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{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{PBB|geneid=573}}
{{Infobox_gene}}
'''BAG family molecular chaperone regulator 1''' is a [[protein]] that in humans is encoded by the ''BAG1'' [[gene]].<ref name="pmid7834747">{{cite journal | author = Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC | title = Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity | journal = Cell | volume = 80 | issue = 2 | pages = 279–84 |date=March 1995 | pmid = 7834747 | pmc = | doi =10.1016/0092-8674(95)90410-7 }}</ref>
'''BAG family molecular chaperone regulator 1''' is a [[protein]] that in humans is encoded by the ''BAG1'' [[gene]].<ref name="pmid7834747">{{cite journal | vauthors = Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC | title = Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity | journal = Cell | volume = 80 | issue = 2 | pages = 279–84 |date=March 1995 | pmid = 7834747 | doi =10.1016/0092-8674(95)90410-7 | s2cid = 17824475 | doi-access = free }}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
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| summary_text = The [[oncogene]] BCL2 is a membrane protein that blocks a step in a pathway leading to [[apoptosis]] or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated [[athanogene]]. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this [[mRNA]] through the use of alternative [[translation]] initiation sites, including a non-[[start codon|AUG]] site.<ref name="entrez">{{cite web | title = Entrez Gene: BAG1 BCL2-associated athanogene| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573| accessdate = }}</ref>
}}


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The [[oncogene]] BCL2 is a membrane protein that blocks a step in a pathway leading to [[apoptosis]] or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated [[athanogene]]. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this [[mRNA]] through the use of alternative [[Translation (biology)|translation]] initiation sites, including a non-[[start codon|AUG]] site.<ref name="entrez">{{cite web | title = Entrez Gene: BAG1 BCL2-associated athanogene| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=573}}</ref>
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BAG gene has been implicated in age related neurodegenerative diseases as [[Alzheimer]]'s. It has been demonstrated that BAG1 and BAG 3 regulate the [[proteasome|proteasomal]] and [[lysosome|lysosomal]] protein elimination pathways, respectively.<ref>Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C. 2009. EMBO J. 28(7):889-901.</ref><ref>[http://www.physorg.com/news155141336.html Physorg:Old Cells Work Differently]</ref>


