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Linda Randall is a Professor Emerita of Biochemistry and Wurdack Chair Emerita of Biological Chemistry at University of Missouri.<ref name=":0">{{Cite web|url=https://biochem.missouri.edu/faculty/faculty-members/randalll/index.php|title=Linda Randall|last=|first=|date=|website=University of Missouri|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> Her research has shown unexpected and complex details of the movement of newly made proteins from the cytosol across membranes into organelles of the cell. In particular, she found that the entire protein was kept unfolded by association with a chaperone and not just directed to cross membranes by its terminal leader sequence.<ref name=":1">{{Cite web|url=http://www.nasonline.org/member-directory/members/3003916.html|title=Linda Randall|last=|first=|date=|website=National Academy of Sciences|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> In 1997, she was elected to the National Academy of Sciences of the USA because of the excellence of this work. She has received a number of other honors and awards.<ref name=":1" /> |
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'''Elizabeth Ann Winzeler''' is a professor at the [[University of California, San Diego, School of Medicine]] and a [[microbiology]] researcher.<ref name=":0">{{Cite web|url=https://www.asm.org/index.php/aam-fellows/aam-fellows/fellows-elected-in-2016/item/4549-elizabeth-winzeler|title=Elizabeth Ann Winzeler|last=|first=|date=|website=American Society for Microbiology|archive-url=|archive-date=|dead-url=|access-date=October 27, 2018}}</ref> She is particularly noted for genomic level investigation of yeast and the malaria parasite and for development of new drugs to treat malaria more effectively. Winzeler has been elected to the American Academy of Microbiology in 2016<ref name=":0" /> and received a Gates Foundation grant to pursue her design of anti-malarial drugs in |
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== Education == |
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'''Early life and education''' |
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Linda Randall received the BS at Colorado State University in Zoology and the PhD at University of Wisconsin in Molecular Biology.<ref name=":0" /> |
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== Academic Research Career == |
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Elizabeth was born in Canton, Ohio to Robert Lee Winzeler and Judith Kay Winzeler on May 8, 1962. She had malaria when her family was in Malasia for her father's sabbatical leave, which may have put malaria on her mind early.<ref name=":1">{{Cite web|url=https://www.lclark.edu/live/news/35158-ending-malaria|title=Ending Malaria|last=Valo|first=Ellisa|date=January 24, 2017|website=Lewis and Clark College|archive-url=|archive-date=|dead-url=|access-date=October 27, 2018}}</ref> |
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Linda Randall was a professor at University of Uppsala, Sweden for eight years and joined the faculty at Washington State University in 1981.<ref>{{Cite web|url=https://s3.wp.wsu.edu/uploads/sites/9/2016/09/WSUchemNewsletter-Summer1997ocr.pdf|title=Biochemists Elected to the National Academy of Sciences|last=|first=|date=1997|website=Washington State University Biochemistry Department|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> She was a professor at Washington State University for twenty years, but in 2000, she received an attractive offer from University of Missouri and moved there along with her husband.<ref name=":2">{{Cite web|url=https://lmtribune.com/education/departing-profs-have-harsh-words-for-wsu-research-team-leaders/article_d030c0b4-dfc8-58ed-8e9b-7a5829f4f839.html|title=Departing Professors Have Harsh Words for WSU|last=Smith|first=Debra|date=September 22, 2000|website=The Lewiston Tribune|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> She and her husband, Gerald Hazelbauer, chair of biochemistry, gave an interview to ''The Lewiston Tribune'' saying that they had decided to leave the Pullman campus partly due to the inability of WSU to promote academic excellence and set a high standard for student behavior. The excessive drinking and wild behavior was their main issue.<ref name=":2" /> The two professors took over three quarters of a million dollars in federal research funding with them to Missouri.<ref name=":2" /> |
