Thiamine-triphosphatase: Difference between revisions
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{{infobox enzyme |
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| EC_number = 3.6.1.28 |
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| CAS_number = 9068-47-7 |
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| GO_code = 0050333 |
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}} |
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{{infobox protein |
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|Name=thiamine triphosphatase |
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|caption= |
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|image= |
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|HGNCid=18987 |
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|Symbol=THTPA |
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|AltSymbols= |
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|EntrezGene=79178 |
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|OMIM= |
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|RefSeq=NM_024328 |
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|UniProt=Q9BU02 |
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|PDB= |
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|ECnumber=3.6.1.28 |
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|Chromosome=14 |
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|Arm=q |
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|Band=11.2 |
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|LocusSupplementaryData= |
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}} |
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:thiamine triphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> thiamine diphosphate + phosphate |
:[[thiamine triphosphate]] + H<sub>2</sub>O <math>\rightleftharpoons</math> [[thiamine diphosphate]] + [[phosphate]] |
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[thiamine triphosphate]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[thiamine diphosphate]] and [[phosphate]]. |
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==Structural studies== |
==Structural studies== |
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As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2JMU}}. |
As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2JMU}}. |
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==See also== |
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* [[Thiamine-diphosphate kinase]] |
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==References== |
==References== |
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{{ |
{{Reflist}} |
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{{Enzyme references|EC_number=3.6.1.28|IUBMB_EC_number=3/6/1/28}} |
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{{Acid anhydride hydrolases}} |
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==External links== |
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{{Enzymes}} |
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::''The [[CAS registry number]] for this enzyme class is {{CAS registry|9068-47-7}}.'' |
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{{Portal bar|Biology|border=no}} |
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{{Enzyme links|EC_number=3.6.1.28|IUBMB_EC_number=3/6/1/28}} |
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===Gene Ontology (GO) codes=== |
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[[Category:EC 3.6.1]] |
[[Category:EC 3.6.1]] |
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[[Category:Enzymes of known structure]] |
[[Category:Enzymes of known structure]] |
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Latest revision as of 16:01, 26 August 2023
thiamin triphosphatase | |||||||||
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Identifiers | |||||||||
EC no. | 3.6.1.28 | ||||||||
CAS no. | 9068-47-7 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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thiamine triphosphatase | |||||||
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Identifiers | |||||||
Symbol | THTPA | ||||||
NCBI gene | 79178 | ||||||
HGNC | 18987 | ||||||
RefSeq | NM_024328 | ||||||
UniProt | Q9BU02 | ||||||
Other data | |||||||
EC number | 3.6.1.28 | ||||||
Locus | Chr. 14 q11.2 | ||||||
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Thiamine-triphosphatase is an enzyme involved in thiamine metabolism. It catalyzes the chemical reaction
This enzyme belongs to the family of acid anhydride hydrolases, specifically those acting on phosphorus-containing anhydrides. Its systematic name is thiamine triphosphate phosphohydrolase.
Structural studies
[edit]As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JMU.
See also
[edit]References
[edit]- Hashitani Y, Cooper JR (1972). "The partial purification of thiamine triphosphatase from rat brain". J. Biol. Chem. 247 (7): 2117–9. doi:10.1016/S0021-9258(19)45498-7. PMID 4335862.