== Clinical significance ==
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==Interactions==
BAG1 has been shown to [[Protein-protein interaction|interact]] with [[Retinoic acid receptor alpha]],<ref name=pmid9642262>{{cite journal |doi=10.1074/jbc.273.27.16985 |last=Liu |first=R |authorlink= |coauthors=Takayama S, Zheng Y, Froesch B, Chen G Q, Zhang X, Reed J C, Zhang X K |date=July 1998 |title=Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells |journal=J. Biol. Chem. |volume=273 |issue=27 |pages=16985–92 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9642262 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[C-Raf]],<ref name=pmid8692945>{{cite journal |doi=10.1073/pnas.93.14.7063 |last=Wang |first=H G |authorlink= |coauthors=Takayama S, Rapp U R, Reed J C |date=July 1996 |title=Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=14 |pages=7063–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8692945 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=38936 }}</ref> [[PPP1R15A]],<ref name=pmid12724406>{{cite journal |doi=10.1128/MCB.23.10.3477-3486.2003 |last=Hung |first=Wesley J |authorlink= |coauthors=Roberson Rachel S, Taft Jaime, Wu Daniel Y |date=May 2003 |title=Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions |journal=Mol. Cell. Biol. |volume=23 |issue=10 |pages=3477–86 |publisher= |location = United States| issn = 0270-7306| pmid = 12724406 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=164759 }}</ref> [[Androgen receptor]],<ref name=pmid14517289>{{cite journal |doi=10.1128/MCB.23.20.7189-7197.2003 |last=Shatkina |first=Liubov |authorlink= |coauthors=Mink Sigrun, Rogatsch Hermann, Klocker Helmut, Langer Gernot, Nestl Andrea, Cato Andrew C B |date=October 2003 |title=The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor |journal=Mol. Cell. Biol. |volume=23 |issue=20 |pages=7189–97 |publisher= |location = United States| issn = 0270-7306| pmid = 14517289 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=230325 }}</ref><ref name=pmid11278763>{{cite journal |last=Knee |first=D A |authorlink= |coauthors=Froesch B A, Nuber U, Takayama S, Reed J C |date=April 2001 |title=Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity |journal=J. Biol. Chem. |volume=276 |issue=16 |pages=12718–24 |publisher= |location = United States| issn = 0021-9258| pmid = 11278763 |doi = 10.1074/jbc.M010841200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9565586>{{cite journal |doi=10.1074/jbc.273.19.11660 |last=Froesch |first=B A |authorlink= |coauthors=Takayama S, Reed J C |date=May 1998 |title=BAG-1L protein enhances androgen receptor function |journal=J. Biol. Chem. |volume=273 |issue=19 |pages=11660–6 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9565586 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[HSPA8]],<ref name=pmid9305631>{{cite journal |last=Takayama |first=S |authorlink= |coauthors=Bimston D N, Matsuzawa S, Freeman B C, Aime-Sempe C, Xie Z, Morimoto R I, Reed J C |date=August 1997 |title=BAG-1 modulates the chaperone activity of Hsp70/Hsc70 |journal=EMBO J. |volume=16 |issue=16 |pages=4887–96 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9305631 |doi = 10.1093/emboj/16.16.4887 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1170124 }}</ref><ref name=pmid9873016>{{cite journal |doi=10.1074/jbc.274.2.781 |last=Takayama |first=S |authorlink= |coauthors=Xie Z, Reed J C |date=January 1999 |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators |journal=J. Biol. Chem. |volume=274 |issue=2 |pages=781–6 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9873016 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Heparin-binding EGF-like growth factor]],<ref name=pmid11340068>{{cite journal |last=Lin |first=J |authorlink= |coauthors=Hutchinson L, Gaston S M, Raab G, Freeman M R |date=August 2001 |title=BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation |journal=J. Biol. Chem. |volume=276 |issue=32 |pages=30127–32 |publisher= |location = United States| issn = 0021-9258| pmid = 11340068 |doi = 10.1074/jbc.M010237200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Glucocorticoid receptor]],<ref name=pmid9603979>{{cite journal |doi=10.1074/jbc.273.23.14620 |last=Kullmann |first=M |authorlink= |coauthors=Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato A C |date=June 1998 |title=RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis |journal=J. Biol. Chem. |volume=273 |issue=23 |pages=14620–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9603979 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11101523>{{cite journal |last=Schneikert |first=J |authorlink= |coauthors=Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato A C |date=Dec 2000 |title=Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor |journal=EMBO J. |volume=19 |issue=23 |pages=6508–16 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 11101523 |doi = 10.1093/emboj/19.23.6508 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=305849 }}</ref> [[Calcitriol receptor]]<ref name=pmid10967105>{{cite journal |last=Guzey |first=M |authorlink= |coauthors=Takayama S, Reed J C |date=Dec 2000 |title=BAG1L enhances trans-activation function of the vitamin D receptor |journal=J. Biol. Chem. |volume=275 |issue=52 |pages=40749–56 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10967105 |doi = 10.1074/jbc.M004977200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[SIAH1]].<ref name=pmid9582267>{{cite journal |last=Matsuzawa |first=S |authorlink= |coauthors=Takayama S, Froesch B A, Zapata J M, Reed J C |date=May 1998 |title=p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1 |journal=EMBO J. |volume=17 |issue=10 |pages=2736–47 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9582267 |doi = 10.1093/emboj/17.10.2736 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1170614 }}</ref>


⚫
BAG gene has been implicated in age related neurodegenerative diseases as [[Alzheimer]]'s. It has been demonstrated that BAG1 and BAG 3 regulate the [[proteasome|proteasomal]] and [[lysosome|lysosomal]] protein elimination pathways, respectively.<ref name="pmid19229298">{{cite journal | vauthors = Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C | title = Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 | journal = EMBO J. | volume = 28 | issue = 7 | pages = 889–901 | year = 2009 | pmid = 19229298 | pmc = 2647772 | doi = 10.1038/emboj.2009.29}} *{{lay source |template=cite web |url = https://phys.org/news/2009-03-cells-differently.html|title=Old Cells Work Differently|date = March 1, 2009|website = Phys.org }}</ref>
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==References==

