Myoepithelial cell: Difference between revisions
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| ⚫ | are as a thin layer above the [[basement membrane]] but generally beneath the [[lumen (anatomy)|luminal]] cells. These may be positive for [[ACTA2|alpha smooth muscle]] [[actin]] and can contract and expel the [[secretions]] of [[exocrine glands]]. They are found in the [[sweat gland]]s, [[mammary gland]]s, [[lacrimal gland]]s, and [[salivary gland]]s. Myoepithelial cells in these cases constitute the [[basal cell layer]] of an [[epithelium]] that harbors the epithelial [[Progenitor cell|progenitor]]. In the case of wound healing, myoepithelial cells reactively [[cell growth|proliferate]]. Presence of myoepithelial cells in a [[hyperplasia|hyperplastic]] tissue proves the benignity of the gland and, when absent, indicates [[cancer]]. Only rare cancers like [[adenoid cystic carcinoma]]s contains [[myoepithelial cells]] as one of the [[malignant]] components. |
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| Name = Myoepithelial cell |
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| Latin = myoepitheliocytus |
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| Image = Normal breast histology.png |
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| Caption = Normal [[histology]] of the [[breast]], with myoepithelial cell annotated near bottom right. |
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| ⚫ | '''Myoepithelial cells''' (sometimes referred to as '''myoepithelium''') are cells usually found in [[glandular epithelium]] as a thin layer above the [[basement membrane]] but generally beneath the [[lumen (anatomy)|luminal]] cells. These may be positive for [[ACTA2|alpha smooth muscle]] [[actin]] and can contract and expel the [[secretions]] of [[exocrine glands]]. They are found in the [[sweat gland]]s, [[mammary gland]]s, [[lacrimal gland]]s, and [[salivary gland]]s. Myoepithelial cells in these cases constitute the [[basal cell layer]] of an [[epithelium]] that harbors the epithelial [[Progenitor cell|progenitor]]. In the case of wound healing, myoepithelial cells reactively [[cell growth|proliferate]]. Presence of myoepithelial cells in a [[hyperplasia|hyperplastic]] tissue proves the benignity of the gland and, when absent, indicates [[cancer]]. Only rare cancers like [[adenoid cystic carcinoma]]s contains [[myoepithelial cells]] as one of the [[malignant]] components. |
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It can be found in [[endoderm]] or [[ectoderm]].<ref name="Berman2009">{{cite book|author=Jules J. Berman|title=Neoplasms: principles of development and diversity|url= |
It can be found in [[endoderm]] or [[ectoderm]].<ref name="Berman2009">{{cite book|author=Jules J. Berman|title=Neoplasms: principles of development and diversity|url=https://books.google.com/books?id=WWnJ1-IM1yUC&pg=PA207|accessdate=16 April 2010|year=2009|publisher=Jones & Bartlett Learning|isbn=978-0-7637-5570-6|pages=207–}}</ref> |
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==Markers== |
==Markers== |
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Myoepithelial cells are true [[epithelial cell]]s positive for [[keratin]]s, not to be confused with |
Myoepithelial cells are true [[epithelial cell]]s positive for [[keratin]]s, not to be confused with [[myofibroblast]]s which are true [[mesenchymal cell]]s positive for [[vimentin]]. These cells are generally positive for [[alpha smooth muscle]] actin (αSMA), [[cytokeratin]] 5/6 and other high [[molecular weight]] cytokeratins, [[TP73L|p63]] and [[caldesmon]]. |
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Myoepithelial cells are stellate in shape and are also known as basket cells. |
Myoepithelial cells are stellate in shape and are also known as basket cells. |
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They lie between the basement membrane and glandular epithelium. |
They lie between the basement membrane and glandular epithelium. |
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Each cell consists of a cell body from which 4-8 processes radiate and embrace the secretory unit. Myoepithelial cells have contractile functions. They help in expelling secretions from the lumen of secretory units and facilitate the movement of saliva in salivary ducts. |
Each cell consists of a cell body from which 4-8 processes radiate and embrace the secretory unit. Myoepithelial cells have contractile functions. They help in expelling secretions from the lumen of secretory units and facilitate the movement of saliva in salivary ducts. |
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== Other Cancers Involving This Type of Cell == |
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[[File:Myoepithelioma - very high mag.jpg|thumb|[[Myoepithelioma]], here with [[plasma cell]]-like myoepithelial cell.]] |
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* [[Myoepithelioma of the head and neck]] - A (usually) benign tumor of the head/neck consisting of solely myoepithelial cells. |
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*[[Epithelial-myoepithelial carcinoma|Epithelial-myoepithelial carcinoma (of the salivary glands)]] - A low-grade malignant tumor composed of both neoplastic epithelial and neoplastic myoepithelial cells (a biphasic tumor). |
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* [[Epithelial-myoepithelial carcinoma of the lung]]- A malignant tumor composed of both epithelial and myoepithelial tissues whose pathology resemble salivary cells. |
