Microtubule-severing ATPase: Difference between revisions
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{{Short description|Class of enzymes}} |
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{{enzyme |
{{infobox enzyme |
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| Name = microtubule-severing ATPase |
| Name = microtubule-severing ATPase |
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| EC_number = 3.6.4.3 |
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| EC_number = 3.6.4.3 |
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| IUBMB_EC_number = 3/6/4/3 |
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| GO_code = 0008568 |
| GO_code = 0008568 |
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In [[enzymology]], a '''microtubule-severing ATPase''' ({{EC number|3.6.4.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
In [[enzymology]], a '''microtubule-severing ATPase''' ({{EC number|3.6.4.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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{{reflist|1}} |
{{reflist|1}} |
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* {{cite journal | vauthors = McNally FJ, Vale RD | date = 1993 | title = Identification of katanin, an ATPase that severs and disassembles stable microtubules | journal = Cell | volume = 75 | pages = 419–29 | pmid = 8221885 | doi = 10.1016/0092-8674(93)90377-3 | issue = 3 }} |
* {{cite journal | vauthors = McNally FJ, Vale RD | date = 1993 | title = Identification of katanin, an ATPase that severs and disassembles stable microtubules | journal = Cell | volume = 75 | pages = 419–29 | pmid = 8221885 | doi = 10.1016/0092-8674(93)90377-3 | issue = 3 }} |
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* {{cite journal | vauthors = Cheesman S, Heuser J, Vale RD, McNally FJ | date = 1998 | title = Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit | journal = Cell | volume = 93 | pages = 277–87 | pmid = 9568719 | doi = 10.1016/S0092-8674(00)81578-0 | issue = 2 }} |
* {{cite journal | vauthors = Cheesman S, Heuser J, Vale RD, McNally FJ | date = 1998 | title = Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit | journal = Cell | volume = 93 | pages = 277–87 | pmid = 9568719 | doi = 10.1016/S0092-8674(00)81578-0 | issue = 2 | doi-access = free }} |
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{{Acid anhydride hydrolases}} |
{{Acid anhydride hydrolases}} |
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{{Enzymes}} |
{{Enzymes}} |
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{{Portal bar|Biology|border=no}} |
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[[Category:EC 3.6.4]] |
[[Category:EC 3.6.4]] |
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Latest revision as of 14:58, 26 August 2023
| microtubule-severing ATPase | |||||||||
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| Identifiers | |||||||||
| EC no. | 3.6.4.3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a microtubule-severing ATPase (EC 3.6.4.3) is an enzyme that catalyzes the chemical reaction
- ATP + H2O ADP + phosphate
Thus, the two substrates of this enzyme are ATP and H2O, whereas its two products are ADP and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to facilitate cellular and subcellular movement. The systematic name of this enzyme class is ATP phosphohydrolase (tubulin-dimerizing).
See also
[edit]References
[edit]- McNally FJ, Vale RD (1993). "Identification of katanin, an ATPase that severs and disassembles stable microtubules". Cell. 75 (3): 419–29. doi:10.1016/0092-8674(93)90377-3. PMID 8221885.
- Cheesman S, Heuser J, Vale RD, McNally FJ (1998). "Katanin, a microtubule-severing protein, is a novel AAA ATPase that targets to the centrosome using a WD40-containing subunit". Cell. 93 (2): 277–87. doi:10.1016/S0092-8674(00)81578-0. PMID 9568719.