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Linda Randall showed the mechanism of protein export in the bacterium ''Escherichia coli''.<ref name=":3">{{Cite web|url=https://biochem.missouri.edu/faculty/faculty-members/randalll/index.php|title=Linda Randall|last=|first=|date=|website=University of Missouri Biochemistry Department|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> It is not an easy task to move a protein folded into its tertiary and quaternary structures through a membrane, but many proteins must be moved from their synthesis site in the cytosol to other places in the cell that are separated from the cytosol by membranes. It was known that proteins that move across membranes are synthesized with a particular leader peptide and it was once thought that any transport process would focus on that leader peptide.<ref name=":1" /> However, Randall’s laboratory showed that the whole length of nascent proteins are kept in their unfolded state by associating them with a chaperone protein to facilitate their transfer to another compartment in the cell bounded by a membrane.<ref name=":1" /> The role of the SecB chaperone and its ATPase partner SecA in assisting newly made polypeptides to cross membranes was worked out in her laboratory.<ref name=":3" /> Her development of a system to study membrane translocation in the test tube has been important in her own research and that of others.<ref name=":3" /> |
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Dr. Winzeler attended [[Lewis and Clark College]] in [[Portland, Oregon]] where she first intended to become an art major, but when she took physics with Professor of Physics Robert Deery during senior year she discovered she liked mathematics and was good at it.<ref name=":1" /> She added a major in Natural Sciences and received her B.A. in Natural Sciences and Art in 1984.<ref name=":1" /> After college, she learned to be a computer programmer by working at the Bureau of Labor Statistics in Washington, D.C.<ref name=":1" /> She then returned to academia to receive her M.S. in Biophysics and Biochemistry in 1990 at [[Oregon State University]] in [[Corvallis, Oregon]].<ref name=":1" /> In 1996, she was awarded the Ph.D. from [[Stanford University]] in [[Stanford, California]] in [[Developmental Biology]].<ref name=":1" /> |
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== Honors and Awards == |
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National Academy of Sciences, 1997<ref name=":1" /> |
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From 2007 to 2012, Winzeler headed the Department of Cellular Biology at the Genomics Institute of the Novartis Research Foundation.<ref name=":1" /> From 2010 to 2012, she was also Associate Professor in the Department of Genetics and Department of Immunology & Microbial Science at Scripps Research Institute.<ref name=":1" /> In 2012, she became Professor of Peidatrics at University of California, San Diego and Director of Translational Research at the UCSD Heath Sciences Center for Immunity, Infection, and Inflammation.<ref name=":1" /> |
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American Academy of Microbiology<ref name=":3" /> |
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'''Research''' |
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American Academy of Arts and Sciences, 1984<ref>{{Cite web|url=https://www.amacad.org/content/news/pressReleases.aspx?pr=59 |
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'''Contributions to science:''' |
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American Academy Announces 2004 Fellows and Foreign Honorary Members |
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4/30/2004|title=American Academy of Arts and Sciences Announces 2004 Fellows and Foreign Hnorary Members|last=|first=|date=April 30, 2004|website=|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> |
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Fellow of American Association for the Advancement of Science<ref name=":3" /> |
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* Evidence-based annotation of the malaria parasite's genome using comparative expression profiling.<sup>[[Elizabeth A. Winzeler#cite%20note-3|[3]]]</sup> |
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* The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification.<sup>[[Elizabeth A. Winzeler#cite%20note-4|[4]]]</sup> |
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* In silico discovery of transcription regulatory elements in Plasmodium falciparum.<sup>[[Elizabeth A. Winzeler#cite%20note-5|[5]]]</sup> |
