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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Short description|Protein found in humans}}
{{Infobox_gene}}
{{Infobox_gene}}
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025}}</ref><ref name="pmid8530078">{{cite journal | vauthors = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | date = Sep 1995 | pmid = 8530078 | doi = 10.1006/geno.1995.1237 }}</ref> This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s.
'''COUP-TF1''' (<u>COUP</u> <u>T</u>ranscription <u>F</u>actor <u>1</u>) also known as '''NR2F1''' (<u>N</u>uclear <u>R</u>eceptor subfamily <u>2</u>, group <u>F</u>, member <u>1</u>) is a [[protein]] that in humans is encoded by the ''NR2F1'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7025}}</ref><ref name="pmid8530078">{{cite journal | vauthors = Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY | title = Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes | journal = Genomics | volume = 29 | issue = 1 | pages = 240–6 | date = Sep 1995 | pmid = 8530078 | doi = 10.1006/geno.1995.1237 | doi-access = free }}</ref> This protein is a member of [[nuclear receptor|nuclear hormone receptor]] family of [[steroid hormone receptor]]s.


== Function ==
== Function ==


Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | vauthors = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 12 | pages = 4259–67 | date = Dec 1986 | pmid = 3796602 | pmc = 367207 | doi = 10.1128/MCB.6.12.4259 }}</ref><ref name="pmid3040258">{{cite journal | vauthors = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | date = Aug 1987 | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X | s2cid = 25136877 }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal | vauthors = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocrine Reviews | volume = 18 | issue = 2 | pages = 229–40 | date = Apr 1997 | doi = 10.1210/edrv.18.2.0294 | pmid = 9101138 | doi-access = free }}</ref>
Coup (chicken [[ovalbumin]] upstream promoter) [[transcription factor]] binds to the ovalbumin [[promoter (biology)|promoter]] and, in conjunction with another protein ([[GTF2B|S300-II]]) stimulates [[initiation of transcription]].<ref name="pmid3796602">{{cite journal | vauthors = Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW | title = Identification of two factors required for transcription of the ovalbumin gene | journal = Molecular and Cellular Biology | volume = 6 | issue = 12 | pages = 4259–67 | date = Dec 1986 | pmid = 3796602 | pmc = 367207 | doi = 10.1128/MCB.6.12.4259 }}</ref><ref name="pmid3040258">{{cite journal | vauthors = Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW | title = Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II) | journal = Cell | volume = 50 | issue = 5 | pages = 701–9 | date = Aug 1987 | pmid = 3040258 | doi = 10.1016/0092-8674(87)90328-X | s2cid = 25136877 }}</ref> COUP-TF1 binds to both direct repeats and [[palindromes]] of the 5'-AGGTCA-3' motif.<ref name="pmid9101138">{{cite journal |author2-link=Ming-Jer Tsai | vauthors = Tsai SY, Tsai MJ | title = Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age | journal = Endocrine Reviews | volume = 18 | issue = 2 | pages = 229–40 | date = Apr 1997 | doi = 10.1210/edrv.18.2.0294 | pmid = 9101138 | doi-access = free }}</ref>


== Interactions ==
== Interactions ==

Latest revision as of 00:10, 6 October 2023

NR2F1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNR2F1, BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1
External IDsOMIM: 132890; MGI: 1352451; HomoloGene: 21158; GeneCards: NR2F1; OMA:NR2F1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

7025

13865

Ensembl

ENSG00000175745

ENSMUSG00000069171

UniProt

P10589

Q60632

RefSeq (mRNA)

NM_005654

NM_010151
NM_001347538
NM_001347539

RefSeq (protein)

NP_005645

Location (UCSC)Chr 5: 93.58 – 93.59 MbChr 13: 78.34 – 78.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

COUP-TF1 (COUP Transcription Factor 1) also known as NR2F1 (Nuclear Receptor subfamily 2, group F, member 1) is a protein that in humans is encoded by the NR2F1 gene.[5][6] This protein is a member of nuclear hormone receptor family of steroid hormone receptors.

Function

[edit]

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription.[7][8] COUP-TF1 binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif.[9]

Interactions

[edit]

COUP-TFI has been shown to interact with:

Clinical

[edit]

Mutations in this gene have been associated with Bosch-Boonstra-Schaaf optic atrophy syndrome.[13]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000175745 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069171 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1".
  6. ^ Qiu Y, Krishnan V, Zeng Z, Gilbert DJ, Copeland NG, Gibson L, Yang-Feng T, Jenkins NA, Tsai MJ, Tsai SY (Sep 1995). "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics. 29 (1): 240–6. doi:10.1006/geno.1995.1237. PMID 8530078.
  7. ^ Sagami I, Tsai SY, Wang H, Tsai MJ, O'Malley BW (Dec 1986). "Identification of two factors required for transcription of the ovalbumin gene". Molecular and Cellular Biology. 6 (12): 4259–67. doi:10.1128/MCB.6.12.4259. PMC 367207. PMID 3796602.
  8. ^ Tsai SY, Sagami I, Wang H, Tsai MJ, O'Malley BW (Aug 1987). "Interactions between a DNA-binding transcription factor (COUP) and a non-DNA binding factor (S300-II)". Cell. 50 (5): 701–9. doi:10.1016/0092-8674(87)90328-X. PMID 3040258. S2CID 25136877.
  9. ^ Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews. 18 (2): 229–40. doi:10.1210/edrv.18.2.0294. PMID 9101138.
  10. ^ a b Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. doi:10.1074/jbc.275.14.10315. PMC 2819356. PMID 10744719.
  11. ^ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily". Molecular and Cellular Biology. 19 (5): 3383–94. doi:10.1128/mcb.19.5.3383. PMC 84131. PMID 10207062.
  12. ^ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK". The EMBO Journal. 21 (13): 3443–53. doi:10.1093/emboj/cdf344. PMC 126093. PMID 12093745.
  13. ^ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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