PRMT2: Difference between revisions

PRMT2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X2P
Identifiers
Aliases	PRMT2, HRMT1L1, protein arginine methyltransferase 2
External IDs	OMIM: 601961; MGI: 1316652; HomoloGene: 55587; GeneCards: PRMT2; OMA:PRMT2 - orthologs
EC number	2.1.1.321
Gene location (Human)
Chr.	Chromosome 21 (human)
End	46,665,124 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	76,073,699 bp
RNA expression pattern
	Top expressed in
	C1 segment; ; right coronary artery; ; ganglionic eminence; ; tibial nerve; ; popliteal artery; ; tibial arteries; ; granulocyte; ; thoracic aorta; ; ascending aorta; ; ventricular zone;
	Top expressed in
	Hypothalamus; ; neural tube; ; Mesencephalon; ; rhombencephalon; ; dentate gyrus of hippocampal formation granule cell; ; ganglionic eminence; ; hippocampus proper; ; placenta; ; olfactory bulb; ; lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity; protein homodimerization activity; progesterone receptor binding; transcription coactivator activity; signal transducer activity; thyroid hormone receptor binding; protein binding; androgen receptor binding; peroxisome proliferator activated receptor binding; retinoic acid receptor binding; estrogen receptor binding; protein-arginine N-methyltransferase activity; histone-arginine N-methyltransferase activity; protein-arginine omega-N asymmetric methyltransferase activity; protein-containing complex binding;
Cellular component	cytoplasm; cytosol; Rb-E2F complex; nucleoplasm; nucleolus; nucleus;
Biological process	developmental cell growth; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of transcription, DNA-templated; methylation; positive regulation of apoptotic process; regulation of androgen receptor signaling pathway; histone methylation; negative regulation of transcription, DNA-templated; negative regulation of NF-kappaB transcription factor activity; signal transduction; protein methylation; histone arginine methylation; peptidyl-arginine N-methylation; peptidyl-arginine methylation, to asymmetrical-dimethyl arginine; regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	3275
	15468
	ENSG00000160310
	ENSMUSG00000020230
	P55345
	Q9R144
NM_001242864; NM_001242865; NM_001242866; NM_001286676; NM_001286677;
	NM_001286678; NM_001535; NM_206962
	NM_001077638; NM_133182; NM_001302965
NP_001229793; NP_001229794; NP_001229795; NP_001273605; NP_001273606;
	NP_001273607; NP_001526; NP_996845
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:15, 15 October 2023

Protein arginine N-methyltransferase 2 is an enzyme that in humans is encoded by the PRMT2 gene.^[5]^[6]

Functions

The enzyme methylates final nitrogen atom of arginine residue in some proteins. It transfers two methyl groups from S-adenosyl-L-methionine.

Interactions

PRMT2 has been shown to interact with Estrogen receptor alpha^[7] and HNRPUL1.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160310 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020230 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.
^ "Entrez Gene: PRMT2 protein arginine methyltransferase 2".
^ Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32). United States: 28624–30. doi:10.1074/jbc.M201053200. ISSN 0021-9258. PMID 12039952.
^ Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2). England: 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Katsanis N, Yaspo ML, Fisher EM (1997). "Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene". Mamm. Genome. 8 (7): 526–9. doi:10.1007/s003359900491. PMID 9196002. S2CID 32074112.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Kzhyshkowska J, Schütt H, Liss M, et al. (2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2): 305–14. doi:10.1042/0264-6021:3580305. PMC 1222062. PMID 11513728.
Qi C, Chang J, Zhu Y, et al. (2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32): 28624–30. doi:10.1074/jbc.M201053200. PMID 12039952.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ganesh L, Yoshimoto T, Moorthy NC, et al. (2006). "Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis". Mol. Cell. Biol. 26 (10): 3864–74. doi:10.1128/MCB.26.10.3864-3874.2006. PMC 1488990. PMID 16648481.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000160310 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020230 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545638-5] Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF (Jun 1998). "Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2)". Genomics. 48 (3): 330–40. doi:10.1006/geno.1997.5190. PMID 9545638.

[entrez-6] "Entrez Gene: PRMT2 protein arginine methyltransferase 2".

[pmid12039952-7] Qi, Chao; Chang Jeffrey; Zhu Yiwei; Yeldandi Anjana V; Rao Sambasiva M; Zhu Yi-Jun (Aug 2002). "Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha". J. Biol. Chem. 277 (32). United States: 28624–30. doi:10.1074/jbc.M201053200. ISSN 0021-9258. PMID 12039952.

[pmid11513728-8] Kzhyshkowska, J; Schütt H; Liss M; Kremmer E; Stauber R; Wolf H; Dobner T (Sep 2001). "Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1". Biochem. J. 358 (Pt 2). England: 305–14. doi:10.1042/0264-6021:3580305. ISSN 0264-6021. PMC 1222062. PMID 11513728.

