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{{Short description|Protein-coding gene in humans}}
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'''T-lymphocyte surface antigen Ly-9''' is a [[protein]] that in humans is encoded by the ''LY9'' [[gene]].<ref name="pmid8537117">{{cite journal | author = Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF | title = Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9 | journal = Immunogenetics | volume = 43 | issue = 1–2 | pages = 13–9 |date=Feb 1996 | pmid = 8537117 | pmc = | doi = 10.1007/bf00186599}}</ref><ref name="pmid7797269">{{cite journal | author = Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF | title = Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1 | journal = Immunogenetics | volume = 42 | issue = 1 | pages = 59–62 |date=Aug 1995 | pmid = 7797269 | pmc = | doi =10.1007/BF00164988 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LY9 lymphocyte antigen 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4063| accessdate = }}</ref> LY9 has also recently been designated '''CD229''' ([[cluster of differentiation]] 229).
{{Infobox_gene}}
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'''T-lymphocyte surface antigen Ly-9''' is a [[protein]] that in humans is encoded by the ''LY9'' [[gene]].<ref name="pmid8537117">{{cite journal | vauthors = Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF |authorlink5=Grant Robert Sutherland | title = Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9 | journal = Immunogenetics | volume = 43 | issue = 1–2 | pages = 13–9 | date = Feb 1996 | pmid = 8537117 | doi = 10.1007/bf00186599 | s2cid = 10045488 }}</ref><ref name="pmid7797269">{{cite journal | vauthors = Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF | title = Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1 | journal = Immunogenetics | volume = 42 | issue = 1 | pages = 59–62 | date = Aug 1995 | pmid = 7797269 | doi = 10.1007/BF00164988 | s2cid = 28529549 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LY9 lymphocyte antigen 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4063}}</ref> LY9 has also recently been designated '''CD229''' ([[cluster of differentiation]] 229).


