Mitochondrial ribosomal protein L37: Difference between revisions

MRPL37
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843; MGI: 1926268; HomoloGene: 9536; GeneCards: MRPL37; OMA:MRPL37 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,225,464 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,924,065 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; right adrenal gland; ; skin of arm; ; right adrenal cortex; ; tibialis anterior muscle; ; left ventricle; ; right lobe of liver; ; left adrenal gland; ; apex of heart;
	Top expressed in
	genital tubercle; ; tail of embryo; ; muscle of thigh; ; right kidney; ; ventricular zone; ; embryo; ; lip; ; skeletal muscle tissue; ; embryo; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrial large ribosomal subunit; mitochondrion;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
	51253
	56280
	ENSG00000116221
	ENSMUSG00000028622
	Q9BZE1
	Q921S7
	NM_016491; NM_001330602
	NM_025500
	NP_001317531; NP_057575
	NP_079776
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 16:23, 11 October 2022

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.^[5]^[6]

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000116221 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028622 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
^ ^a ^b "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

External links

Overview of all the structural information available in the PDB for UniProt: Q9BZE1 (39S ribosomal protein L37, mitochondrial) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This protein-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000116221 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10600119-5] Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.

[entrez-6] "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''39S ribosomal protein L37, mitochondrial''' is a [[protein]] that in humans is encoded by the ''MRPL37'' [[gene]].<ref name="pmid10600119">{{cite journal |vauthors=Graack HR, Bryant ML, O'Brien TW | title = Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle | journal = Biochemistry | volume = 38 | issue = 50 | pages = 16569–77 |date=Jan 2000 | pmid = 10600119 | pmc =  | doi =10.1021/bi991543s  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRPL37 mitochondrial ribosomal protein L37| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51253| accessdate = }}</ref>
+'''39S ribosomal protein L37, mitochondrial''' is a [[protein]] that in humans is encoded by the ''MRPL37'' [[gene]].<ref name="pmid10600119">{{cite journal |vauthors=Graack HR, Bryant ML, O'Brien TW | title = Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle | journal = Biochemistry | volume = 38 | issue = 50 | pages = 16569–77 |date=Jan 2000 | pmid = 10600119 | doi =10.1021/bi991543s  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MRPL37 mitochondrial ribosomal protein L37| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51253}}</ref>
+Mammalian [[Mitochondrial ribosome|mitochondrial ribosomal]] proteins are encoded by [[nuclear gene]]s and help in [[protein synthesis]] within the [[mitochondrion]]. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% [[protein]] to [[rRNA]] composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a [[5S rRNA]]. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by [[sequence homology]]. This gene encodes a 39S subunit protein.<ref name="entrez" />
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = Mammalian [[Mitochondrial ribosome|mitochondrial ribosomal]] proteins are encoded by [[nuclear gene]]s and help in [[protein synthesis]] within the [[mitochondrion]]. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% [[protein]] to [[rRNA]] composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a [[5S rRNA]]. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by [[sequence homology]]. This gene encodes a 39S subunit protein.<ref name="entrez" />
-}}
 ==References==
@@ Line 13: / Line 10: @@
 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
+*{{cite journal   |vauthors=Gregory SG, Barlow KF, McLay KE, etal |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |bibcode=2006Natur.441..315G |doi-access= free }}
-*{{cite journal   |vauthors=Levshenkova EV, Ukraintsev KE, Orlova VV, etal |title=[The structure and specific features of the cDNA expression of the human gene MRPL37] |journal=Bioorg. Khim. |volume=30 |issue= 5 |pages= 499–506 |year= 2005 |pmid= 15562971 |doi=  }}
+*{{cite journal   |vauthors=Levshenkova EV, Ukraintsev KE, Orlova VV, etal |title=[The structure and specific features of the cDNA expression of the human gene MRPL37] |journal=Bioorg. Khim. |volume=30 |issue= 5 |pages= 499–506 |year= 2005 |pmid= 15562971 |doi=  10.1023/b:rubi.0000043788.86955.ea|s2cid=342310 }}
 *{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
 *{{cite journal  |vauthors=Zhang Z, Gerstein M |title=Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome. |journal=Genomics |volume=81 |issue= 5 |pages= 468–80 |year= 2003 |pmid= 12706105 |doi=10.1016/S0888-7543(03)00004-1  }}
-*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal   |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1-2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
+*{{cite journal   |vauthors=Kenmochi N, Suzuki T, Uechi T, etal |title=The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. |journal=Genomics |volume=77 |issue= 1–2 |pages= 65–70 |year= 2001 |pmid= 11543634 |doi= 10.1006/geno.2001.6622 }}
 *{{cite journal   |vauthors=Zhang QH, Ye M, Wu XY, etal |title=Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. |journal=Genome Res. |volume=10 |issue= 10 |pages= 1546–60 |year= 2001 |pmid= 11042152 |doi=10.1101/gr.140200  | pmc=310934  }}
 {{refend}}
+== External links ==
+* {{PDBe-KB2|Q9BZE1|39S ribosomal protein L37, mitochondrial}}
 {{GeneticTranslation}}