Cholemia: Difference between revisions
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#REDIRECT [[Jaundice#Hepatic pathophysiology]] |
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{{Infobox medical condition (new) |
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| name = Cholemia |
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| synonyms = Hyperbilirubinemia type 1 |
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'''Cholemia''' is a condition caused by the presence of excess [[bile]] in the blood. Its symptoms can include [[somnolence]] (drowsiness), yellow tinge to skin and whites of eyes, fatigue, nausea and, in extreme cases, [[coma]]. It is often an early sign of [[liver disease]].<ref>{{cite book |first=George S. |last=Weger |title=The Genesis and Control of Disease |year=1996 |publisher=[[Kessinger Publishing Company]] |isbn=978-1-56459-979-7 |page=525 |url=https://books.google.com/books?id=CDyqy80Vr4QC&pg=PA525}}</ref> |
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==Cause== |
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Cholemia is caused by a blood disorder caused by [[genetics|genetic]] factors. As a result of obstruction of bile duct, buildup of bile acids ([[Taurocholic acid|taurocholic]] and [[Glycocholic acid|glycocholic acids]]) affects the central nervous system, irritation of the [[vagus nerve]] causing [[Arrhythmia|arrhythmias]], direct tissue damage, [[hypercholesterolemia]] and [[Hyperbilirubinemia|hyperbillirubinemia]].{{citation needed|date=July 2020}} |
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==Diagnosis== |
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There is no specific diagnostic test for this condition. It is usually detected by [[colonoscopy]]. It is caused by a disease of the liver. It is most commonly seen in patients with [[hepatitis b]]. It's confirmed by the diagnosis as it shows a higher level of bilirubin ( <3 mg/dl ) but it is necessary to rule out liver diseases if the diagnosis is uncertain.<ref>{{cite journal |last1=Gromashevskaia |first1=L. L. |title=Isoenzymes of blood serum alkaline phosphatase under experimental cholemia |last2=Kasatkina |first2=M. G. |year=1979 |script-title=uk:мы исследовали изоферменты щелочной фосфатазы в сыворотке крови |trans-title=Isoenzymes of blood serum alkaline phosphatase under experimental cholemia |language=Ukrainian |journal=Ukrainskii Biokhimicheskii Zhurnal |volume=51 |issue=5 |pages=459–62 |pmid=516178}}</ref> |
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==Treatment== |
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Treatment aims to prevent the fast breakdown of [[Red blood cell|red blood cells]] causing high bile in blood. Cholemia is currently untreatable.{{citation needed|date=September 2020}} |
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==References== |
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{{reflist}} |
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==Further reading== |
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* {{cite journal |last1=Green |first1=J |last2=Beyar |first2=R |last3=Sideman |first3=S |last4=Mordechovitz |first4=D |last5=Better |first5=O. S. |year=1986 |title=The 'jaundiced heart': A possible explanation for postoperative shock in obstructive jaundice |journal=Surgery |volume=100 |issue=1 |pages=14–20 |pmid=3726756}} |
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* {{cite journal |last1=Green |first1=Jacob |last2=Beyar |first2=Rafael |last3=Bomzon |first3=Lionel |last4=Finberg |first4=John P.M. |last5=Better |first5=Ori S. |year=1984 |title=Jaundice, the Circulation and the Kidney |journal=Nephron |volume=37 |issue=3 |pages=145–52 |doi=10.1159/000183235 |pmid=6738765}} |
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* {{cite journal |last1=Fajers |first1=Carl-Mabtin |year=2009 |title=Experimental Studies in Cholemic Nephrosis |journal=Acta Pathologica et Microbiologica Scandinavica |volume=41 |issue=1 |pages=44–55 |doi=10.1111/j.1699-0463.1957.tb00996.x |pmid=13443982}} |
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== External links == |
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[[Category:Blood disorders]] |
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{{genetic-disease-stub}} |
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Latest revision as of 09:13, 30 September 2023
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