(S)-usnate reductase: Difference between revisions
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{{Short description|Class of enzymes}} |
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{{DISPLAYTITLE:(''S'')-usnate reductase}} |
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| Name = (''S'')-usnate reductase |
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| CAS_number = 77237-99-1 |
| CAS_number = 77237-99-1 |
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| GO_code = 0046998 |
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| IUBMB_EC_number = 1/1/1/199 |
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In [[enzymology]], a '''(S)-usnate reductase''' ({{EC number|1.1.1.199}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
In [[enzymology]], a '''(''S'')-usnate reductase''' ({{EC number|1.1.1.199}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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:(6''R'')-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6- methyl-2,4-cyclohexadien-1-one + NAD{{sup|+}} <math>\rightleftharpoons</math> (''S'')-usnic acid + NADH + H{{sup|+}} |
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| ⚫ | This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD |
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| ⚫ | This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD{{sup|+}} or NADP{{sup|+}} as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''reduced-(''S'')-usnate:NAD{{sup|+}} oxidoreductase (ether-bond-forming)'''. This enzyme is also called '''L-usnic acid dehydrogenase'''. |
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==References== |
==References== |
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{{reflist|1}} |
{{reflist|1}} |
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* {{cite journal | |
* {{cite journal |vauthors=Barbini N, Gorini G, Ferrucci L, Biggeri A | date = 2005 | title = [Analysis of arterial hypertension and work in the epidemiologic study "Aging, Health and Work"] | journal = Epidemiol. Prev. | volume = 29 | pages = 160–165 | pmid = 16454408 | issue = 3–4 }} |
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{{Alcohol oxidoreductases}} |
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{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 1.1.1]] |
[[Category:EC 1.1.1]] |
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[[Category:NADH-dependent enzymes]] |
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[[Category:Enzymes of unknown structure]] |
[[Category:Enzymes of unknown structure]] |
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[[it:(S)-usnato reduttasi]] |
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[[ja:(S)-ウスニン酸レダクターゼ]] |
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[[sr:(S)-usnat reduktaza]] |
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Latest revision as of 12:21, 26 August 2023
| (S)-usnate reductase | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.1.1.199 | ||||||||
| CAS no. | 77237-99-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a (S)-usnate reductase (EC 1.1.1.199) is an enzyme that catalyzes the chemical reaction
- (6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6- methyl-2,4-cyclohexadien-1-one + NAD+ (S)-usnic acid + NADH + H+
In the reverse direction, (S)-usnate is reduced by NADH with cleavage of the ether bond to form a 7-hydroxy group.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming). This enzyme is also called L-usnic acid dehydrogenase.
References
[edit]- Barbini N, Gorini G, Ferrucci L, Biggeri A (2005). "[Analysis of arterial hypertension and work in the epidemiologic study "Aging, Health and Work"]". Epidemiol. Prev. 29 (3–4): 160–165. PMID 16454408.
