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{{lowercasetitle}}
{{Chembox
{{Chembox
| Name = α-Neoendorphin
| ImageFile = alpha-neoendorphin.svg
| ImageFile = alpha-neoendorphin.svg
| ImageSize = 250px
| ImageSize = 250px
| ImageAlt =
| ImageAlt =
| IUPACName =
| IUPACName =
| OtherNames = Alpha-Neoendorphin
| OtherNames = Alpha-Neoendorphin
| Section1 = {{Chembox Identifiers
|Section1={{Chembox Identifiers
| CASNo = 69671-17-6
| CASNo = 69671-17-6
| PubChem =
| PubChem = 5311003
| IUPHAR_ligand = 1600
⚫
| SMILES = N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O}}
| ChEMBL = 2409222
| Section2 = {{Chembox Properties
| KEGG = C16039
⚫
| C=60|H=89|N=15|O=13
| Appearance =
| ChEBI = 80261
| Density =
| ChemSpiderID = 4470544
| StdInChI=1S/C60H89N15O13/c1-36(2)30-46(73-56(84)47(32-37-12-4-3-5-13-37)69-51(79)35-67-50(78)34-68-52(80)42(63)31-38-18-22-40(76)23-19-38)55(83)71-44(16-10-28-66-60(64)65)53(81)70-43(14-6-8-26-61)54(82)74-48(33-39-20-24-41(77)25-21-39)58(86)75-29-11-17-49(75)57(85)72-45(59(87)88)15-7-9-27-62/h3-5,12-13,18-25,36,42-49,76-77H,6-11,14-17,26-35,61-63H2,1-2H3,(H,67,78)(H,68,80)(H,69,79)(H,70,81)(H,71,83)(H,72,85)(H,73,84)(H,74,82)(H,87,88)(H4,64,65,66)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
⚫
| MeltingPt =
| StdInChIKey = KZTDMJBCZSGHOG-XJIZABAQSA-N
⚫
| BoilingPt =
⚫
| SMILES = N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O}}
⚫
| Solubility = }}
| Section3 = {{Chembox Hazards
|Section2={{Chembox Properties
⚫
| C=60 | H=89 | N=15 | O=13
⚫
| MainHazards =
| FlashPt =
| Appearance =
| Autoignition = }}
| Density =
⚫
| MeltingPt =
⚫
| BoilingPt =
⚫
| Solubility = }}
|Section3={{Chembox Hazards
⚫
| MainHazards =
| FlashPt =
| AutoignitionPt = }}
}}
}}


'''α-neo-endorphin''' is an endogenous [[opioid peptide]] whose amino acid sequence is: [[tyrosine|Tyr]]-[[glycine|Gly]]-Gly-[[phenylalanine|Phe]]-[[leucine|Leu]]-[[arginine|Arg]]-[[lysine|Lys]]-Tyr-[[proline|Pro]]-Lys.<ref>{{cite journal | doi = 10.1016/0006-291X(81)91244-4 | author = Kangawa K., Minamino N., Chino N | title = The complete amino acid sequence of α-neo-endorphin | year = 1981 | journal = Biochemical and Biophysical Research Communications | volume = 99 | issue = 3 | pages = 871–878 | pmid = 7247946}}</ref>
'''α-Neoendorphin''' is an [[endogenous]] [[opioid peptide]] with a [[decapeptide]] structure and the [[amino acid sequence]] [[tyrosine|Tyr]]-[[glycine|Gly]]-Gly-[[phenylalanine|Phe]]-[[leucine|Leu]]-[[arginine|Arg]]-[[lysine|Lys]]-Tyr-[[proline|Pro]]-Lys.<ref>{{cite journal | doi = 10.1016/0006-291X(81)91244-4 |author1=Kangawa K. |author2=Minamino N. |author3=Chino N | title = The complete amino acid sequence of α-neo-endorphin | year = 1981 | journal = Biochemical and Biophysical Research Communications | volume = 99 | issue = 3 | pages = 871–878 | pmid = 7247946}}</ref>

