GUCY1B3: Difference between revisions

GUCY1B1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2WZ1, 3UVJ, 4NI2
Identifiers
Aliases	GUCY1B1, guanylate cyclase 1, soluble, beta 3, GUCSB3, guanylate cyclase 1 soluble subunit beta, GC-SB3, GUC1B3, GC-S-beta-1, guanylate cyclase 1 soluble subunit beta 1, GUCB3, GUCY1B3
External IDs	OMIM: 139397; MGI: 1860604; HomoloGene: 664; GeneCards: GUCY1B1; OMA:GUCY1B1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	155,807,811 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	81,981,996 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; Brodmann area 46; ; postcentral gyrus; ; Brodmann area 23; ; pars compacta; ; Pons; ; entorhinal cortex;
	Top expressed in
	olfactory tubercle; ; habenula; ; lateral septal nucleus; ; anterior amygdaloid area; ; globus pallidus; ; left lung lobe; ; ventromedial nucleus; ; dorsomedial hypothalamic nucleus; ; dorsal tegmental nucleus; ; mammillary body;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; guanylate cyclase activity; GTP binding; metal ion binding; protein binding; heme binding; lyase activity; phosphorus-oxygen lyase activity; signaling receptor activity; adenylate cyclase activity;
Cellular component	plasma membrane; guanylate cyclase complex, soluble; cytoplasm; presynaptic active zone;
Biological process	intracellular signal transduction; cyclic nucleotide biosynthetic process; blood circulation; nitric oxide-cGMP-mediated signaling pathway; cGMP biosynthetic process; nitric oxide mediated signal transduction; cellular response to nitric oxide; cGMP-mediated signaling; trans-synaptic signaling by nitric oxide, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	2983
	54195
	ENSG00000061918
	ENSMUSG00000028005
	Q02153
	O54865
NM_000857; NM_001291951; NM_001291952; NM_001291953; NM_001291954;
	NM_001291955
	NM_001161796; NM_017469
NP_000848; NP_001278880; NP_001278881; NP_001278882; NP_001278883;
	NP_001278884
	NP_001155268; NP_059497
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 09:24, 8 November 2023

Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.^[5]^[6]

Function

Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.^[6]

Interactions

GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1^[7] and Endothelial NOS.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000061918 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028005 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.
^ ^a ^b "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".
^ ^a ^b Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.

Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA (2000). "Guanylyl cyclases and signaling by cyclic GMP". Pharmacol. Rev. 52 (3): 375–414. PMID 10977868.
Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE (1991). "Heterogeneity in human soluble guanylate cyclase due to alternative splicing". FEBS Lett. 290 (1–2): 157–8. doi:10.1016/0014-5793(91)81248-7. PMID 1680753. S2CID 35130409.
Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G (1993). "Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33". Hum. Genet. 91 (3): 257–60. doi:10.1007/BF00218267. PMID 8097486. S2CID 24237232.
Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD (1996). "cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue". J. Cell. Physiol. 167 (2): 213–21. doi:10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S. PMID 8613461. S2CID 25406282.
Zabel U, Weeger M, La M, Schmidt HH (1998). "Human soluble guanylate cyclase: functional expression and revised isoenzyme family". Biochem. J. 335 (1): 51–7. doi:10.1042/bj3350051. PMC 1219751. PMID 9742212.
Russwurm M, Wittau N, Koesling D (2002). "Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes". J. Biol. Chem. 276 (48): 44647–52. doi:10.1074/jbc.M105587200. PMID 11572861.
Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.
Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–54. doi:10.1074/jbc.M410565200. PMID 15381706.
Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ (2006). "Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction". Int. J. Impot. Res. 18 (5): 432–7. doi:10.1038/sj.ijir.3901461. PMID 16528291.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000061918 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028005 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1352257-5] Giuili G, Scholl U, Bulle F, Guellaën G (Jul 1992). "Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain". FEBS Lett. 304 (1): 83–8. doi:10.1016/0014-5793(92)80594-7. PMID 1352257. S2CID 26032197.

[entrez-6] "Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3".

[pmid12676772-7] Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD (Aug 2003). "Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase". Am. J. Physiol. Heart Circ. Physiol. 285 (2): H669–78. doi:10.1152/ajpheart.01025.2002. PMID 12676772.

