RNF41: Difference between revisions

RNF41
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2FZP, 2GWF
Identifiers
Aliases	RNF41, FLRF, NRDP1, SBBI03, ring finger protein 41
External IDs	MGI: 1914838; HomoloGene: 4226; GeneCards: RNF41; OMA:RNF41 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,221,933 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,277,310 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; paraflocculus of cerebellum; ; frontal pole; ; islet of Langerhans; ; monocyte; ; lateral nuclear group of thalamus; ; stromal cell of endometrium; ; gallbladder; ; right coronary artery; ; popliteal artery;
	Top expressed in
	seminiferous tubule; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; spermatid; ; superior frontal gyrus; ; ventricular zone; ; granulocyte; ; ganglionic eminence; ; Rostral migratory stream; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	interleukin-3 receptor binding; erythropoietin receptor binding; zinc ion binding; metal ion binding; protein binding; transferase activity; ubiquitin-protein transferase activity; protein domain specific binding; receptor tyrosine kinase binding; ubiquitin protein ligase activity;
Cellular component	cytosol; perinuclear region of cytoplasm; endoplasmic reticulum tubular network;
Biological process	regulation of MAPK cascade; extrinsic apoptotic signaling pathway; positive regulation of DNA-binding transcription factor activity; protein polyubiquitination; regulation of reactive oxygen species metabolic process; autophagy; negative regulation of cell migration; regulation of lymphocyte differentiation; positive regulation of reactive oxygen species metabolic process; protein ubiquitination; regulation of protein kinase B signaling; regulation of gene expression; proteasomal protein catabolic process; regulation of myeloid cell differentiation; regulation of establishment of cell polarity; negative regulation of cell population proliferation; protein autoubiquitination; apoptotic process; negative regulation of mitophagy; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	10193
	67588
	ENSG00000181852
	ENSMUSG00000025373
	Q9H4P4
	Q8BH75
	NM_001242826; NM_005785; NM_194358; NM_194359
	NM_001164237; NM_026259
	NP_001229755; NP_005776; NP_919339; NP_919340
	NP_001157709; NP_080535
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 01:10, 4 March 2023

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.^[5]

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[5]

Interactions

RNF41 has been shown to interact with USP8.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000181852 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025373 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: RNF41 ring finger protein 41".
^ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

External links

RNF41+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
RNF41 human gene location in the UCSC Genome Browser.
RNF41 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000181852 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025373 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: RNF41 ring finger protein 41".