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+{{Short description|Protein-coding gene in the species Homo sapiens}}
+{{Infobox_gene}}
+'''Protein arginine N-methyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''PRMT2'' [[gene]].<ref name="pmid9545638">{{cite journal |vauthors=Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF | title = Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2) | journal = Genomics | volume = 48 | issue = 3 | pages = 330–40 |date=Jun 1998 | pmid = 9545638 | doi = 10.1006/geno.1997.5190 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRMT2 protein arginine methyltransferase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3275}}</ref>
+==Functions==
-{{PBB|geneid=3275}}
+The enzyme methylates final nitrogen atom of [[arginine]] residue in some proteins. It transfers two [[methyl group]]s from [[S-adenosyl-L-methionine|''S''-adenosyl-<small>L</small>-methionine]].
-'''Protein arginine N-methyltransferase 2''' is an [[enzyme]] that in humans is encoded by the ''PRMT2'' [[gene]].<ref name="pmid9545638">{{cite journal | author = Scott HS, Antonarakis SE, Lalioti MD, Rossier C, Silver PA, Henry MF | title = Identification and characterization of two putative human arginine methyltransferases (HRMT1L1 and HRMT1L2) | journal = Genomics | volume = 48 | issue = 3 | pages = 330–40 |date=Jun 1998 | pmid = 9545638 | pmc =  | doi = 10.1006/geno.1997.5190 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRMT2 protein arginine methyltransferase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3275| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text =
-}}
 ==Interactions==
-PRMT2 has been shown to [[Protein-protein_interaction|interact]] with [[Estrogen receptor alpha]]<ref name=pmid12039952>{{cite journal |last=Qi |first=Chao |authorlink= |author2=Chang Jeffrey |author3=Zhu Yiwei |author4=Yeldandi Anjana V |author5=Rao Sambasiva M |author6=Zhu Yi-Jun  |date=Aug 2002 |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha |journal=J. Biol. Chem. |volume=277 |issue=32 |pages=28624–30 |publisher= |location = United States| issn = 0021-9258| pmid = 12039952 |doi = 10.1074/jbc.M201053200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[HNRPUL1]].<ref name=pmid11513728>{{cite journal |last=Kzhyshkowska |first=J |authorlink= |author2=Schütt H |author3=Liss M |author4=Kremmer E |author5=Stauber R |author6=Wolf H |author7=Dobner T  |date=Sep 2001 |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue=Pt 2 |pages=305–14 |publisher= |location = England| issn = 0264-6021| pmid = 11513728 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1042/0264-6021:3580305 |pmc=1222062 }}</ref>
+PRMT2 has been shown to [[Protein-protein interaction|interact]] with [[Estrogen receptor alpha]]<ref name=pmid12039952>{{cite journal |last=Qi |first=Chao |author2=Chang Jeffrey |author3=Zhu Yiwei |author4=Yeldandi Anjana V |author5=Rao Sambasiva M |author6=Zhu Yi-Jun  |date=Aug 2002 |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha |journal=J. Biol. Chem. |volume=277 |issue=32 |pages=28624–30 |location = United States| issn = 0021-9258| pmid = 12039952 |doi = 10.1074/jbc.M201053200 |doi-access=free }}</ref> and [[HNRPUL1]].<ref name=pmid11513728>{{cite journal |last=Kzhyshkowska |first=J |author2=Schütt H |author3=Liss M |author4=Kremmer E |author5=Stauber R |author6=Wolf H |author7=Dobner T  |date=Sep 2001 |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue=Pt 2 |pages=305–14 |location = England| issn = 0264-6021| pmid = 11513728 |doi=10.1042/0264-6021:3580305 |pmc=1222062 }}</ref>
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-{{PBB_Further_reading
+*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138  |name-list-style=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
-| citations =
+*{{cite journal  | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |name-list-style=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138  |name-list-format=vanc| author2=Wentland MA  | author3=Ricafrente JY  | display-authors=3  | last4=Liu  | first4=W  | last5=Gibbs  | first5=RA }}
+*{{cite journal  |vauthors=Katsanis N, Yaspo ML, Fisher EM |title=Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene |journal=Mamm. Genome |volume=8 |issue= 7 |pages= 526–9 |year= 1997 |pmid= 9196002 |doi=10.1007/s003359900491  |s2cid=32074112 }}
-*{{cite journal  | author=Yu W |title=Large-Scale Concatenation cDNA Sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=  10.1101/gr.7.4.353| pmc=139146  |name-list-format=vanc| author2=Andersson B  | author3=Worley KC  | display-authors=3  | last4=Muzny  | first4=DM  | last5=Ding  | first5=Y  | last6=Liu  | first6=W  | last7=Ricafrente  | first7=JY  | last8=Wentland  | first8=MA  | last9=Lennon  | first9=G  }}
+*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-style=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
