QRFP: Difference between revisions

QRFP
Identifiers
Aliases	QRFP, 26RFa, P518, pyroglutamylated RFamide peptide
External IDs	OMIM: 609795; MGI: 3630329; HomoloGene: 52341; GeneCards: QRFP; OMA:QRFP - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	130,896,812 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	31,700,592 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; mucosa of transverse colon; ; muscle layer of sigmoid colon; ; stromal cell of endometrium; ; popliteal artery; ; tibial arteries; ; sural nerve; ; left coronary artery; ; Descending thoracic aorta;
	Top expressed in
	embryo; ; islet of Langerhans; ; white adipose tissue; ; spermatocyte; ; adrenal gland; ; duodenum; ; lip; ; spleen; ; Hypothalamus; ; uterus;
	More reference expression data
	n/a
Gene ontology
Molecular function	orexigenic neuropeptide QRFP receptor binding; neuropeptide hormone activity;
Cellular component	extracellular region; cellular component;
Biological process	grooming behavior; positive regulation of blood pressure; neuropeptide signaling pathway; regulation of feeding behavior; locomotory behavior; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	347148
	227717
	ENSG00000188710
	ENSMUSG00000043102
	P83859
	Q8CE23
	NM_198180
	NM_183424
	NP_937823
	NP_906269
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 23:00, 18 August 2023

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human protein.^[5]

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.^[6] The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of aldosterone, suggesting that QRFP and GPR103 regulate adrenal function.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000188710 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000043102 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".
^ Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
^ Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.

External links

"Peptide P518 Receptor". IUPHAR/BPS Guide to PHARMACOLOGY.

Bruzzone F, Lectez B, Tollemer H, et al. (2007). "Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord". J. Neurochem. 99 (2): 616–27. doi:10.1111/j.1471-4159.2006.04090.x. PMID 16899066. S2CID 41427365.
Chartrel N, Bruzzone F, Dujardin C, et al. (2006). "Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals". Ann. N. Y. Acad. Sci. 1040 (1): 80–3. Bibcode:2005NYASA1040...80C. doi:10.1196/annals.1327.009. PMID 15891009. S2CID 21012765.
Thuau R, Guilhaudis L, Ségalas-Milazzo I, et al. (2005). "Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity". Peptides. 26 (5): 779–89. doi:10.1016/j.peptides.2005.01.006. PMID 15808908. S2CID 24088690.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Chartrel N, Dujardin C, Anouar Y, et al. (2004). "Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity". Proc. Natl. Acad. Sci. U.S.A. 100 (25): 15247–52. Bibcode:2003PNAS..10015247C. doi:10.1073/pnas.2434676100. PMC 299975. PMID 14657341.
Fukusumi S, Yoshida H, Fujii R, et al. (2004). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.
Jiang Y, Luo L, Gustafson EL, et al. (2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000188710 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000043102 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide".

[pmid12714592-6] Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL (July 2003). "Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155". J. Biol. Chem. 278 (30): 27652–7. doi:10.1074/jbc.M302945200. PMID 12714592.