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* Discovery of gene function by expression profiling of the malaria parasite life cycle.<sup>[[Elizabeth A. Winzeler#cite%20note-6|[6]]]</sup> |
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* High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission.<sup>[[Elizabeth A. Winzeler#cite%20note-7|[7]]]</sup> |
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* KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission.<sup>[[Elizabeth A. Winzeler#cite%20note-8|[8]]]</sup> |
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* Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria.<sup>[[Elizabeth A. Winzeler#cite%20note-9|[9]]]</sup> |
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* In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen.<sup>[[Elizabeth A. Winzeler#cite%20note-10|[10]]]</sup> |
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* Diagana TT. Spiroindolones, a potent compound class for the treatment of malaria.<sup>[[Elizabeth A. Winzeler#cite%20note-11|[11]]]</sup> |
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* Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery.<sup>[[Elizabeth A. Winzeler#cite%20note-12|[12]]]</sup> |
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* Targeting Plasmodium PI(4)K to eliminate malaria.<sup>[[Elizabeth A. Winzeler#cite%20note-13|[13]]]</sup> |
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* Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials.<sup>[[Elizabeth A. Winzeler#cite%20note-14|[14]]]</sup> |
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* Direct allelic variation scanning of the yeast genome.<sup>[[Elizabeth A. Winzeler#cite%20note-15|[15]]]</sup> |
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* Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.<sup>[[Elizabeth A. Winzeler#cite%20note-16|[16]]]</sup> |
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* Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays.<sup>[[Elizabeth A. Winzeler#cite%20note-17|[17]]]</sup> |
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* Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.<sup>[[Elizabeth A. Winzeler#cite%20note-18|[18]]]</sup> |
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Eli Lilly Award in Microbiology or Immunology (American Society for Microbiology)<ref>{{Cite web|url=https://www.asm.org/index.php/component/content/article/140-awards-a-grants/past-laureates/7791-eli-lilly-and-company-elanco-research-award-past-laureates|title=Eli Lilly and Company Elanco Research Award Past Laureates|last=|first=|date=|website=American Society for Microbiology|archive-url=|archive-date=|access-date=December 4, 2018}}</ref> |
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'''Patents:''' |
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== Selected Works == |
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* Method for Parallel Screening of Allelic Variation<sup>[[Elizabeth A. Winzeler#cite%20note-19|[19]]]</sup> |
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Bariya P, Randall LL. (2018). “Co-assembly of SecYEG and SecA fully restores the properties of the native translocon.” ''J Bacteriol''. 2018 Oct 1. doi: 10.1128 JB.00493-18 Epub ahead of print. |
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* Compounds and Compositions as Kinase Inhibitors<sup>[[Elizabeth A. Winzeler#cite%20note-20|[20]]]</sup> |
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'''Awards and honors''' |
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* The Ellison Medical Foundation<sup>[[Elizabeth A. Winzeler#cite%20note-23|[23]]]</sup> New Scholar Award (2001) |
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* [[American Society of Tropical Medicine and Hygiene]] (ASTMH) Molecular, Cellular and Immuno Parasitology Award (2002) |
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* W.M. Keck Foundation, Distinguished Young Scholar in Medical Research Award (2004) |
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* Worm Free World<sup>[[Elizabeth A. Winzeler#cite%20note-27|[27]]]</sup> Board of Directors (2012-2013) |
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* Scientific Advisory Board, Structural Drug Discovery Consortium (2013-present) |
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* Bailey Ashford Medal<sup>[[Elizabeth A. Winzeler#cite%20note-28|[28]]]</sup> American Society of Tropical Medicine and Hygiene (2014) |
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* Scientific Advisory Board, [[Tres Cantos]] Open Laboratory Foundation (2014-present) |
