Flavonol 3-sulfotransferase: Difference between revisions

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flavonol 3-sulfotransferase
flavonol 3-sulfotransferase
Identifiers
EC no.	2.8.2.25
CAS no.	121855-10-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PubMed	articles
NCBI	proteins

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Latest revision as of 18:35, 23 January 2024

In enzymology, a flavonol 3-sulfotransferase (EC 2.8.2.25) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + flavonol

\rightleftharpoons

adenosine 3',5'-bisphosphate + flavonol 3-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and a flavonol, whereas its two products are adenosine 3',5'-bisphosphate and flavonol 3-sulfate. A specific examples of a flavonol that can act as a substrate is quercetin.^[1]

This enzyme belongs to the family of transferases termed the sulfotransferases, which transfer sulfate groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:flavonol 3-sulfotransferase.

References

^ Varin L, Ibrahim RK (July 1989). "Partial Purification and Characterization of Three Flavonol-Specific Sulfotransferases from Flaveria chloraefolia". Plant Physiology. 90 (3): 977–81. doi:10.1104/pp.90.3.977. PMC 1061831. PMID 16666908.

This EC 2.8 enzyme-related article is a stub. You can help Wikipedia by expanding it.

[1] Varin L, Ibrahim RK (July 1989). "Partial Purification and Characterization of Three Flavonol-Specific Sulfotransferases from Flaveria chloraefolia". Plant Physiology. 90 (3): 977–81. doi:10.1104/pp.90.3.977. PMC 1061831. PMID 16666908.

[1]

@@ Line 1: / Line 1: @@
+{{Short description|Class of enzymes}}
+{{infobox enzyme
+| Name       = flavonol 3-sulfotransferase
+| EC_number  = 2.8.2.25
+| CAS_number = 121855-10-5
+| GO_code    = 0047894
+| image      =
+| width      =
+| caption    =
+}}
 In [[enzymology]], a '''flavonol 3-sulfotransferase''' ({{EC number|2.8.2.25}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
-:3'-phosphoadenylyl sulfate + quercetin <math>\rightleftharpoons</math> adenosine 3',5'-bisphosphate + quercetin 3-sulfate
+:3'-phosphoadenylyl sulfate + flavonol<math>\rightleftharpoons</math> adenosine 3',5'-bisphosphate + flavonol 3-sulfate
-Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3'-phosphoadenylyl sulfate]] and [[quercetin]], whereas its two [[product (chemistry)|products]] are [[adenosine 3',5'-bisphosphate]] and [[quercetin 3-sulfate]].
+Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3'-phosphoadenylyl sulfate]] and a [[flavonol]], whereas its two [[product (chemistry)|products]] are [[adenosine 3',5'-bisphosphate]] and [[flavonol 3-sulfate]]. A specific examples of a flavonol that can act as a substrate is [[quercetin]].<ref>{{cite journal | vauthors = Varin L, Ibrahim RK | title = Partial Purification and Characterization of Three Flavonol-Specific Sulfotransferases from Flaveria chloraefolia | journal = Plant Physiology | volume = 90 | issue = 3 | pages = 977–81 | date = July 1989 | pmid = 16666908 | pmc = 1061831 | doi = 10.1104/pp.90.3.977 }}</ref>
-This enzyme belongs to the family of [[transferase]]s, specifically the sulfotransferases, which transfer sulfur-containing groups.  The systematic name of this enzyme class is '''3'-phosphoadenylyl-sulfate:quercetin 3-sulfotransferase'''.
+This enzyme belongs to the family of [[transferase]]s termed the [[sulfotransferase]]s, which transfer sulfate groups.  The [[List of enzymes|systematic name]] of this enzyme class is '''3'-phosphoadenylyl-sulfate:flavonol 3-sulfotransferase'''.
-==References==
+== References ==
-{{reflist|1}}
+{{reflist}}
-{{Enzyme references|EC_number=2.8.2.25|IUBMB_EC_number=2/8/2/25}}
-* {{cite journal | author = Varin L and Ibrahim RK | date = 1989 | title = Partial purification and characterization of 3 flavonol-specific sulfotransferases from Flaveria chloraefolia | journal = Plant Physiol.  | volume = 90 | pages = 977&ndash;981 }}
+{{Sulfur-containing group transferases}}
-==External links==
+{{Enzymes}}
-::''The [[CAS registry number]] for this enzyme class is {{CAS registry|121855-10-5}}.''
+{{Portal bar|Biology|border=no}}
-{{Enzyme links|EC_number=2.8.2.25|IUBMB_EC_number=2/8/2/25}}
-===Gene Ontology (GO) codes===
-{{GO code links | GO_code=0047894 | name=flavonol 3-sulfotransferase}}
-{{transferase-stub}}
 [[Category:EC 2.8.2]]
 [[Category:Enzymes of unknown structure]]
+{{2.8-enzyme-stub}}

