Cu2+-exporting ATPase: Difference between revisions

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Cu²⁺-exporting ATPase
Cu2+-exporting ATPase
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EC no.	3.6.3.4
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Cu²⁺-exporting ATPase (EC 3.6.3.4) is an enzyme with systematic name ATP phosphohydrolase (Cu²⁺-exporting).^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

ATP + H₂O + Cu²⁺_in

\rightleftharpoons

ADP + phosphate + Cu²⁺_out

This P-type ATPase undergoes covalent phosphorylation during the transport cycle.

References

^ Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J (January 1993). "Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase". Nature Genetics. 3 (1): 7–13. doi:10.1038/ng0193-7. PMID 8490659.
^ Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC (September 1994). "Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions". Human Molecular Genetics. 3 (9): 1647–56. doi:10.1093/hmg/3.9.1647. PMID 7833924.
^ Fagan MJ, Saier MH (January 1994). "P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees". Journal of Molecular Evolution. 38 (1): 57–99. doi:10.1007/bf00175496. PMID 8151716.

External links

Cu2+-exporting+ATPase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

[1] Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J (January 1993). "Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase". Nature Genetics. 3 (1): 7–13. doi:10.1038/ng0193-7. PMID 8490659.

[2] Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC (September 1994). "Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions". Human Molecular Genetics. 3 (9): 1647–56. doi:10.1093/hmg/3.9.1647. PMID 7833924.

[3] Fagan MJ, Saier MH (January 1994). "P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees". Journal of Molecular Evolution. 38 (1): 57–99. doi:10.1007/bf00175496. PMID 8151716.

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@@ Line 1: / Line 1: @@
 {{Infobox enzyme
-| Name = Cu<sup>2+</sup>-exporting ATPase
+| Name       = Cu<sup>2+</sup>-exporting ATPase
-| EC_number = 3.6.3.4
+| EC_number  = 3.6.3.4
 | CAS_number =
+| GO_code    =
-| IUBMB_EC_number = 3/6/3/4
-| GO_code =
+| image      =
-| image =
+| width      =
-| width =
+| caption    =
-| caption =
 }}
-'''Cu<sup>2+</sup>-exporting ATPase''' ({{EC number|3.6.3.4}}) is an [[enzyme]] with [[List of enzymes|systematic name]] ''ATP phosphohydrolase (Cu<sup>2+</sup>-exporting)''.<ref>{{cite journal | title = Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase |author1 = Vulpe, C. |author2 =Levinson, B. |author3 =Whitney, S. |author4 =Packman, S. |author5 =Gitschier, J. |journal = Nat. Genet. |year = 1993 |volume = 3 |pages = 7–13 |pmid = 8490659 |doi=10.1038/ng0193-7 |issue=1}}</ref><ref>{{cite journal | title = Characterization of the Wilson disease gene encoding a P-type copper-transporting ATPase: genomic organization, alternative splicing, and structure/function predictions |author1 = Petrukhin, K. |author2 =Lutsenko, S. |author3 =Chernov, I. |author4 =Ross, B.M. |author5 =Kaplan, J.H. |author6 =Gilliam, T.C. | journal = Hum. Mol. Genet. |year = 1994 |volume = 3 |pages = 1647–1656 |pmid = 7833924 |issue=9 |doi=10.1093/hmg/3.9.1647}}</ref><ref>{{cite journal | title = P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees |author1 = Fagan, M.J. |author2 =Saier, M.H., Jr. |journal = J. Mol. Evol. |year = 1994 |volume = 38 |pages = 57–99 |pmid = 8151716 |issue=1 |doi=10.1007/bf00175496}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
+'''Cu<sup>2+</sup>-exporting ATPase''' ({{EC number|3.6.3.4}}) is an [[enzyme]] with [[List of enzymes|systematic name]] ''ATP phosphohydrolase (Cu<sup>2+</sup>-exporting)''.<ref>{{cite journal | vauthors = Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J | title = Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase | journal = Nature Genetics | volume = 3 | issue = 1 | pages = 7–13 | date = January 1993 | pmid = 8490659 | doi = 10.1038/ng0193-7 }}</ref><ref>{{cite journal | vauthors = Petrukhin K, Lutsenko S, Chernov I, Ross BM, Kaplan JH, Gilliam TC | title = Characterization of the Wilson disease gene encoding a P-type copper transporting ATPase: genomic organization, alternative splicing, and structure/function predictions | journal = Human Molecular Genetics | volume = 3 | issue = 9 | pages = 1647–56 | date = September 1994 | pmid = 7833924 | doi = 10.1093/hmg/3.9.1647 }}</ref><ref>{{cite journal | vauthors = Fagan MJ, Saier MH | title = P-type ATPases of eukaryotes and bacteria: sequence analyses and construction of phylogenetic trees | journal = Journal of Molecular Evolution | volume = 38 | issue = 1 | pages = 57–99 | date = January 1994 | pmid = 8151716 | doi = 10.1007/bf00175496 }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
 : ATP + H<sub>2</sub>O + Cu<sup>2+</sup><sub>in</sub> <math>\rightleftharpoons</math> ADP + [[phosphate]] + Cu<sup>2+</sup><sub>out</sub>
 This [[P-type ATPase]] undergoes [[covalent]] [[phosphorylation]] during the transport cycle.
-== References ==
-{{reflist}}
 == See also ==
 * [[ATP7A]]
+== References ==
+{{reflist}}
 == External links ==
@@ Line 26: / Line 25: @@
 {{Acid anhydride hydrolases}}
 {{Enzymes}}
-{{Portal bar|Molecular and Cellular Biology|border=no}}
+{{Portal bar|Biology|border=no}}
 [[Category:EC 3.6.3]]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)