Cyclic nucleotide-gated channel alpha 4: Difference between revisions

CNGA4
Identifiers
Aliases	CNGA4, CNCA2, CNG-4, CNG4, CNG5, CNGB2, OCNC2, OCNCBETA, OCNCb, Cyclic nucleotide-gated channel alpha 4, cyclic nucleotide gated channel alpha 4, cyclic nucleotide gated channel subunit alpha 4
External IDs	OMIM: 609472; MGI: 2664099; HomoloGene: 13579; GeneCards: CNGA4; OMA:CNGA4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,244,479 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	105,057,949 bp
RNA expression pattern
	Top expressed in
	gonad; ; right uterine tube; ; testicle; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; left testis; ; right testis; ; C1 segment; ; right lung; ; mucosa of paranasal sinus;
	Top expressed in
	olfactory epithelium; ; zygote; ; secondary oocyte; ; granulocyte; ; primary oocyte; ; dentate gyrus of hippocampal formation granule cell; ; spermatid; ; superior frontal gyrus; ; primary visual cortex; ; testicle;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; cAMP binding; voltage-gated potassium channel activity; ion channel activity; intracellular cAMP-activated cation channel activity; intracellular cGMP-activated cation channel activity; cGMP binding;
Cellular component	Golgi-associated vesicle membrane; integral component of membrane; Golgi membrane; membrane; ciliary membrane; integral component of plasma membrane;
Biological process	transmembrane transport; response to stimulus; sensory perception of smell; ion transport; ion transmembrane transport; regulation of membrane potential; potassium ion transmembrane transport; cation transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	1262
	233649
	ENSG00000132259
	ENSMUSG00000030897
	Q8IV77
	Q3UW12
	NM_001037329
	NM_001033317
	NP_001032406
	NP_001028489
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 00:25, 4 March 2023

Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene.^[5]^[6]^[7]

CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000132259 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030897 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.
^ Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.
^ ^a ^b "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

External links

CNGA4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000132259 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030897 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11764791-5] Bradley J, Frings S, Yau KW, Reed R (Dec 2001). "Nomenclature for Ion channel Subunits". Science. 294 (5549): 2095–6. doi:10.1126/science.294.5549.2095. PMC 2901924. PMID 11764791.

[pmid16382102-6] Hofmann F, Biel M, Kaupp UB (Dec 2005). "International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels". Pharmacol Rev. 57 (4): 455–62. doi:10.1124/pr.57.4.8. PMID 16382102. S2CID 45853869.

[entrez-7] "Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4".

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
 {{Infobox_gene}}
-'''Cyclic nucleotide-gated cation channel alpha-4''' is a [[protein]] that in humans is encoded by the ''CNGA4'' [[gene]].<ref name="pmid11764791">{{cite journal | vauthors = Bradley J, Frings S, Yau KW, Reed R | title = Nomenclature for Ion channel Subunits | journal = Science | volume = 294 | issue = 5549 | pages = 2095–6 |date=Dec 2001 | pmid = 11764791 | pmc =  2901924| doi =10.1126/science.294.5549.2095  }}</ref><ref name="pmid16382102">{{cite journal | vauthors = Hofmann F, Biel M, Kaupp UB | title = International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 455–62 |date=Dec 2005 | pmid = 16382102 | pmc =  | doi = 10.1124/pr.57.4.8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1262| accessdate = }}</ref>
+'''Cyclic nucleotide-gated cation channel alpha-4''' is a [[protein]] that in humans is encoded by the ''CNGA4'' [[gene]].<ref name="pmid11764791">{{cite journal | vauthors = Bradley J, Frings S, Yau KW, Reed R | title = Nomenclature for Ion channel Subunits | journal = Science | volume = 294 | issue = 5549 | pages = 2095–6 |date=Dec 2001 | pmid = 11764791 | pmc =  2901924| doi =10.1126/science.294.5549.2095  }}</ref><ref name="pmid16382102">{{cite journal | vauthors = Hofmann F, Biel M, Kaupp UB | title = International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 455–62 |date=Dec 2005 | pmid = 16382102 | doi = 10.1124/pr.57.4.8 | s2cid = 45853869 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CNGA4 cyclic nucleotide gated channel alpha 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1262}}</ref>
+CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]<ref name="entrez" />
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = CNGA4 is a modulatory subunit of vertebrate cyclic nucleotide-gated membrane channels that transduce odorant signals (Munger et al., 2001).[supplied by OMIM]<ref name="entrez" />
-}}
 ==See also==
@@ Line 16: / Line 13: @@
 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-style=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
-*{{cite journal  | author=Kelliher KR |title=Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4299–304 |year= 2003 |pmid= 12649326 |doi= 10.1073/pnas.0736071100  | pmc=153087  |name-list-format=vanc| author2=Ziesmann J  | author3=Munger SD  | display-authors=3  | last4=Reed  | first4=RR  | last5=Zufall  | first5=F }}
+*{{cite journal  | author=Kelliher KR |title=Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4299–304 |year= 2003 |pmid= 12649326 |doi= 10.1073/pnas.0736071100  | pmc=153087  |name-list-style=vanc| author2=Ziesmann J  | author3=Munger SD  | display-authors=3  | last4=Reed  | first4=RR  | last5=Zufall  | first5=F |bibcode=2003PNAS..100.4299K |doi-access=free }}
-*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Munger SD |title=Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin–Dependent Odor Adaptation |journal=Science |volume=294 |issue= 5549 |pages= 2172–5 |year= 2002 |pmid= 11739959 |doi= 10.1126/science.1063224  | pmc=2885906  |name-list-format=vanc| author2=Lane AP  | author3=Zhong H  | display-authors=3  | last4=Leinders-Zufall  | first4=T  | last5=Yau  | first5=KW  | last6=Zufall  | first6=F  | last7=Reed  | first7=RR }}
+*{{cite journal  | author=Munger SD |title=Central Role of the CNGA4 Channel Subunit in Ca2+-Calmodulin–Dependent Odor Adaptation |journal=Science |volume=294 |issue= 5549 |pages= 2172–5 |year= 2002 |pmid= 11739959 |doi= 10.1126/science.1063224  | pmc=2885906  |name-list-style=vanc| author2=Lane AP  | author3=Zhong H  | display-authors=3  | last4=Leinders-Zufall  | first4=T  | last5=Yau  | first5=KW  | last6=Zufall  | first6=F  | last7=Reed  | first7=RR }}
-*{{cite journal  | vauthors=Sautter A, Zong X, Hofmann F, Biel M |title=An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 8 |pages= 4696–701 |year= 1998 |pmid= 9539801 |doi=10.1073/pnas.95.8.4696  | pmc=22553  }}
+*{{cite journal  | vauthors=Sautter A, Zong X, Hofmann F, Biel M |title=An isoform of the rod photoreceptor cyclic nucleotide-gated channel β subunit expressed in olfactory neurons |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 8 |pages= 4696–701 |year= 1998 |pmid= 9539801 |doi=10.1073/pnas.95.8.4696  | pmc=22553  |bibcode=1998PNAS...95.4696S |doi-access=free }}
 {{refend}}