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* [[Adenomyoepithelioma of the breast]]- A (usually) benign tumor of the breast composed of Myoepithelial and [[Adeno]] (glandular) cells. |
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* Myoepithelioma of the Breast- A usually benign or exceedingly rare malignant tumor of the breast which mimics [[Invasive carcinoma of no special type|IDC]] but with cells resembling [[adenoid]] [[cyst]]s. If malignant, this is also known as a Myoepithelial Carcinoma. |
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== See also == |
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[[List of distinct cell types in the adult human body]] |
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==References== |
==References== |
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{{ |
{{Reflist}} |
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==External links== |
==External links== |
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* {{OklahomaHistology|43_13}} - "thick skin" |
* {{OklahomaHistology|43_13}} - "thick skin" |
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* {{KansasHistology|glands|glands09}} "Simple Tubular Coiled" |
* {{KansasHistology|glands|glands09}} "Simple Tubular Coiled" |
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* {{citation|author=Costoff, A.|url=http://humanphysiology.tuars.com/program/section6/6ch4/s6ch4_4.htm|title=Essentials of Human Physiology|url-status=bot: unknown|archiveurl=https://web.archive.org/web/20151120082426/http://humanphysiology.tuars.com/program/section6/6ch4/s6ch4_4.htm|archivedate=2015-11-20}} |
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* {{GeorgiaPhysiology|6/6ch4/s6ch4_4}} |
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{{Epithelium and epithelial tissue}} |
{{Epithelium and epithelial tissue}} |
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{{Authority control}} |
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[[Category:Cell biology]] |
[[Category:Cell biology]] |
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Latest revision as of 09:51, 18 July 2023
| Myoepithelial cell | |
|---|---|
 | |
| Details | |
| Identifiers | |
| Latin | myoepitheliocytus |
| TH | H2.00.02.0.03059 |
| FMA | 67799 67805, 67799 |
| Anatomical terminology | |
Myoepithelial cells (sometimes referred to as myoepithelium) are cells usually found in glandular epithelium as a thin layer above the basement membrane but generally beneath the luminal cells. These may be positive for alpha smooth muscle actin and can contract and expel the secretions of exocrine glands. They are found in the sweat glands, mammary glands, lacrimal glands, and salivary glands. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. In the case of wound healing, myoepithelial cells reactively proliferate. Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer. Only rare cancers like adenoid cystic carcinomas contains myoepithelial cells as one of the malignant components.
It can be found in endoderm or ectoderm.[1]
Markers
[edit]Myoepithelial cells are true epithelial cells positive for keratins, not to be confused with myofibroblasts which are true mesenchymal cells positive for vimentin. These cells are generally positive for alpha smooth muscle actin (αSMA), cytokeratin 5/6 and other high molecular weight cytokeratins, p63 and caldesmon. Myoepithelial cells are stellate in shape and are also known as basket cells. They lie between the basement membrane and glandular epithelium. Each cell consists of a cell body from which 4-8 processes radiate and embrace the secretory unit. Myoepithelial cells have contractile functions. They help in expelling secretions from the lumen of secretory units and facilitate the movement of saliva in salivary ducts.
Other Cancers Involving This Type of Cell
[edit]
- Myoepithelioma of the head and neck - A (usually) benign tumor of the head/neck consisting of solely myoepithelial cells.
- Epithelial-myoepithelial carcinoma (of the salivary glands) - A low-grade malignant tumor composed of both neoplastic epithelial and neoplastic myoepithelial cells (a biphasic tumor).
- Epithelial-myoepithelial carcinoma of the lung- A malignant tumor composed of both epithelial and myoepithelial tissues whose pathology resemble salivary cells.
- Adenomyoepithelioma of the breast- A (usually) benign tumor of the breast composed of Myoepithelial and Adeno (glandular) cells.
- Myoepithelioma of the Breast- A usually benign or exceedingly rare malignant tumor of the breast which mimics IDC but with cells resembling adenoid cysts. If malignant, this is also known as a Myoepithelial Carcinoma.
See also
[edit]List of distinct cell types in the adult human body
References
[edit]- ^ Jules J. Berman (2009). Neoplasms: principles of development and diversity. Jones & Bartlett Learning. pp. 207–. ISBN 978-0-7637-5570-6. Retrieved 16 April 2010.
External links
[edit]- Anatomy Atlases – Microscopic Anatomy, plate 07.141 - "Axillary Sweat Gland: Myoepithelium"
- Histology image: 43_13 at the University of Oklahoma Health Sciences Center - "thick skin"
- Histology at KUMC glands-glands09 "Simple Tubular Coiled"
- Costoff, A., Essentials of Human Physiology, archived from the original on 2015-11-20
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