NCAPG: Difference between revisions

NCAPG
Identifiers
Aliases	NCAPG, CAPG, CHCG, NY-MEL-3, YCG1, non-SMC condensin I complex subunit G
External IDs	OMIM: 606280; MGI: 1930197; HomoloGene: 44071; GeneCards: NCAPG; OMA:NCAPG - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	17,844,865 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	45,857,888 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; embryo; ; ganglionic eminence; ; gonad; ; trabecular bone; ; sperm; ; bone marrow; ; gingival epithelium; ; testicle; ; amniotic fluid;
	Top expressed in
	otic placode; ; secondary oocyte; ; otic vesicle; ; primary oocyte; ; zygote; ; saccule; ; spermatocyte; ; epiblast; ; spermatid; ; tail of embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	condensin complex; cytosol; membrane; condensed chromosome; nucleus; chromosome; condensed chromosome, centromeric region; cytoplasm;
Biological process	cell division; cell cycle; mitotic chromosome condensation; chromosome condensation;
	Sources:Amigo / QuickGO
Orthologs
	64151
	54392
	ENSG00000109805
	ENSMUSG00000015880
	Q9BPX3
	E9PWG6
	NM_022346
	NM_019438
	NP_071741
	NP_062311
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:49, 3 March 2023

Condensin complex subunit 3 also known as condensin subunit CAP-G (CAP-G) or non-SMC condensin I complex subunit G (NCAPG) is a protein that in humans is encoded by the NCAPG gene.^[5]^[6]^[7] CAP-G is a subunit of condensin I, a large protein complex involved in chromosome condensation.

Interactions

NCAPG has been shown to interact with DNMT3B.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000109805 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015880 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jäger D, Stockert E, Jäger E, Güre AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.
^ Kimura K, Cuvier O, Hirano T (Feb 2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.
^ "Entrez Gene: NCAPG non-SMC condensin I complex, subunit G".
^ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD (2005). "Mechanism of hsp70i gene bookmarking". Science. 307 (5708): 421–3. Bibcode:2005Sci...307..421X. doi:10.1126/science.1106478. PMID 15662014. S2CID 37132180.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000109805 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015880 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10910072-5] Jäger D, Stockert E, Jäger E, Güre AO, Scanlan MJ, Knuth A, Old LJ, Chen YT (Aug 2000). "Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library". Cancer Res. 60 (13): 3584–91. PMID 10910072.

[pmid11136719-6] Kimura K, Cuvier O, Hirano T (Feb 2001). "Chromosome condensation by a human condensin complex in Xenopus egg extracts". J. Biol. Chem. 276 (8): 5417–20. doi:10.1074/jbc.C000873200. PMID 11136719.

[entrez-7] "Entrez Gene: NCAPG non-SMC condensin I complex, subunit G".

[pmid15148359-8] Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Res. 32 (9): 2716–29. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Condensin complex subunit 3''' also known as '''condensin subunit CAP-G''' (CAP-G) or '''non-SMC condensin I complex subunit G''' (NCAPG) is a [[protein]] that in humans is encoded by the ''NCAPG'' [[gene]].<ref name="pmid10910072">{{cite journal | vauthors = Jäger D, Stockert E, Jäger E, Güre AO, Scanlan MJ, Knuth A, Old LJ, Chen YT | title = Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library | journal = Cancer Res. | volume = 60 | issue = 13 | pages = 3584–91  | date = Aug 2000 | pmid = 10910072 }}</ref><ref name="pmid11136719">{{cite journal | vauthors = Kimura K, Cuvier O, Hirano T | title = Chromosome condensation by a human condensin complex in Xenopus egg extracts | journal = J. Biol. Chem. | volume = 276 | issue = 8 | pages = 5417–20  | date = Feb 2001 | pmid = 11136719 | doi = 10.1074/jbc.C000873200 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG non-SMC condensin I complex, subunit G| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64151}}</ref> CAP-G is a subunit of [[condensin]] I, a large protein complex involved in chromosome condensation.
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== Interactions ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Non-SMC condensin I complex, subunit G
- | HGNCid = 24304
- | Symbol = NCAPG
- | AltSymbols =; CAPG; CHCG; FLJ12450; HCAP-G; MGC126525; NY-MEL-3
- | OMIM = 606280
- | ECnumber =
- | Homologene = 44071
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_NCAPG_218662_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_NCAPG_218663_at_tn.png
- | Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
- | Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007067 |text = mitosis}} {{GNF_GO|id=GO:0007076 |text = mitotic chromosome condensation}} {{GNF_GO|id=GO:0051301 |text = cell division}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 64151
-    | Hs_Ensembl = ENSG00000109805
-    | Hs_RefseqProtein = NP_071741
-    | Hs_RefseqmRNA = NM_022346
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 17421623
-    | Hs_GenLoc_end = 17455583
-    | Hs_Uniprot = Q9BPX3
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Non-SMC condensin I complex, subunit G''', also known as '''NCAPG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NCAPG non-SMC condensin I complex, subunit G| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64151| accessdate = }}</ref>
+NCAPG has been shown to [[Protein-protein interaction|interact]] with [[DNMT3B]].<ref name="pmid15148359">{{cite journal | vauthors = Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD | title = Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery | journal = Nucleic Acids Res. | volume = 32 | issue = 9 | pages = 2716–29 | year = 2004 | pmid = 15148359 | pmc = 419596 | doi = 10.1093/nar/gkh589 }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
-==References==
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, Schmiesing JA, Kim W, Yokomori K, Zhao Y, Robertson KD | title = Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery | journal = Nucleic Acids Res. | volume = 32 | issue = 9 | pages = 2716–29 | year = 2004 | pmid = 15148359 | pmc = 419596 | doi = 10.1093/nar/gkh589 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Xing H, Wilkerson DC, Mayhew CN, Lubert EJ, Skaggs HS, Goodson ML, Hong Y, Park-Sarge OK, Sarge KD | title = Mechanism of hsp70i gene bookmarking | journal = Science | volume = 307 | issue = 5708 | pages = 421–3 | year = 2005 | pmid = 15662014 | doi = 10.1126/science.1106478 | bibcode = 2005Sci...307..421X | s2cid = 37132180 }}
-| citations =
+* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
-*{{cite journal  | author=Jäger D, Stockert E, Jäger E, ''et al.'' |title=Serological cloning of a melanocyte rab guanosine 5'-triphosphate-binding protein and a chromosome condensation protein from a melanoma complementary DNA library. |journal=Cancer Res. |volume=60 |issue= 13 |pages= 3584–91 |year= 2000 |pmid= 10910072 |doi=  }}
-*{{cite journal  | author=Kimura K, Cuvier O, Hirano T |title=Chromosome condensation by a human condensin complex in Xenopus egg extracts. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5417–20 |year= 2001 |pmid= 11136719 |doi= 10.1074/jbc.C000873200 }}
+* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
+* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Geiman TM, Sankpal UT, Robertson AK, ''et al.'' |title=Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. |journal=Nucleic Acids Res. |volume=32 |issue= 9 |pages= 2716–29 |year= 2004 |pmid= 15148359 |doi= 10.1093/nar/gkh589 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Xing H, Wilkerson DC, Mayhew CN, ''et al.'' |title=Mechanism of hsp70i gene bookmarking. |journal=Science |volume=307 |issue= 5708 |pages= 421–3 |year= 2005 |pmid= 15662014 |doi= 10.1126/science.1106478 }}
-*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
-*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
-}}
 {{refend}}
+{{Nucleus}}
+[[Category:Human proteins]]
 {{gene-4-stub}}