⚫
== Interactions ==

BAG1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Androgen receptor]],<ref name = pmid14517289>{{cite journal | date = October 2003 | vauthors = Shatkina L, Mink S, Rogatsch H, Klocker H, Langer G, Nestl A, Cato AC | title = The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor | journal = Mol. Cell. Biol. | volume = 23 | issue = 20 | pages = 7189–97 | pmid = 14517289 | pmc = 230325 | doi = 10.1128/mcb.23.20.7189-7197.2003}}</ref><ref name = pmid11278763>{{cite journal | date = April 2001 | vauthors = Knee DA, Froesch BA, Nuber U, Takayama S, Reed JC | title = Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 12718–24 | pmid = 11278763 | doi = 10.1074/jbc.M010841200| doi-access = free }}</ref><ref name = pmid9565586>{{cite journal | date = May 1998 | vauthors = Froesch BA, Takayama S, Reed JC | title = BAG-1L protein enhances androgen receptor function | journal = J. Biol. Chem. | volume = 273 | issue = 19 | pages = 11660–6 | pmid = 9565586 | doi = 10.1074/jbc.273.19.11660| doi-access = free }}</ref>
* [[C-Raf]],<ref name = pmid8692945>{{cite journal | date = July 1996 | vauthors = Wang HG, Takayama S, Rapp UR, Reed JC | title = Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 14 | pages = 7063–8 | pmid = 8692945 | pmc = 38936 | doi = 10.1073/pnas.93.14.7063| bibcode = 1996PNAS...93.7063W | doi-access = free }}</ref>
* [[Calcitriol receptor]],<ref name = pmid10967105>{{cite journal | date = Dec 2000 | vauthors = Guzey M, Takayama S, Reed JC | title = BAG1L enhances trans-activation function of the vitamin D receptor | journal = J. Biol. Chem. | volume = 275 | issue = 52 | pages = 40749–56 | pmid = 10967105 | doi = 10.1074/jbc.M004977200| doi-access = free }}</ref>
* [[Glucocorticoid receptor]],<ref name = pmid9603979>{{cite journal | date = June 1998 | vauthors = Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato AC | title = RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis | journal = J. Biol. Chem. | volume = 273 | issue = 23 | pages = 14620–5 | pmid = 9603979 | doi = 10.1074/jbc.273.23.14620| doi-access = free }}</ref><ref name = pmid11101523>{{cite journal | date = Dec 2000 | vauthors = Schneikert J, Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato AC | title = Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor | journal = EMBO J. | volume = 19 | issue = 23 | pages = 6508–16 | pmid = 11101523 | pmc = 305849 | doi = 10.1093/emboj/19.23.6508}}</ref>
* [[HSPA8]],<ref name = pmid9305631>{{cite journal | date = August 1997 | vauthors = Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC | title = BAG-1 modulates the chaperone activity of Hsp70/Hsc70 | journal = EMBO J. | volume = 16 | issue = 16 | pages = 4887–96 | pmid = 9305631 | pmc = 1170124 | doi = 10.1093/emboj/16.16.4887}}</ref><ref name = pmid9873016>{{cite journal | date = January 1999 | vauthors = Takayama S, Xie Z, Reed JC | title = An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators | journal = J. Biol. Chem. | volume = 274 | issue = 2 | pages = 781–6 | pmid = 9873016 | doi = 10.1074/jbc.274.2.781| doi-access = free }}</ref>
* [[Heparin-binding EGF-like growth factor|HBEGF]],<ref name = pmid11340068>{{cite journal | date = August 2001 | vauthors = Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR | title = BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation | journal = J. Biol. Chem. | volume = 276 | issue = 32 | pages = 30127–32 | pmid = 11340068 | doi = 10.1074/jbc.M010237200| doi-access = free }}</ref>
* [[PPP1R15A]],<ref name = pmid12724406>{{cite journal | date = May 2003 | vauthors = Hung WJ, Roberson RS, Taft J, Wu DY | title = Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions | journal = Mol. Cell. Biol. | volume = 23 | issue = 10 | pages = 3477–86 | pmid = 12724406 | pmc = 164759 | doi = 10.1128/mcb.23.10.3477-3486.2003}}</ref>
* [[Retinoic acid receptor alpha|NR1B1]],<ref name = pmid9642262>{{cite journal | date = July 1998 | vauthors = Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK | title = Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells | journal = J. Biol. Chem. | volume = 273 | issue = 27 | pages = 16985–92 | pmid = 9642262 | doi = 10.1074/jbc.273.27.16985| doi-access = free }}</ref> and
* [[SIAH1]].<ref name = pmid9582267>{{cite journal | date = May 1998 | vauthors = Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC | title = p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1 | journal = EMBO J. | volume = 17 | issue = 10 | pages = 2736–47 | pmid = 9582267 | pmc = 1170614 | doi = 10.1093/emboj/17.10.2736}}</ref>
{{Div col end}}