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== Interactions ==
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LY9 has been shown to [[Protein-protein interaction|interact]] with [[SH2D1A]].<ref name=pmid11389028>{{cite journal | vauthors = Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C | title = Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP | journal = Blood | volume = 97 | issue = 12 | pages = 3867–3874 | date = Jun 2001 | pmid = 11389028 | doi = 10.1182/blood.V97.12.3867 | doi-access = free }}</ref><ref name=pmid11477068>{{cite journal | vauthors = Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C | title = Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36809–36816 | date = Sep 2001 | pmid = 11477068 | doi = 10.1074/jbc.M101305200 | s2cid = 39889619 | url = https://dea.lib.unideb.hu/dea/bitstream/2437/230556/1/file_up_Lanyi%20J.%20Biol.%20Chem.pdf | doi-access = free }}</ref>
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==Interactions==
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LY9 has been shown to [[Protein-protein interaction|interact]] with [[SH2D1A]].<ref name=pmid11389028>{{cite journal |last=Sayós |first=J |authorlink= |author2=Martín M |author3=Chen A |author4=Simarro M |author5=Howie D |author6=Morra M |author7=Engel P |author8=Terhorst C |date=Jun 2001 |title=Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP |journal=Blood |volume=97 |issue=12 |pages=3867–3874 |publisher= |location = United States| issn = 0006-4971| pmid = 11389028 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1182/blood.V97.12.3867 }}</ref><ref name=pmid11477068>{{cite journal |last=Morra |first=M |authorlink= |coauthors=Simarro-Grande M, Martin M, Chen A S, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck M J, Sumegi J, Engel P, Li S C, Terhorst C |date=Sep 2001 |title=Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients |journal=J. Biol. Chem. |volume=276 |issue=39 |pages=36809–36816 |publisher= |location = United States| issn = 0021-9258| pmid = 11477068 |doi = 10.1074/jbc.M101305200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
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* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–113 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
| citations =
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* {{cite journal | vauthors = Tovar V, de la Fuente MA, Pizcueta P, Bosch J, Engel P | title = Gene structure of the mouse leukocyte cell surface molecule Ly9 | journal = Immunogenetics | volume = 51 | issue = 10 | pages = 788–793 | year = 2000 | pmid = 10970093 | doi = 10.1007/s002510000209 | s2cid = 23932012 }}
⚫
*{{cite journal | author=Andersson B |title=A "double adaptor" method for improved shotgun library construction |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–113 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 | author-separator=, | author2=Wentland MA | author3=Ricafrente JY | display-authors=3 | last4=Liu | first4=W | last5=Gibbs | first5=RA }}
* {{cite journal | vauthors = de la Fuente MA, Tovar V, Villamor N, Zapater N, Pizcueta P, Campo E, Bosch J, Engel P | title = Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9 | journal = Blood | volume = 97 | issue = 11 | pages = 3513–3520 | year = 2001 | pmid = 11369645 | doi = 10.1182/blood.V97.11.3513 | doi-access = free }}
*{{cite journal | author=Yu W |title=Large-scale concatenation cDNA sequencing |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi= 10.1101/gr.7.4.353| pmc=139146 | author-separator=, | author2=Andersson B | author3=Worley KC | display-authors=3 | last4=Muzny | first4=DM | last5=Ding | first5=Y | last6=Liu | first6=W | last7=Ricafrente | first7=JY | last8=Wentland | first8=MA | last9=Lennon | first9=G }}
⚫
* {{cite journal | vauthors = Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C | title = Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP | journal = Blood | volume = 97 | issue = 12 | pages = 3867–3874 | year = 2001 | pmid = 11389028 | doi = 10.1182/blood.V97.12.3867 | doi-access = free }}
⚫
*{{cite journal | author=Tovar V |title=Gene structure of the mouse leukocyte cell surface molecule Ly9 |journal=Immunogenetics |volume=51 |issue= 10 |pages= 788–793 |year= 2000 |pmid= 10970093 |doi=10.1007/s002510000209 | author-separator=, | author2=de la Fuente MA | author3=Pizcueta P | display-authors=3 | last4=Bosch | first4=Jaime | last5=Engel | first5=Pablo }}
*{{cite journal | author=de la Fuente MA |title=Molecular characterization and expression of a novel human leukocyte cell-surface marker homologous to mouse Ly-9 |journal=Blood |volume=97 |issue= 11 |pages= 3513–3520 |year= 2001 |pmid= 11369645 |doi=10.1182/blood.V97.11.3513 | author-separator=, }}
* {{cite journal | vauthors = Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C | title = Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36809–36816 | year = 2001 | pmid = 11477068 | doi = 10.1074/jbc.M101305200 | doi-access = free | hdl = 2437/230556 | hdl-access = free }}
* {{cite journal | vauthors = Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C | title = Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells | journal = EMBO J. | volume = 20 | issue = 21 | pages = 5840–5852 | year = 2001 | pmid = 11689425 | pmc = 125701 | doi = 10.1093/emboj/20.21.5840 }}
⚫
*{{cite journal | author=Sayós J |title=Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP |journal=Blood |volume=97 |issue= 12 |pages= 3867–3874 |year= 2001 |pmid= 11389028 |doi=10.1182/blood.V97.12.3867 | author-separator=, | author2=Martín M | author3=Chen A | display-authors=3 | last4=Simarro | first4=M | last5=Howie | first5=D | last6=Morra | first6=M | last7=Engel | first7=P | last8=Terhorst | first8=C }}
⚫
* {{cite journal | vauthors = Tovar V, del Valle J, Zapater N, Martin M, Romero X, Pizcueta P, Bosch J, Terhorst C, Engel P | title = Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors | journal = Immunogenetics | volume = 54 | issue = 6 | pages = 394–402 | year = 2002 | pmid = 12242590 | doi = 10.1007/s00251-002-0483-3 | s2cid = 38277782 }}
*{{cite journal | author=Morra M |title=Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients |journal=J. Biol. Chem. |volume=276 |issue= 39 |pages= 36809–36816 |year= 2001 |pmid= 11477068 |doi= 10.1074/jbc.M101305200 | author-separator=, | author2=Simarro-Grande M | author3=Martin M | display-authors=3 | last4=Chen | first4=AS | last5=Lanyi | first5=A | last6=Silander | first6=O | last7=Calpe | first7=S | last8=Davis | first8=J | last9=Pawson | first9=T }}
⚫
* {{cite journal | vauthors = Del Valle JM, Engel P, Martín M | title = The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 17430–17437 | year = 2003 | pmid = 12621057 | doi = 10.1074/jbc.M301569200 | doi-access = free}}
*{{cite journal | author=Morra M |title=Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells |journal=EMBO J. |volume=20 |issue= 21 |pages= 5840–5852 |year= 2001 |pmid= 11689425 |doi= 10.1093/emboj/20.21.5840 | pmc=125701 | author-separator=, | author2=Lu J | author3=Poy F | display-authors=3 | last4=Martin | first4=M | last5=Sayos | first5=J | last6=Calpe | first6=S | last7=Gullo | first7=C | last8=Howie | first8=D | last9=Rietdijk | first9=S }}
⚫
* {{cite journal | vauthors = Martín M, Del Valle JM, Saborit I, Engel P | title = Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229 | journal = J. Immunol. | volume = 174 | issue = 10 | pages = 5977–86 | year = 2005 | pmid = 15879090 | doi = 10.4049/jimmunol.174.10.5977 | doi-access = free }}
⚫
*{{cite journal | author=Tovar V |title=Mouse novel Ly9: a new member of the expanding CD150 (SLAM) family of leukocyte cell-surface receptors |journal=Immunogenetics |volume=54 |issue= 6 |pages= 394–402 |year= 2002 |pmid= 12242590 |doi= 10.1007/s00251-002-0483-3 | author-separator=, | author2=del Valle J | author3=Zapater N | display-authors=3 | last4=Martin | first4=Margarita | last5=Romero | first5=Xavier | last6=Pizcueta | first6=Pilar | last7=Bosch | first7=Jaime | last8=Terhorst | first8=Cox | last9=Engel | first9=Pablo }}
⚫
* {{cite journal | vauthors = Romero X, Zapater N, Calvo M, Kalko SG, de la Fuente MA, Tovar V, Ockeloen C, Pizcueta P, Engel P | title = CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse | journal = J. Immunol. | volume = 174 | issue = 11 | pages = 7033–42 | year = 2005 | pmid = 15905546 | doi = 10.4049/jimmunol.174.11.7033 | doi-access = free }}
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 | author-separator=, | author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}
⚫
*{{cite journal | author=Del Valle JM, Engel P, Martín M |title=The cell surface expression of SAP-binding receptor CD229 is regulated via its interaction with clathrin-associated adaptor complex 2 (AP-2) |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 17430–17437 |year= 2003 |pmid= 12621057 |doi= 10.1074/jbc.M301569200 }}
⚫
*{{cite journal | author=Martín M, Del Valle JM, Saborit I, Engel P |title=Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229 |journal=J. Immunol. |volume=174 |issue= 10 |pages= 5977–86 |year= 2005 |pmid= 15879090 |doi= 10.4049/jimmunol.174.10.5977}}
⚫
*{{cite journal | author=Romero X |title=CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse |journal=J. Immunol. |volume=174 |issue= 11 |pages= 7033–42 |year= 2005 |pmid= 15905546 |doi= 10.4049/jimmunol.174.11.7033| author-separator=, | author2=Zapater N | author3=Calvo M | display-authors=3 | last4=Kalko | first4=SG | last5=De La Fuente | first5=MA | last6=Tovar | first6=V | last7=Ockeloen | first7=C | last8=Pizcueta | first8=P | last9=Engel | first9=P }}
*{{cite journal | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–321 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 | author-separator=, | author2=Barlow KF | author3=McLay KE | display-authors=3 | last4=Kaul | first4=R. | last5=Swarbreck | first5=D. | last6=Dunham | first6=A. | last7=Scott | first7=C. E. | last8=Howe | first8=K. L. | last9=Woodfine | first9=K. }}
}}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|LY9+protein,+human}}
* {{MeshName|LY9+protein,+human}}


