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{{Infobox enzyme
{{Infobox enzyme
| Name = Macrophage elastase
| Name = Macrophage elastase
| EC_number = 3.4.24.65
| EC_number = 3.4.24.65
| CAS_number = 2594837
| CAS_number = 2594837
| GO_code =
| IUBMB_EC_number = 3/4/24/65
| GO_code =
| image =
| image =
| width =
| width =
| caption =
| caption =
}}
}}
'''Macrophage elastase''' ({{EC number|3.4.24.65}}, ''metalloelastase'', ''human macrophage metalloelastase (HME), [[Matrix metallopeptidase 12|MMP-12]]'') is an [[enzyme]].<ref>{{cite journal | vauthors = Banda MJ, Werb Z | title = Mouse macrophage elastase. Purification and characterization as a metalloproteinase | journal = The Biochemical Journal | volume = 193 | issue = 2 | pages = 589–605 | date = February 1981 | pmid = 7030312 }}</ref><ref>{{cite journal | vauthors = Kettner C, Shaw E, White R, Janoff A | title = The specificity of macrophage elastase on the insulin B-chain | journal = The Biochemical Journal | volume = 195 | issue = 2 | pages = 369–72 | date = May 1981 | pmid = 7032505 }}</ref><ref>{{cite journal | vauthors = Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ | title = Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase | journal = The Journal of Biological Chemistry | volume = 267 | issue = 7 | pages = 4664–71 | date = March 1992 | pmid = 1537850 }}</ref><ref>{{cite journal | vauthors = Shapiro SD, Kobayashi DK, Ley TJ | title = Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages | journal = The Journal of Biological Chemistry | volume = 268 | issue = 32 | pages = 23824–9 | date = November 1993 | pmid = 8226919 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
'''Macrophage elastase''' ({{EC number|3.4.24.65}}, ''metalloelastase'', ''human macrophage metalloelastase (HME), [[Matrix metallopeptidase 12|MMP-12]]'') is an [[enzyme]].<ref>{{cite journal | vauthors = Banda MJ, Werb Z | title = Mouse macrophage elastase. Purification and characterization as a metalloproteinase | journal = The Biochemical Journal | volume = 193 | issue = 2 | pages = 589–605 | date = February 1981 | pmid = 7030312 }}</ref><ref>{{cite journal | vauthors = Kettner C, Shaw E, White R, Janoff A | title = The specificity of macrophage elastase on the insulin B-chain | journal = The Biochemical Journal | volume = 195 | issue = 2 | pages = 369–72 | date = May 1981 | pmid = 7032505 }}</ref><ref>{{cite journal | vauthors = Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ | title = Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase | journal = The Journal of Biological Chemistry | volume = 267 | issue = 7 | pages = 4664–71 | date = March 1992 | pmid = 1537850 }}</ref><ref>{{cite journal | vauthors = Shapiro SD, Kobayashi DK, Ley TJ | title = Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages | journal = The Journal of Biological Chemistry | volume = 268 | issue = 32 | pages = 23824–9 | date = November 1993 | pmid = 8226919 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

Latest revision as of 14:49, 26 August 2023

Macrophage elastase
Identifiers
EC no.3.4.24.65
CAS no.2594837
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME), MMP-12) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin

This enzyme belongs to the peptidase family M10.

See also

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References

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  1. ^ Banda MJ, Werb Z (February 1981). "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". The Biochemical Journal. 193 (2): 589–605. PMID 7030312.
  2. ^ Kettner C, Shaw E, White R, Janoff A (May 1981). "The specificity of macrophage elastase on the insulin B-chain". The Biochemical Journal. 195 (2): 369–72. PMID 7032505.
  3. ^ Shapiro SD, Griffin GL, Gilbert DJ, Jenkins NA, Copeland NG, Welgus HG, Senior RM, Ley TJ (March 1992). "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". The Journal of Biological Chemistry. 267 (7): 4664–71. PMID 1537850.
  4. ^ Shapiro SD, Kobayashi DK, Ley TJ (November 1993). "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". The Journal of Biological Chemistry. 268 (32): 23824–9. PMID 8226919.
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