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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{Infobox_gene}}
{{Infobox_gene}}
The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal |vauthors=Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Res | volume = 57 | issue = 18 | pages = 4063–9 |date=Oct 1997 | pmid = 9307294 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539| accessdate = }}</ref>
The human [[gene]] '''API5''' encodes the [[protein]] '''Apoptosis inhibitor 5'''.<ref name="pmid9307294">{{cite journal | vauthors = Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R | title = AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal | journal = Cancer Research | volume = 57 | issue = 18 | pages = 4063–9 | date = September 1997 | pmid = 9307294 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: API5 apoptosis inhibitor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8539}}</ref>


This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction.
This gene encodes an [[apoptosis]] inhibitory protein whose expression prevents apoptosis after [[growth factor]] deprivation. This protein suppresses the [[transcription factor]] [[E2F1]]-induced apoptosis and also interacts with, and negatively regulates acinus, a [[Cell nucleus|nuclear]] factor involved in apoptotic [[DNA]] fragmentation. Its depletion enhances the [[Cytotoxicity|cytotoxic]] action of [[Chemotherapy|chemotherapeutic]] drugs. Crystal structure of API5 exhibited the function for protein-protein interaction <ref>{{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = The Journal of Biological Chemistry | volume = 287 | issue = 14 | pages = 10727–37 | date = March 2012 | pmid = 22334682 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | doi-access = free }}</ref>


Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].
Diseases associated with API5 include colon [[adenocarcinoma]], and [[cervical cancer]].


API5 functions in nuclear export of mRNA.<ref>{{cite journal | vauthors = Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI | title = Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction. | journal = Nucleic Acids Res. | doi = 10.1093/nar/gkaa335 | pmid= 32383752 | year=2020| doi-access = free | volume = 48 | issue = 11 | pmc = 7293033 | pages = 6340–6352 }} </ref>
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== References==
<ref>{{cite journal|last1=Han|first1=BG|title=Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules|journal=J. Biol. Chem.|volume=287|page=10727|doi=10.1074/jbc.M111.317594.|pmid=22334682}}</ref>==References==
{{reflist}}
{{reflist}}


