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Coordinates: 43°14′34″N 79°52′58″W / 43.2428°N 79.8828°W / 43.2428; -79.8828
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{{Infobox Organization
{{Infobox organization
|name = Firestone Institute for Respiratory Health
| name = Firestone Institute for Respiratory Health
|image = FIRHlogo128.png
| image = FIRHlogo128.png
|size = 128
| size = 128
|formation = 1978
| formation = 1978
|location = [[Hamilton, Ontario|Hamilton, ON, Canada]]
| location = [[Hamilton, Ontario]], Canada
⚫
| region_served = Hamilton Niagara Haldimand Brant
|address = 50 Charlton Avenue East
⚫
| language = English
⚫
|region_served = Hamilton Niagara Haldimand Brant
⚫
| leader_title = Executive Director
⚫
|language = English
⚫
| leader_name = Dr. [[Dawn Bowdish]]
⚫
|leader_title = Exec. Director
| leader_title2 = Research Director
⚫
|leader_name = Dr. Paul O'Byrne
| leader_name2 = Dr. Martin Kolb
|affiliations = St. Joseph's Healthcare
| affiliations = [[St. Joseph's Healthcare Hamilton]], [[McMaster University Medical School]], [[McMaster University]]
|num_staff = 30+
| num_staff = 30+
|website = [http://www.firh.ca firh.ca]
| website = [http://www.firh.ca firh.ca]
}}
}}


The '''Firestone Institute for Respiratory Health''' (FIRH) is a world-renowned center for the investigation and treatment of [[respiratory disease]]s. Based out of St. Joseph's Healthcare in [[Hamilton, Ontario|Hamilton, Ontario, Canada]], the institute is a clinical facility with strong research directions. FIRH faculty are also heavily involved at [[McMaster University]] with education at the undergraduate, graduate, post-graduate and continuing medical education levels.
The '''Firestone Institute for Respiratory Health''' (FIRH) is a center for the investigation and treatment of [[respiratory disease]]s. Based out of St. Joseph's Healthcare in [[Hamilton, Ontario]], Canada, the institute is a clinical facility with strong research directions. FIRH faculty are also heavily involved at [[McMaster University]] with education at the undergraduate, graduate, post-graduate and continuing medical education levels.


==History==
==History==


Founded in 1978 as the Firestone Regional Chest and Allergy Unit(FRCAU), the institute was designated as the Regional Referral Center by the District Health Council. The institute has maintained this designation, and as of 2006, it services the Hamilton Niagara Haldimand Brant Local Health Integration Network, a community of 1.4 million people. <ref name=firhhist>{{citation|title= Firestone Institute for Respiratory Health: History |url= http://www.firh.ca/Documents/firh_history.htm |accessdate= 2009-02-07 }}</ref> The institute's research developed in collaboration with clinical activities in order to comprehensively investigate mechanisms and outcomes. Accordingly, a number of [[asthma]] and [[Chronic obstructive pulmonary disease|COPD]] initiatives were launched, including the development of standardized techniques for symptom assessment, airflow limitation and [[bronchial hyperresponsiveness]]. Further investigations have included studies of exercise and allergen-induced bronchoconstriction as well as epidemiological studies examining the relationship between prevalence of respiratory illness and pollution.<ref name=Johnston>{{Citation |author=Johnston NW; Sears MR |title=The epidemiology of asthma exacerbations |journal=Thorax |volume=61 |issue=8 |pages=722–728 |year=2006 |pmid=16877691 |pmc=2104697 |url=http://thorax.bmj.com/cgi/content/abstract/61/8/722?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Johnston+N&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT |doi=10.1136/thx.2005.045161}}</ref>. From 2004-2005, the institute was relocated to four floors of the brand new Juravinski Innovation Tower, where more modern research laboratories and expanded clinical facilities were available.<ref name="firhhist" />
Founded in 1978 as the Firestone Regional Chest and Allergy Unit (FRCAU), the institute was designated as the Regional Referral Center by the District Health Council. The institute has maintained this designation, and as of 2006, it services the Hamilton Niagara Haldimand Brant Local Health Integration Network, a community of 1.4 million people.<ref name=firhhist>{{citation |title= Firestone Institute for Respiratory Health: History |url= http://www.firh.ca/Documents/firh_history.htm |accessdate= 2009-02-07 |archive-url= https://web.archive.org/web/20091004042022/http://www.firh.ca/Documents/firh_history.htm |archive-date= 2009-10-04 |url-status= dead }}</ref> The institute's research developed in collaboration with clinical activities in order to comprehensively investigate mechanisms and outcomes. Accordingly, a number of [[asthma]] and [[Chronic obstructive pulmonary disease|COPD]] initiatives were launched, including the development of standardized techniques for symptom assessment, airflow limitation and [[bronchial hyperresponsiveness]]. Further investigations have included studies of exercise and allergen-induced bronchoconstriction as well as epidemiological studies examining the relationship between prevalence of respiratory illness and pollution.<ref name=Johnston>{{Citation |author=Johnston NW; Sears MR |title=The epidemiology of asthma exacerbations |journal=Thorax |volume=61 |issue=8 |pages=722–728 |year=2006 |pmid=16877691 |pmc=2104697 |url=|doi=10.1136/thx.2005.045161}}</ref> From 2004-2005, the institute was relocated to four floors of the brand new Juravinski Innovation Tower, where more modern research laboratories and expanded clinical facilities were available.<ref name="firhhist" />