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== References ==
{{Reflist}}
{{Reflist}}


==Further reading==
==External links==
* {{UCSC gene info|BAG1}}

== Further reading ==
{{Refbegin | 2}}
{{Refbegin | 2}}
*{{cite journal | author=Tang SC |title=BAG-1, an anti-apoptotic tumour marker. |journal=IUBMB Life |volume=53 |issue= 2 |pages= 99–105 |year= 2003 |pmid= 12049201 |doi=10.1080/15216540211473 |s2cid=8704191 |doi-access=free }}
{{PBB_Further_reading
*{{cite journal | vauthors=Clemo NK, Arhel NJ, Barnes JD |title=The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 4 |pages= 676–8 |year= 2005 |pmid= 16042572 |doi= 10.1042/BST0330676 |display-authors=etal}}
| citations =
*{{cite journal | author=Tang SC |title=BAG-1, an anti-apoptotic tumour marker. |journal=IUBMB Life |volume=53 |issue= 2 |pages= 99–105 |year= 2003 |pmid= 12049201 |doi=10.1080/15216540211473 }}
*{{cite journal | author=Gehring U |title=Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms. |journal=Cell Stress & Chaperones |volume=11 |issue= 4 |pages= 295–303 |year= 2007 |doi=10.1379/1466-1268(2006)11[295:aotcba]2.0.co;2 |pmid= 17278878 | pmc=1712677 }}
*{{cite journal | author=Clemo NK, Arhel NJ, Barnes JD, ''et al.'' |title=The role of the retinoblastoma protein (Rb) in the nuclear localization of BAG-1: implications for colorectal tumour cell survival. |journal=Biochem. Soc. Trans. |volume=33 |issue= Pt 4 |pages= 676–8 |year= 2005 |pmid= 16042572 |doi= 10.1042/BST0330676 }}
*{{cite journal | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Gehring U |title=Activities of the cochaperones Hap46/BAG-1M and Hap50/BAG-1L and isoforms. |journal=Cell Stress Chaperones |volume=11 |issue= 4 |pages= 295–303 |year= 2007 |pmid= 17278878 |doi=10.1379/1466-1268(2006)11[295:AOTCBA]2.0.CO;2 | pmc=1712677 }}
*{{cite journal | vauthors=Zeiner M, Gehring U |title=A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11465–9 |year= 1996 |pmid= 8524784 |doi=10.1073/pnas.92.25.11465 | pmc=40422 |doi-access=free }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | vauthors=Wang HG, Takayama S, Rapp UR, Reed JC |title=Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7063–8 |year= 1996 |pmid= 8692945 |doi=10.1073/pnas.93.14.7063 | pmc=38936 |bibcode=1996PNAS...93.7063W |doi-access=free }}
*{{cite journal | author=Zeiner M, Gehring U |title=A protein that interacts with members of the nuclear hormone receptor family: identification and cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11465–9 |year= 1996 |pmid= 8524784 |doi=10.1073/pnas.92.25.11465 | pmc=40422 }}
*{{cite journal | vauthors=Takayama S, Kochel K, Irie S |title=Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. |journal=Genomics |volume=35 |issue= 3 |pages= 494–8 |year= 1996 |pmid= 8812483 |doi= 10.1006/geno.1996.0389 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Wang HG, Takayama S, Rapp UR, Reed JC |title=Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 14 |pages= 7063–8 |year= 1996 |pmid= 8692945 |doi=10.1073/pnas.93.14.7063 | pmc=38936 }}
*{{cite journal |author1-link=Alberto Bardelli | vauthors=Bardelli A, Longati P, Albero D |title=HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. |journal=EMBO J. |volume=15 |issue= 22 |pages= 6205–12 |year= 1997 |pmid= 8947043 |doi= 10.1002/j.1460-2075.1996.tb01009.x| pmc=452442 |display-authors=etal}}
*{{cite journal | author=Takayama S, Kochel K, Irie S, ''et al.'' |title=Cloning of cDNAs encoding the human BAG1 protein and localization of the human BAG1 gene to chromosome 9p12. |journal=Genomics |volume=35 |issue= 3 |pages= 494–8 |year= 1996 |pmid= 8812483 |doi= 10.1006/geno.1996.0389 }}
*{{cite journal | vauthors=Takayama S, Bimston DN, Matsuzawa S |title=BAG-1 modulates the chaperone activity of Hsp70/Hsc70. |journal=EMBO J. |volume=16 |issue= 16 |pages= 4887–96 |year= 1997 |pmid= 9305631 |doi= 10.1093/emboj/16.16.4887 | pmc=1170124 |display-authors=etal}}
*{{cite journal | author=Bardelli A, Longati P, Albero D, ''et al.'' |title=HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death. |journal=EMBO J. |volume=15 |issue= 22 |pages= 6205–12 |year= 1997 |pmid= 8947043 |doi= | pmc=452442 }}
*{{cite journal | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal | author=Takayama S, Bimston DN, Matsuzawa S, ''et al.'' |title=BAG-1 modulates the chaperone activity of Hsp70/Hsc70. |journal=EMBO J. |volume=16 |issue= 16 |pages= 4887–96 |year= 1997 |pmid= 9305631 |doi= 10.1093/emboj/16.16.4887 | pmc=1170124 }}
