Monoamine receptor: Difference between revisions

Content deleted Content added

Inline

Latest revision as of 11:14, 6 November 2023

The serotonin 5-HT_1B receptor as an example of a monoamine receptor.^[1] Its crystallographic structure in ribbon representation.

A monoamine receptor is a receptor for the monoamine neurotransmitters and/or trace amines, endogenous small-molecule signaling molecules with a monoamine structure. The monoamine receptors are almost all G protein-coupled receptors, with the serotonin 5-HT₃ receptor being a notable exception as a ligand-gated ion channel.^[1] Monoamine receptors are the biological targets of many drugs; such drugs may be referred to as "monoaminergic".

List of receptors

Monoamine receptors include the following classes:

Adrenergic receptors – bound by epinephrine (adrenaline) and norepinephrine (noradrenaline)
Dopamine receptors – bound by dopamine
Histamine receptors – bound by histamine
Melatonin receptors – bound by melatonin
Serotonin receptors – bound by serotonin (5-HT)
Trace amine-associated receptors – bound by trace amines, thyronamines, monoamine neurotransmitters (TAAR1 only), and trimethylamine (TAAR5 only)

References

^ ^a ^b Martin, Andres; Scahill, Lawrence; Kratochvil, Christopher (14 December 2010). Pediatric Psychopharmacology. Oxford University Press. p. 31. ISBN 9780199842667. Retrieved 27 January 2017. The 5-HT3 receptor is the only monoamine receptor coupled to an ion channel, probably a Ca2+ channel.

This article about a biochemical receptor is a stub. You can help Wikipedia by expanding it.

[MartinScahill2010-1] Martin, Andres; Scahill, Lawrence; Kratochvil, Christopher (14 December 2010). Pediatric Psychopharmacology. Oxford University Press. p. 31. ISBN 9780199842667. Retrieved 27 January 2017. The 5-HT3 receptor is the only monoamine receptor coupled to an ion channel, probably a Ca2+ channel.

[1]

@@ Line 1: / Line 1: @@
-[[File:4IAR.png|thumb|200px|The [[serotonin]] [[5-HT1B receptor|5-HT<sub>1B</sub> receptor]] as an example of a monoamine receptor.<ref name="MartinScahill2010">{{cite book|last1=Martin|first1=Andres|last2=Scahill|first2=Lawrence|last3=Kratochvil|first3=Christopher|title=Pediatric Psychopharmacology|url=http://books.google.com/books?id=25lymOnrWw4C&pg=PA31|accessdate=27 January 2017|date=14 December 2010|publisher=Oxford University Press|language=English|isbn=9780199842667|page=31|quote=The 5-HT3 receptor is the only monoamine receptor coupled to an ion channel, probably a Ca2+ channel.}}</ref> Its [[X-ray crystallography#Biological macromolecular crystallography|crystallographic structure]] in [[ribbon representation]].]]
+[[File:4IAR.png|thumb|200px|The [[serotonin]] [[5-HT1B receptor|5-HT<sub>1B</sub> receptor]] as an example of a monoamine receptor.<ref name="MartinScahill2010">{{cite book|last1=Martin|first1=Andres|last2=Scahill|first2=Lawrence|last3=Kratochvil|first3=Christopher|title=Pediatric Psychopharmacology|url=https://books.google.com/books?id=25lymOnrWw4C&pg=PA31|accessdate=27 January 2017|date=14 December 2010|publisher=Oxford University Press|language=English|isbn=9780199842667|page=31|quote=The 5-HT3 receptor is the only monoamine receptor coupled to an ion channel, probably a Ca2+ channel.}}</ref> Its [[X-ray crystallography#Biological macromolecular crystallography|crystallographic structure]] in [[ribbon representation]].]]
-A '''monoamine receptor''' is a [[receptor (biochemistry)|receptor]] for the [[monoamine neurotransmitter]]s and/or [[trace amine]]s, [[endogenous]] [[small-molecule]] [[signaling molecule]]s with a [[monoamine]] [[chemical structure|structure]]. The monoamine receptors are almost all [[G protein-coupled receptor]]s, with the [[serotonin]] [[5-HT3 receptor|5-HT<sub>3</sub> receptor]] being a notable exception as a [[ligand-gated ion channel]].<ref name="MartinScahill2010" />
+A '''monoamine receptor''' is a [[receptor (biochemistry)|receptor]] for the [[monoamine neurotransmitter]]s and/or [[trace amine]]s, [[endogenous]] [[small-molecule]] [[signaling molecule]]s with a [[monoamine]] [[chemical structure|structure]]. The monoamine receptors are almost all [[G protein-coupled receptor]]s, with the [[serotonin]] [[5-HT3 receptor|5-HT<sub>3</sub> receptor]] being a notable exception as a [[ligand-gated ion channel]].<ref name="MartinScahill2010" /> Monoamine receptors are the [[biological target]]s of many [[drug]]s; such drugs may be referred to as "[[monoaminergic]]".
-Monoamine receptors include the following:
+==List of receptors==
+Monoamine receptors include the following classes:
 * [[Adrenergic receptor]]s – bound by [[epinephrine]] (adrenaline) and [[norepinephrine]] (noradrenaline)
 * [[Dopamine receptor]]s – bound by [[dopamine]]
+* [[Histamine receptor]]s – bound by [[histamine]]
 * [[Melatonin receptor]]s – bound by [[melatonin]]
 * [[Serotonin receptor]]s – bound by [[serotonin]] (5-HT)
-* [[Trace amine-associated receptor]]s – bound by monoamine neurotransmitters, [[trace amine]]s, and [[thyronamine]]s
+* [[Trace amine-associated receptor]]s – bound by [[trace amine]]s, [[thyronamine]]s, [[monoamine neurotransmitter]]s ([[TAAR1]] only), and [[trimethylamine]] ([[TAAR5]] only)
-Monoamine receptors are the [[biological target]]s of many [[drug]]s.
-[[Histamine]] is a [[diamine]] and hence the [[histamine receptor]]s are not technically monoamine receptors, although the monoamine and histamine receptors may be appropriately grouped together as [[biogenic amine receptor]]s.
 ==References==
 {{Reflist}}
 {{Transmembrane receptors}}
 {{G protein-coupled receptors}}
 {{Navboxes
-| title = Monoaminergics
+| title = Monoamine receptor modulators
 | list1 =
 {{Adrenergic receptor modulators}}