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{{Infobox gene}}
{{Infobox gene}}
'''[[Kibris Turk devleti|Kibris tutk devketi]] protein 44''' is a [[protein]] that in humans is encoded by the TMEM44 [[gene]].
'''Transmembrane protein 44''' is a [[protein]] that in humans is encoded by the TMEM44 [[gene]].
<ref name="entrez">
<ref name="entrez">
{{cite web
{{cite web
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== Gene ==
== Gene ==


mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/nuccore/BC034353.1?report=genbank|title=Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI|website=www.ncbi.nlm.nih.gov|access-date=2018-02-18}}</ref>
mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.<ref>{{Cite journal|url=https://www.ncbi.nlm.nih.gov/nuccore/BC034353.1?report=genbank|title=Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI|website=www.ncbi.nlm.nih.gov|date=16 March 2005|access-date=2018-02-18}}</ref>


== Locus ==
== Locus ==
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=== Expression ===
=== Expression ===


There is a overall low level expression of TMEM44 protein throughout the developmental stages of an organism.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.478729|title=EST Profile - Hs.478729|last=Group|first=Schuler|website=www.ncbi.nlm.nih.gov|access-date=2018-04-23}}</ref>
There is an overall low level expression of TMEM44 protein throughout the developmental stages of an organism.<ref>{{Cite web|url=https://www.ncbi.nlm.nih.gov/UniGene/ESTProfileViewer.cgi?uglist=Hs.478729|title=EST Profile - Hs.478729|last=Group|first=Schuler|website=www.ncbi.nlm.nih.gov|access-date=2018-04-23}}</ref>


=== Transcripts ===
=== Transcripts ===
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=== Interacting Proteins ===
=== Interacting Proteins ===


[[GSK3B]] (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.<ref>{{Cite web|url=https://www.ebi.ac.uk/intact/|title=https://www.ebi.ac.uk/intact/|last=IntAct|website=www.ebi.ac.uk|language=en|access-date=2018-04-22}}</ref><ref>{{Cite web|url=https://thebiogrid.org/|title=BioGRID {{!}} Database of Protein, Chemical, and Genetic Interactions|last=Lab|first=Mike Tyers|website=thebiogrid.org|language=en|access-date=2018-04-22}}</ref><ref>{{Cite web|url=https://mint.bio.uniroma2.it/|title=The Molecular INTeraction Database – An ELIXIR Core Resource|website=mint.bio.uniroma2.it|language=en-US|access-date=2018-04-22}}</ref>
[[GSK3B]] (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.<ref>{{Cite web|url=https://www.ebi.ac.uk/intact/|last=IntAct|title=IntAct Portal |website=www.ebi.ac.uk|language=en|access-date=2018-04-22}}</ref><ref>{{Cite web|url=https://thebiogrid.org/|title=BioGRID {{!}} Database of Protein, Chemical, and Genetic Interactions|last=Lab|first=Mike Tyers|website=thebiogrid.org|language=en|access-date=2018-04-22}}</ref><ref>{{Cite web|url=https://mint.bio.uniroma2.it/|title=The Molecular INTeraction Database – An ELIXIR Core Resource|website=mint.bio.uniroma2.it|language=en-US|access-date=2018-04-22}}</ref>


=== Post-Translational Modification ===
=== Post-Translational Modification ===


TMEM44 is predicted to undergo threonine, tyrosine and serine [[Protein phosphorylation|phosphorylations]].<ref>{{Cite web|url=http://www.cbs.dtu.dk/services/NetPhos/|title=NetPhos 3.1 Server|website=www.cbs.dtu.dk|language=en|access-date=2018-04-22}}</ref>
TMEM44 is predicted to undergo threonine, tyrosine and serine [[Protein phosphorylation|phosphorylations]].<ref>{{Cite web|url=http://www.cbs.dtu.dk/services/NetPhos/|title=NetPhos 3.1 Server|website=www.cbs.dtu.dk|language=en|access-date=2018-04-22}}</ref>
[[File:TMEM44 Phospho.png|none|thumb|Predicted phosphorylation sites in human TMEM44 protein]]
[[File:TMEM44_Phospho.png|none|thumb|Predicted phosphorylation sites in human TMEM44 protein]]


=== Orthologs ===
=== Orthologs ===
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{{refend}}
{{refend}}