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[2]

[3]

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[6]

[7]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=2983}}
+{{Infobox_gene}}
-'''Guanylate cyclase soluble subunit beta-1''' is an [[enzyme]] that in humans is encoded by the ''GUCY1B3'' [[gene]].<ref name="pmid1352257">{{cite journal | author = Giuili G, Scholl U, Bulle F, Guellaen G | title = Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain | journal = FEBS Lett | volume = 304 | issue = 1 | pages = 83–8 | year = 1992 | month = Jul | pmid = 1352257 | pmc =  | doi =10.1016/0014-5793(92)80594-7  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983| accessdate = }}</ref>
+'''Guanylate cyclase soluble subunit beta-1''' is an [[enzyme]] that in humans is encoded by the ''GUCY1B3'' [[gene]].<ref name="pmid1352257">{{cite journal |vauthors=Giuili G, Scholl U, Bulle F, Guellaën G | title = Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain | journal = FEBS Lett | volume = 304 | issue = 1 | pages = 83–8 | date = Jul 1992 | pmid = 1352257 | doi = 10.1016/0014-5793(92)80594-7 | s2cid = 26032197 | doi-access = free }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GUCY1B3 guanylate cyclase 1, soluble, beta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2983}}</ref>
+== Function ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs (Zabel et al., 1998).[supplied by OMIM]<ref name="entrez" />
-}}
+[[Soluble guanylate cyclase]] (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of [[guanosine triphosphate|GTP]] to the second messenger [[cyclic guanosine monophosphate|cGMP]] and functions as the main receptor for [[nitric oxide]] and [[nitrovasodilator]] drugs.<ref name="entrez" />
-==Interactions==
-GUCY1B3 has been shown to [[Protein-protein_interaction|interact]] with [[Heat shock protein 90kDa alpha (cytosolic), member A1]]<ref name=pmid12676772>{{cite journal |last=Venema |first=Richard C |authorlink= |coauthors=Venema Virginia J, Ju Hong, Harris M Brennan, Snead Connie, Jilling Tamas, Dimitropoulou Christiana, Maragoudakis Michael E, Catravas John D |year=2003|month=Aug. |title=Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue=2 |pages=H669–78 |publisher= |location = United States| issn = 0363-6135| pmid = 12676772 |doi = 10.1152/ajpheart.01025.2002 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[Endothelial NOS]].<ref name=pmid12676772/>
-==References==
+== Interactions ==
+GUCY1B3 has been shown to [[Protein-protein interaction|interact]] with [[Heat shock protein 90kDa alpha (cytosolic), member A1]]<ref name=pmid12676772>{{cite journal |vauthors=Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD | title = Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase  | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 285 | issue = 2 | pages = H669–78 | date = Aug 2003 | pmid = 12676772 | doi = 10.1152/ajpheart.01025.2002 }}</ref> and [[Endothelial NOS]].<ref name=pmid12676772/>
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+*{{cite journal |vauthors=Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA | title = Guanylyl cyclases and signaling by cyclic GMP | journal = Pharmacol. Rev. | volume = 52 | issue = 3 | pages = 375–414 | year = 2000 | pmid = 10977868 }}
-{{PBB_Further_reading
+*{{cite journal |vauthors=Chhajlani V, Frändberg PA, Ahlner J, Axelsson KL, Wikberg JE | title = Heterogeneity in human soluble guanylate cyclase due to alternative splicing | journal = FEBS Lett. | volume = 290 | issue = 1–2 | pages = 157–8 | year = 1991 | pmid = 1680753 | doi = 10.1016/0014-5793(91)81248-7 | s2cid = 35130409 | doi-access = free }}
-| citations =
-*{{cite journal  | author=Lucas KA, Pitari GM, Kazerounian S, ''et al.'' |title=Guanylyl cyclases and signaling by cyclic GMP |journal=Pharmacol. Rev. |volume=52 |issue= 3 |pages= 375–414 |year= 2000 |pmid= 10977868 |doi=  }}
+*{{cite journal |vauthors=Giuili G, Roechel N, Scholl U, Mattei MG, Guellaen G | title = Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33 | journal = Hum. Genet. | volume = 91 | issue = 3 | pages = 257–60 | year = 1993 | pmid = 8097486 | doi = 10.1007/BF00218267 | s2cid = 24237232 }}
-*{{cite journal  | author=Chhajlani V, Frändberg PA, Ahlner J, ''et al.'' |title=Heterogeneity in human soluble guanylate cyclase due to alternative splicing |journal=FEBS Lett. |volume=290 |issue= 1–2 |pages= 157–8 |year= 1991 |pmid= 1680753 |doi=10.1016/0014-5793(91)81248-7  }}