v t e Transferases: sulfur-containing group (EC 2.8)
2.8.1: Sulfurtransferases	Thiosulfate sulfurtransferase Rhodanese 3-mercaptopyruvate sulfurtransferase thiosulfate—thiol sulfurtransferase tRNA sulfurtransferase thiosulfate—dithiol sulfurtransferase biotin synthase cysteine desulfurase lipoyl synthase molybdenum cofactor sulfurtransferase thiazole synthase molybdopterin synthase sulfurtransferase molybdopterin synthase tRNA-uridine 2-sulfurtransferase () tRNA-5-taurinomethyluridine 2-sulfurtransferase () tRNA-5-methyluridine⁵⁴ 2-sulfurtransferase () L-aspartate semialdehyde sulfurtransferase ()
2.8.2: Sulfotransferases	aryl sulfotransferase amine sulfotransferase estrone sulfotransferase chondroitin 4-sulfotransferase choline sulfotransferase UDP-N-acetylgalactosamine-4-sulfate sulfotransferase heparan sulfate-glucosamine N-sulfotransferase tyrosine-ester sulfotransferase Renilla-luciferin sulfotransferase galactosylceramide sulfotransferase psychosine sulfotransferase bile salt sulfotransferase steroid sulfotransferase thiol sulfotransferase chondroitin 6-sulfotransferase cortisol sulfotransferase triglucosylalkylacylglycerol sulfotransferase protein-tyrosine sulfotransferase keratan sulfotransferase aryl-sulfate sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 1 desulfoglucosinolate sulfotransferase flavonol 3-sulfotransferase quercetin-3-sulfate 3′-sulfotransferase quercetin-3-sulfate 4′-sulfotransferase quercetin-3,3′-bissulfate 7-sulfotransferase (heparan sulfate)-glucosamine 3-sulfotransferase 2 (heparan sulfate)-glucosamine 3-sulfotransferase 3 petromyzonol sulfotransferase scymnol sulfotransferase N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase glycochenodeoxycholate sulfotransferase dermatan 4-sulfotransferase desulfo-A47934 sulfotransferase () trehalose 2-sulfotransferase () aliphatic desulfoglucosinolate sulfotransferase () hydroxyjasmonate sulfotransferase () ω-hydroxy-β-dihydromenaquinone-9 sulfotransferase (*) Alcohol sulfotransferase Tyrosylprotein sulfotransferase
2.8.3: CoA-transferases	Propionate CoA-transferase oxalate CoA-transferase malonate CoA-transferase 3-oxoacid CoA-transferase 3-oxoadipate CoA-transferase succinyl-CoA—Dcitramalate CoA-transferase acetate CoA-transferase butyrate—acetoacetate CoA-transferase citrate CoA-transferase citramalate CoA-transferase glutaconate CoA-transferase succinate—hydroxymethylglutarate CoA-transferase 5-hydroxypentanoate CoA-transferase succinyl-CoA:(R)-benzylsuccinate CoA-transferase formyl-CoA transferase cinnamoyl-CoA:phenyllactate CoA-transferase succinyl-CoA:acetate CoA-transferase () CoA:oxalate CoA-transferase () succinyl-CoA—D-citramalate CoA-transferase () L-carnitine CoA-transferase () succinyl-CoA—L-malate CoA-transferase () caffeate CoA-transferase () (R)-2-hydroxy-4-methylpentanoate CoA-transferase () bile acid CoA-transferase () succinyl-CoA:mesaconate CoA transferase (*)
2.8.4: Alkylthio	2.8.4: Coenzyme-B sulfoethylthiotransferase arsenate-mycothiol transferase tRNA-2-methylthio-N⁶-dimethylallyladenosine synthase () [ribosomal protein S12] (aspartate⁸⁹-C³)-methylthiotransferase () tRNA (N⁶-L-threonylcarbamoyladenosine³⁷-C²)-methylthiotransferase (*)
2.8.5:	2.8.5: S-sulfo-L-cysteine synthase (3-phospho-L-serine-dependent) () L-cysteine S-thiosulfotransferase ()

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)