CTTNBP2: Difference between revisions

CTTNBP2
Identifiers
Aliases	CTTNBP2, C7orf8, CORTBP2, Orf4, cortactin binding protein 2
External IDs	OMIM: 609772; MGI: 1353467; HomoloGene: 14125; GeneCards: CTTNBP2; OMA:CTTNBP2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	117,874,139 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	18,514,842 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; ganglionic eminence; ; subthalamic nucleus; ; inferior ganglion of vagus nerve; ; pars reticulata; ; lateral nuclear group of thalamus; ; primary visual cortex; ; endothelial cell; ; external globus pallidus; ; C1 segment;
	Top expressed in
	lateral septal nucleus; ; subiculum; ; lateral geniculate nucleus; ; piriform cortex; ; medial geniculate nucleus; ; superior cervical ganglion; ; medial dorsal nucleus; ; olfactory tubercle; ; visual cortex; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	SH3 domain binding;
Cellular component	cytoplasm; dendritic spine; cell projection; cell cortex; synaptic vesicle; postsynaptic actin cytoskeleton; glutamatergic synapse;
Biological process	brain development; regulation of synapse organization; regulation of modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologs
	83992
	30785
	ENSG00000077063
	ENSMUSG00000000416
	Q8WZ74
	B9EJA2
	NM_033427; NM_001363349; NM_001363350; NM_001363351
	NM_080285
	NP_219499; NP_001350278; NP_001350279; NP_001350280
	NP_525024
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 10:31, 13 January 2024

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.^[5]^[6]

Function

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.^[6]

Interactions

CTTNBP2 has been shown to interact with:

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000077063 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000416 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.
^ ^a ^b "Entrez Gene: CTTNBP2 cortactin binding protein 2".
^ ^a ^b ^c ^d ^e Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

External links

Human CTTNBP2 genome location and CTTNBP2 gene details page in the UCSC Genome Browser.

Ohoka Y, Takai Y (1998). "Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90". Genes Cells. 3 (9): 603–12. doi:10.1046/j.1365-2443.1998.00216.x. PMID 9813110. S2CID 22413036.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D (2004). "Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei". J. Cell Biol. 166 (6): 815–25. doi:10.1083/jcb.200404107. PMC 2172106. PMID 15364959.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000077063 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000416 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11707066-5] Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.

[entrez-6] "Entrez Gene: CTTNBP2 cortactin binding protein 2".

[pmid18782753-7] Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{cs1 config|name-list-style=vanc}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Cortactin-binding protein 2''' is a [[protein]] that in humans is encoded by the ''CTTNBP2'' [[gene]].<ref name="pmid11707066">{{cite journal | vauthors = Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW | title = Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 | journal = Genomics | volume = 78 | issue = 1–2 | pages = 7–11  | date = Nov 2001 | pmid = 11707066 | doi = 10.1006/geno.2001.6651 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992}}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+== Function ==
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Cortactin binding protein 2
- | HGNCid = 15679
- | Symbol = CTTNBP2
- | AltSymbols =; C7orf8; CORTBP2; FLJ34229; KIAA1758; MGC104579; Orf4
- | OMIM = 609772
- | ECnumber =
- | Homologene = 14125
- | MGIid = 1353467
- | GeneAtlas_image1 = PBB_GE_CTTNBP2_gnf1h06054_at_tn.png
- | Function =
- | Component =
- | Process =
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 83992
-    | Hs_Ensembl = ENSG00000077063
-    | Hs_RefseqProtein = NP_219499
-    | Hs_RefseqmRNA = NM_033427
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 117137944
-    | Hs_GenLoc_end = 117300797
-    | Hs_Uniprot = Q8WZ74
-    | Mm_EntrezGene = 30785
-    | Mm_Ensembl = ENSMUSG00000000416
-    | Mm_RefseqmRNA = XM_001000629
-    | Mm_RefseqProtein = XP_001000629
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 6
-    | Mm_GenLoc_start = 18316565
-    | Mm_GenLoc_end = 18464749
-    | Mm_Uniprot =
-  }}
-}}
-'''Cortactin binding protein 2''', also known as '''CTTNBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992| accessdate = }}</ref>
+This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.<ref name="entrez" />
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
+== Interactions ==
-| section_title =
-| summary_text = This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.<ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992| accessdate = }}</ref>
+CTTNBP2 has been shown to [[Protein-protein interaction|interact]] with:
-}}
+* [[MOBKL3]],<ref name = pmid18782753/>
+* [[PPP2CA]],<ref name = pmid18782753/>
+* [[RP6-213H19.1]],<ref name = pmid18782753>{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Mol. Cell. Proteomics | volume = 8 | issue = 1 | pages = 157–71  | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | doi-access = free }}</ref>
+* [[STRN3]],<ref name = pmid18782753/>  and
+* [[STRN]].<ref name = pmid18782753/>
 ==References==
 {{reflist}}
-==Further reading==
+==External links==
+* {{UCSC gene info|CTTNBP2}}
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Ohoka Y, Takai Y | title = Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90 | journal = Genes Cells | volume = 3 | issue = 9 | pages = 603–12 | year = 1998 | pmid = 9813110 | doi = 10.1046/j.1365-2443.1998.00216.x | s2cid = 22413036 | doi-access = free }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347–55 | year = 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 | doi-access = free }}
-| citations =
-*{{cite journal  | author=Ohoka Y, Takai Y |title=Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. |journal=Genes Cells |volume=3 |issue= 9 |pages= 603-12 |year= 1998 |pmid= 9813110 |doi=  }}
+* {{cite journal | vauthors = Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D | title = Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei | journal = J. Cell Biol. | volume = 166 | issue = 6 | pages = 815–25 | year = 2004 | pmid = 15364959 | pmc = 2172106 | doi = 10.1083/jcb.200404107 }}
-*{{cite journal  | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347-55 |year= 2001 |pmid= 11214970 |doi=  }}
-*{{cite journal  | author=Cheung J, Petek E, Nakabayashi K, ''et al.'' |title=Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31. |journal=Genomics |volume=78 |issue= 1-2 |pages= 7-11 |year= 2002 |pmid= 11707066 |doi= 10.1006/geno.2001.6651 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
-*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
-*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Zink D, Amaral MD, Englmann A, ''et al.'' |title=Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. |journal=J. Cell Biol. |volume=166 |issue= 6 |pages= 815-25 |year= 2004 |pmid= 15364959 |doi= 10.1083/jcb.200404107 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-}}
 {{refend}}
 {{gene-7-stub}}