⚫
[[Category:Transmembrane proteins]]




{{gene-3-stub}}
{{gene-3-stub}}



⚫
[[Category:Transmembrane proteins]]

Latest revision as of 10:26, 22 July 2022

TMEM44
Identifiers
AliasesTMEM44, transmembrane protein 44
External IDsMGI: 1924489; HomoloGene: 26702; GeneCards: TMEM44; OMA:TMEM44 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

93109

224090

Ensembl

ENSG00000145014

ENSMUSG00000022537

UniProt

Q2T9K0

n/a

RefSeq (mRNA)

NM_001011655
NM_001166305
NM_001166306
NM_138399

NM_172614
NM_001357413
NM_001357414
NM_001357415
NM_001361297

RefSeq (protein)

NP_001011655
NP_001159777
NP_001159778
NP_612408

n/a

Location (UCSC)Chr 3: 194.59 – 194.63 MbChr 16: 30.51 – 30.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transmembrane protein 44 is a protein that in humans is encoded by the TMEM44 gene. [5]

Gene

[edit]

mRNA sequence of the TMEM44 gene is 1483 base pairs long, with 13 exons.[6]

Locus

[edit]

TMEM44 gene is located at the end of the long arm of chromosome 3 in humans (Homo sapiens).[7]

TMEM44 gene on human chromosome 3

Protein

[edit]

TMEM44 is 428 amino acids in length. The molecular weight of the protein is 47.1kDa, and its formula is C2086H3315N585O611S22, with a total of 6619 atoms.[8] TMEM44 is predicted to be integrated in the plasma membrane of the endoplasmic reticulum.

Expression

[edit]

There is an overall low level expression of TMEM44 protein throughout the developmental stages of an organism.[9]

Transcripts

[edit]

There are 12 isoforms of TMEM44 including isoform a, isoform b, isoform c, isoform d, isoform X1, isoform X2, isoform X3, isoform X4, isoform X5, isoform X6, isoform X7, isoform X8.[7]

Transmembrane Region Allocation

[edit]

There are seven predicted transmembrane domains in TMEM44 protein.

Phobius posterior probabilities of human TMEM44 protein

Interacting Proteins

[edit]

GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44.[10][11][12]

Post-Translational Modification

[edit]

TMEM44 is predicted to undergo threonine, tyrosine and serine phosphorylations.[13]

Predicted phosphorylation sites in human TMEM44 protein

Orthologs

[edit]

TMEM44 orthologs includes groups such as amphibians, birds, fish, mammals.[14]

Paralogs

[edit]

Predicted paralogous proteins of TMEM44 are C9IZ85, F8WCY1, F8WE47, H7C3X7, J3KQW3, Q6PL43, and Q96I73.[15]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145014 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022537 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Transmembrane protein 44". Retrieved 2018-05-01.
  6. ^ "Homo sapiens transmembrane protein 44, mRNA (cDNA clone IMAGE:4747146) - Nucleotide - NCBI". www.ncbi.nlm.nih.gov. 16 March 2005. Retrieved 2018-02-18.
  7. ^ a b "TMEM44 transmembrane protein 44 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2018-02-15.
  8. ^ "ExPASy - ProtParam tool". web.expasy.org. Retrieved 2018-04-22.
  9. ^ Group, Schuler. "EST Profile - Hs.478729". www.ncbi.nlm.nih.gov. Retrieved 2018-04-23. {{cite web}}: |last= has generic name (help)
  10. ^ IntAct. "IntAct Portal". www.ebi.ac.uk. Retrieved 2018-04-22.
  11. ^ Lab, Mike Tyers. "BioGRID | Database of Protein, Chemical, and Genetic Interactions". thebiogrid.org. Retrieved 2018-04-22.
  12. ^ "The Molecular INTeraction Database – An ELIXIR Core Resource". mint.bio.uniroma2.it. Retrieved 2018-04-22.
  13. ^ "NetPhos 3.1 Server". www.cbs.dtu.dk. Retrieved 2018-04-22.
  14. ^ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2018-02-18.
  15. ^ Database, GeneCards Human Gene. "TMEM44 Gene - GeneCards | TMM44 Protein | TMM44 Antibody". www.genecards.org. Retrieved 2018-04-23.

Further reading

[edit]


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