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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=83992}}
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'''Cortactin binding protein 2''', also known as '''CTTNBP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992| accessdate = }}</ref>
{{Infobox_gene}}
'''Cortactin-binding protein 2''' is a [[protein]] that in humans is encoded by the ''CTTNBP2'' [[gene]].<ref name="pmid11707066">{{cite journal | vauthors = Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW | title = Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31 | journal = Genomics | volume = 78 | issue = 1–2 | pages = 7–11 | date = Nov 2001 | pmid = 11707066 | doi = 10.1006/geno.2001.6651 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992}}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->

{{PBB_Summary
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This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.<ref name="entrez" />
| section_title =

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| summary_text = This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.<ref name="entrez">{{cite web | title = Entrez Gene: CTTNBP2 cortactin binding protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=83992| accessdate = }}</ref>
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== Interactions ==
}}

CTTNBP2 has been shown to [[Protein-protein interaction|interact]] with:
* [[MOBKL3]],<ref name = pmid18782753/>
* [[PPP2CA]],<ref name = pmid18782753/>
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* [[RP6-213H19.1]],<ref name = pmid18782753>{{cite journal | vauthors = Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC | title = A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein | journal = Mol. Cell. Proteomics | volume = 8 | issue = 1 | pages = 157–71 | date = Jan 2009 | pmid = 18782753 | pmc = 2621004 | doi = 10.1074/mcp.M800266-MCP200 | doi-access = free }}</ref>
* [[STRN3]],<ref name = pmid18782753/> and
* [[STRN]].<ref name = pmid18782753/>


⚫
==Interactions==
⚫
'''CTTNBP2''' has been shown to [[Protein-protein_interaction|interact]] with [[RP6-213H19.1]], [[STRN]], [[STRN3]], [[MOBKL3]] and [[PPP2CA]].<ref name=pmid18782753>{{cite journal | quotes = yes |last=Goudreault |first=Marilyn |authorlink= |coauthors=D&apos;Ambrosio Lisa M, Kean Michelle J, Mullin Michael J, Larsen Brett G, Sanchez Amy, Chaudhry Sidharth, Chen Ginny I, Sicheri Frank, Nesvizhskii Alexey I, Aebersold Ruedi, Raught Brian, Gingras Anne-Claude |year=[[2009]]|month=Jan. |title=A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein |journal=[[Mol. Cell Proteomics]] |volume=8 |issue=1 |pages=157-71 |publisher= |location = [[United States]]| issn = | pmid = 18782753 |doi = 10.1074/mcp.M800266-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==References==
==References==
{{reflist}}
{{reflist}}

⚫
==Further reading==
==External links==
* {{UCSC gene info|CTTNBP2}}

⚫
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Ohoka Y, Takai Y | title = Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90 | journal = Genes Cells | volume = 3 | issue = 9 | pages = 603–12 | year = 1998 | pmid = 9813110 | doi = 10.1046/j.1365-2443.1998.00216.x | s2cid = 22413036 | doi-access = free }}
{{PBB_Further_reading
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* {{cite journal | vauthors = Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res. | volume = 7 | issue = 6 | pages = 347–55 | year = 2000 | pmid = 11214970 | doi = 10.1093/dnares/7.6.347 | doi-access = free }}
| citations =
*{{cite journal | author=Ohoka Y, Takai Y |title=Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. |journal=Genes Cells |volume=3 |issue= 9 |pages= 603–12 |year= 1998 |pmid= 9813110 |doi=10.1046/j.1365-2443.1998.00216.x }}
* {{cite journal | vauthors = Zink D, Amaral MD, Englmann A, Lang S, Clarke LA, Rudolph C, Alt F, Luther K, Braz C, Sadoni N, Rosenecker J, Schindelhauer D | title = Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei | journal = J. Cell Biol. | volume = 166 | issue = 6 | pages = 815–25 | year = 2004 | pmid = 15364959 | pmc = 2172106 | doi = 10.1083/jcb.200404107 }}
⚫
*{{cite journal | author=Nagase T, Kikuno R, Hattori A, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 6 |pages= 347–55 |year= 2001 |pmid= 11214970 |doi=10.1093/dnares/7.6.347 }}
*{{cite journal | author=Cheung J, Petek E, Nakabayashi K, ''et al.'' |title=Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31. |journal=Genomics |volume=78 |issue= 1-2 |pages= 7–11 |year= 2002 |pmid= 11707066 |doi= 10.1006/geno.2001.6651 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Zink D, Amaral MD, Englmann A, ''et al.'' |title=Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. |journal=J. Cell Biol. |volume=166 |issue= 6 |pages= 815–25 |year= 2004 |pmid= 15364959 |doi= 10.1083/jcb.200404107 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
{{refend}}
{{refend}}


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{{gene-7-stub}}


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{{gene-7-stub}}
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Latest revision as of 10:31, 13 January 2024

CTTNBP2
Identifiers
AliasesCTTNBP2, C7orf8, CORTBP2, Orf4, cortactin binding protein 2
External IDsOMIM: 609772; MGI: 1353467; HomoloGene: 14125; GeneCards: CTTNBP2; OMA:CTTNBP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

83992

30785

Ensembl

ENSG00000077063

ENSMUSG00000000416

UniProt

Q8WZ74

B9EJA2

RefSeq (mRNA)

NM_033427
NM_001363349
NM_001363350
NM_001363351

NM_080285

RefSeq (protein)

NP_219499
NP_001350278
NP_001350279
NP_001350280

NP_525024

Location (UCSC)Chr 7: 117.71 – 117.87 MbChr 6: 18.37 – 18.51 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cortactin-binding protein 2 is a protein that in humans is encoded by the CTTNBP2 gene.[5][6]

Function

[edit]

This gene encodes a protein with six ankyrin repeats and several proline-rich regions. A similar gene in rat interacts with a central regulator of the actin cytoskeleton.[6]

Interactions

[edit]

CTTNBP2 has been shown to interact with:

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000077063 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000416 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cheung J, Petek E, Nakabayashi K, Tsui LC, Vincent JB, Scherer SW (Nov 2001). "Identification of the human cortactin-binding protein-2 gene from the autism candidate region at 7q31". Genomics. 78 (1–2): 7–11. doi:10.1006/geno.2001.6651. PMID 11707066.
  6. ^ a b "Entrez Gene: CTTNBP2 cortactin binding protein 2".
  7. ^ a b c d e Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Mol. Cell. Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
[edit]

Further reading

[edit]


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