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* Fellow of the American Society of Microbiology (2016) |
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* Medicines for Malaria Venture Project of the Year<sup>[[Elizabeth A. Winzeler#cite%20note-29|[29]]]</sup> (2017) |
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* Alice and C. C. Wang in Molecular Parasitology<sup>[[Elizabeth A. Winzeler#cite%20note-30|[30]]]</sup> (2018) |
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* William Trager Award on behalf of ASTMH and the American Committee of Molecular, Cellular and Immunoparasitology<sup>[[Elizabeth A. Winzeler#cite%20note-31|[31]]]</sup> (2018) |
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Findik BT, Smith VF, Randall LL. (2018). “Penetration into membrane of amino-terminal region of SecA when associated with SecYEG in active complexes.” ''Protein Sci''. '''27'''(3):681-691. doi: 10.1002/pro.3362. |
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'''References''' |
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# |
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· American Academy in Microbiology: <nowiki>https://www.asm.org/index.php/aam</nowiki> |
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Suo Y, Hardy SJS, Randall LL. (2015). “The basis of asymmetry in the SecA:SecB complex.” ''J Mol Biol''. '''427'''(4):887-900. doi: 10.1016/j.jmb.2014.12.008. [PubMed] |
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· · Complete list of Dr. Winzeler's published work: <nowiki>https://www.ncbi.nlm.nih.gov/pubmed/?term=winzeler+e%2A</nowiki> |
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· · ''Zhou, Y; Ramachandran, V; Kumar, K. A; Westenberger, S; Refour, P; Zhou, B; Li, F; Young, J. A; Chen, K; Plouffe, D; Henson, K; Nussenzweig, V; Carlton, J; Vinetz, J. M; Duraisingh, M. T; Winzeler, E. A (2008). "Evidence-based annotation of the malaria parasite's genome using comparative expression profiling". PLOS ONE. '''3''' (2): e1570. [[Bibcode]]:2008PLoSO...3.1570Z. [[Digital object identifier|doi]]:10.1371/journal.pone.0001570. [[PubMed Central|PMC]] 2215772. [[PubMed Identifier|PMID]] 18270564.'' |
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· · ''Young, J. A; Fivelman, Q. L; Blair, P. L; de la Vega, P; Le Roch, K. G; Zhou, Y; Carucci, D. J; Baker, D. A; Winzeler, E. A (2005). "The Plasmodium falciparum sexual development transcriptome: A microarray analysis using ontology-based pattern identification" (PDF). Molecular and Biochemical Parasitology. '''143''' (1): 67–79. [[Digital object identifier|doi]]:10.1016/j.molbiopara.2005.05.007. [[PubMed Identifier|PMID]] 16005087.'' |
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Mao C, Cheadle CE, Hardy SJ, Lilly AA, Suo Y, Sanganna Gari RR, King GM, Randall LL. (2013). “Stoichiometry of SecYEG in the active translocase of ''Escherichia coli'' varies with precursor species.” ''Proc Natl Acad Sci U S A''. '''110'''(29):11815-20. doi: 10.1073/pnas.1303289110. [PubMed] |
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· · ''Young, J. A; Johnson, J. R; Benner, C; Yan, S. F; Chen, K; Le Roch, K. G; Zhou, Y; Winzeler, E. A (2008). "In silico discovery of transcription regulatory elements in Plasmodium falciparum". Bmc Genomics. '''9''': 70. [[Digital object identifier|doi]]:10.1186/1471-2164-9-70. [[PubMed Central|PMC]] 2268928. [[PubMed Identifier|PMID]] 18257930.'' |
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· · ''Le Roch, K. G; Zhou, Y; Blair, P. L; Grainger, M; Moch, J. K; Haynes, J. D; de la Vega, P; Holder, A. A; Batalov, S; Carucci, D. J; Winzeler, E. A (2003). "Discovery of gene function by expression profiling of the malaria parasite life cycle". Science. '''301''' (5639): 1503–8. [[Bibcode]]:2003Sci...301.1503L. [[Digital object identifier|doi]]:10.1126/science.1087025. [[PubMed Identifier|PMID]] 12893887.'' |
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· · ''Plouffe, D. M; Wree, M; Du, A. Y; Meister, S; Li, F; Patra, K; Lubar, A; Okitsu, S. L; Flannery, E. L; Kato, N; Tanaseichuk, O; Comer, E; Zhou, B; Kuhen, K; Zhou, Y; Leroy, D; Schreiber, S. L; Scherer, C. A; Vinetz, J; Winzeler, E. A (2016). "High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission". Cell Host & Microbe. '''19''' (1): 114–26. [[Digital object identifier|doi]]:10.1016/j.chom.2015.12.001. [[PubMed Central|PMC]] 4723716. [[PubMed Identifier|PMID]] 26749441.'' |
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Sanganna Gari RR, Frey NC, Mao C, Randall LL, King GM. (2013). “Dynamic structure of the translocon SecYEG in membrane: direct single molecule observations.” ''J Biol Chem''. '''288'''(23):16848-54. doi: 10.1074/jbc.M113.471870. [PubMed] |
