Bunaftine: Difference between revisions

Bunaftine
Clinical data
ATC code	C01BD03 (WHO) ;
Identifiers
	IUPAC name N-[2-(Diethylamino)ethyl]-N-propylnaphthalene-1-carboxamide;
CAS Number	32421-46-8 ;
PubChem CID	36131;
ChemSpider	33233 ;
UNII	GH09PRQ3FU;
KEGG	D07428 ;
ChEMBL	ChEMBL2104200;
CompTox Dashboard (EPA)	DTXSID90186165 ;
ECHA InfoCard	100.046.373
Chemical and physical data
Formula	C21H30N2O
Molar mass	326.484 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12;
	InChI InChI=1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3 ; Key:WWGZXRYELYWJBD-UHFFFAOYSA-N ;
	(verify)

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Latest revision as of 01:56, 29 January 2023

Bunaftine (or bunaphtine^[1]) is an antiarrhythmic agent.^[2] It is classified in class III.^[3]

References

^ Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628.
^ Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. doi:10.1536/ihj.24.377. PMID 6876382.
^ Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317. PMID 328029.

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[pmid7436628-1] Tamargo J (August 1980). "Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers". Arch Int Pharmacodyn Ther. 246 (2): 224–36. PMID 7436628.

[pmid6876382-2] Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M (May 1983). "Intropic effects of several antiarrhythmic drugs". Jpn Heart J. 24 (3): 377–90. doi:10.1536/ihj.24.377. PMID 6876382.

[pmid328029-3] Fenici R, Marchei M, Bellocci F, Zecchi P (July 1977). "Effect of bunaphtine on right atrial repolarisation in man". Br Heart J. 39 (7): 787–94. doi:10.1136/hrt.39.7.787. PMC 483317. PMID 328029.

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[2]

[3]

@@ Line 1: / Line 1: @@
+{{Short description|Chemical compound}}
-{{drugbox |
+{{Drugbox
-| IUPAC_name =
+| verifiedrevid = 447613606
-| image = {{PAGENAME}}.png
+| IUPAC_name = ''N''-[2-(Diethylamino)ethyl]-''N''-propylnaphthalene-1-carboxamide
+| image = Bunaftine.svg
+<!--Clinical data-->
+| tradename =
+| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
+| pregnancy_US = <!-- A / B            / C / D / X -->
+| pregnancy_category =
+| legal_AU = <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| legal_UK = <!-- GSL         / P       / POM / CD -->
+| legal_US = <!-- OTC                   / Rx-only  -->
+| legal_status =
+| routes_of_administration =
+<!--Pharmacokinetic data-->
+| bioavailability =
+| protein_bound =
+| metabolism =
+| elimination_half-life =
+| excretion =
+<!--Identifiers-->
+| CAS_number_Ref = {{cascite|correct|??}}
 | CAS_number = 32421-46-8
 | ATC_prefix = C01
 | ATC_suffix = BD03
 | PubChem = 36131
-| DrugBank =
+| ChEMBL = 2104200
+| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
-| chemical_formula = C21H30N2O
+| DrugBank =
-| molecular_weight = 326.476
+| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
-| bioavailability =
-| protein_bound =
+| ChemSpiderID = 33233
+| UNII_Ref = {{fdacite|correct|FDA}}
-| metabolism =
+| UNII = GH09PRQ3FU
-| elimination_half-life =
+| KEGG_Ref = {{keggcite|correct|kegg}}
-| excretion =
+| KEGG = D07428
-| pregnancy_AU =  <!-- A / B1 / B2 / B3 / C / D / X -->
-| pregnancy_US =  <!-- A / B            / C / D / X -->
+<!--Chemical data-->
-| pregnancy_category =
+| C=21 | H=30 | N=2 | O=1
-| legal_AU =      <!-- Unscheduled / S2 / S3 / S4  / S8 -->
+| smiles = O=C(N(CCCC)CCN(CC)CC)c2cccc1ccccc12
-| legal_UK =      <!-- GSL         / P       / POM / CD -->
+| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
-| legal_US =      <!-- OTC                   / Rx-only  -->
+| StdInChI = 1S/C21H30N2O/c1-4-7-15-23(17-16-22(5-2)6-3)21(24)20-14-10-12-18-11-8-9-13-19(18)20/h8-14H,4-7,15-17H2,1-3H3
-| legal_status =
+| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
-| routes_of_administration =
+| StdInChIKey = WWGZXRYELYWJBD-UHFFFAOYSA-N
 }}
-'''Bunaftine''' is a class III [[antiarrhythmic agent]].
+'''Bunaftine''' (or '''bunaphtine'''<ref name="pmid7436628">{{cite journal |author=Tamargo J |title=Electrophysiological effects of bunaphtine in guinea-pig ventricular fibers |journal=Arch Int Pharmacodyn Ther |volume=246 |issue=2 |pages=224–36 |date=August 1980 |pmid=7436628 }}</ref>) is an [[antiarrhythmic agent]].<ref name="pmid6876382">{{cite journal |vauthors=Ferro G, Chiariello M, Tari MG, Vigorito C, Ungaro B, Condorelli M |title=Intropic effects of several antiarrhythmic drugs |journal=Jpn Heart J |volume=24 |issue=3 |pages=377–90 |date=May 1983 |pmid=6876382 |doi= 10.1536/ihj.24.377|doi-access=free }}</ref> It is classified in [[class III antiarrhythmic|class III]].<ref name="pmid328029">{{cite journal |vauthors=Fenici R, Marchei M, Bellocci F, Zecchi P |title=Effect of bunaphtine on right atrial repolarisation in man |journal=Br Heart J |volume=39 |issue=7 |pages=787–94 |date=July 1977 |pmid=328029 |pmc=483317 |doi= 10.1136/hrt.39.7.787|url=}}</ref>
-{{drug-stub}}
+==References==
+{{reflist}}
+{{Potassium channel blockers}}
 {{Antiarrhythmic agents}}
+[[Category:Antiarrhythmic agents]]
+[[Category:Potassium channel blockers]]
+[[Category:1-Naphthyl compounds]]
+[[Category:Carboxamides]]
+[[Category:Diethylamino compounds]]
+{{cardiovascular-drug-stub}}