[pmid15314180-6] Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''E3 ubiquitin-protein ligase NRDP1''' is an [[enzyme]] that in humans is encoded by the ''RNF41'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== Function ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image = PBB_Protein_RNF41_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fzp.
- | PDB = {{PDB2|2fzp}}, {{PDB2|2gwf}}, {{PDB2|2ogb}}
- | Name = Ring finger protein 41
- | HGNCid = 18401
- | Symbol = RNF41
- | AltSymbols =; MGC45228; NRDP1; SBBI03
- | OMIM =
- | ECnumber =
- | Homologene = 4226
- | MGIid = 1914838
- | GeneAtlas_image1 = PBB_GE_RNF41_201961_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RNF41_201962_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10193
-    | Hs_Ensembl = ENSG00000181852
-    | Hs_RefseqProtein = NP_005776
-    | Hs_RefseqmRNA = NM_005785
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 54884555
-    | Hs_GenLoc_end = 54902002
-    | Hs_Uniprot = Q9H4P4
-    | Mm_EntrezGene = 67588
-    | Mm_Ensembl = ENSMUSG00000025373
-    | Mm_RefseqmRNA = NM_026259
-    | Mm_RefseqProtein = NP_080535
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 127814606
-    | Mm_GenLoc_end = 127844390
-    | Mm_Uniprot = Q99MS2
-  }}
-}}
-'''Ring finger protein 41''', also known as '''RNF41''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref>
+The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref name="entrez" />
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
+RNF41 has been shown to [[Protein-protein interaction|interact]] with [[USP8]].<ref name=pmid15314180>{{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Mol. Cell. Biol. | volume = 24 | issue = 17 | pages = 7748–57  | date = September 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }}</ref>
+== See also ==
+* [[RING finger domain]]
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Cao Z, Wu X, Yen L, Sweeney C, Carraway KL | title = Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1 | journal = Mol. Cell. Biol. | volume = 27 | issue = 6 | pages = 2180–8 | year = 2007 | pmid = 17210635 | pmc = 1820496 | doi = 10.1128/MCB.01245-06 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S | title = Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8) | journal = J. Biol. Chem. | volume = 281 | issue = 49 | pages = 38061–70 | year = 2006 | pmid = 17035239 | doi = 10.1074/jbc.M606704200 | doi-access = free }}
-| citations =
-*{{cite journal  | author=Cao Z, Wu X, Yen L, ''et al.'' |title=Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. |journal=Mol. Cell. Biol. |volume=27 |issue= 6 |pages= 2180-8 |year= 2007 |pmid= 17210635 |doi= 10.1128/MCB.01245-06 }}
+* {{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Mol. Cell. Biol. | volume = 24 | issue = 17 | pages = 7748–57 | year = 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }}
-*{{cite journal  | author=Avvakumov GV, Walker JR, Xue S, ''et al.'' |title=Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 38061-70 |year= 2007 |pmid= 17035239 |doi= 10.1074/jbc.M606704200 }}
+* {{cite journal | vauthors = Qiu XB, Markant SL, Yuan J, Goldberg AL | title = Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis | journal = EMBO J. | volume = 23 | issue = 4 | pages = 800–10 | year = 2004 | pmid = 14765125 | pmc = 380992 | doi = 10.1038/sj.emboj.7600075 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+* {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 | doi-access = free }}
-*{{cite journal  | author=Wu X, Yen L, Irwin L, ''et al.'' |title=Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7748-57 |year= 2004 |pmid= 15314180 |doi= 10.1128/MCB.24.17.7748-7757.2004 }}
+* {{cite journal | vauthors = Qiu XB, Goldberg AL | title = Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 23 | pages = 14843–8 | year = 2002 | pmid = 12411582 | pmc = 137506 | doi = 10.1073/pnas.232580999 | bibcode = 2002PNAS...9914843Q | doi-access = free }}
-*{{cite journal  | author=Qiu XB, Markant SL, Yuan J, Goldberg AL |title=Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. |journal=EMBO J. |volume=23 |issue= 4 |pages= 800-10 |year= 2005 |pmid= 14765125 |doi= 10.1038/sj.emboj.7600075 }}
+* {{cite journal | vauthors = Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL | title = An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2866–71 | year = 2002 | pmid = 11867753 | pmc = 122439 | doi = 10.1073/pnas.052709799 | bibcode = 2002PNAS...99.2866D | doi-access = free }}
-*{{cite journal  | author=Brajenovic M, Joberty G, Küster B, ''et al.'' |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804-11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200 }}
+* {{cite journal | vauthors = Abdullah JM, Li X, Nachtman RG, Jurecic R | title = FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors | journal = Blood Cells Mol. Dis. | volume = 27 | issue = 1 | pages = 320–33 | year = 2001 | pmid = 11358394 | doi = 10.1006/bcmd.2001.0390 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
-*{{cite journal  | author=Qiu XB, Goldberg AL |title=Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 23 |pages= 14843-8 |year= 2003 |pmid= 12411582 |doi= 10.1073/pnas.232580999 }}
+* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
-*{{cite journal  | author=Diamonti AJ, Guy PM, Ivanof C, ''et al.'' |title=An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2866-71 |year= 2002 |pmid= 11867753 |doi= 10.1073/pnas.052709799 }}
-*{{cite journal  | author=Abdullah JM, Li X, Nachtman RG, Jurecic R |title=FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 1 |pages= 320-33 |year= 2001 |pmid= 11358394 |doi= 10.1006/bcmd.2001.0390 }}
-*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
-*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
-}}
 {{refend}}
+== External links ==
-{{protein-stub}}
+* {{MeshName|RNF41+protein,+human}}
+* {{UCSC genome browser|RNF41}}
+* {{UCSC gene details|RNF41}}
+{{PDB Gallery|geneid=10193}}
+[[Category:RING finger proteins]]
+{{gene-12-stub}}