*{{cite journal | vauthors=Packham G, Brimmell M, Cleveland JL |title=Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. | series=328 |journal=Biochem. J. |volume=( Pt 3) |issue= 3|pages= 807–13 |year= 1998 |pmid= 9396724 |doi= 10.1042/bj3280807| pmc=1218990 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | vauthors=Matsuzawa S, Takayama S, Froesch BA |title=p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. |journal=EMBO J. |volume=17 |issue= 10 |pages= 2736–47 |year= 1998 |pmid= 9582267 |doi= 10.1093/emboj/17.10.2736 | pmc=1170614 |display-authors=etal}}
*{{cite journal | author=Packham G, Brimmell M, Cleveland JL |title=Mammalian cells express two differently localized Bag-1 isoforms generated by alternative translation initiation. | series=328 |journal=Biochem. J. |volume=( Pt 3) |issue= |pages= 807–13 |year= 1998 |pmid= 9396724 |doi= | pmc=1218990 }}
*{{cite journal | vauthors=Kullmann M, Schneikert J, Moll J |title=RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14620–5 |year= 1998 |pmid= 9603979 |doi=10.1074/jbc.273.23.14620 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Matsuzawa S, Takayama S, Froesch BA, ''et al.'' |title=p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1. |journal=EMBO J. |volume=17 |issue= 10 |pages= 2736–47 |year= 1998 |pmid= 9582267 |doi= 10.1093/emboj/17.10.2736 | pmc=1170614 }}
*{{cite journal | vauthors=Liu R, Takayama S, Zheng Y |title=Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16985–92 |year= 1998 |pmid= 9642262 |doi=10.1074/jbc.273.27.16985 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Kullmann M, Schneikert J, Moll J, ''et al.'' |title=RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis. |journal=J. Biol. Chem. |volume=273 |issue= 23 |pages= 14620–5 |year= 1998 |pmid= 9603979 |doi=10.1074/jbc.273.23.14620 }}
*{{cite journal | vauthors=Takayama S, Krajewski S, Krajewska M |title=Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. |journal=Cancer Res. |volume=58 |issue= 14 |pages= 3116–31 |year= 1998 |pmid= 9679980 |display-authors=etal}}
*{{cite journal | author=Liu R, Takayama S, Zheng Y, ''et al.'' |title=Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16985–92 |year= 1998 |pmid= 9642262 |doi=10.1074/jbc.273.27.16985 }}
*{{cite journal | vauthors=Takayama S, Xie Z, Reed JC |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 781–6 |year= 1999 |pmid= 9873016 |doi=10.1074/jbc.274.2.781 |doi-access=free }}
*{{cite journal | author=Takayama S, Krajewski S, Krajewska M, ''et al.'' |title=Expression and location of Hsp70/Hsc-binding anti-apoptotic protein BAG-1 and its variants in normal tissues and tumor cell lines. |journal=Cancer Res. |volume=58 |issue= 14 |pages= 3116–31 |year= 1998 |pmid= 9679980 |doi= }}
*{{cite journal | vauthors=Yang X, Pater A, Tang SC |title=Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants. |journal=Oncogene |volume=18 |issue= 32 |pages= 4546–53 |year= 1999 |pmid= 10467399 |doi= 10.1038/sj.onc.1202843 |doi-access= free }}
*{{cite journal | author=Takayama S, Xie Z, Reed JC |title=An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators. |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 781–6 |year= 1999 |pmid= 9873016 |doi=10.1074/jbc.274.2.781 }}
*{{cite journal | vauthors=Schneikert J, Hübner S, Martin E, Cato AC |title=A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 929–40 |year= 1999 |pmid= 10477749 |doi=10.1083/jcb.146.5.929 | pmc=2169481 }}
*{{cite journal | author=Yang X, Pater A, Tang SC |title=Cloning and characterization of the human BAG-1 gene promoter: upregulation by tumor-derived p53 mutants. |journal=Oncogene |volume=18 |issue= 32 |pages= 4546–53 |year= 1999 |pmid= 10467399 |doi= 10.1038/sj.onc.1202843 }}
*{{cite journal | vauthors=Lüders J, Demand J, Höhfeld J |title=The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4613–7 |year= 2000 |pmid= 10671488 |doi=10.1074/jbc.275.7.4613 |doi-access=free }}
*{{cite journal | author=Schneikert J, Hübner S, Martin E, Cato AC |title=A nuclear action of the eukaryotic cochaperone RAP46 in downregulation of glucocorticoid receptor activity. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 929–40 |year= 1999 |pmid= 10477749 |doi=10.1083/jcb.146.5.929 | pmc=2169481 }}
*{{cite journal | author=Lüders J, Demand J, Höhfeld J |title=The ubiquitin-related BAG-1 provides a link between the molecular chaperones Hsc70/Hsp70 and the proteasome. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4613–7 |year= 2000 |pmid= 10671488 |doi=10.1074/jbc.275.7.4613 }}
}}
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{{Refend}}
{{PDB Gallery|geneid=573}}


