NCAPG2: Difference between revisions

NCAPG2
Identifiers
Aliases	NCAPG2, CAP-G2, CAPG2, LUZP5, MTB, hCAP-G2, non-SMC condensin II complex subunit G2, 3KS
External IDs	OMIM: 608532; MGI: 1923294; HomoloGene: 9820; GeneCards: NCAPG2; OMA:NCAPG2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	158,704,804 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	116,427,351 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; secondary oocyte; ; sperm; ; ganglionic eminence; ; bone marrow; ; bone marrow cells; ; trabecular bone; ; stromal cell of endometrium; ; gonad; ; right testis;
	Top expressed in
	nasal epithelium; ; olfactory epithelium; ; secondary oocyte; ; primary oocyte; ; zygote; ; ventricular zone; ; fetal liver hematopoietic progenitor cell; ; tail of embryo; ; dermis; ; superior cervical ganglion;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methylated histone binding; protein binding; bHLH transcription factor binding; molecular function regulator;
Cellular component	membrane; nucleus; nucleoplasm; condensin complex; nuclear speck;
Biological process	cell division; cell cycle; chromosome condensation; inner cell mass cell proliferation; transcription by RNA polymerase II; erythrocyte differentiation; negative regulation of erythrocyte differentiation; positive regulation of protein tyrosine kinase activity; positive regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	54892
	76044
	ENSG00000146918
	ENSMUSG00000042029
	Q86XI2
	Q6DFV1
	NM_001281932; NM_001281933; NM_017760
	NM_133762
	NP_001268861; NP_001268862; NP_060230
	NP_598523
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:49, 3 March 2023

Condensin-2 complex subunit G2 (CAP-G2) also known as chromosome-associated protein G2 (CAP-G2) or leucine zipper protein 5 (LUZP5) is a protein that in humans is encoded by the NCAPG2 gene.^[5]^[6] CAP-G2 is a subunit of condensin II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis^[7]

Clinical importance

Mutations in this gene in humans have been associated with severe neurodevelopmental defects, failure to thrive, ocular abnormalities, and defects in urogenital and limb morphogenesis.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146918 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042029 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T (October 2003). "Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells". Cell. 115 (1): 109–21. doi:10.1016/S0092-8674(03)00724-4. PMID 14532007. S2CID 18811084.
^ "Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2".
^ Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT (August 2014). "The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores". Nature Communications. 5: 4588. Bibcode:2014NatCo...5.4588K. doi:10.1038/ncomms5588. PMID 25109385.
^ Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N, et al. (Task Force for Neonatal Genomics) (January 2019). "Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies". American Journal of Human Genetics. 104 (1): 94–111. doi:10.1016/j.ajhg.2018.11.017. PMC 6323578. PMID 30609410.

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=54892}}
+{{Infobox_gene}}
-'''Condensin-2 complex subunit G2''' (CAP-G2) also known as '''chromosome-associated protein G2''' (CAP-G2) or '''leucine zipper protein 5''' (LUZP5) is a [[protein]] that in humans is encoded by the ''NCAPG2'' [[gene]].<ref name="pmid14532007">{{cite journal | author = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | year = 2003 | month = Oct | pmid = 14532007 | pmc =  | doi =10.1016/S0092-8674(03)00724-4  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892| accessdate = }}</ref> CAP-G2 is a subunit of [[condensin]] II, a large protein complex involved in chromosome condensation.
+'''Condensin-2 complex subunit G2''' (CAP-G2) also known as '''chromosome-associated protein G2''' (CAP-G2) or '''leucine zipper protein 5''' (LUZP5) is a [[protein]] that in humans is encoded by the ''NCAPG2'' [[gene]].<ref name="pmid14532007">{{cite journal | vauthors = Ono T, Losada A, Hirano M, Myers MP, Neuwald AF, Hirano T | title = Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells | journal = Cell | volume = 115 | issue = 1 | pages = 109–21 | date = October 2003 | pmid = 14532007 | doi = 10.1016/S0092-8674(03)00724-4 | s2cid = 18811084 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NCAPG2 non-SMC condensin II complex, subunit G2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54892}}</ref> CAP-G2 is a subunit of [[condensin]] II, a large protein complex involved in chromosome condensation. It interacts with PLK1 through its C-terminal region during mitosis<ref>{{cite journal | vauthors = Kim JH, Shim J, Ji MJ, Jung Y, Bong SM, Jang YJ, Yoon EK, Lee SJ, Kim KG, Kim YH, Lee C, Lee BI, Kim KT | title = The condensin component NCAPG2 regulates microtubule-kinetochore attachment through recruitment of Polo-like kinase 1 to kinetochores | journal = Nature Communications | volume = 5 | pages = 4588 | date = August 2014 | pmid = 25109385 | doi = 10.1038/ncomms5588 | bibcode = 2014NatCo...5.4588K | doi-access = free }}</ref>
+==Clinical importance==
-==References==
+Mutations in this gene in humans have been associated with severe neurodevelopmental defects, [[failure to thrive]], ocular abnormalities, and defects in urogenital and limb morphogenesis.<ref name=Khan2019>{{cite journal | vauthors = Khan TN, Khan K, Sadeghpour A, Reynolds H, Perilla Y, McDonald MT, Gallentine WB, Baig SM, Davis EE, Katsanis N | collaboration =  Task Force for Neonatal Genomics | title = Mutations in NCAPG2 Cause a Severe Neurodevelopmental Syndrome that Expands the Phenotypic Spectrum of Condensinopathies | journal = American Journal of Human Genetics | volume = 104 | issue = 1 | pages = 94–111 | date = January 2019 | pmid = 30609410 | doi = 10.1016/j.ajhg.2018.11.017 | pmc = 6323578 }}</ref>
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+* {{cite journal | vauthors = Smith ED, Xu Y, Tomson BN, Leung CG, Fujiwara Y, Orkin SH, Crispino JD | title = More than blood, a novel gene required for mammalian postimplantation development | journal = Molecular and Cellular Biology | volume = 24 | issue = 3 | pages = 1168–73 | date = February 2004 | pmid = 14729962 | pmc = 321451 | doi = 10.1128/MCB.24.3.1168-1173.2004 }}
-*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423  | pmc=2882961 }}
+* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 14 | pages = 5391–6 | date = April 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 | bibcode = 2006PNAS..103.5391N | doi-access = free }}
-*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Smith ED, Xu Y, Tomson BN, ''et al.'' |title=More than blood, a novel gene required for mammalian postimplantation development. |journal=Mol. Cell. Biol. |volume=24 |issue= 3 |pages= 1168–73 |year= 2004 |pmid= 14729962 |doi=10.1128/MCB.24.3.1168-1173.2004  | pmc=321451  }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103  | pmc=1459365 }}
 {{refend}}
-{{gene-7-stub}}
 {{Nucleus}}
 [[Category:Human proteins]]
+{{gene-7-stub}}