RINT1: Difference between revisions

RINT1
Identifiers
Aliases	RINT1, RINT-1, RAD50 interactor 1, ILFS3
External IDs	OMIM: 610089; MGI: 1916233; HomoloGene: 11070; GeneCards: RINT1; OMA:RINT1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	105,567,677 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,025,367 bp
RNA expression pattern
	Top expressed in
	tibia; ; testicle; ; body of pancreas; ; muscle of thigh; ; gastrocnemius muscle; ; right uterine tube; ; Achilles tendon; ; skin of abdomen; ; skin of leg; ; cerebellar hemisphere;
	Top expressed in
	Rostral migratory stream; ; spermatocyte; ; tail of embryo; ; islet of Langerhans; ; fossa; ; right kidney; ; esophagus; ; genital tubercle; ; stomach; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; Dsl1/NZR complex; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; cytosol;
Biological process	protein transport; cell cycle; regulation of ER to Golgi vesicle-mediated transport; Golgi vesicle transport; vesicle-mediated transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; Golgi organization;
	Sources:Amigo / QuickGO
Orthologs
	60561
	72772
	ENSG00000135249
	ENSMUSG00000028999
	Q6NUQ1
	Q8BZ36
	NM_021930; NM_001346599; NM_001346600; NM_001346601; NM_001346603
	NM_177323; NM_001310467
	NP_001333528; NP_001333529; NP_001333530; NP_001333532; NP_068749
	NP_001297396; NP_796297
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 00:01, 4 March 2023

RAD50-interacting protein 1 is a protein that in humans is encoded by the RINT1 gene.^[5]^[6]^[7]

Interactions

RINT1 has been shown to interact with Rad50^[5] and ZW10.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135249 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028999 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi:10.1074/jbc.M008893200. PMID 11096100.
^ ^a ^b Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.
^ "Entrez Gene: RINT1 RAD50 interactor 1".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nakajima K, Hirose H, Taniguchi M, et al. (2005). "Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion". EMBO J. 23 (16): 3216–26. doi:10.1038/sj.emboj.7600333. PMC 514507. PMID 15272311.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Arasaki K, Taniguchi M, Tani K, Tagaya M (2006). "RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex". Mol. Biol. Cell. 17 (6): 2780–8. doi:10.1091/mbc.E05-10-0973. PMC 1474792. PMID 16571679.
Kong LJ, Meloni AR, Nevins JR (2006). "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1". Mol. Cell. 22 (1): 63–71. doi:10.1016/j.molcel.2006.02.016. PMID 16600870.
Lin X, Liu CC, Gao Q, et al. (2007). "RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival". Mol. Cell. Biol. 27 (13): 4905–16. doi:10.1128/MCB.02396-06. PMC 1951495. PMID 17470549.
Sun Y, Shestakova A, Hunt L, et al. (2007). "Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis". Mol. Biol. Cell. 18 (10): 4129–42. doi:10.1091/mbc.E07-01-0080. PMC 1995728. PMID 17699596.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135249 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028999 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11096100-5] Xiao J, Liu CC, Chen PL, Lee WH (Mar 2001). "RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control". J Biol Chem. 276 (9): 6105–11. doi:10.1074/jbc.M008893200. PMID 11096100.

[pmid15029241-6] Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M (Mar 2004). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMC 381410. PMID 15029241.

[entrez-7] "Entrez Gene: RINT1 RAD50 interactor 1".

[1]

[2]

[3]

