BRAT1: Difference between revisions
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Importing Wikidata short description: "Protein-coding gene in the species Homo sapiens" (Shortdesc helper) |
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'''BRCA1-associated ATM activator 1''' is a [[protein]] in humans that is encoded by the BRAT1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRCA1-associated ATM activator 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=221927 }}</ref> |
'''BRCA1-associated ATM activator 1''' is a [[protein]] in humans that is encoded by the BRAT1 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: BRCA1-associated ATM activator 1 | url = https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=retrieve&list_uids=221927 }}</ref> |
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Latest revision as of 19:38, 12 April 2022
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | BRAT1, BAAT1, C7orf27, RMFSL, BRCA1 associated ATM activator 1, NEDCAS | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614506; MGI: 1891679; HomoloGene: 16776; GeneCards: BRAT1; OMA:BRAT1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene.[5]
Function
[edit]The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint signalling pathways that are required for cellular responses to DNA damage such as double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.[5]
References
[edit]- ^ a b c GRCh38: Ensembl release 89: ENSG00000106009 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000148 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: BRCA1-associated ATM activator 1".
External links
[edit]- Human BRAT1 genome location and BRAT1 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human BRCA1-associated ATM activator
 | This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it. |