BRAT1: Difference between revisions

BRAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4IFI
Identifiers
Aliases	BRAT1, BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS
External IDs	OMIM: 614506; MGI: 1891679; HomoloGene: 16776; GeneCards: BRAT1; OMA:BRAT1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	2,555,694 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	140,705,134 bp
RNA expression pattern
	Top expressed in
	left adrenal cortex; ; granulocyte; ; right adrenal gland; ; right adrenal cortex; ; right testis; ; left testis; ; gonad; ; right hemisphere of cerebellum; ; right uterine tube; ; right ovary;
	Top expressed in
	interventricular septum; ; granulocyte; ; Rostral migratory stream; ; spermatocyte; ; lumbar spinal ganglion; ; right kidney; ; ascending aorta; ; endocardial cushion; ; external carotid artery; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; membrane; nucleus; nucleoplasm;
Biological process	mitochondrion localization; response to ionizing radiation; cell growth; positive regulation of protein phosphorylation; cell population proliferation; cell migration; glucose metabolic process; cellular response to DNA damage stimulus; apoptotic process; positive regulation of cell growth;
	Sources:Amigo / QuickGO
Orthologs
	221927
	231841
	ENSG00000106009
	ENSMUSG00000000148
	Q6PJG6
	Q8C3R1
	NM_152743; NM_001350626; NM_001350627
	NM_001276287; NM_172724; NM_181066
	NP_689956; NP_001337555; NP_001337556
	NP_001263216; NP_851411
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:38, 12 April 2022

BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.^[5]

Function

The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: BRCA1-associated ATM activator 1".

External links

Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser.
PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BRCA1-associated ATM activator 1".

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{multiple issues|
+{{Infobox_gene}}
-{{Underlinked|date=July 2013}}
+'''BRCA1-associated ATM activator 1''' is a [[protein]] in humans that is encoded by the BRAT1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRCA1-associated ATM activator 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=221927 }}</ref>
-{{Orphan|date=July 2013}}
-}}
+== Function ==
-{{PBB|geneid=221927}}
+The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing [[BRCA1]] (breast cancer 1) protein and the [[ataxia telangiectasia mutated|ATM]] ([[ataxia telangiectasia]] mutated) protein. ATM is thought to be a master controller of [[cell cycle checkpoint]] signalling pathways that are required for cellular responses to [[DNA damage]] such as [[double-strand break]]s that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.<ref name="entrez"/>
-'''BRCA1-associated ATM activator 1''' is a [[protein]] in humans that is encoded by the BRAT1 [[gene]].
-<ref name="entrez">
-{{cite web
-| title = Entrez Gene: BRCA1-associated ATM activator 1
-| url = http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=221927
-| accessdate = 2013-07-10 <!-- T03:38:35.214165-08:00 -->
-}}</ref>
-The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. [provided by RefSeq, Mar 2012]. ##Evidence-Data-START## Transcript exon combination :: BC015632.2 [ECO:0000332] RNAseq introns              :: single sample supports all introns                                ERS025088 [ECO:0000348] ##Evidence-Data-END##
 == References ==
 {{reflist}}
+==External links==
-== Further reading ==
+* {{UCSC gene info|BRAT1}}
+* [https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q6PJG6 PDBe-KB] provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator
-{{refbegin | 2}}
-{{refend}}
 [[Category:Genes]]
 [[Category:Human proteins]]
 {{gene-7-stub}}