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· · ''Kuhen, K. L; Chatterjee, A. K; Rottmann, M; Gagaring, K; Borboa, R; Buenviaje, J; Chen, Z; Francek, C; Wu, T; Nagle, A; Barnes, S. W; Plouffe, D; Lee, M. C; Fidock, D. A; Graumans, W; Van De Vegte-Bolmer, M; Van Gemert, G. J; Wirjanata, G; Sebayang, B; Marfurt, J; Russell, B; Suwanarusk, R; Price, R. N; Nosten, F; Tungtaeng, A; Gettayacamin, M; Sattabongkot, J; Taylor, J; Walker, J. R; et al. (2014). "KAF156 is an Antimalarial Clinical Candidate with Potential for Use in Prophylaxis, Treatment, and Prevention of Disease Transmission". Antimicrobial Agents and Chemotherapy. '''58''' (9): 5060–5067. [[Digital object identifier|doi]]:10.1128/AAC.02727-13. [[PubMed Central|PMC]] 4135840. [[PubMed Identifier|PMID]] 24913172.'' |
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· · ''Yeung, B. K; Zou, B; Rottmann, M; Lakshminarayana, S. B; Ang, S. H; Leong, S. Y; Tan, J; Wong, J; Keller-Maerki, S; Fischli, C; Goh, A; Schmitt, E. K; Krastel, P; Francotte, E; Kuhen, K; Plouffe, D; Henson, K; Wagner, T; Winzeler, E. A; Petersen, F; Brun, R; Dartois, V; Diagana, T. T; Keller, T. H (2010). "Spirotetrahydro beta-carbolines (spiroindolones): A new class of potent and orally efficacious compounds for the treatment of malaria". Journal of Medicinal Chemistry. '''53''' (14): 5155–64. [[Digital object identifier|doi]]:10.1021/jm100410f. [[PubMed Identifier|PMID]] 20568778.'' |
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· · ''Plouffe, D; Brinker, A; McNamara, C; Henson, K; Kato, N; Kuhen, K; Nagle, A; Adrián, F; Matzen, J. T; Anderson, P; Nam, T. G; Gray, N. S; Chatterjee, A; Janes, J; Yan, S. F; Trager, R; Caldwell, J. S; Schultz, P. G; Zhou, Y; Winzeler, E. A (2008). "In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen". Proceedings of the National Academy of Sciences. '''105''' (26): 9059–64. [[Bibcode]]:2008PNAS..105.9059P. [[Digital object identifier|doi]]:10.1073/pnas.0802982105. [[PubMed Central|PMC]] 2440361. [[PubMed Identifier|PMID]] 18579783.'' |
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Suo Y, Hardy SJ, Randall LL. (2011). “Orientation of SecA and SecB in complex, derived from disulfide cross-linking.” ''J Bacteriol''. '''193'''(1):190-6. doi: 10.1128/JB.00975-10. [PubMed] |
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· · ''Rottmann, M; McNamara, C; Yeung, B. K; Lee, M. C; Zou, B; Russell, B; Seitz, P; Plouffe, D. M; Dharia, N. V; Tan, J; Cohen, S. B; Spencer, K. R; González-Páez, G. E; Lakshminarayana, S. B; Goh, A; Suwanarusk, R; Jegla, T; Schmitt, E. K; Beck, H. P; Brun, R; Nosten, F; Renia, L; Dartois, V; Keller, T. H; Fidock, D. A; Winzeler, E. A; Diagana, T. T (2010). "Spiroindolones, a potent compound class for the treatment of malaria". Science. '''329''' (5996): 1175–80. [[Bibcode]]:2010Sci...329.1175R. [[Digital object identifier|doi]]:10.1126/science.1193225. [[PubMed Central|PMC]] 3050001. [[PubMed Identifier|PMID]] 20813948.'' |
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Randall LL, Henzl MT. (2010). “Direct identification of the site of binding on the chaperone SecB for the amino terminus of the translocon motor SecA.” ''Protein Sci''. '''19'''(6):1173-9. doi: 10.1002/pro.392. [PubMed] |
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· · ''Meister, S; Plouffe, D. M; Kuhen, K. L; Bonamy, G. M; Wu, T; Barnes, S. W; Bopp, S. E; Borboa, R; Bright, A. T; Che, J; Cohen, S; Dharia, N. V; Gagaring, K; Gettayacamin, M; Gordon, P; Groessl, T; Kato, N; Lee, M. C; McNamara, C. W; Fidock, D. A; Nagle, A; Nam, T. G; Richmond, W; Roland, J; Rottmann, M; Zhou, B; Froissard, P; Glynne, R. J; Mazier, D; et al. (2011). "Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery". Science. '''334''' (6061): 1372–7. [[Bibcode]]:2011Sci...334.1372M. [[Digital object identifier|doi]]:10.1126/science.1211936. [[PubMed Central|PMC]] 3473092. [[PubMed Identifier|PMID]] 22096101.'' |
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· · ''McNamara, C. W; Lee, M. C; Lim, C. S; Lim, S. H; Roland, J; Simon, O; Yeung, B. K; Chatterjee, A. K; McCormack, S. L; Manary, M. J; Zeeman, A. M; Dechering, K. J; Kumar, T. S; Henrich, P. P; Gagaring, K; Ibanez, M; Kato, N; Kuhen, K. L; Fischli, C; Nagle, A; Rottmann, M; Plouffe, D. M; Bursulaya, B; Meister, S; Rameh, L; Trappe, J; Haasen, D; Timmerman, M; Sauerwein, R. W; et al. (2013). "Targeting Plasmodium PI(4)K to eliminate malaria". Nature. '''504''' (7479): 248–253. [[Bibcode]]:2013Natur.504..248M. [[Digital object identifier|doi]]:10.1038/nature12782. [[PubMed Central|PMC]] 3940870. [[PubMed Identifier|PMID]] 24284631.'' |