⚫
== Further reading ==
==External links==
* {{UCSC gene info|API5}}

⚫
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Gianfrancesco F, Esposito T, Ciccodicola A, D'Esposito M, Mazzarella R, D'Urso M, Forabosco A | title = Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene | journal = Cytogenetics and Cell Genetics | volume = 84 | issue = 3–4 | pages = 164–6 | year = 1999 | pmid = 10393420 | doi = 10.1159/000015247 | s2cid = 44601647 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Kim JW, Cho HS, Kim JH, Hur SY, Kim TE, Lee JM, Kim IK, Namkoong SE | title = AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis | journal = Laboratory Investigation; A Journal of Technical Methods and Pathology | volume = 80 | issue = 4 | pages = 587–94 | date = April 2000 | pmid = 10780674 | doi = 10.1038/labinvest.3780008 | doi-access = free }}
| citations =
*{{cite journal |vauthors=Gianfrancesco F, Esposito T, Ciccodicola A |title=Molecular cloning and fine mapping of API5L1, a novel human gene strongly related to an antiapoptotic gene. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 3-4 |pages= 164–6 |year= 1999 |pmid= 10393420 |doi=10.1159/000015247 |display-authors=etal}}
* {{cite journal | vauthors = Van den Berghe L, Laurell H, Huez I, Zanibellato C, Prats H, Bugler B | title = FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2 | journal = Molecular Endocrinology | volume = 14 | issue = 11 | pages = 1709–24 | date = November 2000 | pmid = 11075807 | doi = 10.1210/me.14.11.1709 | doi-access = free }}
*{{cite journal |vauthors=Kim JW, Cho HS, Kim JH |title=AAC-11 overexpression induces invasion and protects cervical cancer cells from apoptosis. |journal=Lab. Invest. |volume=80 |issue= 4 |pages= 587–94 |year= 2000 |pmid= 10780674 |doi=10.1038/labinvest.3780008 |display-authors=etal}}
* {{cite journal | vauthors = Sutherland HG, Mumford GK, Newton K, Ford LV, Farrall R, Dellaire G, Cáceres JF, Bickmore WA | title = Large-scale identification of mammalian proteins localized to nuclear sub-compartments | journal = Human Molecular Genetics | volume = 10 | issue = 18 | pages = 1995–2011 | date = September 2001 | pmid = 11555636 | doi = 10.1093/hmg/10.18.1995 | doi-access = free }}
*{{cite journal |vauthors=Van den Berghe L, Laurell H, Huez I |title=FIF [fibroblast growth factor-2 (FGF-2)-interacting-factor], a nuclear putatively antiapoptotic factor, interacts specifically with FGF-2. |journal=Mol. Endocrinol. |volume=14 |issue= 11 |pages= 1709–24 |year= 2001 |pmid= 11075807 |doi=10.1210/me.14.11.1709 |display-authors=etal}}
* {{cite journal | vauthors = Li Z, Hu CY, Mo BQ, Xu JD, Zhao Y | title = [Effect of beta-carotene on gene expression of breast cancer cells] | journal = AI Zheng = Aizheng = Chinese Journal of Cancer | volume = 22 | issue = 4 | pages = 380–4 | date = April 2003 | pmid = 12703993 }}
*{{cite journal |vauthors=Sutherland HG, Mumford GK, Newton K |title=Large-scale identification of mammalian proteins localized to nuclear sub-compartments. |journal=Hum. Mol. Genet. |volume=10 |issue= 18 |pages= 1995–2011 |year= 2001 |pmid= 11555636 |doi=10.1093/hmg/10.18.1995 |display-authors=etal}}
* {{cite journal | vauthors = Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M | title = Nucleolar proteome dynamics | journal = Nature | volume = 433 | issue = 7021 | pages = 77–83 | date = January 2005 | pmid = 15635413 | doi = 10.1038/nature03207 | bibcode = 2005Natur.433...77A | s2cid = 4344740 }}
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
* {{cite journal | vauthors = Kim JE, Tannenbaum SR, White FM | title = Global phosphoproteome of HT-29 human colon adenocarcinoma cells | journal = Journal of Proteome Research | volume = 4 | issue = 4 | pages = 1339–46 | year = 2005 | pmid = 16083285 | doi = 10.1021/pr050048h }}
*{{cite journal |vauthors=Li Z, Hu CY, Mo BQ |title=[Effect of beta-carotene on gene expression of breast cancer cells] |journal=Ai Zheng |volume=22 |issue= 4 |pages= 380–4 |year= 2003 |pmid= 12703993 |doi= |display-authors=etal}}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 | s2cid = 7827573 | doi-access = free }}
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
* {{cite journal | vauthors = Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ | title = Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo | journal = PLOS Genetics | volume = 2 | issue = 11 | pages = e196 | date = November 2006 | pmid = 17112319 | pmc = 1636698 | doi = 10.1371/journal.pgen.0020196 | doi-access = free }} {{open access}}
*{{cite journal |vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
* {{cite journal | vauthors = Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI | title = Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules | journal = J Biol Chem | volume = 287 | pages = 10727–37 | doi = 10.1074/jbc.M111.317594 | pmc = 3322819 | pmid=22334682 | year=2012| issue = 14 | doi-access = free }}
*{{cite journal |vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
* {{cite journal | vauthors = Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI | title = Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction. | journal = Nucleic Acids Res. | doi = 10.1093/nar/gkaa335 | pmid= 32383752 | year=2020| doi-access = free | volume = 48 | issue = 11 | pmc = 7293033 | pages = 6340–6352 }}
*{{cite journal |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal |vauthors=Morris EJ, Michaud WA, Ji JY |title=Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. |journal=PLoS Genet. |volume=2 |issue= 11 |pages= e196 |year= 2006 |pmid= 17112319 |doi= 10.1371/journal.pgen.0020196 | pmc=1636698 |display-authors=etal}} {{open access}}
}}
{{refend}}
{{refend}}

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{{gene-11-stub}}

Latest revision as of 03:07, 1 December 2023

API5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAPI5, AAC-11, AAC11, apoptosis inhibitor 5
External IDsOMIM: 609774; MGI: 1888993; HomoloGene: 4809; GeneCards: API5; OMA:API5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

8539

11800

Ensembl

ENSG00000166181

ENSMUSG00000027193

UniProt

Q9BZZ5

O35841

RefSeq (mRNA)

NM_001142930
NM_001142931
NM_001243747
NM_006595

NM_007466
NM_001305258
NM_001349003

RefSeq (protein)

NP_001136402
NP_001136403
NP_001230676
NP_006586

NP_001292187
NP_031492
NP_001335932

Location (UCSC)Chr 11: 43.31 – 43.34 MbChr 2: 94.24 – 94.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The human gene API5 encodes the protein Apoptosis inhibitor 5.[5][6]

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs. Crystal structure of API5 exhibited the function for protein-protein interaction [7]

Diseases associated with API5 include colon adenocarcinoma, and cervical cancer.

API5 functions in nuclear export of mRNA.[8]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166181 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027193 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tewari M, Yu M, Ross B, Dean C, Giordano A, Rubin R (September 1997). "AAC-11, a novel cDNA that inhibits apoptosis after growth factor withdrawal". Cancer Research. 57 (18): 4063–9. PMID 9307294.
  6. ^ "Entrez Gene: API5 apoptosis inhibitor 5".
  7. ^ Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI (March 2012). "Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules". The Journal of Biological Chemistry. 287 (14): 10727–37. doi:10.1074/jbc.M111.317594. PMC 3322819. PMID 22334682.
  8. ^ Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI (2020). "Regulation of mRNA Export Through API5 and Nuclear FGF2 Interaction". Nucleic Acids Res. 48 (11): 6340–6352. doi:10.1093/nar/gkaa335. PMC 7293033. PMID 32383752.

Further reading

[edit]
Retrieved from "https://en.wikipedia.org/enwiki/w/index.php?title=API5&oldid=1187738092"