIM: 604388; MGI: 102703; HomoloGene: 3299; GeneCards: GNG4; OMA:GNG4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	235,650,754 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	14,002,481 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; islet of Langerhans; ; ventricular zone; ; Hypothalamus; ; Amygdala; ; left ovary; ; Pituitary Gland; ; caudate nucleus; ; nucleus accumbens; ; prefrontal cortex;
	Top expressed in
	facial motor nucleus; ; substantia nigra; ; olfactory bulb; ; lateral septal nucleus; ; islet of Langerhans; ; Rostral migratory stream; ; supraoptic nucleus; ; paraventricular nucleus of hypothalamus; ; molar; ; condyle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signal transducer activity; GTPase activity; G-protein beta-subunit binding;
Cellular component	plasma membrane; extracellular exosome; membrane; heterotrimeric G-protein complex; G-protein beta/gamma-subunit complex;
Biological process	G protein-coupled receptor signaling pathway; cellular response to glucagon stimulus; negative regulation of cell growth; regulation of G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	2786
	14706
	ENSG00000168243; ENSG00000282972
	ENSMUSG00000021303
	P50150
	P50153
	NM_001098721; NM_001098722; NM_004485
	NM_010317; NM_001302997
	NP_001092191; NP_001092192; NP_004476
	NP_001289926; NP_034447
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 01:59, 8 April 2022

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 is a protein that in humans is encoded by the GNG4 gene.^[5]^[6]

Interactions

GNG4 has been shown to sometimes interact with GNB1.^[5]{^[7]

References

^ ^a ^b ^c ENSG00000282972 GRCh38: Ensembl release 89: ENSG00000168243, ENSG00000282972 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021303 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.
^ "Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4".
^ Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

Downes GB, Gautam N (1999). "The G protein subunit gene families". Genomics. 62 (3): 544–52. doi:10.1006/geno.1999.5992. PMID 10644457.
Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ (1995). "A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase". J. Biol. Chem. 270 (24): 14251–4. doi:10.1074/jbc.270.24.14251. PMID 7782277.
Yan K, Kalyanaraman V, Gautam N (1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.
Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T (2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta". J. Biol. Chem. 278 (9): 7220–6. doi:10.1074/jbc.M210304200. PMID 12486123.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000282972 GRCh38: Ensembl release 89: ENSG00000168243, ENSG00000282972 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021303 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7665596-5] Ray K, Kunsch C, Bonner LM, Robishaw JD (Oct 1995). "Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits". J. Biol. Chem. 270 (37): 21765–71. doi:10.1074/jbc.270.37.21765. PMID 7665596.

[entrez-6] "Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4".

[pmid8636150-7] Yan K, Kalyanaraman V, Gautam N (Mar 1996). "Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families". J. Biol. Chem. 271 (12): 7141–6. doi:10.1074/jbc.271.12.7141. PMID 8636150.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=2786}}
+{{Infobox_gene}}
-'''Guanine nucleotide binding protein (G protein), gamma 4''', also known as '''GNG4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2786| accessdate = }}</ref>
+'''Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4''' is a [[protein]] that in humans is encoded by the ''GNG4'' [[gene]].<ref name="pmid7665596">{{cite journal | vauthors = Ray K, Kunsch C, Bonner LM, Robishaw JD | title = Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21765–71  | date = Oct 1995 | pmid = 7665596 | doi = 10.1074/jbc.270.37.21765 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNG4 guanine nucleotide binding protein (G protein), gamma 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2786}}</ref>
+== Interactions ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
+GNG4 has been shown to sometimes [[Protein-protein interaction|interact]] with [[GNB1]].<ref name=pmid7665596 />{<ref name=pmid8636150>{{cite journal | vauthors = Yan K, Kalyanaraman V, Gautam N | title = Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families | journal = J. Biol. Chem. | volume = 271 | issue = 12 | pages = 7141–6  | date = Mar 1996 | pmid = 8636150 | doi = 10.1074/jbc.271.12.7141 | doi-access = free }}</ref>
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 | year = 1999 | pmid = 10644457 | doi = 10.1006/geno.1999.5992 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Pumiglia KM, LeVine H, Haske T, Habib T, Jove R, Decker SJ | title = A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase | journal = J. Biol. Chem. | volume = 270 | issue = 24 | pages = 14251–4 | year = 1995 | pmid = 7782277 | doi = 10.1074/jbc.270.24.14251 | doi-access = free }}
-| citations =
-*{{cite journal  | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544–52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
+* {{cite journal | vauthors = Yan K, Kalyanaraman V, Gautam N | title = Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families | journal = J. Biol. Chem. | volume = 271 | issue = 12 | pages = 7141–6 | year = 1996 | pmid = 8636150 | doi = 10.1074/jbc.271.12.7141 | doi-access = free }}
-*{{cite journal  | author=Ray K, Kunsch C, Bonner LM, Robishaw JD |title=Isolation of cDNA clones encoding eight different human G protein gamma subunits, including three novel forms designated the gamma 4, gamma 10, and gamma 11 subunits. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21765–71 |year= 1995 |pmid= 7665596 |doi=  }}
+* {{cite journal | vauthors = Cuello F, Schulze RA, Heemeyer F, Meyer HE, Lutz S, Jakobs KH, Niroomand F, Wieland T | title = Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta | journal = J. Biol. Chem. | volume = 278 | issue = 9 | pages = 7220–6 | year = 2003 | pmid = 12486123 | doi = 10.1074/jbc.M210304200 | doi-access = free }}
+* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
-*{{cite journal  | author=Pumiglia KM, LeVine H, Haske T, ''et al.'' |title=A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase. |journal=J. Biol. Chem. |volume=270 |issue= 24 |pages= 14251–4 |year= 1995 |pmid= 7782277 |doi=  }}
-*{{cite journal  | author=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Cuello F, Schulze RA, Heemeyer F, ''et al.'' |title=Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B and Gbeta subunits. Complex formation of NDPK B with Gbeta gamma dimers and phosphorylation of His-266 IN Gbeta. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7220–6 |year= 2003 |pmid= 12486123 |doi= 10.1074/jbc.M210304200 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
-}}
 {{refend}}
 {{gene-1-stub}}
+{{Intracellular signaling peptides and proteins}}
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