Adiponectin receptor 2: Difference between revisions

ADIPOR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WXW
Identifiers
Aliases	ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDs	OMIM: 607946; MGI: 93830; HomoloGene: 56119; GeneCards: ADIPOR2; OMA:ADIPOR2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	1,788,674 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	119,394,665 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; C1 segment; ; right adrenal cortex; ; right lung; ; left adrenal gland; ; left adrenal cortex; ; substantia nigra; ; liver; ; epithelium of colon; ; hippocampus proper;
	Top expressed in
	lactiferous gland; ; brown adipose tissue; ; transitional epithelium of urinary bladder; ; vestibular membrane of cochlear duct; ; epithelium of small intestine; ; epithelium of stomach; ; pyloric antrum; ; left lobe of liver; ; white adipose tissue; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	adipokinetic hormone receptor activity; adiponectin binding; metal ion binding; identical protein binding; protein heterodimerization activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane;
Biological process	positive regulation of glucose import; glucose homeostasis; response to nutrient; lipid metabolism; female pregnancy; adiponectin-activated signaling pathway; fatty acid metabolic process; vascular wound healing; heart development; negative regulation of cell growth; fatty acid oxidation; hormone-mediated signaling pathway; regulation of fatty acid biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	79602
	68465
	ENSG00000006831; ENSG00000285070
	ENSMUSG00000030168
	Q86V24
	Q8BQS5
	NM_024551; NM_001375363; NM_001375364; NM_001375365
	NM_197985; NM_001355692
	NP_078827; NP_001362292; NP_001362293; NP_001362294
	NP_932102; NP_001342621
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 00:55, 4 March 2023

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.^[6]

Structure

Similar to G protein-coupled receptors (GPCRs), AdipoR2 also possesses 7 transmembrane domains. However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic N-terminus, extracellular C-terminus) and does not associate with G proteins.^[5]

Function

The adiponectin receptors, AdipoR1 and AdipoR2, serve as receptors for globular and full-length adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as fatty acid oxidation and glucose uptake by adiponectin.^[5] In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called Ordinary_researchers.^[7]

Ligands

Agonists

Peptide

Non-peptide

Antagonists

Peptide

ADP-400^[8]

References

^ ^a ^b ^c ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.
^ University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016
^ ^a ^b ^c Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.
^ Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.
^ ^a ^b ^c ^d Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

External links

Human ADIPOR2 genome location and ADIPOR2 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

[Dennis-7] University of Tokyo to investigate data manipulation charges against six prominent research groups ScienceInsider, Dennis Normile, Sep 20, 2016

[pmid25368867-8] Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S (2014). "Development of second generation peptides modulating cellular adiponectin receptor responses". Frontiers in Chemistry. 2: 93. Bibcode:2014FrCh....2...93O. doi:10.3389/fchem.2014.00093. PMC 4201147. PMID 25368867.

[pmid24172895-9] Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T (November 2013). "A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity". Nature. 503 (7477): 493–9. Bibcode:2013Natur.503..493O. doi:10.1038/nature12656. PMID 24172895. S2CID 4447039.