In early March 2009, Firestone researchers demonstrated that an experimental drug, [[mepolizumab]] can help reduce [[eosinophil]] production in sufferers of severe asthma.<ref>{{Citation |first=Paul |last=Taylor |title=Asthma Control |url=http://www.theglobeandmail.com/servlet/story/RTGAM.20090306.wldoses06/BNStory/specialScienceandHealth/ |work=The Globe and Mail |publisher=CTV Globe Media |location=Toronto |date= 6 March 2009 |accessdate=10 March 2009 }}</ref> The study, published in the [[New England Journal of Medicine]] found that treatment with mepolizumab allowed these patients to cut back on treatments of [[prednisone]].
In early March 2009, Firestone researchers demonstrated that an experimental drug, [[mepolizumab]] can help reduce [[eosinophil]] production in sufferers of severe asthma.<ref>{{Citation |first=Paul |last=Taylor |title=Asthma Control |url=https://www.theglobeandmail.com/servlet/story/RTGAM.20090306.wldoses06/BNStory/specialScienceandHealth/ |work=The Globe and Mail |publisher=CTV Globe Media |location=Toronto |date= 6 March 2009 |accessdate=10 March 2009 }}</ref> The study, published in the [[New England Journal of Medicine]] found that treatment with mepolizumab allowed these patients to cut back on treatments of [[prednisone]].


==Education==
==Education==


The FIRH has trained over 100 graduate students and post-doctoral fellows. In addition to this, the FIRH faculty currently teach numerous undergraduate and postgraduate courses at McMaster University.<ref name=firheducation>{{citation|title= Firestone Institute for Respiratory Health: About FIRH |url= http://www.firh.ca/Documents/about_firh.htm |accessdate= 2009-02-07 }}</ref>
The FIRH has trained over 100 graduate students and post-doctoral fellows. In addition to this, the FIRH faculty currently teach numerous undergraduate and postgraduate courses at McMaster University.<ref name=firheducation>{{citation |title= Firestone Institute for Respiratory Health: About FIRH |url= http://www.firh.ca/Documents/about_firh.htm |accessdate= 2009-02-07 |archive-url= https://web.archive.org/web/20091004042001/http://www.firh.ca/Documents/about_firh.htm |archive-date= 2009-10-04 |url-status= dead }}</ref>


==Research Pursuits==
==Research pursuits==


The following is a list of the research areas currently being investigated at the FIRH:<ref name=firhresearch>{{citation|title= Firestone Institute for Respiratory Health: Research Interests |url= http://www.firh.ca/Documents/research_resources.htm |accessdate= 2009-02-07 }}</ref>
The following is a list of the research areas currently being investigated at the FIRH:<ref name=firhresearch>{{citation |title= Firestone Institute for Respiratory Health: Research Interests |url= http://www.firh.ca/Documents/research_resources.htm |accessdate= 2009-02-07 }}{{Dead link|date=December 2019 |bot=InternetArchiveBot |fix-attempted=yes }}</ref>


*Population studies of asthma epidemiology and causation
*Population studies of asthma epidemiology and causation
Line 45: Line 46:
*Functional and structural imaging of the lung
*Functional and structural imaging of the lung
*Chronic cough
*Chronic cough

⚫
==External links==
⚫
* [http://www.firh.ca/index.htm Firestone Institute for Respiratory Health]


==References==
==References==
{{reflist}}
{{reflist}}

⚫
==External links==
⚫
* [https://web.archive.org/web/20090508143558/http://www.firh.ca/index.htm Firestone Institute for Respiratory Health]


