VCX: Difference between revisions

VCX
Identifiers
Aliases	VCX, VCX-10r, VCX-B1, VCX1, VCX10R, VCXB1, variable charge, X-linked, variable charge X-linked
External IDs	OMIM: 300229; HomoloGene: 88395; GeneCards: VCX; OMA:VCX - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	7,844,143 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; gonad; ; testicle; ; ventricular zone; ; putamen; ; right uterine tube; ; primary visual cortex; ; nucleus accumbens; ; duodenum;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	chromatin binding;
Cellular component	nucleolus; nucleus;
Biological process	ribosome assembly; chromatin organization; spermatogenesis; brain development;
	Sources:Amigo / QuickGO
Orthologs
	26609
	n/a
	ENSG00000182583
	n/a
	Q9H320
	n/a
	NM_013452; NM_001393662
	n/a
	NP_038480
	n/a
	Wikidata
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Latest revision as of 22:52, 4 September 2022

Variable charge X-linked protein 1 is a protein that in humans is encoded by the VCX gene.^[3]^[4]^[5]

This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000182583 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lahn BT, Page DC (Feb 2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet. 9 (2): 311–9. doi:10.1093/hmg/9.2.311. PMID 10607842.
^ Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA (Sep 2000). "A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation". Am J Hum Genet. 67 (3): 563–73. doi:10.1086/303047. PMC 1287516. PMID 10903929.
^ ^a ^b "Entrez Gene: VCX variable charge, X-linked".

Zou SW, Zhang JC, Zhang XD, et al. (2004). "Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis". Cell Res. 13 (3): 171–7. doi:10.1038/sj.cr.7290161. PMID 12862317.
Sy SM, Wong N, Mok TS, et al. (2003). "Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity". Lung Cancer. 41 (1): 91–9. doi:10.1016/S0169-5002(03)00138-7. PMID 12826317.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000182583 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10607842-3] Lahn BT, Page DC (Feb 2000). "A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins". Hum Mol Genet. 9 (2): 311–9. doi:10.1093/hmg/9.2.311. PMID 10607842.

[pmid10903929-4] Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA (Sep 2000). "A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation". Am J Hum Genet. 67 (3): 563–73. doi:10.1086/303047. PMC 1287516. PMID 10903929.

[entrez-5] "Entrez Gene: VCX variable charge, X-linked".

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[2]

[3]

[4]