[pmid23691032-10] Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z (2013). "Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay". PLOS ONE. 8 (5): e63354. Bibcode:2013PLoSO...863354S. doi:10.1371/journal.pone.0063354. PMC 3653934. PMID 23691032.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=79602}}
+{{Infobox_gene}}
-'''Adiponectin receptor 2''' ('''AdipoR2''') is a [[protein]] which in humans is encoded by the ''ADIPOR2'' [[gene]].<ref name="pmid12802337">{{cite journal | author = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 |date=June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | url = | issn = }}</ref>
+'''Adiponectin receptor 2''' ('''AdipoR2''') is a [[protein]] which in humans is encoded by the ''ADIPOR2'' [[gene]].<ref name="pmid12802337">{{cite journal | vauthors = Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T | title = Cloning of adiponectin receptors that mediate antidiabetic metabolic effects | journal = Nature | volume = 423 | issue = 6941 | pages = 762–9 | date = June 2003 | pmid = 12802337 | doi = 10.1038/nature01705 | bibcode = 2003Natur.423..762Y | s2cid = 52860797 }}</ref> It is a member of the [[progestin and adipoQ receptor]] (PAQR) family, and is also known as '''PAQR2'''.<ref name="TangHu2005">{{cite journal | vauthors = Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD | title = PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif | journal = Journal of Molecular Evolution | volume = 61 | issue = 3 | pages = 372–80 | date = September 2005 | pmid = 16044242 | doi = 10.1007/s00239-004-0375-2 | bibcode = 2005JMolE..61..372T | s2cid = 31473802 }}</ref>
 ==Structure==
-Similar to [[G protein-coupled receptor]]s (GPCRs), ADIPOR2 also possesses 7 [[transmembrane domain]]s.  However ADIPOR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic [[N-terminus]], extracellular [[C-terminus]]) and does not associate with [[G protein]]s.<ref name="pmid12802337"/>
+Similar to [[G protein-coupled receptor]]s (GPCRs), AdipoR2 also possesses 7 [[transmembrane domain]]s.  However, AdipoR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic [[N-terminus]], extracellular [[C-terminus]]) and does not associate with [[G protein]]s.<ref name="pmid12802337"/>
-==Function==
+== Function ==
-The adiponectin receptors, [[ADIPOR1]] and ADIPOR2 (this protein), serve as receptors for globular and full-length [[adiponectin]]  and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/>
+The [[adiponectin receptor]]s, [[AdipoR1]] and AdipoR2, serve as receptors for globular and full-length [[adiponectin]]  and mediate increased [[AMP-activated protein kinase|AMPK]] and [[Peroxisome proliferator-activated receptor alpha|PPAR-α]] ligand activities, as well as [[fatty acid]] oxidation and glucose uptake by adiponectin.<ref name="pmid12802337"/>  In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoR1 and AdipoR2 identification data, as accused by an anonymous person/group called [[Ordinary_researchers]].<ref name="Dennis">[https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups] ScienceInsider, Dennis Normile, Sep 20, 2016</ref>
 ==Ligands==
@@ Line 12: / Line 13: @@
 ====Peptide====
 * [[Adiponectin]]
+* [[ADP-355]]<ref name="pmid25368867">{{cite journal | vauthors = Otvos L, Knappe D, Hoffmann R, Kovalszky I, Olah J, Hewitson TD, Stawikowska R, Stawikowski M, Cudic P, Lin F, Wade JD, Surmacz E, Lovas S | title = Development of second generation peptides modulating cellular adiponectin receptor responses | journal = Frontiers in Chemistry | volume = 2 | pages = 93 | year = 2014 | pmid = 25368867 | pmc = 4201147 | doi = 10.3389/fchem.2014.00093 | bibcode = 2014FrCh....2...93O | doi-access = free }}</ref>
-* [[ADP-355]]
-* [[ADP-399]]
+* [[ADP-399]]<ref name="pmid25368867" />
 ====Non-peptide====
+* [[AdipoRon]]<ref name="pmid24172895">{{cite journal | vauthors = Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, Yamaguchi M, Tanabe H, Kimura-Someya T, Shirouzu M, Ogata H, Tokuyama K, Ueki K, Nagano T, Tanaka A, Yokoyama S, Kadowaki T | title = A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity | journal = Nature | volume = 503 | issue = 7477 | pages = 493–9 | date = November 2013 | pmid = 24172895 | doi = 10.1038/nature12656 | bibcode = 2013Natur.503..493O | s2cid = 4447039 }}</ref>
-* [[AdipoRon]]
+* [[Deoxyschizandrin]]<ref name="pmid23691032">{{cite journal | vauthors = Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z | title = Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay | journal = PLOS ONE | volume = 8 | issue = 5 | pages = e63354 | year = 2013 | pmid = 23691032 | pmc = 3653934 | doi = 10.1371/journal.pone.0063354 | bibcode = 2013PLoSO...863354S | doi-access = free }}</ref>
-* [[(–)-Arctigenin]]
+* [[Parthenolide]]<ref name="pmid23691032" />
-* [[Arctiin]]
+* [[Syringing (drug)|Syringing]]<ref name="pmid23691032" />
-* [[Gramine]]
+* [[Taxifoliol]]<ref name="pmid23691032" />
-* [[Matairesinol]]
 ===Antagonists===
 ====Peptide====
-* [[ADP-400]]
+* [[ADP-400]]<ref name="pmid25368867" />
-==See also==
+== See also ==
 * [[Adiponectin receptor]]
+* [[Adiponectin receptor 1]]
-==References==
+== References ==
 {{Reflist|2}}
+==External links==
+* {{UCSC gene info|ADIPOR2}}
+{{Cell surface receptors}}
 [[Category:7TM receptors]]
 {{gene-12-stub}}