{{NLM content}}
{{NLM content}}
{{Clusters of differentiation}}
{{Clusters of differentiation}}
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[[Category:Clusters of differentiation]]
[[Category:Clusters of differentiation]]

Latest revision as of 04:08, 4 January 2024

LY9
Identifiers
AliasesLY9, CD229, SLAMF3, hly9, mlymphocyte antigen 9
External IDsOMIM: 600684; MGI: 96885; HomoloGene: 1759; GeneCards: LY9; OMA:LY9 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

4063

17085

Ensembl

ENSG00000122224

ENSMUSG00000004707

UniProt

Q9HBG7
Q5VYI1

Q01965

RefSeq (mRNA)

NM_001033667
NM_001261456
NM_001261457
NM_002348

NM_001277968
NM_008534

RefSeq (protein)

NP_001028839
NP_001248385
NP_001248386
NP_002339

NP_001264897
NP_032560

Location (UCSC)Chr 1: 160.8 – 160.83 MbChr 1: 171.42 – 171.43 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.[5][6][7] LY9 has also recently been designated CD229 (cluster of differentiation 229).

Interactions

[edit]

LY9 has been shown to interact with SH2D1A.[8][9]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000122224 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004707 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sandrin MS, Henning MM, Lo MF, Baker E, Sutherland GR, McKenzie IF (Feb 1996). "Isolation and characterization of cDNA clones for Humly9: the human homologue of mouse Ly9". Immunogenetics. 43 (1–2): 13–9. doi:10.1007/bf00186599. PMID 8537117. S2CID 10045488.
  6. ^ Kingsmore SF, Souryal CA, Watson ML, Patel DD, Seldin MF (Aug 1995). "Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1". Immunogenetics. 42 (1): 59–62. doi:10.1007/BF00164988. PMID 7797269. S2CID 28529549.
  7. ^ "Entrez Gene: LY9 lymphocyte antigen 9".
  8. ^ Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP". Blood. 97 (12): 3867–3874. doi:10.1182/blood.V97.12.3867. PMID 11389028.
  9. ^ Morra M, Simarro-Grande M, Martin M, Chen AS, Lanyi A, Silander O, Calpe S, Davis J, Pawson T, Eck MJ, Sumegi J, Engel P, Li SC, Terhorst C (Sep 2001). "Characterization of SH2D1A missense mutations identified in X-linked lymphoproliferative disease patients" (PDF). J. Biol. Chem. 276 (39): 36809–36816. doi:10.1074/jbc.M101305200. PMID 11477068. S2CID 39889619.

Further reading

[edit]
[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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