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· · ''Flannery, E. L; McNamara, C. W; Kim, S. W; Kato, T. S; Li, F; Teng, C. H; Gagaring, K; Manary, M. J; Barboa, R; Meister, S; Kuhen, K; Vinetz, J. M; Chatterjee, A. K; Winzeler, E. A (2015). "Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials". Acs Chemical Biology. '''10''' (2): 413–20. [[Digital object identifier|doi]]:10.1021/cb500616x. [[PubMed Central|PMC]] 4340351. [[PubMed Identifier|PMID]] 25322084.'' |
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Crane JM, Lilly AA, '''R'''andall LL. (2010). “Characterization of interactions between proteins using site-directed spin labeling and electron paramagnetic resonance spectroscopy.” ''Methods Mol Biol''. '''619''':173-90. doi: 10.1007/978-1-60327-412-8_11. [PubMed] |
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· · ''Winzeler, E. A; Richards, D. R; Conway, A. R; Goldstein, A. L; Kalman, S; McCullough, M. J; McCusker, J. H; Stevens, D. A; Wodicka, L; Lockhart, D. J; Davis, R. W (1998). "Direct allelic variation scanning of the yeast genome". Science. '''281''' (5380): 1194–7. [[Bibcode]]:1998Sci...281.1194W. [[Digital object identifier|doi]]:10.1126/science.281.5380.1194. [[PubMed Identifier|PMID]] 9712584.'' |
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· · ''Winzeler, E. A; Shoemaker, D. D; Astromoff, A; Liang, H; Anderson, K; Andre, B; Bangham, R; Benito, R; Boeke, J. D; Bussey, H; Chu, A. M; Connelly, C; Davis, K; Dietrich, F; Dow, S. W; El Bakkoury, M; Foury, F; Friend, S. H; Gentalen, E; Giaever, G; Hegemann, J. H; Jones, T; Laub, M; Liao, H; Liebundguth, N; Lockhart, D. J; Lucau-Danila, A; Lussier, M; m'Rabet, N; et al. (1999). "Functional characterization of the S. Cerevisiae genome by gene deletion and parallel analysis". Science. '''285''' (5429): 901–6. [[PubMed Identifier|PMID]] 10436161.'' |
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· · ''Winzeler, E. A; Castillo-Davis, C. I; Oshiro, G; Liang, D; Richards, D. R; Zhou, Y; Hartl, D. L (2003). "Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays". Genetics. '''163''' (1): 79–89. [[PubMed Central|PMC]] 1462430. [[PubMed Identifier|PMID]] 12586698.'' |
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Lilly AA, Crane JM, Randall LL. (2009). “Export chaperone SecB uses one surface of interaction for diverse unfolded polypeptide ligands.” ''Protein Sci''. '''18'''(9):1860-8. doi: 10.1002/pro.197. [PubMed] |
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· · ''Hoepfner, D; McNamara, C. W; Lim, C. S; Studer, C; Riedl, R; Aust, T; McCormack, S. L; Plouffe, D. M; Meister, S; Schuierer, S; Plikat, U; Hartmann, N; Staedtler, F; Cotesta, S; Schmitt, E. K; Petersen, F; Supek, F; Glynne, R. J; Tallarico, J. A; Porter, J. A; Fishman, M. C; Bodenreider, C; Diagana, T. T; Movva, N. R; Winzeler, E. A (2012). "Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin". Cell Host & Microbe. '''11''' (6): 654–63. [[Digital object identifier|doi]]:10.1016/j.chom.2012.04.015. [[PubMed Central|PMC]] 3391680. [[PubMed Identifier|PMID]] 22704625.'' |
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· · Method for Parallel Screening of Allelic Variation: <nowiki>https://patents.google.com/patent/CA2273616A1/de</nowiki> |
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· · Compounds and Compositions as Kinase Inhibitors: <nowiki>https://patents.google.com/patent/CA2676138A1/hr</nowiki> |
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Randall, L.L. and Hardy, S.J.S. (1995) “High selectivity with low specificity: how SecB has solved the paradox of chaperone binding.” ''Trends in Biochem Sci'' '''20''':65-69. |
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· · National Science Foundation Fellowship: <nowiki>https://www.nsf.gov/</nowiki> |
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DOI:<nowiki>https://doi.org/10.1016/S0968-0004(00)88959-8</nowiki> |
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<br /> |
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· · The Ellison Medical Foundation: <nowiki>http://www.ellisonfoundation.org/</nowiki> |
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· · RECOMB: [[Research in Computational Molecular Biology|https://en.wikipedia.org/wiki/Research_in_Computational_Molecular_Biology]] |
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· · Howard Hughes Medical Institute: <nowiki>https://www.hhmi.org/</nowiki> |
