Pyrroline-2-carboxylate reductase: Difference between revisions
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{{infobox enzyme |
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| EC_number = 1.5.1.1 |
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| CAS_number = 9029-16-7 |
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| GO_code = 0050241 |
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In [[enzymology]], a '''pyrroline-2-carboxylate reductase''' ({{EC number|1.5.1.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
In [[enzymology]], a '''pyrroline-2-carboxylate reductase''' ({{EC number|1.5.1.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]] |
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The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[L-proline]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[1-pyrroline-2-carboxylate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]]. |
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[L-proline]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[1-pyrroline-2-carboxylate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]]. |
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This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is '''L-proline:NAD(P)+ 2-oxidoreductase'''. This enzyme is also called '''Delta1-pyrroline-2-carboxylate reductase'''. This enzyme participates in [[lysine degradation]] and [[arginine and proline metabolism]]. |
This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The [[List of enzymes|systematic name]] of this enzyme class is '''L-proline:NAD(P)+ 2-oxidoreductase'''. This enzyme is also called '''Delta1-pyrroline-2-carboxylate reductase'''. This enzyme participates in [[lysine degradation]] and [[arginine and proline metabolism]]. |
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==References== |
==References== |
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{{reflist|1}} |
{{reflist|1}} |
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{{Enzyme references|EC_number=1.5.1.1|IUBMB_EC_number=1/5/1/1}} |
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{{CH-NH oxidoreductases}} |
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==External links== |
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{{Enzymes}} |
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::''The [[CAS registry number]] for this enzyme class is {{CAS registry|9029-16-7}}.'' |
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{{Portal bar|Biology|border=no}} |
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{{Enzyme links|EC_number=1.5.1.1|IUBMB_EC_number=1/5/1/1}} |
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===Gene Ontology (GO) codes=== |
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[[Category:EC 1.5.1]] |
[[Category:EC 1.5.1]] |
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[[Category:NADH-dependent enzymes]] |
[[Category:NADH-dependent enzymes]] |
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[[Category:Enzymes of unknown structure]] |
[[Category:Enzymes of unknown structure]] |
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Latest revision as of 15:39, 26 August 2023
| pyrroline-2-carboxylate reductase | |||||||||
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| Identifiers | |||||||||
| EC no. | 1.5.1.1 | ||||||||
| CAS no. | 9029-16-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a pyrroline-2-carboxylate reductase (EC 1.5.1.1) is an enzyme that catalyzes the chemical reaction
- L-proline + NAD(P)+ 1-pyrroline-2-carboxylate + NAD(P)H + H+
The 3 substrates of this enzyme are L-proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-2-carboxylate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-proline:NAD(P)+ 2-oxidoreductase. This enzyme is also called Delta1-pyrroline-2-carboxylate reductase. This enzyme participates in lysine degradation and arginine and proline metabolism.
References
[edit]- Meister A, Radhakrishnan AN, Buckley SD (1957). "Enzymatic synthesis of L-pipecolic acid and L-proline". J. Biol. Chem. 229 (2): 789–800. PMID 13502341.