α-Neoendorphin is a [[neuropeptide]]. [[Prodynorphin]] or Proenkephalin B is its precursor. Researchers and anatomists have not yet studied the distribution of α-neoendorphin in the human in detail. However, some studies have been done which supports the presence of α-neoendorphin [[Immunoassay|immunoreactive]] fibers throughout the human brainstem. According to a study done by Duque, Ewing, Arturo Mangas, Pablo Salinas, Zaida Díaz-cabiale, José Narváez, and Rafael Coveñas; α-neoendorphin immunoreactive fibers can be found in the caudal part of the solitary nucleus, in the caudal and the gelatinosa parts of the spinal trigeminal nucleus, and only low density was found in the central grey matter of medulla.<ref>{{Cite journal|last1=Duque|first1=Ewing|last2=Mangas|first2=Arturo|last3=Salinas|first3=Pablo|last4=Díaz-Cabiale|first4=Zaida|last5=Narváez|first5=José Angel|last6=Coveñas|first6=Rafael|date=2012-02-09|title=Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem|journal=Brain Structure and Function|volume=218|issue=1|pages=131–149|doi=10.1007/s00429-012-0388-3|pmid=22318412|s2cid=253974523 |issn=1863-2653}}</ref>


==See also==
==See also==
*[[Beta-Neoendorphin|β-Neoendorphin]]
*[[β-neo-endorphin]]


==References==
==References==
{{reflist}}
{{Reflist|2}}



{{Neuropeptides}}
{{Neuropeptides}}
{{Opioidergics}}

{{DEFAULTSORT:Neoendorphin, alpha-}}


⚫
[[Category:Opioid peptides]]
{{DEFAULTSORT:Α-Neo-Endorphin}}
[[Category:Peptides]]
[[Category:Decapeptides]]
⚫
[[Category:Opioids]]


⚫
{{biochem-stub}}


⚫
{{biochemistry-stub}}
[[sr:Alfa-neo-endorfin]]

Latest revision as of 01:23, 1 October 2023

α-Neoendorphin
Names
Other names
Alpha-Neoendorphin
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
KEGG
  • InChI=1S/C60H89N15O13/c1-36(2)30-46(73-56(84)47(32-37-12-4-3-5-13-37)69-51(79)35-67-50(78)34-68-52(80)42(63)31-38-18-22-40(76)23-19-38)55(83)71-44(16-10-28-66-60(64)65)53(81)70-43(14-6-8-26-61)54(82)74-48(33-39-20-24-41(77)25-21-39)58(86)75-29-11-17-49(75)57(85)72-45(59(87)88)15-7-9-27-62/h3-5,12-13,18-25,36,42-49,76-77H,6-11,14-17,26-35,61-63H2,1-2H3,(H,67,78)(H,68,80)(H,69,79)(H,70,81)(H,71,83)(H,72,85)(H,73,84)(H,74,82)(H,87,88)(H4,64,65,66)/t42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
    Key: KZTDMJBCZSGHOG-XJIZABAQSA-N
  • N[C@@H](CC1=CC=C(O)C=C1)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC3=CC=C(O)C=C3)C(N4CCC[C@H]4C(N[C@H](C(O)=O)CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O
Properties
C60H89N15O13
Molar mass 1228.464 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

α-Neoendorphin is an endogenous opioid peptide with a decapeptide structure and the amino acid sequence Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys.[1]

α-Neoendorphin is a neuropeptide. Prodynorphin or Proenkephalin B is its precursor. Researchers and anatomists have not yet studied the distribution of α-neoendorphin in the human in detail. However, some studies have been done which supports the presence of α-neoendorphin immunoreactive fibers throughout the human brainstem. According to a study done by Duque, Ewing, Arturo Mangas, Pablo Salinas, Zaida Díaz-cabiale, José Narváez, and Rafael Coveñas; α-neoendorphin immunoreactive fibers can be found in the caudal part of the solitary nucleus, in the caudal and the gelatinosa parts of the spinal trigeminal nucleus, and only low density was found in the central grey matter of medulla.[2]

See also

[edit]

References

[edit]
  1. ^ Kangawa K.; Minamino N.; Chino N (1981). "The complete amino acid sequence of α-neo-endorphin". Biochemical and Biophysical Research Communications. 99 (3): 871–878. doi:10.1016/0006-291X(81)91244-4. PMID 7247946.
  2. ^ Duque, Ewing; Mangas, Arturo; Salinas, Pablo; Díaz-Cabiale, Zaida; Narváez, José Angel; Coveñas, Rafael (2012-02-09). "Mapping of alpha-neo-endorphin- and neurokinin B-immunoreactivity in the human brainstem". Brain Structure and Function. 218 (1): 131–149. doi:10.1007/s00429-012-0388-3. ISSN 1863-2653. PMID 22318412. S2CID 253974523.



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