Estradiol 6beta-monooxygenase: Difference between revisions
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{{enzyme |
{{infobox enzyme |
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| Name = estradiol 6-beta-monooxygenase |
| Name = estradiol 6-beta-monooxygenase |
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| EC_number = 1.14.99.11 |
| EC_number = 1.14.99.11 |
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| CAS_number = 9029-70-3 |
| CAS_number = 9029-70-3 |
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| GO_code = 0047882 |
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| IUBMB_EC_number = 1/14/99/11 |
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In [[enzymology]], an '''estradiol 6beta-monooxygenase''' ({{EC number|1.14.99.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
In [[enzymology]], an '''estradiol 6beta-monooxygenase''' ({{EC number|1.14.99.11}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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:estradiol-17beta + AH<sub>2</sub> + O<sub>2</sub> <math>\rightleftharpoons</math> 6beta-hydroxyestradiol-17beta + A + H<sub>2</sub>O |
:estradiol-17beta + AH<sub>2</sub> + O<sub>2</sub> <math>\rightleftharpoons</math> 6beta-hydroxyestradiol-17beta + A + H<sub>2</sub>O |
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The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[estradiol-17beta]], [[ |
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[estradiol-17beta]], an [[electron acceptor]] AH<sub>2</sub>, and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[6beta-hydroxyestradiol-17beta]], the reduction product A, and [[water|H<sub>2</sub>O]]. |
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This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is '''estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)'''. This enzyme is also called '''estradiol 6beta-hydroxylase'''. This enzyme participates in [[androgen and estrogen metabolism]]. |
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The [[List of enzymes|systematic name]] of this enzyme class is '''estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating)'''. This enzyme is also called '''estradiol 6beta-hydroxylase'''. This enzyme participates in [[androgen and estrogen metabolism]]. |
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==References== |
==References== |
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{{reflist|1}} |
{{reflist|1}} |
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* {{cite journal | |
* {{cite journal | vauthors = Haines WJ | date = 1952 | title = The biosynthesis of adrenal cortex hormones | journal = Recent Progr. Hormone Res. | volume = 7 | pages = 255–305 }} |
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* {{cite journal | |
* {{cite journal | vauthors = Mueller GC, Rumney G | date = 1957 | title = Formation of 6beta-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes | journal = J. Am. Chem. Soc. | volume = 79 | pages = 1004–1005 | doi = 10.1021/ja01561a068 | issue = 4 }} |
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{{Dioxygenases}} |
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{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 1.14.99]] |
[[Category:EC 1.14.99]] |
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[[Category:Enzymes of unknown structure]] |
[[Category:Enzymes of unknown structure]] |
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[[it:Estradiolo 6beta-monoossigenasi]] |
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[[ja:エストラジオール-6β-モノオキシゲナーゼ]] |
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Latest revision as of 13:59, 26 August 2023
| estradiol 6-beta-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.99.11 | ||||||||
| CAS no. | 9029-70-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an estradiol 6beta-monooxygenase (EC 1.14.99.11) is an enzyme that catalyzes the chemical reaction
- estradiol-17beta + AH2 + O2 6beta-hydroxyestradiol-17beta + A + H2O
The 3 substrates of this enzyme are estradiol-17beta, an electron acceptor AH2, and O2, whereas its 3 products are 6beta-hydroxyestradiol-17beta, the reduction product A, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derive from O miscellaneous. The systematic name of this enzyme class is estradiol-17beta,hydrogen-donor:oxygen oxidoreductase (6beta-hydroxylating). This enzyme is also called estradiol 6beta-hydroxylase. This enzyme participates in androgen and estrogen metabolism.
References
[edit]- Haines WJ (1952). "The biosynthesis of adrenal cortex hormones". Recent Progr. Hormone Res. 7: 255–305.
- Mueller GC, Rumney G (1957). "Formation of 6beta-hydroxy and 6-keto derivatives of estradiol-16-C14 by mouse liver microsomes". J. Am. Chem. Soc. 79 (4): 1004–1005. doi:10.1021/ja01561a068.