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[[Category:Ageing]]
[[Category:Ageing]]
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[[Category:Aging-related genes]]
[[Category:Aging-related genes]]
[[Category:Aging-related proteins]]
[[Category:Aging-related proteins]]
[[Category:Co-chaperones]]

Latest revision as of 15:47, 12 August 2023

BAG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesBAG1, BAG-1, HAP, RAP46, BCL2 associated athanogene 1, BAG cochaperone 1
External IDsOMIM: 601497; MGI: 108047; HomoloGene: 3190; GeneCards: BAG1; OMA:BAG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

573

12017

Ensembl

ENSG00000107262

ENSMUSG00000028416

UniProt

Q99933

Q60739

RefSeq (mRNA)

NM_004323
NM_001172415
NM_001349286
NM_001349299

NM_001171739
NM_009736

RefSeq (protein)

NP_001165886
NP_004314
NP_001336215
NP_001336228

NP_001165210
NP_033866

Location (UCSC)Chr 9: 33.25 – 33.26 MbChr 4: 40.94 – 40.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.[5]

Function

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The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[6]

Clinical significance

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BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.[7]

Interactions

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BAG1 has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000107262 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028416 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC (March 1995). "Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity". Cell. 80 (2): 279–84. doi:10.1016/0092-8674(95)90410-7. PMID 7834747. S2CID 17824475.
  6. ^ "Entrez Gene: BAG1 BCL2-associated athanogene".
  7. ^ Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009). "Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3". EMBO J. 28 (7): 889–901. doi:10.1038/emboj.2009.29. PMC 2647772. PMID 19229298. *Lay summary in: "Old Cells Work Differently". Phys.org. March 1, 2009.
  8. ^ Shatkina L, Mink S, Rogatsch H, Klocker H, Langer G, Nestl A, Cato AC (October 2003). "The cochaperone Bag-1L enhances androgen receptor action via interaction with the NH2-terminal region of the receptor". Mol. Cell. Biol. 23 (20): 7189–97. doi:10.1128/mcb.23.20.7189-7197.2003. PMC 230325. PMID 14517289.
  9. ^ Knee DA, Froesch BA, Nuber U, Takayama S, Reed JC (April 2001). "Structure-function analysis of Bag1 proteins. Effects on androgen receptor transcriptional activity". J. Biol. Chem. 276 (16): 12718–24. doi:10.1074/jbc.M010841200. PMID 11278763.
  10. ^ Froesch BA, Takayama S, Reed JC (May 1998). "BAG-1L protein enhances androgen receptor function". J. Biol. Chem. 273 (19): 11660–6. doi:10.1074/jbc.273.19.11660. PMID 9565586.
  11. ^ Wang HG, Takayama S, Rapp UR, Reed JC (July 1996). "Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7063–8. Bibcode:1996PNAS...93.7063W. doi:10.1073/pnas.93.14.7063. PMC 38936. PMID 8692945.
  12. ^ Guzey M, Takayama S, Reed JC (Dec 2000). "BAG1L enhances trans-activation function of the vitamin D receptor". J. Biol. Chem. 275 (52): 40749–56. doi:10.1074/jbc.M004977200. PMID 10967105.
  13. ^ Kullmann M, Schneikert J, Moll J, Heck S, Zeiner M, Gehring U, Cato AC (June 1998). "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". J. Biol. Chem. 273 (23): 14620–5. doi:10.1074/jbc.273.23.14620. PMID 9603979.
  14. ^ Schneikert J, Hübner S, Langer G, Petri T, Jäättelä M, Reed J, Cato AC (Dec 2000). "Hsp70-RAP46 interaction in downregulation of DNA binding by glucocorticoid receptor". EMBO J. 19 (23): 6508–16. doi:10.1093/emboj/19.23.6508. PMC 305849. PMID 11101523.
  15. ^ Takayama S, Bimston DN, Matsuzawa S, Freeman BC, Aime-Sempe C, Xie Z, Morimoto RI, Reed JC (August 1997). "BAG-1 modulates the chaperone activity of Hsp70/Hsc70". EMBO J. 16 (16): 4887–96. doi:10.1093/emboj/16.16.4887. PMC 1170124. PMID 9305631.
  16. ^ Takayama S, Xie Z, Reed JC (January 1999). "An evolutionarily conserved family of Hsp70/Hsc70 molecular chaperone regulators". J. Biol. Chem. 274 (2): 781–6. doi:10.1074/jbc.274.2.781. PMID 9873016.
  17. ^ Lin J, Hutchinson L, Gaston SM, Raab G, Freeman MR (August 2001). "BAG-1 is a novel cytoplasmic binding partner of the membrane form of heparin-binding EGF-like growth factor: a unique role for proHB-EGF in cell survival regulation". J. Biol. Chem. 276 (32): 30127–32. doi:10.1074/jbc.M010237200. PMID 11340068.
  18. ^ Hung WJ, Roberson RS, Taft J, Wu DY (May 2003). "Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions". Mol. Cell. Biol. 23 (10): 3477–86. doi:10.1128/mcb.23.10.3477-3486.2003. PMC 164759. PMID 12724406.
  19. ^ Liu R, Takayama S, Zheng Y, Froesch B, Chen GQ, Zhang X, Reed JC, Zhang XK (July 1998). "Interaction of BAG-1 with retinoic acid receptor and its inhibition of retinoic acid-induced apoptosis in cancer cells". J. Biol. Chem. 273 (27): 16985–92. doi:10.1074/jbc.273.27.16985. PMID 9642262.
  20. ^ Matsuzawa S, Takayama S, Froesch BA, Zapata JM, Reed JC (May 1998). "p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1". EMBO J. 17 (10): 2736–47. doi:10.1093/emboj/17.10.2736. PMC 1170614. PMID 9582267.
[edit]

Further reading

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