+*{{cite journal |vauthors=Papapetropoulos A, Cziraki A, Rubin JW, Stone CD, Catravas JD | title = cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue | journal = J. Cell. Physiol. | volume = 167 | issue = 2 | pages = 213–21 | year = 1996 | pmid = 8613461 | doi = 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S | s2cid = 25406282 | doi-access = free }}
-*{{cite journal  | author=Giuili G, Roechel N, Scholl U, ''et al.'' |title=Colocalization of the genes coding for the alpha 3 and beta 3 subunits of soluble guanylyl cyclase to human chromosome 4 at q31.3-q33 |journal=Hum. Genet. |volume=91 |issue= 3 |pages= 257–60 |year= 1993 |pmid= 8097486 |doi=10.1007/BF00218267  }}
+*{{cite journal |vauthors=Zabel U, Weeger M, La M, Schmidt HH | title = Human soluble guanylate cyclase: functional expression and revised isoenzyme family | journal = Biochem. J. | volume = 335 | issue = 1 | pages = 51–7 | year = 1998 | pmid = 9742212 | pmc = 1219751 | doi =  10.1042/bj3350051}}
-*{{cite journal  | author=Papapetropoulos A, Cziraki A, Rubin JW, ''et al.'' |title=cGMP accumulation and gene expression of soluble guanylate cyclase in human vascular tissue |journal=J. Cell. Physiol. |volume=167 |issue= 2 |pages= 213–21 |year= 1996 |pmid= 8613461 |doi= 10.1002/(SICI)1097-4652(199605)167:2<213::AID-JCP4>3.0.CO;2-S }}
+*{{cite journal |vauthors=Russwurm M, Wittau N, Koesling D | title = Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes | journal = J. Biol. Chem. | volume = 276 | issue = 48 | pages = 44647–52 | year = 2002 | pmid = 11572861 | doi = 10.1074/jbc.M105587200 | doi-access = free }}
-*{{cite journal  | author=Zabel U, Weeger M, La M, Schmidt HH |title=Human soluble guanylate cyclase: functional expression and revised isoenzyme family |journal=Biochem. J. |volume=335 |issue=  1|pages= 51–7 |year= 1998 |pmid= 9742212 |doi=  | pmc=1219751  }}
+*{{cite journal |vauthors=Venema RC, Venema VJ, Ju H, Harris MB, Snead C, Jilling T, Dimitropoulou C, Maragoudakis ME, Catravas JD | title = Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase | journal = Am. J. Physiol. Heart Circ. Physiol. | volume = 285 | issue = 2 | pages = H669–78 | year = 2003 | pmid = 12676772 | doi = 10.1152/ajpheart.01025.2002 }}
-*{{cite journal  | author=Russwurm M, Wittau N, Koesling D |title=Guanylyl cyclase/PSD-95 interaction: targeting of the nitric oxide-sensitive alpha2beta1 guanylyl cyclase to synaptic membranes |journal=J. Biol. Chem. |volume=276 |issue= 48 |pages= 44647–52 |year= 2002 |pmid= 11572861 |doi= 10.1074/jbc.M105587200 }}
+*{{cite journal |vauthors=Meurer S, Pioch S, Wagner K, Müller-Esterl W, Gross S | title = AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase | journal = J. Biol. Chem. | volume = 279 | issue = 47 | pages = 49346–54 | year = 2005 | pmid = 15381706 | doi = 10.1074/jbc.M410565200 | doi-access = free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
+*{{cite journal |vauthors=Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, Zamorano-León JJ, Sacristán D, de Prada TP, Calahorra J, Macaya C, Vela-Navarrete R, López-Farré AJ | title = Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction | journal = Int. J. Impot. Res. | volume = 18 | issue = 5 | pages = 432–7 | year = 2006 | pmid = 16528291 | doi = 10.1038/sj.ijir.3901461 | doi-access = free }}
-*{{cite journal  | author=Venema RC, Venema VJ, Ju H, ''et al.'' |title=Novel complexes of guanylate cyclase with heat shock protein 90 and nitric oxide synthase |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=285 |issue= 2 |pages= H669–78 |year= 2003 |pmid= 12676772 |doi= 10.1152/ajpheart.01025.2002 }}
-*{{cite journal  | author=Meurer S, Pioch S, Wagner K, ''et al.'' |title=AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase |journal=J. Biol. Chem. |volume=279 |issue= 47 |pages= 49346–54 |year= 2005 |pmid= 15381706 |doi= 10.1074/jbc.M410565200 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Mateos-Cáceres PJ, Garcia-Cardoso J, Lapuente L, ''et al.'' |title=Soluble guanylate cyclase beta1-subunit expression is increased in mononuclear cells from patients with erectile dysfunction |journal=Int. J. Impot. Res. |volume=18 |issue= 5 |pages= 432–7 |year= 2006 |pmid= 16528291 |doi= 10.1038/sj.ijir.3901461 }}
-}}
 {{refend}}
-{{gene-4-stub}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-{{PBB_Controls
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-| require_manual_inspection = no
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 {{Phosphorus-oxygen lyases}}
+{{Enzymes}}
+{{Portal bar|Biology|border=no}}
+[[Category:EC 4.6.1]]
+{{gene-4-stub}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)