{{McMaster}}
{{McMaster}}


{{coord|43.2428|N|79.8828|W|display=title}}
{{coord missing|Canada}}

{{authority control}}


{{DEFAULTSORT:Firestone Institute For Respiratory Health}}
[[Category:McMaster University]]
[[Category:McMaster University]]
[[Category:Research institutes in Canada]]
[[Category:Research institutes in Canada]]

Latest revision as of 21:11, 4 January 2024

Firestone Institute for Respiratory Health
Formation1978
Location
Region served
Hamilton Niagara Haldimand Brant
Official language
English
Executive Director
Dr. Dawn Bowdish
Research Director
Dr. Martin Kolb
AffiliationsSt. Joseph's Healthcare Hamilton, McMaster University Medical School, McMaster University
Staff30+
Websitefirh.ca

The Firestone Institute for Respiratory Health (FIRH) is a center for the investigation and treatment of respiratory diseases. Based out of St. Joseph's Healthcare in Hamilton, Ontario, Canada, the institute is a clinical facility with strong research directions. FIRH faculty are also heavily involved at McMaster University with education at the undergraduate, graduate, post-graduate and continuing medical education levels.

History

[edit]

Founded in 1978 as the Firestone Regional Chest and Allergy Unit (FRCAU), the institute was designated as the Regional Referral Center by the District Health Council. The institute has maintained this designation, and as of 2006, it services the Hamilton Niagara Haldimand Brant Local Health Integration Network, a community of 1.4 million people.[1] The institute's research developed in collaboration with clinical activities in order to comprehensively investigate mechanisms and outcomes. Accordingly, a number of asthma and COPD initiatives were launched, including the development of standardized techniques for symptom assessment, airflow limitation and bronchial hyperresponsiveness. Further investigations have included studies of exercise and allergen-induced bronchoconstriction as well as epidemiological studies examining the relationship between prevalence of respiratory illness and pollution.[2] From 2004-2005, the institute was relocated to four floors of the brand new Juravinski Innovation Tower, where more modern research laboratories and expanded clinical facilities were available.[1]

In early March 2009, Firestone researchers demonstrated that an experimental drug, mepolizumab can help reduce eosinophil production in sufferers of severe asthma.[3] The study, published in the New England Journal of Medicine found that treatment with mepolizumab allowed these patients to cut back on treatments of prednisone.

Education

[edit]

The FIRH has trained over 100 graduate students and post-doctoral fellows. In addition to this, the FIRH faculty currently teach numerous undergraduate and postgraduate courses at McMaster University.[4]

Research pursuits

[edit]

The following is a list of the research areas currently being investigated at the FIRH:[5]

  • Population studies of asthma epidemiology and causation
  • Studies of asthma management utilizing biomarkers of inflammation
  • Investigation of novel pharmaceutical therapies for asthma
  • Investigation of novel procedural therapies for asthma and COPD
  • Mechanisms of airway hyperresponsiveness and airway remodelling
  • Trafficking and lung homing of bone-marrow derived hemopoietic stem cells in allergic asthma and COPD
  • Immunobiology of allergic asthma
  • Control of airway and vascular smooth muscle structure, function and intracellular signalling
  • COPD epidemiology and treatment
  • COPD and Respiratory Rehabilitation
  • Pathobiology of pulmonary fibrosis
  • Clinical trial center for idiopathic pulmonary fibrosis
  • Functional and structural imaging of the lung
  • Chronic cough

References

[edit]
  1. ^ a b Firestone Institute for Respiratory Health: History, archived from the original on 2009-10-04, retrieved 2009-02-07
  2. ^ Johnston NW; Sears MR (2006), "The epidemiology of asthma exacerbations", Thorax, 61 (8): 722–728, doi:10.1136/thx.2005.045161, PMC 2104697, PMID 16877691{{citation}}: CS1 maint: multiple names: authors list (link)
  3. ^ Taylor, Paul (6 March 2009), "Asthma Control", The Globe and Mail, Toronto: CTV Globe Media, retrieved 10 March 2009
  4. ^ Firestone Institute for Respiratory Health: About FIRH, archived from the original on 2009-10-04, retrieved 2009-02-07
  5. ^ Firestone Institute for Respiratory Health: Research Interests, retrieved 2009-02-07[permanent dead link‍]
[edit]

43°14′34″N 79°52′58″W / 43.2428°N 79.8828°W / 43.2428; -79.8828

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