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· · Howard T. Ricketts: <nowiki>https://htrl-sites.uchicago.edu/page/about</nowiki> |
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· · Worm Free World: <nowiki>https://experiment.com/projects/wormfree-world-finding-new-cures</nowiki> |
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· · Bailey Ashford Medal: <nowiki>http://www.astmh.org/awards-fellowships-medals/awards-and-honors/bailey-k-ashford-medal</nowiki> |
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· · Medicines for Malaria Venture: <nowiki>https://www.mmv.org/research-development/project-year-award/mmv-project-year-award-2016</nowiki> |
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· · Alice and C. C. Wang Award: <nowiki>http://www.asbmb.org/awards/wang/</nowiki> |
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31. · William Trager Award: <nowiki>http://www.astmh.org/subgroups/acmcip#trager</nowiki> |
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'''External links''' |
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* <nowiki>http://winzeler.ucsd.edu/</nowiki> |
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* Elizabeth Winzeler at Science Magazine 2017 |
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* Elizabeth Winzeler at Science Magazine 1998 |
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Latest revision as of 15:25, 6 June 2022
Linda Randall is a Professor Emerita of Biochemistry and Wurdack Chair Emerita of Biological Chemistry at University of Missouri.[1] Her research has shown unexpected and complex details of the movement of newly made proteins from the cytosol across membranes into organelles of the cell. In particular, she found that the entire protein was kept unfolded by association with a chaperone and not just directed to cross membranes by its terminal leader sequence.[2] In 1997, she was elected to the National Academy of Sciences of the USA because of the excellence of this work. She has received a number of other honors and awards.[2]
Education
[edit]Linda Randall received the BS at Colorado State University in Zoology and the PhD at University of Wisconsin in Molecular Biology.[1]
Academic Research Career
[edit]Linda Randall was a professor at University of Uppsala, Sweden for eight years and joined the faculty at Washington State University in 1981.[3] She was a professor at Washington State University for twenty years, but in 2000, she received an attractive offer from University of Missouri and moved there along with her husband.[4] She and her husband, Gerald Hazelbauer, chair of biochemistry, gave an interview to The Lewiston Tribune saying that they had decided to leave the Pullman campus partly due to the inability of WSU to promote academic excellence and set a high standard for student behavior. The excessive drinking and wild behavior was their main issue.[4] The two professors took over three quarters of a million dollars in federal research funding with them to Missouri.[4]
Linda Randall showed the mechanism of protein export in the bacterium Escherichia coli.[5] It is not an easy task to move a protein folded into its tertiary and quaternary structures through a membrane, but many proteins must be moved from their synthesis site in the cytosol to other places in the cell that are separated from the cytosol by membranes. It was known that proteins that move across membranes are synthesized with a particular leader peptide and it was once thought that any transport process would focus on that leader peptide.[2] However, Randall’s laboratory showed that the whole length of nascent proteins are kept in their unfolded state by associating them with a chaperone protein to facilitate their transfer to another compartment in the cell bounded by a membrane.[2] The role of the SecB chaperone and its ATPase partner SecA in assisting newly made polypeptides to cross membranes was worked out in her laboratory.[5] Her development of a system to study membrane translocation in the test tube has been important in her own research and that of others.[5]
Honors and Awards
[edit]National Academy of Sciences, 1997[2]
American Academy of Microbiology[5]
American Academy of Arts and Sciences, 1984[6]
Fellow of American Association for the Advancement of Science[5]
Eli Lilly Award in Microbiology or Immunology (American Society for Microbiology)[7]
Selected Works
[edit]Bariya P, Randall LL. (2018). “Co-assembly of SecYEG and SecA fully restores the properties of the native translocon.” J Bacteriol. 2018 Oct 1. doi: 10.1128 JB.00493-18 Epub ahead of print.