+*{{cite journal  | author=Hattori M |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518  |name-list-style=vanc| author2=Fujiyama A  | author3=Taylor TD  | display-authors=3  | last4=Taylor  | first4=T. D.  | last5=Watanabe  | first5=H.  | last6=Yada  | first6=T.  | last7=Park  | first7=H.-S.  | last8=Toyoda  | first8=A.  | last9=Ishii  | first9=K. | doi-access=free | bibcode=2000Natur.405..311H }}
-*{{cite journal  | author=Katsanis N, Yaspo ML, Fisher EM |title=Identification and mapping of a novel human gene, HRMT1L1, homologous to the rat protein arginine N-methyltransferase 1 (PRMT1) gene |journal=Mamm. Genome |volume=8 |issue= 7 |pages= 526–9 |year= 1997 |pmid= 9196002 |doi=10.1007/s003359900491  }}
-*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
+*{{cite journal  | author=Kzhyshkowska J |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 305–14 |year= 2001 |pmid= 11513728 |doi=10.1042/0264-6021:3580305  | pmc=1222062  |name-list-style=vanc| author2=Schütt H  | author3=Liss M  | display-authors=3  | last4=Kremmer  | first4=Elisabeth  | last5=Stauber  | first5=Roland  | last6=Wolf  | first6=Hans  | last7=Dobner  | first7=Thomas  }}
-*{{cite journal  | author=Hattori M |title=The DNA sequence of human chromosome 21 |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518  |name-list-format=vanc| author2=Fujiyama A  | author3=Taylor TD  | display-authors=3  | last4=Taylor  | first4=T. D.  | last5=Watanabe  | first5=H.  | last6=Yada  | first6=T.  | last7=Park  | first7=H.-S.  | last8=Toyoda  | first8=A.  | last9=Ishii  | first9=K. }}
+*{{cite journal  | author=Qi C |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28624–30 |year= 2002 |pmid= 12039952 |doi= 10.1074/jbc.M201053200  |name-list-style=vanc| author2=Chang J  | author3=Zhu Y  | display-authors=3  | last4=Yeldandi  | first4=AV  | last5=Rao  | first5=SM  | last6=Zhu  | first6=YJ | doi-access=free}}
-*{{cite journal  | author=Kzhyshkowska J |title=Heterogeneous nuclear ribonucleoprotein E1B-AP5 is methylated in its Arg-Gly-Gly (RGG) box and interacts with human arginine methyltransferase HRMT1L1 |journal=Biochem. J. |volume=358 |issue= Pt 2 |pages= 305–14 |year= 2001 |pmid= 11513728 |doi=10.1042/0264-6021:3580305  | pmc=1222062  |name-list-format=vanc| author2=Schütt H  | author3=Liss M  | display-authors=3  | last4=Kremmer  | first4=Elisabeth  | last5=Stauber  | first5=Roland  | last6=Wolf  | first6=Hans  | last7=Dobner  | first7=Thomas  }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-style=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M|doi-access=free }}
-*{{cite journal  | author=Qi C |title=Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28624–30 |year= 2002 |pmid= 12039952 |doi= 10.1074/jbc.M201053200  |name-list-format=vanc| author2=Chang J  | author3=Zhu Y  | display-authors=3  | last4=Yeldandi  | first4=AV  | last5=Rao  | first5=SM  | last6=Zhu  | first6=YJ }}
+*{{cite journal  | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0  |name-list-style=vanc| author2=Semple JI  | author3=Brown SE  | display-authors=3  | last4=Counsell  | first4=Damian  | last5=Campbell  | first5=R.Duncan  | last6=Sanderson  | first6=Christopher M  }}
-*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-style=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki | doi-access=free  }}
-*{{cite journal  | author=Lehner B |title=Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region |journal=Genomics |volume=83 |issue= 1 |pages= 153–67 |year= 2004 |pmid= 14667819 |doi=10.1016/S0888-7543(03)00235-0  |name-list-format=vanc| author2=Semple JI  | author3=Brown SE  | display-authors=3  | last4=Counsell  | first4=Damian  | last5=Campbell  | first5=R.Duncan  | last6=Sanderson  | first6=Christopher M  }}
+*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-style=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
-*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
+*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-style=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija |bibcode=2005Natur.437.1173R|s2cid=4427026 }}
-*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
+*{{cite journal  | author=Ganesh L |title=Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3864–74 |year= 2006 |pmid= 16648481 |doi= 10.1128/MCB.26.10.3864-3874.2006  | pmc=1488990  |name-list-style=vanc| author2=Yoshimoto T  | author3=Moorthy NC  | display-authors=3  | last4=Akahata  | first4=W.  | last5=Boehm  | first5=M.  | last6=Nabel  | first6=E. G.  | last7=Nabel  | first7=G. J. }}
-*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
-*{{cite journal  | author=Ganesh L |title=Protein Methyltransferase 2 Inhibits NF-κB Function and Promotes Apoptosis |journal=Mol. Cell. Biol. |volume=26 |issue= 10 |pages= 3864–74 |year= 2006 |pmid= 16648481 |doi= 10.1128/MCB.26.10.3864-3874.2006  | pmc=1488990  |name-list-format=vanc| author2=Yoshimoto T  | author3=Moorthy NC  | display-authors=3  | last4=Akahata  | first4=W.  | last5=Boehm  | first5=M.  | last6=Nabel  | first6=E. G.  | last7=Nabel  | first7=G. J. }}
-}}
 {{refend}}
 {{PDB Gallery|geneid=3275}}
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