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Importing Wikidata short description: Protein-coding gene in the species Homo sapiens (shortdescs-in-category)
 
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{{Short description|Protein-coding gene in the species Homo sapiens}}
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'''Rap guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''RAPGEF5'' [[gene]].<ref name="pmid9039502">{{cite journal | author = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 | year = 1997 | month = May | pmid = 9039502 | pmc = | doi =10.1093/dnares/3.5.321 }}</ref><ref name="pmid10486569">{{cite journal | author = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 | year = 1999 | month = Oct | pmid = 10486569 | pmc = | doi =10.1016/S0014-5793(99)01012-1 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771| accessdate = }}</ref>
'''Rap guanine nucleotide exchange factor 5''' is a [[protein]] that in humans is encoded by the ''RAPGEF5'' [[gene]].<ref name="pmid9039502">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N | title = Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain | journal = DNA Res | volume = 3 | issue = 5 | pages = 321–9, 341–54 |date=May 1997 | pmid = 9039502 | doi =10.1093/dnares/3.5.321 | doi-access = free }}</ref><ref name="pmid10486569">{{cite journal | vauthors = Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y | title = Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 | journal = FEBS Lett | volume = 457 | issue = 1 | pages = 85–9 |date=Oct 1999 | pmid = 10486569 | doi =10.1016/S0014-5793(99)01012-1 | s2cid = 20296877 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9771}}</ref>


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Members of the [[Ras subfamily|RAS subfamily]] (see [[HRAS]]; MIM 190020) of [[GTPases]] function in [[signal transduction]] as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. [[Guanine nucleotide exchange factors]] (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of [[Guanosine triphosphate|GTP]] to maintain the active GTP-bound state and are the key link between [[cell surface receptors]] and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez" />
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| section_title =
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| summary_text = Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]<ref name="entrez" />
}}


==References==
==References==
{{reflist}}
{{reflist}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal |vauthors=de Rooij J, Rehmann H, van Triest M, etal |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829–36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200 |doi-access= free }}
{{PBB_Further_reading
*{{cite journal | vauthors=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 |doi-access= free }}
| citations =
*{{cite journal | author=de Rooij J, Rehmann H, van Triest M, ''et al.'' |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829–36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
*{{cite journal | author=Rebhun JF, Castro AF, Quilliam LA |title=Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34901–8 |year= 2001 |pmid= 10934204 |doi= 10.1074/jbc.M005327200 }}
*{{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |bibcode=2003Sci...300..767S }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal |vauthors=Suzuki Y, Yamashita R, Shirota M, etal |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 }}
*{{cite journal |vauthors=Dupuy AG, L'Hoste S, Cherfils J, etal |title=Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac |journal=Oncogene |volume=24 |issue= 28 |pages= 4509–20 |year= 2005 |pmid= 15856025 |doi= 10.1038/sj.onc.1208647 |doi-access= free }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Dupuy AG, L'Hoste S, Cherfils J, ''et al.'' |title=Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac |journal=Oncogene |volume=24 |issue= 28 |pages= 4509–20 |year= 2005 |pmid= 15856025 |doi= 10.1038/sj.onc.1208647 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9771}}
{{PDB Gallery|geneid=9771}}


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Latest revision as of 00:00, 4 March 2023

RAPGEF5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAPGEF5, GFR, MR-GEF, REPAC, Rap guanine nucleotide exchange factor 5, MRGEF
External IDsOMIM: 609527; MGI: 2444365; HomoloGene: 56563; GeneCards: RAPGEF5; OMA:RAPGEF5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

9771

217944

Ensembl

ENSG00000136237

ENSMUSG00000041992

UniProt

Q92565

Q8C0Q9

RefSeq (mRNA)

NM_012294
NM_001367600
NM_001367601
NM_001367602
NM_001367603

NM_175930
NM_001373989

RefSeq (protein)

NP_036426
NP_001354529
NP_001354530
NP_001354531
NP_001354532

NP_787126
NP_001360918

Location (UCSC)Chr 7: 22.12 – 22.36 MbChr 12: 117.48 – 117.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.[5][6][7]

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM][7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136237 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041992 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (May 1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
  6. ^ Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y (Oct 1999). "Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1". FEBS Lett. 457 (1): 85–9. doi:10.1016/S0014-5793(99)01012-1. PMID 10486569. S2CID 20296877.
  7. ^ a b "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5".

Further reading

[edit]


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