[5]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Variable charge X-linked protein 1''' is a [[protein]] that in humans is encoded by the ''VCX'' [[gene]].<ref name="pmid10607842">{{cite journal |vauthors=Lahn BT, Page DC | title = A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins | journal = Hum Mol Genet | volume = 9 | issue = 2 | pages = 311–9 |date=Feb 2000 | pmid = 10607842 | doi =10.1093/hmg/9.2.311  | doi-access = free }}</ref><ref name="pmid10903929">{{cite journal |vauthors=Fukami M, Kirsch S, Schiller S, Richter A, Benes V, Franco B, Muroya K, Rao E, Merker S, Niesler B, Ballabio A, Ansorge W, Ogata T, Rappold GA | title = A Member of a Gene Family on Xp22.3, VCX-A, Is Deleted in Patients with X-Linked Nonspecific Mental Retardation | journal = Am J Hum Genet | volume = 67 | issue = 3 | pages = 563–73 |date=Sep 2000 | pmid = 10903929 | pmc = 1287516 | doi = 10.1086/303047 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VCX variable charge, X-linked| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.<ref name="entrez" />
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Variable charge, X-linked
- | HGNCid = 12667
- | Symbol = VCX
- | AltSymbols =; MGC118975; VCX-10r; VCX-B1; VCX1; VCX10R; VCXB1; MGC118976; MGC125730; VCX-8r; VCX-A; VCX3; VCX8R; VCXA; MGC119815
- | OMIM = 300229
- | ECnumber =
- | Homologene = 88395
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_VCX_207281_x_at_tn.png
- | GeneAtlas_image2 = PBB_GE_VCX_211403_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0003682 |text = chromatin binding}}{{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005730 |text = nucleolus}}
- | Process = {{GNF_GO|id=GO:0006325 |text = establishment and/or maintenance of chromatin architecture}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0042255 |text = ribosome assembly}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007420 |text = brain development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 26609
-    | Hs_Ensembl = ENSG00000182583
-    | Hs_RefseqProtein = NP_038480
-    | Hs_RefseqmRNA = NM_013452
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = X
-    | Hs_GenLoc_start = 7770303
-    | Hs_GenLoc_end = 7772184
-    | Hs_Uniprot = Q9H320
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Variable charge, X-linked''', also known as '''VCX''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VCX variable charge, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene belongs to the VCX/Y gene family, which has multiple members on both X and Y chromosomes, and all are expressed exclusively in male germ cells. The X-linked members are clustered on chromosome Xp22 and Y-linked members are two identical copies of the gene within a palindromic region on Yq11. The family members share a high degree of sequence identity, with the exception that a 30-bp unit is tandemly repeated in X-linked members but occurs only once in Y-linked members. The VCX gene cluster is polymorphic in terms of copy number; different individuals may have a different number of VCX genes. VCX/Y genes encode small and highly charged proteins of unknown function. The presence of a putative bipartite nuclear localization signal suggests that VCX/Y members are nuclear proteins. This gene contains 10 repeats of the 30-bp unit.<ref name="entrez">{{cite web | title = Entrez Gene: VCX variable charge, X-linked| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26609| accessdate = }}</ref>
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  | author=Zou SW |title=Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis |journal=Cell Res. |volume=13 |issue= 3 |pages= 171–7 |year= 2004 |pmid= 12862317 |doi= 10.1038/sj.cr.7290161  |name-list-style=vanc| author2=Zhang JC  | author3=Zhang XD  | display-authors=3  | last4=Miao  | first4=Shi Ying  | last5=Zong  | first5=Shu Dong  | last6=Sheng  | first6=Qi  | last7=Wang  | first7=Lin Fang | doi-access=free  }}
-{{PBB_Further_reading
+*{{cite journal  | author=Sy SM |title=Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity |journal=Lung Cancer |volume=41 |issue= 1 |pages= 91–9 |year= 2003 |pmid= 12826317 |doi=10.1016/S0169-5002(03)00138-7  |name-list-style=vanc| author2=Wong N  | author3=Mok TS  | display-authors=3  | last4=Tsao  | first4=Ming-Sound  | last5=Lee  | first5=Tak-Wai  | last6=Tse  | first6=Gary  | last7=Blackhall  | first7=Fiona H.  | last8=Johnson  | first8=Philip J.  | last9=Yim  | first9=Anthony P.  }}
-| citations =
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Zou SW, Zhang JC, Zhang XD, ''et al.'' |title=Expression and localization of VCX/Y proteins and their possible involvement in regulation of ribosome assembly during spermatogenesis. |journal=Cell Res. |volume=13 |issue= 3 |pages= 171-7 |year= 2004 |pmid= 12862317 |doi= 10.1038/sj.cr.7290161 }}
-*{{cite journal  | author=Sy SM, Wong N, Mok TS, ''et al.'' |title=Genetic alterations of lung adenocarcinoma in relation to smoking and ethnicity. |journal=Lung Cancer |volume=41 |issue= 1 |pages= 91-9 |year= 2003 |pmid= 12826317 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Fukami M, Kirsch S, Schiller S, ''et al.'' |title=A member of a gene family on Xp22.3, VCX-A, is deleted in patients with X-linked nonspecific mental retardation. |journal=Am. J. Hum. Genet. |volume=67 |issue= 3 |pages= 563-73 |year= 2000 |pmid= 10903929 |doi=  }}
-*{{cite journal  | author=Lahn BT, Page DC |title=A human sex-chromosomal gene family expressed in male germ cells and encoding variably charged proteins. |journal=Hum. Mol. Genet. |volume=9 |issue= 2 |pages= 311-9 |year= 2000 |pmid= 10607842 |doi=  }}
-}}
 {{refend}}
-{{protein-stub}}
+{{gene-X-stub}}