Cholemia: Difference between revisions
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Causes and effects of cholemia |
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#REDIRECT [[Jaundice#Hepatic pathophysiology]] |
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'''Cholemia''' is a condition caused by the presence of excess [[bile]] in the blood. Its symptoms can include [[somnolence]] (drowsiness), yellow tinge to skin and whites of eyes, fatigue, nausea and, in extreme cases, [[coma]]. It is often an early sign of [[liver disease]].<ref>{{cite book |first=George S. |last=Weger |title=The Genesis and Control of Disease |year=1996 |publisher=[[Kessinger Publishing Company]] |isbn=978-1-56459-979-7 |page=525 |url=https://books.google.com/books?id=CDyqy80Vr4QC&pg=PA525}}</ref> |
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==Cause== |
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Cholemia is caused by a blood disorder caused by [[genetics|genetic]] factors. Also as a result of obstruction of bile duct leading to cholemic syndrome which is clinically significant because of the presence of bile acids (taurocholic and glycocholic acids). this build up causes CNS affection, irritation of vagus nerve causing arrythmia, direct tissue damage, hypercholesterolemia and hyperbillirubinemia. |
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==Diagnosis== |
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There is no specific diagnostic test for this condition. Usually detected colonoscopy. It is caused by a disease of the liver. It is most commonly seen in patients with [[hepatitis b]]. It's confirmed by the diagnosis as it shows a higher level of bilirubin ( <3 mg/dl ) but it is necessary to rule out liver diseases if the diagnosis is uncertain.<ref>{{cite journal |last1=Gromashevskaia |first1=L. L. |last2=Kasatkina |first2=M. G. |year=1979 |script-title=uk:мы исследовали изоферменты щелочной фосфатазы в сыворотке крови |trans-title=Isoenzymes of blood serum alkaline phosphatase under experimental cholemia |language=Ukrainian |journal=Ukrainskii biokhimicheskii zhurnal |volume=51 |issue=5 |pages=459–62 |pmid=516178}}</ref> |
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==Treatment== |
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Treatment aims to prevent the fast breakdown of red blood cells causing high bile in blood. Cholemia is currently untreatable. |
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==References== |
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{{reflist}} |
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==Further reading== |
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*{{cite journal |last1=Green |first1=J |last2=Beyar |first2=R |last3=Sideman |first3=S |last4=Mordechovitz |first4=D |last5=Better |first5=O. S. |year=1986 |title=The 'jaundiced heart': A possible explanation for postoperative shock in obstructive jaundice |journal=Surgery |volume=100 |issue=1 |pages=14–20 |pmid=3726756}} |
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*{{cite journal |last1=Green |first1=Jacob |last2=Beyar |first2=Rafael |last3=Bomzon |first3=Lionel |last4=Finberg |first4=John P.M. |last5=Better |first5=Ori S. |year=1984 |title=Jaundice, the Circulation and the Kidney |journal=Nephron |volume=37 |issue=3 |pages=145–52 |doi=10.1159/000183235 |pmid=6738765}} |
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*{{cite journal |last1=Fajers |first1=Carl-Mabtin |year=2009 |title=Experimental Studies in Cholemic Nephrosis |journal=Acta Pathologica Microbiologica Scandinavica |volume=41 |doi=10.1111/j.1699-0463.1957.tb00996.x |pmid=13443982}} |
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== External links == |
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[[Category:Blood disorders]] |
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{{genetic-disease-stub}} |
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Latest revision as of 09:13, 30 September 2023
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