[pmid12960173-7] Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M (November 2003). "A new peptidic ligand and its receptor regulating adrenal function in rats". J. Biol. Chem. 278 (47): 46387–95. doi:10.1074/jbc.M305270200. PMID 12960173.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=347148}}
+{{Infobox_gene}}
-'''RF(Arg-Phe)amide family 26 amino acid peptide''', also known as '''P518''', is a human [[protein]].<ref name="entrez">{{cite web | title = Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=347148| accessdate = }}</ref>
+'''RF(Arg-Phe)amide family 26 amino acid peptide''', also known as '''P518''', is a human [[protein]].<ref name="entrez">{{cite web | title = Entrez Gene: P518 RF(Arg-Phe)amide family 26 amino acid peptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=347148}}</ref>
-The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of [[GPR103]]. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.<ref name="pmid12714592">{{cite journal | author = Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL | title = Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27652–7 |date=July 2003 | pmid = 12714592 | doi = 10.1074/jbc.M302945200 | url =  }}</ref> The 43-amino acid  QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of [[aldosterone]], suggesting that QRFP and GPR103 regulate [[adrenal]] function.<ref name="pmid12960173">{{cite journal | author = Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M | title = A new peptidic ligand and its receptor regulating adrenal function in rats | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 46387–95 |date=November 2003 |pmid = 12960173 | doi = 10.1074/jbc.M305270200 | url =  }}</ref>
+The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of [[GPR103]]. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain.<ref name="pmid12714592">{{cite journal | vauthors = Jiang Y, Luo L, Gustafson EL, Yadav D, Laverty M, Murgolo N, Vassileva G, Zeng M, Laz TM, Behan J, Qiu P, Wang L, Wang S, Bayne M, Greene J, Monsma F, Zhang FL | title = Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155 | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27652–7 |date=July 2003 | pmid = 12714592 | doi = 10.1074/jbc.M302945200 | doi-access = free }}</ref> The 43-amino acid  QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of [[aldosterone]], suggesting that QRFP and GPR103 regulate [[adrenal]] function.<ref name="pmid12960173">{{cite journal | vauthors = Fukusumi S, Yoshida H, Fujii R, Maruyama M, Komatsu H, Habata Y, Shintani Y, Hinuma S, Fujino M | title = A new peptidic ligand and its receptor regulating adrenal function in rats | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 46387–95 |date=November 2003 |pmid = 12960173 | doi = 10.1074/jbc.M305270200 | doi-access = free }}</ref>
 ==References==
@@ Line 8: / Line 9: @@
 ==External links==
-*{{cite web | url = http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1347 | title = Peptide P518 Receptor | accessdate = | author = | authorlink = | coauthors = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
+*{{cite web | url = http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=54 | title = Peptide P518 Receptor | work = IUPHAR/BPS Guide to PHARMACOLOGY }}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal   |vauthors=Bruzzone F, Lectez B, Tollemer H, etal |title=Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. |journal=J. Neurochem. |volume=99 |issue= 2 |pages= 616–27 |year= 2007 |pmid= 16899066 |doi= 10.1111/j.1471-4159.2006.04090.x |s2cid=41427365 |doi-access= }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Chartrel N, Bruzzone F, Dujardin C, etal |title=Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals |journal=Ann. N. Y. Acad. Sci. |volume=1040 |pages= 80–3 |year= 2006 |issue=1 |pmid= 15891009 |doi= 10.1196/annals.1327.009 |bibcode=2005NYASA1040...80C |s2cid=21012765 }}
-| citations =
-*{{cite journal  | author=Bruzzone F, Lectez B, Tollemer H, ''et al.'' |title=Anatomical distribution and biochemical characterization of the novel RFamide peptide 26RFa in the human hypothalamus and spinal cord. |journal=J. Neurochem. |volume=99 |issue= 2 |pages= 616–27 |year= 2007 |pmid= 16899066 |doi= 10.1111/j.1471-4159.2006.04090.x }}
+*{{cite journal   |vauthors=Thuau R, Guilhaudis L, Ségalas-Milazzo I, etal |title=Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. |journal=Peptides |volume=26 |issue= 5 |pages= 779–89 |year= 2005 |pmid= 15808908 |doi= 10.1016/j.peptides.2005.01.006 |s2cid=24088690 }}
-*{{cite journal  | author=Chartrel N, Bruzzone F, Dujardin C, ''et al.'' |title=Identification of 26RFa from frog brain: a novel hypothalamic neuropeptide with orexigenic activity in mammals. |journal=Ann. N. Y. Acad. Sci. |volume=1040 |issue=  |pages= 80–3 |year= 2006 |pmid= 15891009 |doi= 10.1196/annals.1327.009 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Thuau R, Guilhaudis L, Ségalas-Milazzo I, ''et al.'' |title=Structural studies on 26RFa, a novel human RFamide-related peptide with orexigenic activity. |journal=Peptides |volume=26 |issue= 5 |pages= 779–89 |year= 2005 |pmid= 15808908 |doi= 10.1016/j.peptides.2005.01.006 }}
+*{{cite journal   |vauthors=Chartrel N, Dujardin C, Anouar Y, etal |title=Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 25 |pages= 15247–52 |year= 2004 |pmid= 14657341 |doi= 10.1073/pnas.2434676100  | pmc=299975 |bibcode=2003PNAS..10015247C |doi-access=free }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
+*{{cite journal   |vauthors=Fukusumi S, Yoshida H, Fujii R, etal |title=A new peptidic ligand and its receptor regulating adrenal function in rats. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46387–95 |year= 2004 |pmid= 12960173 |doi= 10.1074/jbc.M305270200 |doi-access= free }}
-*{{cite journal  | author=Chartrel N, Dujardin C, Anouar Y, ''et al.'' |title=Identification of 26RFa, a hypothalamic neuropeptide of the RFamide peptide family with orexigenic activity. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 25 |pages= 15247–52 |year= 2004 |pmid= 14657341 |doi= 10.1073/pnas.2434676100  | pmc=299975 }}
+*{{cite journal   |vauthors=Jiang Y, Luo L, Gustafson EL, etal |title=Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27652–7 |year= 2003 |pmid= 12714592 |doi= 10.1074/jbc.M302945200 |doi-access= free }}
-*{{cite journal  | author=Fukusumi S, Yoshida H, Fujii R, ''et al.'' |title=A new peptidic ligand and its receptor regulating adrenal function in rats. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46387–95 |year= 2004 |pmid= 12960173 |doi= 10.1074/jbc.M305270200 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Jiang Y, Luo L, Gustafson EL, ''et al.'' |title=Identification and characterization of a novel RF-amide peptide ligand for orphan G-protein-coupled receptor SP9155. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27652–7 |year= 2003 |pmid= 12714592 |doi= 10.1074/jbc.M302945200 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
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