Findik BT, Smith VF, Randall LL. (2018). “Penetration into membrane of amino-terminal region of SecA when associated with SecYEG in active complexes.” Protein Sci. 27(3):681-691. doi: 10.1002/pro.3362.
Suo Y, Hardy SJS, Randall LL. (2015). “The basis of asymmetry in the SecA:SecB complex.” J Mol Biol. 427(4):887-900. doi: 10.1016/j.jmb.2014.12.008. [PubMed]
Mao C, Cheadle CE, Hardy SJ, Lilly AA, Suo Y, Sanganna Gari RR, King GM, Randall LL. (2013). “Stoichiometry of SecYEG in the active translocase of Escherichia coli varies with precursor species.” Proc Natl Acad Sci U S A. 110(29):11815-20. doi: 10.1073/pnas.1303289110. [PubMed]
Sanganna Gari RR, Frey NC, Mao C, Randall LL, King GM. (2013). “Dynamic structure of the translocon SecYEG in membrane: direct single molecule observations.” J Biol Chem. 288(23):16848-54. doi: 10.1074/jbc.M113.471870. [PubMed]
Suo Y, Hardy SJ, Randall LL. (2011). “Orientation of SecA and SecB in complex, derived from disulfide cross-linking.” J Bacteriol. 193(1):190-6. doi: 10.1128/JB.00975-10. [PubMed]
Randall LL, Henzl MT. (2010). “Direct identification of the site of binding on the chaperone SecB for the amino terminus of the translocon motor SecA.” Protein Sci. 19(6):1173-9. doi: 10.1002/pro.392. [PubMed]
Crane JM, Lilly AA, Randall LL. (2010). “Characterization of interactions between proteins using site-directed spin labeling and electron paramagnetic resonance spectroscopy.” Methods Mol Biol. 619:173-90. doi: 10.1007/978-1-60327-412-8_11. [PubMed]
Lilly AA, Crane JM, Randall LL. (2009). “Export chaperone SecB uses one surface of interaction for diverse unfolded polypeptide ligands.” Protein Sci. 18(9):1860-8. doi: 10.1002/pro.197. [PubMed]
Randall, L.L. and Hardy, S.J.S. (1995) “High selectivity with low specificity: how SecB has solved the paradox of chaperone binding.” Trends in Biochem Sci 20:65-69.
DOI:https://doi.org/10.1016/S0968-0004(00)88959-8
- ^ a b "Linda Randall". University of Missouri. Retrieved December 4, 2018.
- ^ a b c d e "Linda Randall". National Academy of Sciences. Retrieved December 4, 2018.
- ^ "Biochemists Elected to the National Academy of Sciences" (PDF). Washington State University Biochemistry Department. 1997. Retrieved December 4, 2018.
- ^ a b c Smith, Debra (September 22, 2000). "Departing Professors Have Harsh Words for WSU". The Lewiston Tribune. Retrieved December 4, 2018.
- ^ a b c d e "Linda Randall". University of Missouri Biochemistry Department. Retrieved December 4, 2018.
- ^ [https://www.amacad.org/content/news/pressReleases.aspx?pr=59
American Academy Announces 2004 Fellows and Foreign Honorary Members
4/30/2004 "American Academy of Arts and Sciences Announces 2004 Fellows and Foreign Hnorary Members"]. April 30, 2004. Retrieved December 4, 2018.
{{cite web}}: Check|url=value (help); line feed character in|url=at position 61 (help) - ^ "Eli Lilly and Company Elanco Research Award Past Laureates". American Society for Microbiology. Retrieved December 4, 2018.