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{{Short description|Class of enzymes}}
{{Infobox enzyme
{{Infobox enzyme
| Name = Ent-isokaurene C2-hydroxylase
| Name = Ent-isokaurene C2-hydroxylase
| EC_number = 1.14.13.143
| EC_number = 1.14.13.143
| CAS_number =
| CAS_number =
| GO_code =
| IUBMB_EC_number = 1/14/13/143
| GO_code =
| image =
| image =
| width =
| width =
| caption =
| caption =
}}
}}
'''Ent-isokaurene C2-hydroxylase''' ({{EC number|1.14.13.143}}, ''CYP71Z6'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating)''.<ref>{{cite journal | title = Parsing a multifunctional biosynthetic gene cluster from rice: biochemical characterization of CYP71Z6 & 7 |author1 = Wu, Y. |author2 =Hillwig, M.L. |author3 =Wang, Q. |author4 =Peters, R.J. |journal = FEBS Lett. |year = 2011 |volume = 585 |pages = 3446–3451 |pmid = 21985968 |doi=10.1016/j.febslet.2011.09.038 |issue=21 |pmc=3227696}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
'''Ent-isokaurene C2-hydroxylase''' ({{EC number|1.14.13.143}}, ''CYP71Z6'') is an [[enzyme]] with [[List of enzymes|systematic name]] ''ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating)''.<ref>{{cite journal | vauthors = Wu Y, Hillwig ML, Wang Q, Peters RJ | title = Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7 | journal = FEBS Letters | volume = 585 | issue = 21 | pages = 3446–51 | date = November 2011 | pmid = 21985968 | pmc = 3227696 | doi = 10.1016/j.febslet.2011.09.038 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]


: ent-isokaurene + O<sub>2</sub> + NADPH + H<sup>+</sup> <math>\rightleftharpoons</math> ent-2alpha-hydroxyisokaurene + H<sub>2</sub>O + NADP<sup>+</sup>
: ent-isokaurene + O<sub>2</sub> + NADPH + H<sup>+</sup> <math>\rightleftharpoons</math> ent-2alpha-hydroxyisokaurene + H<sub>2</sub>O + NADP<sup>+</sup>
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{{Dioxygenases}}
{{Dioxygenases}}
{{Enzymes}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
{{Portal bar|Biology|border=no}}


[[Category:EC 1.14.13]]
[[Category:EC 1.14.13]]

Latest revision as of 13:58, 26 August 2023

Ent-isokaurene C2-hydroxylase
Identifiers
EC no.1.14.13.143
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Ent-isokaurene C2-hydroxylase (EC 1.14.13.143, CYP71Z6) is an enzyme with systematic name ent-isokaurene,NADPH:oxygen oxidoreductase (hydroxylating).[1] This enzyme catalyses the following chemical reaction

ent-isokaurene + O2 + NADPH + H+ ent-2alpha-hydroxyisokaurene + H2O + NADP+

Ent-isokaurene C2-hydroxylase performs the initial step in the conversion of ent-isokaurene to the antibacterial oryzalides in rice, Oryza sativa.

References

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  1. ^ Wu Y, Hillwig ML, Wang Q, Peters RJ (November 2011). "Parsing a multifunctional biosynthetic gene cluster from rice: Biochemical characterization of CYP71Z6 & 7". FEBS Letters. 585 (21): 3446–51. doi:10.1016/j.febslet.2011.09.038. PMC 3227696. PMID 21985968.
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