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''RAD50-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''RINT1'' [[gene]].<ref name="pmid11096100">{{cite journal | vauthors = Xiao J, Liu CC, Chen PL, Lee WH | title = RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control | journal = J Biol Chem | volume = 276 | issue = 9 | pages = 6105–11 |date=Mar 2001 | pmid = 11096100 | doi = 10.1074/jbc.M008893200 | doi-access = free }}</ref><ref name="pmid15029241">{{cite journal | vauthors = Hirose H, Arasaki K, Dohmae N, Takio K, Hatsuzawa K, Nagahama M, Tani K, Yamamoto A, Tohyama M, Tagaya M | title = Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi | journal = EMBO J | volume = 23 | issue = 6 | pages = 1267–78 |date=Mar 2004 | pmid = 15029241 | pmc = 381410 | doi = 10.1038/sj.emboj.7600135 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RINT1 RAD50 interactor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60561}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = RAD50 interactor 1
- | HGNCid = 21876
- | Symbol = RINT1
- | AltSymbols =; DKFZp667H2324; RINT-1
- | OMIM = 610089
- | ECnumber =
- | Homologene = 11070
- | MGIid = 1916233
- | GeneAtlas_image1 = PBB_GE_RINT1_218598_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
- | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0015031 |text = protein transport}} {{GNF_GO|id=GO:0031572 |text = G2/M transition DNA damage checkpoint}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 60561
-    | Hs_Ensembl = ENSG00000135249
-    | Hs_RefseqProtein = NP_068749
-    | Hs_RefseqmRNA = NM_021930
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 104959768
-    | Hs_GenLoc_end = 104995360
-    | Hs_Uniprot = Q6NUQ1
-    | Mm_EntrezGene = 72772
-    | Mm_Ensembl = ENSMUSG00000028999
-    | Mm_RefseqmRNA = NM_177323
-    | Mm_RefseqProtein = NP_796297
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 23297809
-    | Mm_GenLoc_end = 23330439
-    | Mm_Uniprot = Q8BZ36
-  }}
-}}
-'''RAD50 interactor 1''', also known as '''RINT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RINT1 RAD50 interactor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=60561| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
+==Interactions==
-| section_title =
+RINT1 has been shown to [[Protein-protein interaction|interact]] with [[Rad50]]<ref name=pmid11096100 /> and [[ZW10]].<ref name=pmid15029241 />
-| summary_text =
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097|doi-access=free |last1=Sanger Centre |first1=The |last2=Washington University Genome Sequencing Cente |first2=The }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-| citations =
-*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
+*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |bibcode=2003Natur.424..157H |doi-access= free }}
-*{{cite journal  | author=Xiao J, Liu CC, Chen PL, Lee WH |title=RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6105-11 |year= 2001 |pmid= 11096100 |doi= 10.1074/jbc.M008893200 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |doi-access= free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Nakajima K, Hirose H, Taniguchi M, etal |title=Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion |journal=EMBO J. |volume=23 |issue= 16 |pages= 3216–26 |year= 2005 |pmid= 15272311 |doi= 10.1038/sj.emboj.7600333  | pmc=514507 }}
-*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Arasaki K, Taniguchi M, Tani K, Tagaya M |title=RINT-1 Regulates the Localization and Entry of ZW10 to the Syntaxin 18 Complex |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2780–8 |year= 2006 |pmid= 16571679 |doi= 10.1091/mbc.E05-10-0973  | pmc=1474792 }}
-*{{cite journal  | author=Hirose H, Arasaki K, Dohmae N, ''et al.'' |title=Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi. |journal=EMBO J. |volume=23 |issue= 6 |pages= 1267-78 |year= 2005 |pmid= 15029241 |doi= 10.1038/sj.emboj.7600135 }}
+*{{cite journal  | vauthors=Kong LJ, Meloni AR, Nevins JR |title=The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1 |journal=Mol. Cell |volume=22 |issue= 1 |pages= 63–71 |year= 2006 |pmid= 16600870 |doi= 10.1016/j.molcel.2006.02.016 |doi-access= free }}
-*{{cite journal  | author=Nakajima K, Hirose H, Taniguchi M, ''et al.'' |title=Involvement of BNIP1 in apoptosis and endoplasmic reticulum membrane fusion. |journal=EMBO J. |volume=23 |issue= 16 |pages= 3216-26 |year= 2005 |pmid= 15272311 |doi= 10.1038/sj.emboj.7600333 }}
+*{{cite journal   |vauthors=Lin X, Liu CC, Gao Q, etal |title=RINT-1 Serves as a Tumor Suppressor and Maintains Golgi Dynamics and Centrosome Integrity for Cell Survival |journal=Mol. Cell. Biol. |volume=27 |issue= 13 |pages= 4905–16 |year= 2007 |pmid= 17470549 |doi= 10.1128/MCB.02396-06  | pmc=1951495 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Sun Y, Shestakova A, Hunt L, etal |title=Rab6 Regulates Both ZW10/RINT-1– and Conserved Oligomeric Golgi Complex-dependent Golgi Trafficking and Homeostasis |journal=Mol. Biol. Cell |volume=18 |issue= 10 |pages= 4129–42 |year= 2007 |pmid= 17699596 |doi= 10.1091/mbc.E07-01-0080  | pmc=1995728 }}
-*{{cite journal  | author=Arasaki K, Taniguchi M, Tani K, Tagaya M |title=RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. |journal=Mol. Biol. Cell |volume=17 |issue= 6 |pages= 2780-8 |year= 2006 |pmid= 16571679 |doi= 10.1091/mbc.E05-10-0973 }}
-*{{cite journal  | author=Kong LJ, Meloni AR, Nevins JR |title=The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. |journal=Mol. Cell |volume=22 |issue= 1 |pages= 63-71 |year= 2006 |pmid= 16600870 |doi= 10.1016/j.molcel.2006.02.016 }}
-*{{cite journal  | author=Lin X, Liu CC, Gao Q, ''et al.'' |title=RINT-1 serves as a tumor suppressor and maintains Golgi dynamics and centrosome integrity for cell survival. |journal=Mol. Cell. Biol. |volume=27 |issue= 13 |pages= 4905-16 |year= 2007 |pmid= 17470549 |doi= 10.1128/MCB.02396-06 }}
-*{{cite journal  | author=Sun Y, Shestakova A, Hunt L, ''et al.'' |title=Rab6 regulates both ZW10/RINT-1 and conserved oligomeric Golgi complex-dependent Golgi trafficking and homeostasis. |journal=Mol. Biol. Cell |volume=18 |issue= 10 |pages= 4129-42 |year= 2007 |pmid= 17699596 |doi= 10.1091/mbc.E07-01-0080 }}
-}}
 {{refend}}
-{{protein-stub}}
+{{gene-7-stub}}